Florence APPARAILLY

Documents

Publications

	Gender Equity in Academic Rheumatology, Current Status and Potential for Improvement: A Cross-Sectional Study to Inform an EULAR Task Force Pavel V Ovseiko , Laure Gossec , Laura Andreoli , Uta Kiltz , Leonieke Van Mens RMD Open, 2022, 8 (2), pp.e002518. ⟨10.1136/rmdopen-2022-002518⟩ Article dans une revue hal-03879085v1
	miRNA profile at diagnosis predicts treatment outcome in patients with B-chronic lymphocytic leukemia: A FILO study Isabelle Duroux-Richard , Anne-Laure Gagez , Elina Alaterre , Rémi Letestu , Olfa Khalifa Frontiers in Immunology, 2022, 13, pp.983771. ⟨10.3389/fimmu.2022.983771⟩ Article dans une revue hal-03946290v1
	Integrative Analysis of Human Macrophage Inflammatory Response Related to Mycobacterium tuberculosis Virulence Pauline Bade , Fabrizio Simonetti , Stephanie Sans , Patricia Laboudie , Khadija Kissane Frontiers in Immunology, 2021, 12, pp.668060. ⟨10.3389/fimmu.2021.668060⟩ Article dans une revue hal-03714483v1
	'SMASH' recommendations for standardised microscopic arthritis scoring of histological sections from inflammatory arthritis animal models Silvia Hayer , Margriet J Vervoordeldonk , Maria C Denis , Marietta Armaka , Markus Hoffmann Annals of the Rheumatic Diseases, 2021, pp.annrheumdis-2020-219247. ⟨10.1136/annrheumdis-2020-219247⟩ Article dans une revue hal-03157626v1
	Mitochondrial MicroRNAs Contribute to Macrophage Immune Functions Including Differentiation, Polarization, and Activation Isabelle Duroux-Richard , Florence Apparailly , Maroun Khoury Frontiers in Physiology, 2021, 12, pp.738140. ⟨10.3389/fphys.2021.738140⟩ Article dans une revue hal-03413128v1
	TNFR1-d2 carrying the p.(Thr79Met) pathogenic variant is a potential novel actor of TNFα/TNFR1 signalling regulation in the pathophysiology of TRAPS Cécile Rittore , Déborah Méchin , Elodie Sanchez , Léa Marinèche , Vuthy Ea Scientific Reports, 2021, 11, pp.4172. ⟨10.1038/s41598-021-83539-9⟩ Article dans une revue hal-03145389v1
	POLR1B and neural crest cell anomalies in Treacher Collins syndrome type 4 Elodie Sanchez , Béryl Laplace-Builhé , Frédéric Tran Mau-Them , Eric Richard , Alice Goldenberg Genetics in Medicine, 2020, 22 (3), pp.547-556. ⟨10.1038/s41436-019-0669-9⟩ Article dans une revue hal-02549940v1
	Dissecting the phenotypic and functional heterogeneity of mouse inflammatory osteoclasts by the expression of Cx3cr1 Maria-Bernadette Madel , Lidia Ibáñez , Thomas Ciucci , Julia Halper , Matthieu Rouleau eLife, 2020, 9, ⟨10.7554/eLife.54493⟩ Article dans une revue hal-03048183v1
	Differential Accumulation and Activation of Monocyte and Dendritic Cell Subsets in Inflamed Synovial Fluid Discriminates Between Juvenile Idiopathic Arthritis and Septic Arthritis Maïlys Cren , Nadège Nziza , Aurélia Carbasse , Perrine Mahe , Emilie Dufourcq-Lopez Frontiers in Immunology, 2020, 11, pp.1716. ⟨10.3389/fimmu.2020.01716⟩ Article dans une revue hal-02965159v1
	Clinical and Molecular Spectrum of Nonsyndromic Early‐Onset Osteoarthritis Valentin Ruault , Kevin Yauy , Aurélie Fabre , Mélanie Fradin , Julien Van-Gils Arthritis & rheumatology, 2020, 72 (10), pp.1689 - 1693. ⟨10.1002/art.41387⟩ Article dans une revue hal-03714570v1
	Immune Function and Diversity of Osteoclasts in Normal and Pathological Conditions Maria-Bernadette Madel , Lidia Ibáñez , Abdelilah Wakkach , Teun de Vries , Anna Teti Frontiers in Immunology, 2019, 10, ⟨10.3389/fimmu.2019.01408⟩ Article dans une revue hal-02402778v1
	Arthritis sensory and motor scale: predicting functional deficits from the clinical score in collagen-induced arthritis Anne-Laure Mausset-Bonnefont , Maïlys Cren , Rita Vicente , Julie Quentin , Christian Jorgensen Arthritis Research and Therapy, 2019, 21 (264), ⟨10.1186/s13075-019-2047-z⟩ Article dans une revue hal-02397115v1
	MicroRNAs: Fine Tuners of Monocyte Heterogeneity Isabelle Duroux-Richard , Maxime Robin , Cindy Peillex , Florence Apparailly Frontiers in Immunology, 2019, 10, pp.2145. ⟨10.3389/fimmu.2019.02145⟩ Article dans une revue hal-03714574v1
	MicroRNAs: Key Regulators to Understand Osteoclast Differentiation? Claire Lozano , Isabelle Duroux-Richard , Hüseyin Firat , Eric Schordan , Florence Apparailly Frontiers in Immunology, 2019, 10, ⟨10.3389/fimmu.2019.00375⟩ Article dans une revue hal-02874993v1
	MicroRNAs in juvenile idiopathic arthritis: can we learn more about pathophysiological mechanisms? Nadege Nziza , Isabelle Duroux-Richard , Florence Apparailly Autoimmunity Reviews, 2019, 18 (8), pp.796-804. ⟨10.1016/j.autrev.2019.06.006⟩ Article dans une revue hal-03024109v1
	Synovial-Fluid miRNA Signature for Diagnosis of Juvenile Idiopathic Arthritis Nadege Nziza , Eric Jeziorski , Marion Delpont , Maïlys Cren , Hugues Chevassus Cells, 2019, 8 (12), pp.1521. ⟨10.3390/cells8121521⟩ Article dans une revue hal-02389053v1
	LARP7 variants and further delineation of the Alazami syndrome phenotypic spectrum among primordial dwarfisms: 2 sisters Marion Imbert-Bouteille , Frédéric Tran Mau Them , Julien Thevenon , Thomas Guignard , Vincent Gatinois European Journal of Medical Genetics, 2019, 62 (3), pp.161-166. ⟨10.1016/j.ejmg.2018.07.003⟩ Article dans une revue hal-01845043v1
	Advanced microRNA-based cancer diagnostics using amplified time-gated FRET Xue Qiu , Jingyue Xu , Jiajia Guo , Akram Yahia-Ammar , Nikiforos-Ioannis Kapetanakis Chemical Science, 2018, 9 (42), pp.8046--8055. ⟨10.1039/c8sc03121e⟩ Article dans une revue hal-02183316v1
	Beneficial Effect of Alcohol Withdrawal on Gut Permeability and Microbial Translocation in Patients with Alcohol Use Disorder Hélène Donnadieu-Rigole , Nathalie Pansu , Thibault Mura , Stéphanie Pelletier , Régis Alarcon Alcoholism: Clinical and Experimental Research, 2018, 42 (1), pp.32 - 40. ⟨10.1111/acer.13527⟩ Article dans une revue hal-01845044v1
	Delivery of miR-146a to Ly6C high Monocytes Inhibits Pathogenic Bone Erosion in Inflammatory Arthritis Meryem Ammari , Jessy Presumey , Clara Ponsolles , Gautier Roussignol , Christine Roubert Theranostics, 2018, 8 (21), pp.5972-5985. ⟨10.7150/thno.29313⟩ Article dans une revue hal-02309187v1
	Regenerative medicine: Breaking Prometheus's curse for cartilage regeneration Florence Apparailly Nature Reviews Rheumatology, 2017, 13 (9), pp.516 - 518. ⟨10.1038/nrrheum.2017.116⟩ Article dans une revue hal-01845049v1
	TMEM187-IRAK1 Polymorphisms Associated with Rheumatoid Arthritis Susceptibility in Tunisian and French Female Populations: Influence of Geographic Origin Olfa Khalifa , Nathalie Balandraud , Nathalie Lambert , Isabelle Auger , Jean Roudier Journal of Immunology Research, 2017, 2017, pp.1 - 12 / 4915950. ⟨10.1155/2017/4915950⟩ Article dans une revue hal-01488124v1
	miR-125b and miR-532-3p predict the efficiency of rituximab-mediated lymphodepletion in chronic lymphocytic leukemia patients. A French Innovative Leukemia Organization study. Anne-Laure Gagez , Isabelle Duroux-Richard , Stéphane Leprêtre , Frédérique Orsini-Piocelle , Rémi Letestu Haematologica, 2017, 102 (4), pp.746-754. ⟨10.3324/haematol.2016.153189⟩ Article dans une revue hal-01568353v1
	A new autoinflammatory and autoimmune syndrome associated with NLRP1 mutations: NAIAD ( NLRP1- associated autoinflammation with arthritis and dyskeratosis) Sylvie Grandemange , Elodie Sanchez , Pascale Louis-Plence , Frederic Tran Mau-Them , Didier Bessis Annals of the Rheumatic Diseases, 2017, 76 (7), pp.1191 - 1198. ⟨10.1136/annrheumdis-2016-210021⟩ Article dans une revue hal-01796999v1
	CRISPR-Cas9: A revolution in genome editing in rheumatic diseases Isabelle Duroux-Richard , Carine Giovannangeli , Florence Apparailly Joint Bone Spine, 2017, 84 (1), pp.1 - 4. ⟨10.1016/j.jbspin.2016.09.012⟩ Article dans une revue hal-01845048v1
	microRNA target prediction programs predict many false positives Natalia Pinzón , Blaise Li , Laura Martinez , Anna Sergeeva , Jessy Presumey Genome Research, 2017, 27 (2), pp.234 - 245. ⟨10.1101/gr.205146.116⟩ Article dans une revue hal-01845045v1
	Erratum: Deregulation and therapeutic potential of microRNAs in arthritic diseases Rita Vicente , Danièle Noël , Yves-Marie Pers , Florence Apparailly , Christian Jorgensen Nature Reviews Rheumatology, 2016, 12 (8), pp.496 - 496. ⟨10.1038/nrrheum.2016.119⟩ Article dans une revue hal-01844606v1
	X-Linked miRNAs Associated with Gender Differences in Rheumatoid Arthritis Olfa Khalifa , Yves-Marie Pers , Rosanna Ferreira , Audrey Sénéchal , Christian Jorgensen International Journal of Molecular Sciences, 2016, 17 (11), pp.1852. ⟨10.3390/ijms17111852⟩ Article dans une revue hal-01815741v1
	Effects of alcohol withdrawal on monocyte subset defects in chronic alcohol users Hélène Donnadieu-Rigole , Thibault Mura , Pierre Portales , Isabelle Duroux-Richard , Martine Bouthier Journal of Leukocyte Biology, 2016, 100 (5), pp.1191 - 1199. ⟨10.1189/jlb.5A0216-060RR⟩ Article dans une revue hal-01845051v1
	Deregulation and therapeutic potential of microRNAs in arthritic diseases Rita Vicente , Danièle Noël , Yves-Marie Pers , Florence Apparailly , Christian Jorgensen Nature Reviews Rheumatology, 2016, 12 (4), pp.211 - 220. ⟨10.1038/nrrheum.2015.162⟩ Article dans une revue hal-01834238v1
	miR-125b controls monocyte adaptation to inflammation through mitochondrial metabolism and dynamics Isabelle Duroux-Richard , Christine Roubert , Meryem Ammari , Jessy Presumey , Joachim Grün Blood, 2016, 128 (26), pp.3125-3136. ⟨10.1182/blood-2016-02-697003⟩ Article dans une revue hal-01818909v1
	Inhibition of Inflammation and Bone Erosion by RNA Interference-Mediated Silencing of Heterogeneous Nuclear RNP A2/B1 in Two Experimental Models of Rheumatoid Arthritis Sonja Herman , Anita Fischer , Jessy Presumey , Markus Hoffmann , Marije Koenders Arthritis & rheumatology, 2015, 67 (9), pp.2536 - 2546. ⟨10.1002/art.39223⟩ Article dans une revue hal-01845054v1
	A4.4 MIR-146A deficiency in LY6C high monocytes contributes to pathogenic bone loss during inflammatory arthritis M Ammari , Isabelle Duroux-Richard , P Presumey , C Ponsolles , G Roussignol Annals of the Rheumatic Diseases, 2015, 74 (Suppl 1), pp.A37.2 - A38. ⟨10.1136/annrheumdis-2015-207259.86⟩ Article dans une revue hal-01834614v1
	MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers Isabelle Duroux-Richard , Jimena Cuenca , Clara Ponsolles , Alejandro Badilla Piñeiro , Fernando Gonzalez International Journal of Molecular Sciences, 2015, 16 (8), pp.16953 - 16965. ⟨10.3390/ijms160816953⟩ Article dans une revue hal-01834583v1
	Transcriptomic Network Support Distinct Roles of Classical and Non-Classical Monocytes in Human Kolandaswamy Anbazhagan , Isabelle Duroux-Richard , Christian Jorgensen , Florence Apparailly International Reviews of Immunology, 2014, 33 (6), pp.470 - 489. ⟨10.3109/08830185.2014.902453⟩ Article dans une revue hal-01845071v1
	Circulating miRNA-125b Is a Potential Biomarker Predicting Response to Rituximab in Rheumatoid Arthritis Isabelle Duroux-Richard , Yves-Marie Pers , Sylvie Fabre , Meryem Ammari , Dominique Baeten Mediators of Inflammation, 2014, 2014, pp.1 - 9. ⟨10.1155/2014/342524⟩ Article dans une revue hal-01845068v1
	High efficiency cell-specific targeting of cytokine activity Geneviève Garcin , Franciane Paul , Markus Staufenbiel , Yann Bordat , José van Der Heyden Nature Communications, 2014, 5 (1), ⟨10.1038/ncomms4016⟩ Article dans une revue hal-01845061v1
	E2F transcription factor-1 regulates oxidative metabolism Emilie Blanchet , Jean-Sébastien Annicotte , Sylviane Lagarrigue , Victor Aguilar , Cyrielle Clapé Nature Cell Biology, 2011, 13 (9), pp.1146-1152. ⟨10.1038/ncb2309⟩ Article dans une revue hal-02651296v1
	Therapeutic mesenchymal stem cells in rheumatic diseases: rationale, clinical data and perspectives David Guérit , Marie Maumus , Florence Apparailly , Christian Jorgensen , Danièle Noël Clinical Investigation, 2011, 1 (9), pp.1269-1277 Article dans une revue inserm-00644029v1
	Toll-like receptor dependent autoantigens in animal models and humans in use to improve collagen induced arthritis B Marklein , Z Konthur , T Häupl , M Shlomchik , G Steiner Journal of Translational Medicine, 2010, 8 (Suppl 1), pp.P53 Article dans une revue inserm-00622783v1
	BIK is a novel pro-apoptotic target gene for miR-125b in human monocytes Isabelle Duroux-Richard , Jessy Presumey , Y Pers , Sylvie Fabre , Charles-Henri Lecellier Journal of Translational Medicine, 2010, 8 (Suppl 1), pp.P56. ⟨10.1186/1479-5876-8-S1-P56⟩ Article dans une revue inserm-00668428v1
	Cytosolic phospholipase A2α gene silencing in monocytes alters development of Th1 responses and reduces autoimmune arthritis Gabriel Courties , Jessy Presumey , Michel Baron , Virginie Escriou , Peter van Lent Journal of Translational Medicine, 2010, 8 (Suppl 1), pp.O3. ⟨10.1186/1479-5876-8-S1-O3⟩ Article dans une revue inserm-00934267v1
	miR-143 interferes with ERK5 signaling, and abrogates prostate cancer progression in mice. Cyrielle Clapé , Vanessa Fritz , Corinne Henriquet , Florence Apparailly , Pedro Luis Fernandez PLoS ONE, 2009, 4 (10), pp.e7542. ⟨10.1371/journal.pone.0007542⟩ Article dans une revue inserm-00431462v1
	Antitumoral Activity and Osteogenic Potential of hATF-Expressing Mesenchymal Stem Cells In A Murine Model of Osteolytic Tumor. Vanessa Fritz , Danièle Noël , Céline Bouquet , Paule Opolon , Romain Voide Stem Cells / Stem Cells (Miamisburg), 2008, epub ahead of print. ⟨10.1634/stemcells.2008-0139⟩ Article dans une revue hal-00315969v1
	A comparative study on intra-articular versus systemic gene electrotransfer in experimental arthritis. Maroun Khoury , Pascal Bigey , Pascale Louis-Plence , Danièle Noël , Hervé Rhinn The Journal of Gene Medicine, 2006, 8 (8), pp.1027-36. ⟨10.1002/jgm.922⟩ Article dans une revue inserm-00193122v1
	Efficient new cationic liposome formulation for systemic delivery of small interfering RNA silencing tumor necrosis factor alpha in experimental arthritis. Maroun Khoury , Pascale Louis-Plence , Virginie Escriou , Danièle Noël , Céline Largeau Arthritis and Rheumatism, 2006, 54 (6), pp.1867-77. ⟨10.1002/art.21876⟩ Article dans une revue inserm-00193135v1
	Transcriptional profiles discriminate bone marrow-derived and synovium-derived mesenchymal stem cells. Farida Djouad , Claire Bony , Thomas Häupl , Gilles Uzé , Najiba Lahlou Arthritis Research and Therapy, 2005, 7, pp.R1304-15. ⟨10.1186/ar1827⟩ Article dans une revue inserm-00089978v1

	A7.12 Micro-RNA signature in systemic lupus erythematosus Isabelle Duroux-Richard , C Cuenca , C Ponsolles , A Badilla , F González ANNALS OF THE RHEUMATIC DISEASES, Mar 2015, London, United Kingdom. pp.A79.1 - A79, ⟨10.1136/annrheumdis-2015-207259.182⟩ Communication dans un congrès hal-01834586v1
	NAMPT/Visfatin expression by inflammatory monocytes mediates arthritis pathogenesis by promoting IL-17-producing T cells Jessy Présumey , Gabriel Courties , Pascale Louis-Plence , Virginie Escriou , Daniel Scherman 7th European Workshop on Immune-Mediated Inflammatory Diseases, Nov 2012, Noordwijk aan Zee, Netherlands. pp.P48 Communication dans un congrès inserm-00758223v1
	Targeted delivery to inflammatory monocytes for efficient RNAi-mediated immuno-intervention in auto-immune arthritis Jessy Présumey , Gabriel Courties , Louis-Marie Charbonnier , Virginie Escriou , Daniel Scherman 6th european workshop on immune-mediated inflammatory diseases, Nice, France. pp.P38 Communication dans un congrès inserm-00643966v1

	Persistent Luminescence Nanoparticles for Bioimaging Cyrille Richard , Thomas Maldiney , Quentin Le Masne de Chermont , Johanne Seguin , Nicolas Wattier From Physics to Signal Understanding Issues, 2012 Chapitre d'ouvrage hal-03714607v1

	PSMB10, the last immunoproteasome gene missing for PRAAS Guillaume Sarrabay , Deborah Mechin , Aicha Salhi , Guilaine Boursier , Cécile Rittore 2019 Pré-publication, Document de travail pasteur-02396614v1

Florence APPARAILLY

Publications

Gender Equity in Academic Rheumatology, Current Status and Potential for Improvement: A Cross-Sectional Study to Inform an EULAR Task Force

miRNA profile at diagnosis predicts treatment outcome in patients with B-chronic lymphocytic leukemia: A FILO study

Integrative Analysis of Human Macrophage Inflammatory Response Related to Mycobacterium tuberculosis Virulence

'SMASH' recommendations for standardised microscopic arthritis scoring of histological sections from inflammatory arthritis animal models

Mitochondrial MicroRNAs Contribute to Macrophage Immune Functions Including Differentiation, Polarization, and Activation

TNFR1-d2 carrying the p.(Thr79Met) pathogenic variant is a potential novel actor of TNFα/TNFR1 signalling regulation in the pathophysiology of TRAPS

POLR1B and neural crest cell anomalies in Treacher Collins syndrome type 4

Dissecting the phenotypic and functional heterogeneity of mouse inflammatory osteoclasts by the expression of Cx3cr1

Differential Accumulation and Activation of Monocyte and Dendritic Cell Subsets in Inflamed Synovial Fluid Discriminates Between Juvenile Idiopathic Arthritis and Septic Arthritis

Clinical and Molecular Spectrum of Nonsyndromic Early‐Onset Osteoarthritis

Immune Function and Diversity of Osteoclasts in Normal and Pathological Conditions

Arthritis sensory and motor scale: predicting functional deficits from the clinical score in collagen-induced arthritis

MicroRNAs: Fine Tuners of Monocyte Heterogeneity

MicroRNAs: Key Regulators to Understand Osteoclast Differentiation?

MicroRNAs in juvenile idiopathic arthritis: can we learn more about pathophysiological mechanisms?

Synovial-Fluid miRNA Signature for Diagnosis of Juvenile Idiopathic Arthritis

LARP7 variants and further delineation of the Alazami syndrome phenotypic spectrum among primordial dwarfisms: 2 sisters

Advanced microRNA-based cancer diagnostics using amplified time-gated FRET

Beneficial Effect of Alcohol Withdrawal on Gut Permeability and Microbial Translocation in Patients with Alcohol Use Disorder

Delivery of miR-146a to Ly6C high Monocytes Inhibits Pathogenic Bone Erosion in Inflammatory Arthritis

Regenerative medicine: Breaking Prometheus's curse for cartilage regeneration

TMEM187-IRAK1 Polymorphisms Associated with Rheumatoid Arthritis Susceptibility in Tunisian and French Female Populations: Influence of Geographic Origin

miR-125b and miR-532-3p predict the efficiency of rituximab-mediated lymphodepletion in chronic lymphocytic leukemia patients. A French Innovative Leukemia Organization study.

A new autoinflammatory and autoimmune syndrome associated with NLRP1 mutations: NAIAD ( NLRP1- associated autoinflammation with arthritis and dyskeratosis)

CRISPR-Cas9: A revolution in genome editing in rheumatic diseases

microRNA target prediction programs predict many false positives

Erratum: Deregulation and therapeutic potential of microRNAs in arthritic diseases

X-Linked miRNAs Associated with Gender Differences in Rheumatoid Arthritis

Effects of alcohol withdrawal on monocyte subset defects in chronic alcohol users

Deregulation and therapeutic potential of microRNAs in arthritic diseases

miR-125b controls monocyte adaptation to inflammation through mitochondrial metabolism and dynamics

Inhibition of Inflammation and Bone Erosion by RNA Interference-Mediated Silencing of Heterogeneous Nuclear RNP A2/B1 in Two Experimental Models of Rheumatoid Arthritis

A4.4 MIR-146A deficiency in LY6C high monocytes contributes to pathogenic bone loss during inflammatory arthritis

MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers

Transcriptomic Network Support Distinct Roles of Classical and Non-Classical Monocytes in Human

Circulating miRNA-125b Is a Potential Biomarker Predicting Response to Rituximab in Rheumatoid Arthritis

High efficiency cell-specific targeting of cytokine activity

E2F transcription factor-1 regulates oxidative metabolism

Therapeutic mesenchymal stem cells in rheumatic diseases: rationale, clinical data and perspectives

Toll-like receptor dependent autoantigens in animal models and humans in use to improve collagen induced arthritis

BIK is a novel pro-apoptotic target gene for miR-125b in human monocytes

Cytosolic phospholipase A2α gene silencing in monocytes alters development of Th1 responses and reduces autoimmune arthritis

miR-143 interferes with ERK5 signaling, and abrogates prostate cancer progression in mice.

Antitumoral Activity and Osteogenic Potential of hATF-Expressing Mesenchymal Stem Cells In A Murine Model of Osteolytic Tumor.

A comparative study on intra-articular versus systemic gene electrotransfer in experimental arthritis.

Efficient new cationic liposome formulation for systemic delivery of small interfering RNA silencing tumor necrosis factor alpha in experimental arthritis.

Transcriptional profiles discriminate bone marrow-derived and synovium-derived mesenchymal stem cells.

A7.12 Micro-RNA signature in systemic lupus erythematosus

NAMPT/Visfatin expression by inflammatory monocytes mediates arthritis pathogenesis by promoting IL-17-producing T cells

Targeted delivery to inflammatory monocytes for efficient RNAi-mediated immuno-intervention in auto-immune arthritis

Persistent Luminescence Nanoparticles for Bioimaging

PSMB10, the last immunoproteasome gene missing for PRAAS