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Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase

Alexandre Gidon , Mohammad Al-Bataineh , Frédéric Jean-Alphonse , Hilary Stevenson , Tomoyuki Watanabe , et al.
Nature Chemical Biology, 2014, 10 (9), pp.707-709. ⟨10.1038/nchembio.1589⟩
Article dans une revue hal-03117152v1

β-arrestins and endocrine-related GPCRs

Francesco de Pascali , Pauline Raynaud , Frédéric Jean-Alphonse , Shifa Tahir , Véronique Bozon , et al.
Cellular Endocrinology in Health and Disease, Elsevier, pp.445-458, 2021, 978-0-12-819801-8. ⟨10.1016/B978-0-12-819801-8.00021-1⟩
Chapitre d'ouvrage hal-03462802v1
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Biased agonist pharmacochaperones of the AVP V2 receptor may treat congenital nephrogenic diabetes insipidus.

Frédéric Jean-Alphonse , Sanja Perkovska , Marie-Céline Frantz , Thierry Durroux , Catherine Méjean , et al.
Journal of the American Society of Nephrology, 2009, 20 (10), pp.2190-203. ⟨10.1681/ASN.2008121289⟩
Article dans une revue inserm-00421838v1
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Integration of GPCR signaling and sorting from very early endosomes via opposing APPL1 mechanisms

Silvia Sposini , Frederic G. Jean-Alphonse , Mohammed Akli Ayoub , Affiong Oqua , Camilla West , et al.
Cell Reports, 2017, 21 (10), pp.2855-2867. ⟨10.1016/j.celrep.2017.11.023⟩
Article dans une revue hal-02625571v1

Arachidonic acid-dependent gene regulation during preadipocyte differentiation controls adipocyte potential

Evanthia Nikolopoulou , Georgia Papacleovoulou , Frédéric Jean-Alphonse , Giulia Grimaldi , Malcolm Parker , et al.
Journal of Lipid Research, 2014, 55 (12), pp.2479-2490. ⟨10.1194/jlr.M049551⟩
Article dans une revue hal-03117154v1

Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release

Yalikun Suofu , Wei Li , Frédéric Jean-Alphonse , Jiaoying Jia , Nicolas Khattar , et al.
Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (38), pp.E7997-E8006. ⟨10.1073/pnas.1705768114⟩
Article dans une revue hal-03117160v1

Past, present and future of vasopressin and oxytocin receptor oligomers, prototypical GPCR models to study dimerization processes

M. Cottet , L Albizu , S Perkovska , Frédéric Jean-Alphonse , R Rahmeh , et al.
Current Opinion in Pharmacology, 2010, 10 (1), pp.59-66. ⟨10.1016/j.coph.2009.10.003⟩
Article dans une revue istex hal-03117146v1

Ca 2+ allostery in PTH-receptor signaling

Alex White , Fei Fang , Frédéric Jean-Alphonse , Lisa Clark , Hyun-Jung An , et al.
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (8), pp.3294-3299. ⟨10.1073/pnas.1814670116⟩
Article dans une revue hal-03117164v1

Cdc42 activation couples fluid shear stress to apical endocytosis in proximal tubule cells

Sohinee Bhattacharyya , Frédéric Jean-Alphonse , Venkatesan Raghavan , Jennifer Mcgarvey , Youssef Rbaibi , et al.
Physiological Reports, 2017, 5 (19), pp.1-26. ⟨10.14814/phy2.13460⟩
Article dans une revue hal-03117161v1

Parathyroid hormone initiates dynamic NHERF1 phosphorylation cycling and conformational changes that regulate NPT2A-dependent phosphate transport

Qiangmin Zhang , Kunhong Xiao , Jose Paredes , Tatyana Mamonova , W. Bruce Sneddon , et al.
Journal of Biological Chemistry, 2019, 294 (12), pp.4546-4571. ⟨10.1074/jbc.RA119.007421⟩
Article dans une revue hal-03117163v1
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Editorial: Pharmacology of endocrine related GPCRs

Francesco de Pascali , Aylin Hanyaloglu , Frédéric Jean-Alphonse , Francesco Potì , Eric Reiter
Frontiers in Endocrinology, 2024, 15, pp.1379108. ⟨10.3389/fendo.2024.1379108⟩
Article dans une revue hal-04525032v1

Regulation of GPCR signal networks via membrane trafficking

Frédéric Jean-Alphonse , A.C. Hanyaloglu
Molecular and Cellular Endocrinology, 2011, 331 (2), pp.205-214. ⟨10.1016/j.mce.2010.07.010⟩
Article dans une revue hal-03117149v1

G q/11 -dependent regulation of endosomal cAMP generation by parathyroid hormone class B GPCR

Alex White , Frédéric Jean-Alphonse , Fei Fang , Karina Pena , Shi Liu , et al.
Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (13), pp.7455-7460. ⟨10.1073/pnas.1918158117⟩
Article dans une revue hal-03117167v1

Actin-Sorting Nexin 27 (SNX27)-Retromer Complex Mediates Rapid Parathyroid Hormone Receptor Recycling

Jennifer Mcgarvey , Kunhong Xiao , Shanna Bowman , Tatyana Mamonova , Qiangmin Zhang , et al.
Journal of Biological Chemistry, 2016, 291 (21), pp.10986-11002. ⟨10.1074/jbc.M115.697045⟩
Article dans une revue hal-03117156v1

Allosteric interactions in the parathyroid hormone GPCR–arrestin complex formation

Lisa Clark , James Krieger , Alex White , Vasyl Bondarenko , Saifei Lei , et al.
Nature Chemical Biology, 2020, 16 (10), pp.1096-1104. ⟨10.1038/s41589-020-0567-0⟩
Article dans une revue hal-03117168v1

Structure and dynamics of the active human parathyroid hormone receptor-1

Li-Hua Zhao , Shanshan Ma , Ieva Sutkeviciute , Dan-Dan Shen , X. Edward Zhou , et al.
Science, 2019, 364 (6436), pp.148-153. ⟨10.1126/science.aav7942⟩
Article dans une revue hal-03117165v1

Use of backbone modification to enlarge the spatiotemporal diversity of parathyroid hormone receptor-1 signaling via biased agonism

Shi Liu , Frédéric Jean-Alphonse , Alex D. White , Denise Wootten , Patrick M. Sexton , et al.
Journal of the American Chemical Society, 2019, 141 (37), pp.14486-14490. ⟨10.1021/jacs.9b04179⟩
Article dans une revue hal-03117166v1

Spatially Restricted G Protein-coupled Receptor Activity via Divergent Endocytic Compartments

Frédéric Jean-Alphonse , Shanna Bowersox , Stanford Chen , Gemma Beard , Manojkumar Puthenveedu , et al.
Journal of Biological Chemistry, 2014, 289 (7), pp.3960-3977. ⟨10.1074/jbc.M113.526350⟩
Article dans une revue hal-03117150v1

The polycystin-1, lipoxygenase, and α -toxin domain regulates polycystin-1 trafficking

Yaoxian Xu , Andrew Streets , Andrea Hounslow , Uyen Tran , Frédéric Jean-Alphonse , et al.
Journal of the American Society of Nephrology, 2016, 27 (4), pp.1159-1173. ⟨10.1681/ASN.2014111074⟩
Article dans une revue hal-03117155v1

Design and synthesis of cyclic and linear peptide-agarose tools for baiting interacting protein partners of GPCRs

Sébastien Granier , Frédéric Jean-Alphonse , Hélène Déméné , Gilles Guillon , Robert Pascal , et al.
Bioorganic and Medicinal Chemistry Letters, 2006, 16 (3), pp.521-524. ⟨10.1016/j.bmcl.2005.10.061⟩
Article dans une revue istex hal-03117141v1
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Biased signaling and allosteric modulation at the FSHR

Flavie Landomiel , Francesco de Pascali , Pauline Raynaud , Frédéric Jean-Alphonse , Romain Yvinec , et al.
Frontiers in Endocrinology, 2019, 10, pp.148. ⟨10.3389/fendo.2019.00148⟩
Article dans une revue hal-02362523v1
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A single domain intrabody targeting the follicle-stimulating hormone receptor (FSHR) impacts FSH-induced G protein-dependent signalling

Pauline Raynaud , Vinesh Jugnarain , Océane Vaugrente , Amandine Vallet , Thomas Boulo , et al.
FEBS Letters, 2023, 598 (2), pp.220-232. ⟨10.1002/1873-3468.14765⟩
Article dans une revue hal-04269864v1
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Highly-Sensitive In Vitro Bioassays for FSH, TSH, PTH, Kp, and OT in Addition to LH in Mouse Leydig Tumor Cell

Danièle Klett , Lucie Pellissier , Didier Lomet , Flavie Derouin-Tochon , Vincent Robert , et al.
International Journal of Molecular Sciences, 2023, 24 (15), pp.12047. ⟨10.3390/ijms241512047⟩
Article dans une revue hal-04206799v1

The multifunctional protein GC1q-R interacts specifically with the i3 loop arginine cluster of the vasopressin V-2 receptor

Sebastien Granier , Frederic Jean-Alphonse , Daniel Bacqueville , Arnaud Monteil , Robert Pascal , et al.
Regulatory Peptides, 2008, 148, pp.76-87. ⟨10.1016/j.regpep.2008.01.007⟩
Article dans une revue istex hal-00493436v1
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Biased GPCR signaling by the native parathyroid hormone–related protein 1 to 141 relative to its N-terminal fragment 1 to 36

Karina A Peña , Alex D White , Sofya Savransky , Ignacio Portales Castillo , Frédéric G Jean-Alphonse , et al.
Journal of Biological Chemistry, 2022, 298 (9), pp.102332. ⟨10.1016/j.jbc.2022.102332⟩
Article dans une revue hal-03854828v1
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Parathyroid hormone initiates dynamic NHERF1 phosphorylation cycling and conformational changes that regulate NPT2A-dependent phosphate transport

Qiangmin Zhang , Kunhong Xiao , Jose M. Paredes , Tatyana Mamonova , W. Bruce Sneddon , et al.
Journal of Biological Chemistry, 2019, 294 (12), pp.4546 - 4571. ⟨10.1074/jbc.RA119.007421⟩
Article dans une revue hal-02628955v1

β2-adrenergic receptor control of endosomal PTH receptor signaling via Gβγ

Frédéric Jean-Alphonse , Vanessa Wehbi , Jingming Chen , Masaki Noda , Juan Taboas , et al.
Nature Chemical Biology, 2017, 13 (3), pp.259-261. ⟨10.1038/nchembio.2267⟩
Article dans une revue hal-03117157v1

Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation

Alex D. White , Karina A. Peña , Lisa J. Clark , Christian Santa Maria , Shi Liu , et al.
Science Signaling, 2021, 14 (703), ⟨10.1126/scisignal.abc5944⟩
Article dans une revue hal-03476364v1

PTH hypersecretion triggered by a GABAB1 and Ca2+-sensing receptor heterocomplex in hyperparathyroidism

Wenhan Chang , Chia-Ling Tu , Frédéric Jean-Alphonse , Amanda Herberger , Zhiqiang Cheng , et al.
Nature Metabolism, 2020, 2 (3), pp.243-255. ⟨10.1038/s42255-020-0175-z⟩
Article dans une revue hal-03117169v1

Endosomal generation of cAMP in GPCR signaling

Jean-Pierre Vilardaga , Frédéric Jean-Alphonse , Thomas Gardella
Nature Chemical Biology, 2014, 10 (9), pp.700-706. ⟨10.1038/nchembio.1611⟩
Article dans une revue hal-03117153v1