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Fernanda Fonseca_CV


EDUCATION

 

Habilitation à Diriger des Recherches (HDR). Université de Technologie de Compiègne, 2010. Title : « Stabilization of bio functionalities trough an approach combining the understanding of mechanisms and the product-process engineering”

Ph.D. Degree in Biotechnology and Process Engineering, Institut National Agronomique Paris-Grignon (AgroParisTech),2001Ph.D. thesis title: "Influence of cryoprotection and freezing on the acidification activity of thermopile lactic acid bacteria: relationships between biological and thermodynamic properties."

Master Degree in Biotechnology and Process Engineering, Institut National Agronomique Paris-Grignon (AgroParisTech), 1997 M.Sc. thesis title: "Study of the freezing step on the activity of frozen lactic acid starters."

 Engineer in Chemical Engineering, Montevideo University (Uruguay), 1996.

 

SCIENTIFIC EXPERIENCE

 

 

Research Director (since January 2015), in Paris-Saclay Food and Bioproduct Engineering research unit (UMR 782 SayFood INRAE-AgroParisTech), Versailles-Grignon Centre, at the French National Institute for Agriculture, Food and Environment (INRAE), France.

Researcher Scientist (September 2001 – December 2014), in the Joint Research Unit for Food Process Engineering and Microbiology (UMR 782 GMPA INRA-AgroParisTech), Versailles-Grignon Centre, Institut National de la Recherche Agronomique (INRA), France.

Main fields of expertise:Biotechnology and process engineering: fermentation, formulation, and stabilization of bioproducts.

  • Bioproducts: micro-organisms, proteins, food products.

  • Stabilization processes: freezing and freeze-drying

  • Biophysical characterization of bioproducts (thermal analysis, freeze-drying microscopy, Fourier Transformed InfraRed microspectroscopy)

Research approach: Focusing on biophysical and chemical behaviors of bioproducts during stabilization processes and by relating them to biological and functional responses, to identify and quantify the mechanisms governing the degradation and preservation of bioproducts during the stabilization processes. The ambition is also to find general principles for simplifying and rationalizing the development of newly formulated products and the stabilization process optimization, with particular attention to limiting the environmental impact.

 


Journal articles60 documents

  • Juan Patricio Buceta, Ioan Trelea, Bernadette Scutellà, Erwan Bourlés, Fernanda Fonseca, et al.. Heat Transfer During Freeze-Drying Using a High-throughput vial System in view of Process Scale-up to Serum vials. Journal of Pharmaceutical Sciences, Wiley, In press, ⟨10.1016/j.xphs.2020.11.029⟩. ⟨hal-03117931⟩
  • Thanh Dat Nguyen, Stéphane Guyot, Caroline Pénicaud, Stéphanie Passot, Christophe Sandt, et al.. Highlighting Protective Effect of Encapsulation on Yeast Cell Response to Dehydration Using Synchrotron Infrared Microspectroscopy at the Single-Cell Level. Frontiers in Microbiology, Frontiers Media, 2020, 11, ⟨10.3389/fmicb.2020.01887⟩. ⟨hal-02939385⟩
  • Julie Meneghel, Stéphanie Passot, Frédéric Jamme, Stéphane Lefrançois, Pascale Lieben, et al.. FTIR micro-spectroscopy using synchrotron-based and thermal source-based radiation for probing live bacteria. Analytical and Bioanalytical Chemistry, Springer Verlag, 2020, 412 (26), pp.7049-7061. ⟨10.1007/s00216-020-02835-x⟩. ⟨hal-03004447⟩
  • Amélie Girardeau, C. Puentes, S. Keravec, P. Peteuil, Ioan-Cristian Trelea, et al.. Influence of culture conditions on the technological properties of Carnobacterium maltaromaticum CNCM I-3298 starters. Journal of Applied Microbiology, Wiley, 2019, 126 (5), pp.1468-1479. ⟨10.1111/jam.14223⟩. ⟨hal-02154448⟩
  • Caroline Pénicaud, Liliana Ibanescu, Thomas Allard, Fernanda Fonseca, Stephane Dervaux, et al.. Relating transformation process, eco-design, composition and sensory quality in cheeses using PO2 ontology. International Dairy Journal, Elsevier, 2019, 92, pp.1-10. ⟨10.1016/j.idairyj.2019.01.003⟩. ⟨hal-02043246⟩
  • Caroline Pénicaud, Fernanda Fonseca. Écoconception des aliments, bioproduits, bioprocédés et procédés alimentaires. Techniques de l'Ingénieur, Editions T.I., 2019. ⟨hal-03086204⟩
  • Sebastian Burz, Anne-Laure Abraham, Fernanda Fonseca, Olivier David, Audrey Chapron, et al.. A Guide for Ex Vivo Handling and storage of stool samples Intended for Fecal Microbiota transplantation. Scientific Reports, Nature Publishing Group, 2019, 9 (1), pp.8897. ⟨10.1038/s41598-019-45173-4⟩. ⟨hal-02466120⟩
  • Julie Meneghel, Peter Kilbride, John G. Morris, Fernanda Fonseca. Physical events occurring during the cryopreservation of immortalized human T cells. PLoS ONE, Public Library of Science, 2019, 14 (5), pp.e0217304. ⟨10.1371/journal.pone.0217304⟩. ⟨hal-02154629⟩
  • Jasmin Baboo, Peter Kilbride, Mike Delahaye, Stuart Milne, Fernanda Fonseca, et al.. The Impact of varying cooling and thawing rates on the quality of cryopreserved human peripheral blood t cells. Scientific Reports, Nature Publishing Group, 2019, 9 (1), pp.1-13. ⟨10.1038/s41598-019-39957-x⟩. ⟨hal-02154617⟩
  • Fernanda Fonseca, Caroline Pénicaud, E. Elizabeth Tymczyszyn, Andrea Gómez-Zavaglia, Stéphanie Passot. Factors influencing the membrane fluidity and the impact on production of lactic acid bacteria starters. Applied Microbiology and Biotechnology, Springer Verlag, 2019, 103 (17), pp.6867-6883. ⟨10.1007/s00253-019-10002-1⟩. ⟨hal-02193909⟩
  • Cesar Arturo Aceves-Lara, Violaine Athès, Patrice Buche, Guy Valle, Vincent Farines, et al.. The virtual food system: Innovative models and experiential feedback in technologies for winemaking, the cereals chain, food packaging and eco-designed starter production. Innovative Food Science and Emerging Technologies, Elsevier, 2018, Food Science and Technology in France: INRA’s contribution to this area, 46, pp.54-64. ⟨10.1016/j.ifset.2017.10.006⟩. ⟨lirmm-01651998⟩
  • Caroline Pénicaud, Vincent Monclus, Bruno Perret, Stéphanie Passot, Fernanda Fonseca. Life cycle assessment of the production of stabilized lactic acid bacteria for the environmentally-friendly preservation of living cells. Journal of Cleaner Production, Elsevier, 2018, 184, pp.847-858. ⟨10.1016/j.jclepro.2018.02.191⟩. ⟨hal-01784901⟩
  • Bernadette Scutella, Ioan-Cristian Trelea, Erwan Bourlés, Fernanda Fonseca, Stéphanie Passot. Determination of the dried product resistance variability and its influence on the product temperature in pharmaceutical freeze-drying. European Journal of Pharmaceutics and Biopharmaceutics, Elsevier, 2018, 128, pp.379-388. ⟨10.1016/j.ejpb.2018.05.004⟩. ⟨hal-01789065⟩
  • B. Scutellà, E. Bourlés, A. Plana-Fattori, F. Fonseca, D. Flick, et al.. Effect of freeze-dryer design on heat transfer variability investigated using a 3D mathematical model. Journal of Pharmaceutical Sciences, Wiley, 2018, 107 (8), pp.2098-2106. ⟨10.1016/j.xphs.2018.04.002⟩. ⟨hal-01769104⟩
  • Jean-François Dubuisson, Catherine Juste, Fernanda Fonseca, Patricia Lepage, Christel Béra Maillet, et al.. Nouveaux dispositifs médicaux et nouveau procédé de fabrication pour un transfert de microbiote fécal par voie rectale, sans risque, standardisé et prêt à l’emploi. Journal de Pharmacie Clinique, John Libbey Eurotext, 2018, 37 (2), pp.73-83. ⟨hal-02628188⟩
  • Julie Meneghel, Stéphanie Passot, Sébastien Dupont, Fernanda Fonseca. Biophysical characterization of the Lactobacillus delbrueckii subsp. bulgaricus membrane during cold and osmotic stress and its relevance for cryopreservation. Applied Microbiology and Biotechnology, Springer Verlag, 2017, 101 (4), pp.1427 - 1441. ⟨10.1007/s00253-016-7935-4⟩. ⟨hal-01559240⟩
  • Bernadette Scutellà, Artemio Plana-Fattori, Stéphanie Passot, E Bourlès, Fernanda Fonseca, et al.. 3D mathematical modelling to understand atypical heat transfer observed in vial freeze-drying. Applied Thermal Engineering, Elsevier, 2017, 126, pp.226 - 236. ⟨10.1016/j.applthermaleng.2017.07.096⟩. ⟨hal-01582545⟩
  • Bernadette Scutella, Stéphanie Passot, Erwan Bourlés, Fernanda Fonseca, Ioan-Cristian Trelea. How vial geometry variability influences heat transfer and product temperature during freeze-drying. Journal of Pharmaceutical Sciences, Wiley, 2017, 106 (3), pp.770-778. ⟨10.1016/j.xphs.2016.11.007⟩. ⟨hal-01465155⟩
  • Julie Meneghel, Stéphanie Passot, Stéphanie Cenard, Matthieu Refregiers, Frédéric Jamme, et al.. Subcellular membrane fluidity of Lactobacillus delbrueckii subsp. bulgaricus under cold and osmotic stress. Applied Microbiology and Biotechnology, Springer Verlag, 2017, 101 (18), pp.6907 - 6917. ⟨10.1007/s00253-017-8444-9⟩. ⟨hal-01634459⟩
  • T. Nguyen, Stéphane Guyot, C. Penicaud, S. Passot, C. Sandt, et al.. Understanding the responses of Saccharomyces cerevisiae yeast strain during dehydration processes using synchrotron infrared spectroscopy. Analyst, Royal Society of Chemistry, 2017, 142 (19), pp.3620 - 3628. ⟨10.1039/c7an00257b⟩. ⟨hal-01616052⟩
  • Julie Meneghel, Eric Dugat-Bony, Françoise Irlinger, Valentin Loux, Marie Vidal, et al.. Draft Genome Sequence of Lactobacillus delbrueckii subsp. bulgaricus CFL1, a Lactic Acid Bacterium Isolated from French Handcrafted Fermented Milk. Genome Announcements, American Society for Microbiology, 2016, 4 (2), pp.e00052-16. ⟨10.1128/genomeA.00052-16⟩. ⟨hal-01511494⟩
  • Fernanda Fonseca, Julie Meneghel, Stéphanie Cenard, Stéphanie Passot, G. John Morris. Determination of Intracellular Vitrification Temperatures for Unicellular Micro Organisms under Conditions Relevant for Cryopreservation. PLoS ONE, Public Library of Science, 2016, 11 (4), pp.e0152939. ⟨10.1371/journal.pone.0152939⟩. ⟨hal-01565156⟩
  • Ioan-Cristian Trelea, Fernanda Fonseca, Stéphanie Passot. Dynamic modelling of the secondary drying stage of freeze-drying reveals distinct desorption kinetics for bound water. Drying Technology, Taylor & Francis, 2016, 34 (3), pp.335-345. ⟨10.1080/07373937.2015.1054509⟩. ⟨hal-01531598⟩
  • Thanh Dat Nguyen, Stéphane Guyot, Christophe Sandt, Caroline Pénicaud, Stéphanie Passot, et al.. Protection of yeast cells in micro-organized shells of natural polyelectrolytes during drying process. STP Pharma Pratiques, 2016, 26 (2), pp.133. ⟨hal-01531646⟩
  • Ioan-Cristian Trelea, Fernanda Fonseca, Stéphanie Passot, Denis Flick. A binary gas transport model Improves the prediction of mass transfer in freeze drying. Drying Technology, Taylor & Francis, 2015, 33 (15-16), pp.1849-1858. ⟨10.1080/07373937.2015.1040025⟩. ⟨hal-01269386⟩
  • Stéphanie Passot, Julie Gautier, Frédéric Jamme, Stéphanie Cenard, Paul Dumas, et al.. Understanding the cryotolerance of lactic acid bacteria using combined synchrotron infrared and fluorescence microscopies. Analyst, Royal Society of Chemistry, 2015, 140 (17), pp.5920-5928. ⟨10.1039/C5AN00654F⟩. ⟨hal-01536496⟩
  • Helene Velly, Marielle Bouix, Stéphanie Passot, Caroline Pénicaud, Helene Beinsteiner, et al.. Cyclopropanation of unsaturated fatty acids and membrane rigidification improve the freeze-drying resistance of Lactococcus lactis subsp lactis TOMSC161. Applied Microbiology and Biotechnology, Springer Verlag, 2015, 99 (2), pp.907 - 918. ⟨10.1007/s00253-014-6152-2⟩. ⟨hal-01535230⟩
  • Caroline Pénicaud, Sophie Landaud-Liautaud, Frederic Jamme, Pauline Talbot, Marielle Bouix, et al.. Physiological and biochemical responses of Yarrowia lipolytica to dehydration induced by air-drying and freezing. PLoS ONE, Public Library of Science, 2014, 9 (10), ⟨10.1371/journal.pone.0111138⟩. ⟨hal-01195500⟩
  • Helene Velly, Fernanda Fonseca, Stéphanie Passot, Agnes Delacroix-Buchet, Marielle Bouix. Cell growth and resistance of Lactococcus lactis subsp lactis TOMSC161 following freezing, drying and freeze-dried storage are differentially affected by fermentation conditions. Journal of Applied Microbiology, Wiley, 2014, 117 (3), pp.729 - 740. ⟨10.1111/jam.12577⟩. ⟨hal-01194098⟩
  • Hélène Velly, Pierre Renault, Anne-Laure Abraham, Valentin Loux, Agnes Delacroix-Buchet, et al.. Genome Sequence of the Lactic Acid Bacterium Lactococcus lactis subsp. lactis TOMSC161, Isolated from a Nonscalded Curd Pressed Cheese. Genome Announcements, American Society for Microbiology, 2014, 2 (6), ⟨10.1128/genomeA.01121-14⟩. ⟨hal-01193999⟩
  • Fernanda Fonseca. Synchrotron UV fluorescence microscopy for determining membrane fluidity modification of single bacteria with temperatures. Biomedical Spectroscopy and Imaging, 2014, 3 (3), pp.203-210. ⟨hal-02629469⟩
  • Stéphanie Passot, Frederic Jamme, M. Refregiers, Julie Gautier, Stéphanie Cenard, et al.. Synchrotron UV fluorescence microscopy for determining membrane fluidity modification of single bacteria with temperatures. Biomedical Spectroscopy and Imaging, 2014, 3 (3), pp.203-210. ⟨10.3233/BSI-140062⟩. ⟨hal-02629450⟩
  • Julie Gautier, Stéphanie Passot, Caroline Pénicaud, Herve Guillemin, Stéphanie Cenard, et al.. A low membrane lipid phase transition temperature is associated with a high cryotolerance of [i]Lactobacillus delbrueckii[/i] subspecies [i]bulgaricus[/i] CFL1. Journal of Dairy Science, American Dairy Science Association, 2013, 96 (9), pp.5591-5602. ⟨10.3168/jds.2013-6802⟩. ⟨hal-01001061⟩
  • Andrew Clarke, G. John Morris, Fernanda Fonseca, Benjamin J. Murray, Elizabeth Acton, et al.. A low temperature limit for life on Earth. PLoS ONE, Public Library of Science, 2013, 8 (6), ⟨10.1371/journal.pone.0066207⟩. ⟨hal-01190603⟩
  • A. Clark, G.J. Morris, F. Fonseca, B.J. Murray, E. Acton, et al.. A low temperature limit for life on earth. PLoS ONE, Public Library of Science, 2013, in press. ⟨hal-01564482⟩
  • Stéphanie Passot, Stéphanie Cenard, Inès Douania, Ioan Cristian Trelea, Fernanda Fonseca. Critical water activity and amorphous state for optimal preservation of lyophilised lactic acid bacteria. Food Chemistry, Elsevier, 2012, 132 (4), pp.1699-1705. ⟨10.1016/j.foodchem.2011.06.012⟩. ⟨hal-01536691⟩
  • Luis T. Antelo, Stéphanie Passot, Fernanda Fonseca, Ioan-Cristian Trelea, Antonio A. Alonso. Toward Optimal Operation Conditions of Freeze-Drying Processes via a Multilevel Approach. Drying Technology, Taylor & Francis, 2012, 30 (13), pp.1432 - 1448. ⟨10.1080/07373937.2012.686079⟩. ⟨hal-01053126⟩
  • G. John Morris, Elizabeth Acton, Benjamin J. Murray, Fernanda Fonseca. Freezing injury: The special case of the sperm cell. Cryobiology, Elsevier, 2012, 64 (2), pp.71-80. ⟨10.1016/j.cryobiol.2011.12.002⟩. ⟨hal-02649267⟩
  • G.J. Morris, E. Acton, B. Murray, F. Fonseca. Freezing injury: the special case of the sperm cell. Cryobiology, Elsevier, 2012, 64, pp.71--80. ⟨hal-01564145⟩
  • Sophie Chassagne-Berces, Fernanda Fonseca, Morgane Citeau, Michele Marin. Freezing protocol effect on quality properties of fruit tissue according to the fruit, the variety and the stage of maturity. LWT - Food Science and Technology, Elsevier, 2010, 43 (9), pp.1441 - 1449. ⟨10.1016/j.lwt.2010.04.004⟩. ⟨hal-01195463⟩
  • Stéphanie Passot, Ioan-Cristian Trelea, Michele Marin, Miquel Galan, G. John Morris, et al.. Effect of controlled ice nucleation on primary drying stage and protein recovery in vials cooled in a modified freeze-dryer. Journal of Biomechanical Engineering, American Society of Mechanical Engineers, 2009, 131 (7), pp.074511:1-5. ⟨10.1115/1.3143034⟩. ⟨hal-01537095⟩
  • Ioan-Cristian Trelea, Stephanie Passot, Michele Marin, Fernanda Fonseca. Model for Heat and Mass Transfer in Freeze-Drying of Pellets. Journal of Biomechanical Engineering, American Society of Mechanical Engineers, 2009, 131 (7), pp.074501. ⟨10.1115/1.3142975⟩. ⟨hal-01536947⟩
  • Sophie Chassagne, Cécile Poirier, Marie Francoise Devaux, Fernanda Fonseca, Marc Lahaye, et al.. Changes in texture, cellular structure and cell wall composition in apple tissue as a result of freezing. Food Research International, Elsevier, 2009, 42 (7), pp.788-797. ⟨10.1016/j.foodres.2009.03.001⟩. ⟨hal-01195428⟩
  • Ioan-Cristian Trelea, Stéphanie Passot, Fernanda Fonseca, Michele Marin. An Interactive Tool for the Optimization of Freeze-Drying Cycles Based on Quality Criteria. Drying Technology, Taylor & Francis, 2007, 25 (5), pp.741-751. ⟨10.1080/07373930701370100⟩. ⟨hal-01537101⟩
  • Stéphanie Passot, Fernanda Fonseca, Naziha Barbouche, - M. Alarcon-Lorca, - D. Rolland, et al.. Effect of product temperature applied during primary drying on the long-term stability of lyophilized proteins. Pharmaceutical Development and Technology, Taylor & Francis, 2007, 12 (6), pp.543-53. ⟨hal-02655952⟩
  • G. John Morris, K. Faszer, J. E. Green, D. Draper, B. W. W. Grout, et al.. Rapidly cooled horse spermatozoa: loss of viability is due to osmotic imbalance during thawing, not intracellular ice formation. Theriogenology, Elsevier, 2007, 68 (5), pp.804-812. ⟨hal-02653848⟩
  • Catherine Béal, Fernanda Fonseca, A. Thomas, Michèle Marin. Caractérisation et lyophilisation de matrices fromagères. Sciences des Aliments, Lavoisier Abonnements, 2006, 26 (1), pp.89-102. ⟨10.3166/sda.26.89-102⟩. ⟨hal-02653766⟩
  • Fernanda Fonseca, Michèle Marin, G. J. Morris. Stabilization of frozen Lactobacillus delbrueckii subsp. bulgaricus in glycerol suspensions : freezing kinetics and storage temperature effects. Applied and Environmental Microbiology, American Society for Microbiology, 2006, 72 (10), pp.6474-6482. ⟨10.1128/aem.00998-06⟩. ⟨hal-02663860⟩
  • G. John Morris, Martha Goodrich, Elizabeth Acton, Fernanda Fonseca. The high viscosity encountered during freezing in glycerol solutions: effects on cryopreservation. Cryobiology, Elsevier, 2006, 52 (3), pp.323-334. ⟨10.1016/j.cryobiol.2006.01.003⟩. ⟨hal-02667959⟩
  • Stéphanie Passot, Fernanda Fonseca, M. Alarcon-Lorca, D. Rolland, Michèle Marin. Physical characterisation of formulations for the development of two stable freeze-dried proteins during both dried and liquid storage. European Journal of Pharmaceutics and Biopharmaceutics, Elsevier, 2005, 60 (3), pp.335-348. ⟨10.1016/j.ejpb.2005.02.013⟩. ⟨hal-02679545⟩
  • Harriëtte Oldenhof, Willem F. Wolkers, Fernanda Fonseca, Stéphanie Passot, Michèle Marin. Effect of sucrose and maltodextrin on the physical properties and survival of air-dried Lactobacillus bulgaricus: an in situ fourier transform infrared spectroscopy study. Biotechnology Progress, Wiley, 2005, 21 (3), pp.885-892. ⟨10.1021/bp049559j⟩. ⟨hal-02680835⟩
  • Fernanda Fonseca, Stéphanie Passot, Pascale Lieben, Michèle Marin. Collapse temperature of bacterial suspensions: the effect of cell type and concentration. Cryo Letters, Cryo Letters, 2004, 25 (4), pp.425-434. ⟨hal-02672062⟩
  • Fernanda Fonseca, Stéphanie Passot, O. Cunin, Michèle Marin. Collapse temperature of freeze-dried Lactobacillus bulgaricus suspensions and protective media. Biotechnology Progress, Wiley, 2004, 20 (1), pp.229-238. ⟨10.1021/bp034136n⟩. ⟨hal-02679282⟩
  • Fernanda Fonseca, C. Béal, F. Mihoub, M. Marin, Georges Corrieu. Improvement of cryopreservation of Lactobacillus delbruekii subsp bulgaricus CFL1 with additives displaying different protective effects. International Dairy Journal, Elsevier, 2003, 13 (11), pp.917-926. ⟨hal-02673309⟩
  • Fernanda Fonseca, Catherine Béal, Jean-Baptiste Mihoub, Michèle Marin, Georges Corrieu. Improvement of cryopreservation of Lactobacillus delbrueckii subsp. bulgaricus CFL1 with additives displaying different protective effects. International Dairy Journal, Elsevier, 2003, 13 (11), pp.917-926. ⟨10.1016/S0958-6946(03)00119-5⟩. ⟨hal-02680827⟩
  • I. Béal, Fernanda Fonseca, Georges Corrieu. Resistance to freezing and frozen storage of Streptococcus thermophilus is related to membrane fatty acid composition. Journal of Dairy Science, American Dairy Science Association, 2001, 84 (11), pp.2347-2356. ⟨hal-02670204⟩
  • Catherine Béal, Fernanda Fonseca, Georges Corrieu. Resistance to freezing and to frozen storage of Streptococcus themophilus is related to membrane fatty acid composition. Journal of Dairy Science, American Dairy Science Association, 2001, 84 (11), pp.2347-2356. ⟨hal-02670974⟩
  • Fernanda Fonseca, J. P. Obert, Catherine Béal, Michèle Marin. State diagrams and sorption isotherms of bacterial suspensions and fermented medium. Thermochimica Acta, Elsevier, 2001, 366 (2), pp.167-182. ⟨10.1016/S0040-6031(00)00725-5⟩. ⟨hal-02678486⟩
  • Fernanda Fonseca, C. Béal, Georges Corrieu. Operating conditions that affect the resistance of lactic acid bacteria to freezing and frozen storage. Cryobiology, Elsevier, 2001, 43 (3), pp.189-198. ⟨10.1006/cryo.2001.2343⟩. ⟨hal-02681116⟩
  • Fernanda Fonseca, C. Béal, Georges Corrieu. Method of quantifying the loss of acidification activity of lactic acid starters during freezing and frozen storage. Journal of Dairy Research, Cambridge University Press (CUP), 2000, 67 (1), pp.83-90. ⟨hal-02696403⟩

Conference papers95 documents

  • Peter Kilbride, Hugo, A, Julie Meneghel, Jérôme Delettre, Romano, N, et al.. Fructose oligosaccharides as a novel cryoprotectant for mammalian cells. 59th Annual Meeting of the Society for Cryobiology, Jul 2020, Inconnue, France. ⟨hal-03006765⟩
  • Peter Kilbride, Julie Meneghel, Fernanda Fonseca, John Morris. The critical thermal range for controlled rate cooling for mammalian cell cryopreservation. 56. Annual Meeting of the Society for Cryobiology, Jul 2019, San Diego, United States. ⟨10.1016/j.cryobiol.2019.10.118⟩. ⟨hal-02266912⟩
  • Fernanda Fonseca, Julie Meneghel, Peter Kilbride, Stéphanie Passot, G. John Morris. Physical events during cryopreservation: consequences on cells’ post-thaw performance and on cryobiological protocols optimisation. 9. International Symposium on Lyophilization of Pharmaceuticals ISLFD, Sep 2019, Ghent, Belgium. ⟨hal-02734376⟩
  • Caroline Pénicaud, Bruno Perret, Stéphanie Passot, Camille Quentier, Fernanda Fonseca. Methodological approach towards environmentally friendly processes for preserving lactic acid bacteria. Club des Bactéries Lactiques, Jun 2019, Caen, France. ⟨hal-02266899⟩
  • Stéphanie Passot, Catherine Béal, Fernanda Fonseca. Avancées récentes sur la production et la stabilisation de bactéries lactiques à haute fonctionnalité. CBL 2019 - 22. Colloque du Club des Bactéries Lactiques, Jun 2019, Caen, France. ⟨hal-02998766⟩
  • Stéphanie Passot, Catherine Béal, Fernanda Fonseca. Avancées récentes sur la production et la stabilisation de bactéries lactiques à haute fonctionnalité. CBL 2019 - 22. Colloque du Club des Bactéries Lactiques, Jun 2019, Caen, France. ⟨hal-02268915⟩
  • Amélie Girardeau, Julie Meneghel, Ioan-Cristian Trelea, Stéphanie Passot, Fernanda Fonseca. Complementary analytical approaches improving knowledge on lactic acid bacteria cryoresistance. 56. Annual Meeting of the Society for Cryobiology, Jul 2019, San Diego, CA, United States. 166-166 p., ⟨10.1016/j.cryobiol.2019.10.086⟩. ⟨hal-02266910⟩
  • Fernanda Fonseca, Michele da Silva Pinto, Julie Meneghel, Pascale Lieben, Stéphanie Passot, et al.. Development of a simplified lipid model of bacterial membrane to investigate specific interactions with oligosaccharides. 56. Annual Meeting of the Society for Cryobiology, Jul 2019, San Diego, CA, United States. pp.173, ⟨10.1016/j.cryobiol.2019.10.109⟩. ⟨hal-02266911⟩
  • Thomas Chabin, Marc Barnabe, Nadia Boukhelifa, Fernanda Fonseca, Alberto Tonda, et al.. LIDeOGraM: an interactive evolutionary modelling tool. 13. Biennial International Conference on Artificial Evolution (EA), 2018, CHAM, Switzerland. pp.13, ⟨10.1007/978-3-319-78133-4_14⟩. ⟨hal-02736924⟩
  • Thomas Chabin, Marc Barnabe, Alberto Tonda, Nadia Boukhelifa, Fernanda Fonseca, et al.. A semi-automatic modelling approach for the production and freeze drying of lactic acid bacteria. 10. International Conference on Simulation and Modelling in the Food and Bio-Industry, FOODSIM 2018. Eurosis, 2018., Apr 2018, Ghent, Belgium. ⟨hal-02266291⟩
  • Bernadette Scutellà, Ioan-Cristian Trelea, Erwan Bourlés, Fernanda Fonseca, Stéphanie Passot. Use of a multi-vial mathematical model to design freeze-drying cycles for pharmaceuticals at known risk of failure. 21. International Drying Symposium, Sep 2018, Valencia, Spain. ⟨10.4995/IDS2018.2018.7421⟩. ⟨hal-02266914⟩
  • Thomas Chabin, Marc Barnabe, Nadia Boukhelifa, Fernanda Fonseca, Alberto Tonda, et al.. LIDeOGraM : an interactive evolutionary modelling tool. Biennial International Conference on Artificial Evolution (EA-2017), 2017, Paris, France. ⟨hal-01607681⟩
  • Thomas Chabin, Marc Barnabe, Nadia Boukhelifa, Fernanda Fonseca, Alberto Tonda, et al.. Interactive evolutionary modelling of living complex food systems. Genetic and Evolutionary Computation Conference GECCO' 17, Jul 2017, Berlin, Germany. ⟨10.1145/3067695.3075992⟩. ⟨hal-01607872⟩
  • Francoise Irlinger, Wenfan Cao, Thomas Cattenoz, Stéphanie Passot, Marie Noelle Leclercq-Perlat, et al.. Stabilisation d'écosystèmes microbiens fromagers : preuve de concept. Société Française de Microbiologie, Oct 2017, Paris, France. ⟨hal-02266905⟩
  • Bernadette Scutella, Erwan Bourlés, Cassandre Tordjman, Fernanda Fonseca, Yves Mayeresse, et al.. Can the desorption kinetics explain the residual moisture content heterogeneity observed in pharmaceuticals freeze-drying process?. 6. European Drying Conference: EuroDrying 2017, Jun 2017, Liège, Belgium. ⟨hal-01604833⟩
  • Stéphanie Passot, Frederic Jamme, Mathieu Réfrégiers, Julie Meneghel, Paul Dumas, et al.. Les bactéries lactiques sous la lumière du synchrotron pour comprendre les mécanismes de cryotolérance. Société Française de Microbiologie, Oct 2017, Paris, France. ⟨hal-02266902⟩
  • Caroline Pénicaud, Ioan Cristian Tréléa, Bruno Perret, Fernanda Fonseca, Stéphanie Passot. Freeze-drying control by taking into account environmental considerations (communication orale). FoodFactory, Oct 2016, Laval, France. ⟨hal-01589685⟩
  • Caroline Pénicaud, Vincent Monclus, Bruno Perret, Stéphanie Passot, Fernanda Fonseca. Production of stabilized lactic acid bacteria viewed from a life cycle assessment perspective. LCA Food 2016, Oct 2016, Dublin, Ireland. ⟨hal-01532621⟩
  • Caroline Pénicaud, Vincent Monclus, Bruno Perret, Stéphanie Passot, Ioan-Cristian Trelea, et al.. Eco-design of food and bio-processes: Example of production of stabilized lactic acid bacteria. Lecture at WUR, Sep 2016, Wageningen, Netherlands. ⟨hal-01532620⟩
  • Bernadette Scutella, Erwan Bourlés, Fernanda Fonseca, Artemio Plana Fattori, Denis Flick, et al.. How to manage scale-up using the design space approach. 2016 PDA Conference, Pharmaceutical Freeze Drying Technology, PDA., Sep 2016, Strasbourg, France. ⟨hal-01567201⟩
  • Bernadette Scutella, Stéphanie Passot, Erwan Bourlés, Fernanda Fonseca, Artemio Plana Fattori, et al.. Finite elements model of heat transfer predicts the edge vial effect in different freeze-drying configurations. 2016 CPPR Conference Freeze-Drying of Pharmaceuticals and Biologicals, Jul 2016, Breckenridge, United States. ⟨hal-01567200⟩
  • Julie Meneghel, Stéphanie Passot, Stéphanie Cenard, Matthieu Refregiers, Frédéric Jamme, et al.. Mapping membrane fluidity in single bacterial cells to study the impact of cryopreservation and its related stresses. 2. International Conference on Physics and Biological Systems 2016, Oct 2016, Gif-sur-Yvette, France. ⟨hal-02268917⟩
  • Bernadette Scutella, Stéphanie Passot, Erwan Bourlés, Fernanda Fonseca, Ioan-Cristian Trelea. Inter-vial heat transfer heterogeneity during freeze-drying: role of vial geometry and position on the shelf. 7. International Conference ISL-FD, Jul 2015, Barcelona, Spain. ⟨hal-01567216⟩
  • Julie Meneghel, Stéphanie Passot, Frederic Jamme, Matthieu Refregiers, Stéphanie Cenard, et al.. Dynamic characterization of membrane biophysical properties to better understand bacterial tolerance to osmotic and cold stresses encountered during freezing. Microbial Stress: from molecules to systems, Nov 2015, Sitges, Spain. ⟨hal-01535361⟩
  • Fernanda Fonseca, Julie Meneghel, Stéphanie Cenard, Stéphanie Passot, D. Gilham, et al.. Initial measurement of the intracellular glass transition of a mammalian cell type under cryopreservation conditions. 52nd Annual Meeting of the Society for Crryobiology, Jul 2015, Ostrava, Czech Republic. pp.538, ⟨10.1016/j.cryobiol.2015.10.008⟩. ⟨hal-01535362⟩
  • Julie Meneghel, Jiawei Xu, Stéphanie Cenard, Dhruvananda Sockalingum, Stéphanie Passot, et al.. Using Raman spectroscopy to understand the osmotic stress response of lactic acid bacteria. XXI. Journées du Groupe Français de Spectroscopies Vibrationnelles (GFSV), Jun 2015, Reims, France. ⟨hal-01536574⟩
  • Vincent Monclus, Caroline Pénicaud, Bruno Perret, Stéphanie Passot, Fernanda Fonseca. Life cycle assessment for an eco-friendly management of the production of stabilized microorganisms. Life Cycle Management 2015, Aug 2015, Bordeaux, France. ⟨hal-01536576⟩
  • Julie Meneghel, Stéphane Lefrançois, Stéphanie Passot, Frédéric Jamme, Fernanda Fonseca, et al.. Challenges underlying the in situ analysis of single bacterial cells by synchrotron FTIR spectromicroscopy. European Conference on the Spectroscopy of Biological Molecules (ECSBM 16), Sep 2015, Bochum, Germany. ⟨hal-02269493⟩
  • Antonio Camarasa Junior, Thanh Dat Nguyen, Hélène Simonin, Rémi Saurel, Anne Endrizzi, et al.. Environmentally eco-reasoned design process for functional yeast production and stabilization. 3. European Congress of Applied Biotechnology (ECAB 3), Sep 2015, Nice, France. ⟨hal-02266908⟩
  • Stéphanie Passot, Frédéric Jamme, Matthieu Refregiers, Julie Gautier, Stéphanie Cenard, et al.. Synchrotron UV fluorescence microscopy for determining membrane fluidity modification of single bacteria with temperatures . European Conference on Spectroscopy of Biological Molecules XV, Aug 2014, Oxford, United Kingdom. pp.203-210, ⟨10.3233/BSI-140062⟩. ⟨hal-01584095⟩
  • Caroline Pénicaud, Ioan Cristian Tréléa, Bruno Perret, Fernanda Fonseca, Violaine Athes, et al.. Insights into freeze-drying energy consumptions for an environmentally-reasoned process control (poster). GPE – 4th International Congress on Green Process Engineering, 2014, Seville, Spain. pp.546. ⟨hal-01598171⟩
  • Stéphanie Passot, Fernanda Fonseca, Stéphanie Cenard, Ioan Cristian Tréléa. Freeze-drying modeling: prediction of spatial distribution of product quality. The Freeze Drying of Pharmaceuticals and Biologicals Conference, Sep 2014, Garmisch-Partenkirchen, Germany. ⟨hal-01598172⟩
  • Ioan Cristian Tréléa, Fernanda Fonseca, Stéphanie Passot, Denis Flick. A mutual gas diffusion model improves the prediction of mass transfer in freeze-drying (communication orale). IDS 2014 - 19th International Drying Symposium, Aug 2014, Lyon, France. ⟨hal-01598173⟩
  • Stéphanie Passot, Fernanda Fonseca. Lyophilisation: impact sur la valeur nutritionnelle des aliments. Journées d'Etude de l'Association Française des Diététiciens et Nutritionnistes, Jun 2014, Marseille, France. ⟨hal-01628106⟩
  • Stéphanie Passot, Fernanda Fonseca, J. Skepper, G.J. Morris. How to increase freeze-drying recovery of biological products by manipulating the ice crystal morphology. 45. Annual Conference of the British Association for Crystal Growth, Jul 2014, Leeds, United Kingdom. ⟨hal-01628115⟩
  • Fernanda Fonseca, Stéphanie Passot, Ioan Cristian Tréléa. Controlling ice nucleation: the Pros & the Cons. PDA International Conference of Lyophilization and Freeze-drying, Oct 2013, Dusseldorf, Germany. ⟨hal-01598177⟩
  • Helene Velly, Fernanda Fonseca, Agnes Delacroix-Buchet, Stéphanie Passot, Marielle Bouix. Propriétés de la membrane et résistance à la lyophilisation de ferments lactiques : Intérêt de la mesure de fluidité membranaire par cytométrie en flux. 17. Congrès Annuel de l’Association Française de Cytométrie, Oct 2013, Strasbourg, France. ⟨hal-01628116⟩
  • Caroline Pénicaud, Thibaut Maury, Stéphanie Passot, Bruno Perret, Fernanda Fonseca. Analyse environnementale de procédés bio-industriels. SFGP2013 - XIV. Congrès de la Société Française de Génie des Procédés, Oct 2013, Lyon, France. ⟨hal-01628125⟩
  • Stéphanie Passot, Carlos Vilas, Fernanda Fonseca, Stéphanie Cenard, Eva Balsa-Canto, et al.. Real time optimization of freeze-drying of lactic acid bacteria (communication orale). SDDP2012 - 5th International Symposium on Spray Dried Dairy Products, Jun 2012, Saint-Malo, France. ⟨hal-01598191⟩
  • Stéphanie Passot, Fernanda Fonseca, Stéphanie Cenard, Carlos Vilas, Eva Balsa-Canto, et al.. Developing smart control strategies for the freeze-drying of bacteria. ISL-FD: 5th International Conference on Lyophilization and Freeze Drying, 2012, Bologne, Italy. ⟨hal-01598192⟩
  • Stéphanie Passot, Fernanda Fonseca, Stéphanie Cenard, Ioan-Cristian Trelea. Developing smart control strategies of freeze-drying of lactic acid bacteria. 5. International Conference on Lyophilization and Freeze Drying, Mar 2012, Bologne, Italy. ⟨hal-01628100⟩
  • Stéphanie Passot, Fernanda Fonseca, Stéphanie Cenard, C. Vilas, E. Balsa Canto, et al.. Developing smart control strategies for the freeze-drying of bacteria. EFFoST Annual Meeting, Nov 2012, Montpellier, France. ⟨hal-01628119⟩
  • Julie Gautier, Stéphanie Passot, Stéphanie Cenard, Caroline Pénicaud, Pascale Lieben, et al.. Influence of the membrane phase behaviour and lipid composition on the freezing-resistance of lactic acid bacteria. Faraday Discussion 161: Lipids and Membrane Biophysics, Sep 2012, London, United Kingdom. ⟨hal-01628096⟩
  • Stéphanie Passot, Julie Gautier, Caroline Pénicaud, Frederic Jamme, Stéphanie Cenard, et al.. Towards a better understanding of the freezing resistance of lactic acid bacteria. International Conference on Membrane Domains, Nov 2012, Dijon, France. ⟨hal-01628101⟩
  • J. Gautier, Stéphanie Passot, Frédéric Jamme, Stéphanie Cenard, Fernanda Fonseca. Biophysical and chemical responses of Lb. bulgaricus to freezing by infrared microspectroscopy. 7. Soleil User's Meeting, Jan 2012, Saclay, France. ⟨hal-01628120⟩
  • Caroline Pénicaud, Jean-Marie Beckerich, Yvann Pennont, Fernanda Fonseca, Marielle Bouix, et al.. Réponse physiologique de Saccharomyces cerevisiae et Yarrowia lipolytica aux conditions de production et de stabilisation. Levures, Modèles & Outils – 10ème Rencontre des Levuristes Francophones, Apr 2012, Toulouse, France. ⟨hal-01628122⟩
  • Stéphanie Passot, Stéphanie Cenard, Ioan-Cristian Trelea, Fernanda Fonseca. Freeze-drying of lactic acid bacteria : effect of process variables on cell injury. 48. Annual Meeting of the Society for Cryobiology, Jul 2011, Corvallis, Oregon, United States. ⟨10.1016/j.cryobiol.2011.09.055⟩. ⟨hal-02749196⟩
  • R. Capuano, M. Santonico, E. Martinelli, R. Paolesse, Stéphanie Passot, et al.. Electronic nose characterization of the quality parameters of freeze-dried bacteria. 14. International Symposium on Olfaction and Electronic Nose, May 2011, New York, United States. pp.125-126, ⟨10.1063/1.3626330⟩. ⟨hal-02745659⟩
  • Stéphanie Passot, Fernanda Fonseca, Stéphanie Cenard, Ines Douania, Ioan-Cristian Trelea. Quality degradation of lactic acid bacteria during the freeze drying process : experimental study and mathematical modelling. ICEF 11, International Congress of Engineering and Food, May 2011, Athens, Greece. ⟨hal-02746624⟩
  • Georges Corrieu, Christophe Monnet, Fernanda Fonseca, Catherine Béal. New trends in lactic acid fermentation in the industrial perspectives. International Symposium on Fermentation Microorganisms, Nov 2011, Séoul, South Korea. ⟨hal-02747169⟩
  • Fernanda Fonseca, J. Gautier, Stéphanie Cenard, Stéphanie Passot, Frederic Jamme, et al.. Probing live cellular responses to freezing by infrared spectromicroscopy. CellNanoSpec 2011, Sep 2011, Porquerolles, France. ⟨hal-02748928⟩
  • Stéphanie Passot, Fernanda Fonseca, Fabien Brothier, Said Bouhallab. The physical behavior of food protein's supramolecular structure during freeze-drying. ICEF 11, International Congress of Engineering and Food, May 2011, Athens, Greece. ⟨hal-01454611⟩
  • Stéphanie Passot, Stéphanie Cenard, Ioan-Cristian Trelea, Ines Douania, Fernanda Fonseca. Water in freeze-dried lactic acid bacteria: Friend or Foe. EuroFoodWater, Mar 2010, Reims, France. ⟨hal-02818597⟩
  • Stéphanie Passot, Ines Douania, Stéphanie Cenard, Fernanda Fonseca, Ioan-Cristian Trelea. Modeling for risk assessment of quality failures: Application to microorganisms. Freeze Drying of Pharmaceuticals and Biologicals Conference, Sep 2010, Garmisch-Partenkirchen, Germany. ⟨hal-02751750⟩
  • J.E. Green, I.C. Fernandez, B.W.W. Grout, Fernanda Fonseca. Non-equilibrium ice formation affects the survival of bull sperm at rapid cooling rates. 47. Annual Meeting of the Society for Cryobiology, Jul 2010, Bristol, United Kingdom. ⟨10.1016/j.cryobiol.2010.10.087⟩. ⟨hal-02754341⟩
  • Stéphanie Passot, Aline Rault, Stéphanie Cenard, Fernanda Fonseca. Cryopreservation of Lactobacillus delbrueckii subsp. bulgaricus: towards a quantitative understanding of the cell biophysical response during freezing. 47. Annual Meeting of the Society for Cryobiology, Jul 2010, Bristol, United Kingdom. ⟨10.1016/j.cryobiol.2010.10.039⟩. ⟨hal-02755152⟩
  • G.J. Morris, Fernanda Fonseca. Absence of intracellular ice in rapidly cooled spermatozoa. 47. Annual Meeting of the Society for Cryobiology, Jul 2010, Bristol, United Kingdom. ⟨hal-02814970⟩
  • Fernanda Fonseca, Stéphanie Cenard, Ioan-Cristian Trelea, Michele Marin, Stéphanie Passot. Stabilization of lactic acid bacteria : relevance of physical properties on formulation and process efficiency. X. Congreso Latinoamericano de Microbiologia et Hygiena de los Alimentos, Oct 2009, Punta del Este, Uruguay. ⟨hal-02750465⟩
  • Stéphanie Passot, Ioan-Cristian Trelea, Fernanda Fonseca. Computer modelling to optimise freeze-drying cycles. Visiongain's 2nd Annual Lyophilisation Conference, Sep 2009, London, United Kingdom. ⟨hal-02750950⟩
  • Sophie Chassagne-Berces, Fabienne Guillon, Marie Francoise Devaux, Amidou Traore, Giuseppe Pigorini, et al.. Characterization of water mobility and ice crystallisation in plant tissue during freezing. SLTB Annual Scientific Meeting, AGM and Symposium"Application of Cryobiology from Human Tissue Engineering to Plant Genebank Integration", Sep 2009, Hannovre, Germany. ⟨hal-01195438⟩
  • Stéphanie Passot, Ioan-Cristian Trelea, Fernanda Fonseca. Lyophilisation of pellets : experimental and modelling study. Journée AFSIA-EFCA, 2009, lyon, France. ⟨hal-02819808⟩
  • Catherine Béal, Georges Corrieu, Fernanda Fonseca, Stéphanie Passot, Aline Rault, et al.. Cryotolerance of lactic acid bacteria is influenced by their passive and active responses to cold stress. Society for General Microbiology (SGM) : Autumn Meeting Edimburgh Conference Centre Heriot-Watt University, Sep 2009, Edinburgh, United Kingdom. ⟨hal-02757146⟩
  • Jon E. Green, Fernanda Fonseca, G.John Morris, David Gubb. Towards the cryopreservation of Drosophila melanogaster larvae. Annual Meeting of Society for Low Temperature Biology, Sep 2009, Hannover, Germany. pp.177. ⟨hal-02758000⟩
  • Stéphanie Passot, Fernanda Fonseca, Michele Marin, Ioan-Cristian Trelea. Vacuum freeze-drying of food pellets : experimental study and mathematical modelling. ICEF 10 - International Congress on Engineering and Food, Apr 2008, Vina del Mar, Chile. ⟨hal-02811586⟩
  • Stéphanie Passot, Fernanda Fonseca, Michèle Marin, Ioan-Cristian Trelea. User-friendly modeling of the freeze-drying process. The Freeze Drying of Pharmaceuticals and Biologicals Conference, 2008, Breckenridge, CO, United States. ⟨hal-02812410⟩
  • Stéphanie Passot, Fernanda Fonseca, Ioan-Cristian Trelea, Michèle Marin. Impact of freezing, especially the controlled nucleation, on protein freeze-drying efficiency. Informa Life Sciences. Lyophilization of Pharmaceuticals, 2008, Londres, United Kingdom. ⟨hal-02813150⟩
  • Stéphanie Passot, Michele Marin, Ioan-Cristian Trelea, Fernanda Fonseca. Quality by deisgn approach : the particular case of freeze-drying process. 2008 PDA Conference on Quality by Design, Oct 2008, Frankfurt, Germany. ⟨hal-02814219⟩
  • Stéphanie Passot, Fernanda Fonseca, Ioan-Cristian Trelea, Michèle Marin. Impact of thermal properties on protein formulation and freeze-drying cycle development. ISPE Conference on Manufacturing Excellence 2008. Lyophilization: Meeting the Challenges of a Critical Technology, 2008, Tempa,Fl, United States. ⟨hal-02815517⟩
  • Stéphanie Passot, Fernanda Fonseca, Michèle Marin, Ioan-Cristian Trelea. Vacuum freeze-drying of a bed of food pellets: Experimental study and mathematical modelling. ICEF 10 - International Congress on Engineering and Food, Apr 2008, Vina del Mar, Chile. ⟨hal-02816125⟩
  • Stéphanie Passot, Ioan-Cristian Trelea, Stéphanie Cenard, Fernanda Fonseca. Freezing : a critical step for freeze-drying cycle development and product stability. 2008 ISPE Conference : Lyophilisation: Scientific Issues of the Process and Introduction to a Risk-Based Approach, Dec 2008, Barcelona, Spain. ⟨hal-02750962⟩
  • Fernanda Fonseca, Stéphanie Passot, Stéphanie Cenard, Ioan-Cristian Trelea, Michele Marin, et al.. Stabilization of freeze-dried Lb Bulgaricus cells: the freezing kinetics effect. Annual Meeting of the Society for Cryobiology, Jul 2008, Charlotte, North Carolina, United States. ⟨10.1016/j.cryobiol.2008.10.090⟩. ⟨hal-02752775⟩
  • Sophie Chassagne-Berces, Fabienne Guillon, Marie Francoise Devaux, Marc Lahaye, Giuseppe Piggorini, et al.. Textural, histological and cell wall composition changes in apple tissue caused by freezing. Annual Meeting of Society for Low Temperature Biology, SLTB Symposium 2008, Sep 2008, Copenhagen, Denmark. ⟨10.1016/j.cryobiol.2008.10.051⟩. ⟨hal-02751402⟩
  • Fernanda Fonseca, Stéphanie Passot, Stéphanie Cenard, Ioan-Cristian Trelea, Michele Marin. Stabilisation of lactic acid bacteria: relevance of physical properties on formulation efficiency. 1. Int. DOM Symposium on Microbial Formulation, 2007, Uppsala, Sweden. ⟨hal-02813661⟩
  • Ioan-Cristian Trelea, Stéphanie Passot, Fernanda Fonseca, Michele Marin. An interactive tool for freeze-drying cycle optimisation based on product quality criteria. Informa Life Sciences. Lyophilization of Pharmaceuticals, Dec 2007, London, United Kingdom. ⟨hal-02814381⟩
  • Stéphanie Passot, Fernanda Fonseca, Ioan-Cristian Trelea, Alice Remillieux, M. Galan, et al.. Controlled nucleation improves the efficiency pharmaceutical proteins lyophilization. Journées AFSIA-EFCE, May 2007, Biarritz, France. ⟨hal-02821076⟩
  • Stéphanie Passot, Fernanda Fonseca, Michèle Marin. Impact of thermal properties on formulation and on freeze-drying development. Conférence de l'Institut International du Froid (IIF), Institut International du Froid (IIF). FRA., Nov 2007, Strasbourg, France. ⟨hal-02751565⟩
  • Fernanda Fonseca, Stéphanie Passot, Stéphanie Cenard, Michèle Marin, G. J. Morris. The glassy state of the freeze-concentrated medium formed during freezing: effects on cryopreservation of Lb. bulgaricus cells. 44. Anual Meeting of the Society for Cryobiology, Jul 2007, Lake Louise, Alberta, Canada. ⟨10.1016/j.cryobiol.2007.10.106⟩. ⟨hal-02755460⟩
  • Fernanda Fonseca, Stéphanie Passot, Ioan-Cristian Trelea, Michele Marin. Impact of physical properties of bioproducts on formulation and freeze-drying cycle development. International Society for Pharmaceutical Engineering (ISPE). Lyophilization Technologies and Practice Seminar, Sep 2006, Vienna, Austria. ⟨hal-02812611⟩
  • Fernanda Fonseca, Stéphanie Passot, Ioan-Cristian Trelea, Michele Marin. Impact of physical properties of bioproducts on formulation and on freeze-drying cycle development. International Society for Pharmaceutical Engineering (ISPE). Lyophilization - Technologies and Practice- Seminar, Sep 2006, Vienna, Austria. ⟨hal-02812984⟩
  • Stéphanie Passot, Ioan-Cristian Trelea, Fernanda Fonseca, Naziha Barbouche, Michele Marin. Integration of glass transition in freeze-drying kinetic modelling to improve protein stability. 13. World Congress of Food Science and Technology "Food is Life", IUFOST XIIIth Congress, Jul 2006, Nantes, France. ⟨10.1051/IUFoST:20060715⟩. ⟨hal-02751252⟩
  • Fernanda Fonseca, Stéphanie Passot, Michele Marin, G.John Morris. Cryopreservation of lactic acid bacteria: Effect of linear cooling rates. Annual Meeting of the Society for Cryobiology, Jul 2006, Hamburg, Germany. pp.395-396, ⟨10.1016/j.cryobiol.2006.10.067⟩. ⟨hal-02750461⟩
  • Stéphanie Passot, Fernanda Fonseca, Michèle Marin. Physical and biological stability of freeze-dried polymer-sucrose protein formulations related to water activity. Amorph 2006, Jul 2006, Cambridge, United Kingdom. ⟨hal-02814317⟩
  • Georges Corrieu, Christophe Monnet, Fernanda Fonseca, Catherine Béal. New trends in lactic acid fermentation. First Mediterranean Congress on Biotechnology (MCB1), Mar 2006, Hammamet, Tunisia. ⟨hal-02816738⟩
  • Ioan-Cristian Trelea, Stéphanie Passot, Fernanda Fonseca, Michèle Marin. An interactive tool for freeze-drying cycle optimization based on product quality criteria. Journées AFSIA-EFCE, May 2005, Paris, France. ⟨hal-02827039⟩
  • Fernanda Streit, Fernanda Fonseca, Georges Corrieu, Catherine Béal. Influence of cell conditioning on the resistance to freezing of Lactobacillus bulgaricus CFL1. SINAFERM 2005, XV Simposio Nacional de Bioprocessos, Feb 2005, Recife, Brazil. ⟨hal-02826063⟩
  • Fernanda Fonseca, Stéphanie Passot, Michèle Marin. Physical properties of frozen and freeze-dried starters : Impact on process conditions and formulation efficiency. Minisymposium on Antifungal lactic acid and propionic acid bacteria, May 2005, Uppsala, Sweden. ⟨hal-02827044⟩
  • Stéphanie Passot, Fernanda Fonseca, Ioan-Cristian Trelea, Michèle Marin. Examining the current status of Process Analytical Technology applied to lyophilization: Instrumentation, kinetics, quality criteria and risks area in the cycle. Barnett International’s Annual Conference on Freeze-drying, Jun 2004, Dublin, Ireland. ⟨hal-02829880⟩
  • Fernanda Fonseca, Stéphanie Passot, Michèle Marin. An effective property for the formulation of a freeze-dried food ingredient: Glass transition or Collapse ?. 9.International Congress on Engineering and Food (ICEF ), Nov 2004, Montpellier, France. ⟨hal-02759113⟩
  • Fernanda Fonseca, Michèle Marin, G. J. Morris. Stabilization of frozen Lactobacillus bulgaricus suspensions: interactions between cryoprotectants, freezing rates and storage temperature. 41. Annual Meeting of the Society for Cryobiology, Jul 2004, Bejing, China. ⟨10.1016/j.cryobiol.2004.10.001⟩. ⟨hal-02759750⟩
  • Fernanda Fonseca, Stéphanie Passot, Pascale Lieben, Michele Marin. Collapse temperature of bacterial suspensions: effect of cell concentration. National Institute of Biological Standards and Control and the Society of Low Temperature Biology entitled "Current Trends in Cryobiology and Lyophilization", Sep 2003, London, United Kingdom. ⟨hal-02762945⟩
  • Catherine Béal, Fernanda Fonseca, S. Meurisse, Georges Corrieu. Combining cryoprotective agents may improve the resistance to freezing and storage of lactic acid bacteria. 38. Meeting of the Society for Cryobiology, Jul 2001, Edimburg, United Kingdom. pp.316-389, ⟨10.1006/cryo.2002.2369⟩. ⟨hal-02759622⟩
  • Catherine Béal, Fernanda Fonseca, Georges Corrieu. Resistance of lactic acid bacteria to freezing is controlled by culture and freezing conditions. 36. Annual Meeting of the Society for Cryobiology, Jul 1999, Marseille, France. 272 p. ⟨hal-02765806⟩
  • Catherine Béal, C. Khaoua, Fernanda Fonseca, Georges Corrieu. Culture conditions improve lactic acid bacteria resistance to freezing. International Symposium on Microbial Stress and Recovery in Food, Jun 1999, Quimper, France. 324 p. ⟨hal-02765933⟩
  • Fernanda Fonseca, Michèle Marin, Catherine Béal. Caracterization of water mobility in media used for lactic acid bacteria production. Agoral 99 : 11èmes Rencontres Scientifiques et Technologiques des Industries Alimentaires, Mar 1999, Nantes, France. 466 p. ⟨hal-02766188⟩
  • Fernanda Fonseca, Michèle Marin, Catherine Béal, F. Rene. DSC study of fermentation media and bacterial suspensions. International Symposium on Water Management in the Design and Distribution of Quality Foods, 1998, Helsinki, Finland. ⟨hal-02769493⟩

Poster communications23 documents

  • Juan Buceta Correa de Borba, Stéphanie Passot, Bernadette Scutellà, Fernanda Fonseca, Erwan Bourles, et al.. Freeze-drying in atypical vials: how to model heat transfer during sublimation by using 3D mathematical modelling. 9. International Symposium on Lyophilization and Pharmaceutics ISLFD 2019, Sep 2019, Ghent, Belgium. 2019, 9th International Symposium on Lyophilization and Pharmaceutics ISLFD 2019. ⟨hal-02268926⟩
  • Andrea Gomez-Zavaglia, Stéphanie Passot, Caroline Pénicaud, Paula Castilho, Pedro Nuno Simões, et al.. Preserving bacteria with oligosaccharides and eco-friendly processes (Premium). 55. Annual Meeting of the Society for Cryobiology, Jul 2018, Madrid, Spain. Elsevier Ltd, Cryobiology, 85 (December 2018), 2018, Cryobiology. ⟨10.1016/j.cryobiol.2018.10.203⟩. ⟨hal-02266913⟩
  • Julie Meneghel, Peter Kilbride, Fernanda Fonseca, G.John Morris. Optimising controlled rate freezing protocols. Manufacturing ATMPs – moving from approvable to commercial success, Sep 2018, London, United Kingdom. ⟨hal-02999268⟩
  • Amélie Girardeau, Cristian Felipe Puentes Mancipe, Sophie Keravec, Pierre Peteuil, Ioan-Cristian Trelea, et al.. Mapping the physiological states of Carnobacterium maltaromaticum obtained” by applying stressful fermentation conditions. 4. Microbial Stress: from systems to molecules and back, Apr 2018, Cork, Ireland. 2018, 4th Microbial Stress: from systems to molecules and back. ⟨hal-02268919⟩
  • Julie Meneghel, Fernanda Fonseca, Paul Dumas, Stéphanie Passot, Frederic Jamme. Cryopreservation-related stresses in Lactobacillus delbrueckii SUBSP. Bulgaricus: Global and multi-scale study. 55. Annual Meeting of the Society for Cryobiology, Jul 2018, Madrid, Spain. Elsevier Ltd, Cryobiology, 85 (December 2018), 2018, Cryobiology. ⟨10.1016/j.cryobiol.2018.10.184⟩. ⟨hal-02266904⟩
  • Jasmin Baboo, Peter Kilbride, Mike Delahaye, Stuart Milne, Fernanda Fonseca, et al.. Interdependency of freezing and thawing rates on cryopreserved human t cells. 55. Annual Meeting of the Society for Cryobiology, Jul 2018, Madrid, Spain. Elsevier Ltd, Cryobiology, 85 (December 2018), 2018, Cryobiology. ⟨10.1016/j.cryobiol.2018.10.059⟩. ⟨hal-02266903⟩
  • Frederic Jamme, Isabelle Bouchez, Caroline Pénicaud, Stéphanie Passot, Fernanda Fonseca, et al.. Structural study of lipid droplet using synchrotron label-free multimodal imaging. 4. International Conference on Physics and Biological Systems, Oct 2018, Gif-sur-Yvette, France. 2018, 4th International Conference on Physics and Biological Systems 2018. ⟨hal-02733903⟩
  • Wenfan Cao, Francoise Irlinger, Thomas Cattenoz, Marie Noelle Leclercq-Perlat, Stéphanie Passot, et al.. Preservation of Preservation of a smear surface-ripened cheese ecosystem by freezing and freeze-drying: a proof of concepta smear surface-ripened cheese ecosystem by freezing and freeze-drying: a proof of concept. 7. Congress of European Microbiologists FEMS 2017, Jul 2017, Valencia, Spain. 2017, FEMS 2017 ABSTRACT BOOK. ⟨hal-02268925⟩
  • Stéphanie Passot, Caroline Pénicaud, Marielle Bouix, Bruno Perret, Ioan-Cristian Trelea, et al.. Freeze-drying of bacteria: From the understanding of the mechanisms of cell resistance to the sustainable process development and optimization. 21. Colloque du Club de Bactéries Lactiques, Jun 2017, Lille, France. 2017. ⟨hal-02266907⟩
  • Stéphanie Passot, Fernanda Fonseca. The challenges for freeze-drying complex biological systems: State of the art and future. 8. International Conference of Lyophilization and Freeze-Drying, Apr 2017, La Havana, Cuba. 2017, 8. International Conference of Lyophilization and Freeze-Drying. ⟨hal-02266906⟩
  • Frederic Jamme, Isabelle Bouchez, Caroline Pénicaud, Stéphanie Passot, Fernanda Fonseca, et al.. Synchrotron label free multimodal imaging to explore lipid droplets in living cells. Conférence Jacques Monod Analyses moléculaires de l’organisation et du remodelage des membranes, Apr 2017, Roscoff, France. 2017. ⟨hal-02736520⟩
  • Vincent Monclus, Caroline Pénicaud, Bruno Perret, Fernanda Fonseca. Environmental assessment of different strategies for production of stabilized yeast. LCA Food 2016, Oct 2016, Dublin, Ireland. 2016. ⟨hal-02794231⟩
  • Stéphanie Passot, Ioan-Cristian Trelea, Stéphanie Cenard, Fernanda Fonseca. Freeze-drying of bacteria : state of the art and new perspectives. 7. International Conference of Lyophilization and Freeze-Drying, Jul 2015, Barcelona, Spain. 2015. ⟨hal-01535314⟩
  • Stéphanie Passot, Helene Velly, Caroline Pénicaud, Pascale Lieben, Sarrah Ghorbal, et al.. Strategies for improving freeze-drying resistance of bacteria: Modulating membrane properties during fermentation. 52. Annual Meeting of the Society for Cryobiology, Jul 2015, Ostrava, Czech Republic. Academic Press - Elsevier, Cryobiology, 71 (3), pp.550, 2015, Cryobiology. ⟨hal-01536530⟩
  • Fernanda Fonseca, Stéphanie Passot, Julie Meneghel, Stéphanie Cenard, P. Dumas, et al.. Towards a better understanding of cryotolerance mechanisms in bacteria. 52. Annual Meeting of the Society for Cryobiology, Jul 2015, Ostrava, Czech Republic. Academic Press - Elsevier, Cryobiology, 71 (3), pp.548, 2015, Cryobiology. ⟨hal-01536531⟩
  • Julie Meneghel, Stéphanie Passot, Stéphanie Cenard, Jiawei Xu, Matthieu Refregiers, et al.. Mapping membrane fluidity by fluorescence anisotropy to better understand bacterial toloerance to osmotic and cold stresses encountered during freezing. 52. Annual Meeting of the Society for Cryobiology, Jul 2015, Ostrava, Czech Republic, Czech Republic. Elsevier Ltd, Cryobiology, 71, pp.549, 2015, Cryobiology. ⟨10.1016/j.cryobiol.2015.10.052⟩. ⟨hal-01536575⟩
  • Stéphanie Passot, Frederic Jamme, M. Refregiers, Stéphanie Cenard, Fernanda Fonseca. Towards the in situ study of bacterial single cells following freeze-drying using synchrotron radiation. 6. International Conference of Lyophilization and Freeze-Drying, Oct 2013, Sao Paulo, Brazil. 2013. ⟨hal-01628107⟩
  • Stéphanie Passot, Fernanda Fonseca. An evaluation of the advantages and disadvantages of controlling ice nucleation in the lyophilisation process. SMi Inaugural Meeting on Lyophilisation: Freeze-Drying in Pharmaceuticals and Biopharmaceutical, Feb 2013, London, United Kingdom. 2013. ⟨hal-01628108⟩
  • Stéphanie Passot, Frédéric Jamme, Matthieu Refregiers, J. Gautier, Stéphanie Cenard, et al.. Towards the measurement of membrane fluidity at subzero temperatures for improving cell cryopreservation. European Conference on the Spectroscopy of Biological Molecules (ECSBM 15), Aug 2013, Oxford, United Kingdom. Biomedical Spectroscopy and Imaging, 3(3), 2013, Biomedical Spectroscopy and Imaging. ⟨hal-01628117⟩
  • Stéphanie Passot, Marielle Bouix, Stéphanie Cenard, Julie Gautier, Sarrah Ghorbal, et al.. Cell membrane fluidity : its significance for freezing resistance of lactic acid bacteria. 49. Annual Meeting of the Society for Cryobiology, Jun 2012, Rosario, Argentina. Cryobiology, 2012, Cryobiology. ⟨hal-01628099⟩
  • Julie Gautier, Stéphanie Passot, Frederic Jamme, Stéphanie Cenard, Fernanda Fonseca. Using synchroton infrared microspectroscopy to better understand the freezing-resistance of lactic acid bacteria. 49. Annual Meeting of the Society for Cryobiology, Jun 2012, Rosario, Argentina. Elsevier Ltd, Cryobiology, 65 (3), 2012, Cryobiology. ⟨10.1016/j.cryobiol.2012.07.029⟩. ⟨hal-01628097⟩
  • Stéphanie Passot, Fernanda Fonseca, Fabien Brothier, Said Bouhallab. The physical behaviour of food protein’s supramolecular structures during freezedrying. 11. International Congress on Engineering and Food, May 2011, Athènes, Greece. Petros S. Taoukis;Nikolaos G. Stoforos;Vaios T. Karathanos;George D. Saravacos Cosmosware, Ag. Ioannou 53, Athens, Greece, 0030 2106013922 cosmosware@ath.forthnet.gr, 2011, FOOD PROCESS ENGINEERING IN A CHANGING WORLD Proceedings of the 11 th International Congress on Engineering and Food (ICEF11) 3 volumes. ⟨hal-01190444⟩
  • Stéphanie Passot, Fernanda Fonseca, Michèle Marin. Effect of primary drying above Tg' on the long term stability of freeze-dried proteins. Amorph 2006, Jul 2006, Cambridge, United Kingdom. 2006. ⟨hal-02816303⟩

Book sections5 documents

  • Amélie Girardeau, Vanessa Biscola, Sophie Keravec, Georges Corrieu, Fernanda Fonseca. Application of Lactic Acid Bacteria in Time-Temperature Integrators. Lactic Acid Bacteria, CRC Press, pp.241-260, 2020, ⟨10.1201/9780429422591-14⟩. ⟨hal-02882324⟩
  • Erwan Bourlès, Gael de Lannoy, Bernadette Scutellà, Fernanda Fonseca, Ioan-Cristian Trelea, et al.. Scale-up of freeze-drying cycles, the use of process analytical technology (PAT), and statistical analysis. Lyophilization of Pharmaceuticals and Biologicals, Editions Springer, 2019, Methods in Pharmacology and Toxicology, 978-1-4939-8927-0. ⟨10.1007/978-1-4939-8928-7_10⟩. ⟨hal-02266898⟩
  • Catherine Béal, Fernanda Fonseca. Freezing of Probiotic Bacteria. Advances in Probiotic Technology, Taylor & Francis Group, pp.179 - 212, 2015, 978-1-4987-3453-0. ⟨10.1201/b18807-14⟩. ⟨hal-01511588⟩
  • Fernanda Fonseca, Stéphanie Cenard, Stéphanie Passot. Freeze-drying of lactic acid bacteria. Cryopreservation and Freeze-Drying Protocols, 1257, Humana Press Inc., 12 p., 2015, Methods in Molecular Biology, 978-1-4939-2192-8. ⟨10.1007/978-1-4939-2193-5_24⟩. ⟨hal-01535358⟩
  • Catherine Béal, Michèle Marin, Eloi Fontaine, Fernanda Fonseca, Jean-Philippe Obert. Production et conservation des ferments lactiques et probiotiques. Bactéries lactiques : de la génétique aux ferments., 18, Editions Lavoisier, 848 p., 2008, Sciences et Techniques Agroalimentaires, 978-2-7430-1016-4. ⟨hal-02819364⟩

Patents4 documents

  • Catherine Juste, Joel Dore, Patricia Lepage, Christel Maillet, Sylvie Rabot, et al.. Method for preparing a fecal microbiota sample. France, Patent n° : Absent. 2016. ⟨hal-02268928⟩
  • Hervé Affagard, Carole Schwintner, Catherine Juste, Joel Dore, Audrey Chapron, et al.. Method of lyophilization of a sample of faecal microbiota. France, Patent n° : WO2017103550A1. 2016. ⟨hal-02268930⟩
  • Stéphanie Passot, Fernanda Fonseca, Michèle Marin. Compositions pour la lyophilisation de protéines. 2005. ⟨hal-02833421⟩
  • Catherine Béal, Georges Corrieu, Fernanda Fonseca, Michèle Marin. Procédé de préparation d'une composition lyophilisée contenant des bactéries lactiques à viabilité et activité bactériennes améliorées lors d'un stockage à température ambiante et composition obtenue. 2002. ⟨hal-02830677⟩

Other publications1 document

  • Fernanda Fonseca, Stéphanie Passot, J. Gautier, P Dumas, Frédéric Jamme. Vers la compréhension de la résistance à la congélation de bactéries lactiques grâce à la microspectroscopie infrarouge haute résolution . 2012, pp.64-65. ⟨hal-01586830⟩

Reports3 documents

  • Caroline Pénicaud, Stéphanie Passot, Fernanda Fonseca, Frederic Jamme. Experimental report of proposal 20121064 : multimodal single cell studies of Yarrowia lipolytica yeast under dehydration and thermal stresses. [Research Report] auto-saisine. 2014. ⟨hal-01628126⟩
  • Céline Casenave, Cristian Trelea, Jean-Roch Mouret, Jean-Marie Sablayrolles, Stéphanie Passot, et al.. European project CAFE WP3: Process experiments - Deliverable 3.3: Test of optimal control strategies. [Research Report] inria. 2013. ⟨hal-00859575⟩
  • Ruud van der Sman, Martijntje Vollebregt, Robert David, Denis Dochain, Denis Flick, et al.. European project CAFE WP4: Model reduction, validation and simulation - Deliverable 4.2: Portable and documented simulation software for each demonstration process. [Contract] . 2013. ⟨hal-00859579⟩

Theses1 document

  • Fernanda Fonseca. Influence de la cryoprotection et de la congélation sur l'activité acidifiante de bactéries lactiques thermophiles. Relations entre propriétés biologiques et thermodynamiques. Ingénierie des aliments. Institut National Agronomique Paris Grignon, 2001. Français. ⟨tel-02825586⟩