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Fernanda FONSECA
23
Documents
Affiliations actuelles
Identifiants chercheurs
- fernanda-fonseca
- ResearcherId : AAR-9094-2020
- 0000-0003-3394-182X
- Google Scholar : https://scholar.google.fr/citations?user=roNN7VMAAAAJ&hl=fr
- IdRef : 057054649
Présentation
#### **EDUCATION**
**Habilitation à Diriger des Recherches (HDR).** Université de Technologie de Compiègne, 2010. Title : « Stabilization of bio functionalities trough an approach combining the understanding of mechanisms and the product-process engineering”
**Ph.D. Degree** in **Biotechnology and Process Engineering**, Institut National Agronomique Paris-Grignon (AgroParisTech),**2001**. Ph.D. thesis title: "Influence of cryoprotection and freezing on the acidification activity of thermopile lactic acid bacteria: relationships between biological and thermodynamic properties."
**Master Degree** in **Biotechnology and Process Engineering**, Institut National Agronomique Paris-Grignon (AgroParisTech), **1997**. M.Sc. thesis title: "Study of the freezing step on the activity of frozen lactic acid starters."
Engineer** in **Chemical Engineering**, Montevideo University (Uruguay), **1996.**
**SCIENTIFIC EXPERIENCE**
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**Research Director (since January 2015),** in Paris-Saclay Food and Bioproduct Engineering research unit (UMR 782 SayFood INRAE-AgroParisTech), Versailles-Grignon Centre, at the French National Institute for Agriculture, Food and Environment (INRAE), France.
**Researcher Scientist** (**September 2001 – December 2014**), in the Joint Research Unit for Food Process Engineering and Microbiology (UMR 782 GMPA INRA-AgroParisTech), Versailles-Grignon Centre, Institut National de la Recherche Agronomique (INRA), France.
**Main fields of expertise:**Biotechnology and process engineering: fermentation, formulation, and stabilization of bioproducts.
- Bioproducts: micro-organisms, proteins, food products.
- Stabilization processes: freezing and freeze-drying
- Biophysical characterization of bioproducts (thermal analysis, freeze-drying microscopy, Fourier Transformed InfraRed microspectroscopy)
**Research approach:** Focusing on biophysical and chemical behaviors of bioproducts during stabilization processes and by relating them to biological and functional responses, to identify and quantify the mechanisms governing the degradation and preservation of bioproducts during the stabilization processes. The ambition is also to find general principles for simplifying and rationalizing the development of newly formulated products and the stabilization process optimization, with particular attention to limiting the environmental impact.
Domaines de recherche
Compétences
Publications
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Insights into lactic acid bacteria cryoresistance using FTIR micro-spectroscopyAnalytical and Bioanalytical Chemistry, 2022, 414 (3), pp.1425-1443. ⟨10.1007/s00216-021-03774-x⟩
Article dans une revue
hal-03552585v1
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A Guide for Ex Vivo Handling and storage of stool samples Intended for Fecal Microbiota transplantationScientific Reports, 2019, 9 (1), pp.8897. ⟨10.1038/s41598-019-45173-4⟩
Article dans une revue
hal-02466120v1
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Determination of Intracellular Vitrification Temperatures for Unicellular Micro Organisms under Conditions Relevant for CryopreservationPLoS ONE, 2016, 11 (4), pp.e0152939. ⟨10.1371/journal.pone.0152939⟩
Article dans une revue
hal-01565156v1
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Critical water activity and amorphous state for optimal preservation of lyophilised lactic acid bacteriaFood Chemistry, 2012, 132 (4), pp.1699-1705. ⟨10.1016/j.foodchem.2011.06.012⟩
Article dans une revue
hal-01536691v1
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Using Raman spectroscopy to understand the osmotic stress response of lactic acid bacteriaXXI. Journées du Groupe Français de Spectroscopies Vibrationnelles (GFSV), Jun 2015, Reims, France
Communication dans un congrès
hal-01536574v1
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Dynamic characterization of membrane biophysical properties to better understand bacterial tolerance to osmotic and cold stresses encountered during freezingMicrobial Stress: from molecules to systems, Nov 2015, Sitges, Spain
Communication dans un congrès
hal-01535361v1
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Initial measurement of the intracellular glass transition of a mammalian cell type under cryopreservation conditions52nd Annual Meeting of the Society for Crryobiology, Jul 2015, Ostrava, Czech Republic. pp.538, ⟨10.1016/j.cryobiol.2015.10.008⟩
Communication dans un congrès
hal-01535362v1
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Freeze-drying modeling: prediction of spatial distribution of product qualityThe Freeze Drying of Pharmaceuticals and Biologicals Conference, Sep 2014, Garmisch-Partenkirchen, Germany
Communication dans un congrès
hal-01598172v1
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Developing smart control strategies for the freeze-drying of bacteriaISL-FD: 5th International Conference on Lyophilization and Freeze Drying, 2012, Bologne, Italy
Communication dans un congrès
hal-01598192v1
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Developing smart control strategies for the freeze-drying of bacteriaEFFoST Annual Meeting, Nov 2012, Montpellier, France
Communication dans un congrès
hal-01628119v1
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Real time optimization of freeze-drying of lactic acid bacteria (communication orale)SDDP2012 - 5th International Symposium on Spray Dried Dairy Products, Jun 2012, Saint-Malo, France
Communication dans un congrès
hal-01598191v1
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Biophysical and chemical responses of Lb. bulgaricus to freezing by infrared microspectroscopy7. Soleil User's Meeting, Jan 2012, Saclay, France
Communication dans un congrès
hal-01628120v1
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Modeling for risk assessment of quality failures: Application to microorganismsFreeze Drying of Pharmaceuticals and Biologicals Conference, Sep 2010, Garmisch-Partenkirchen, Germany
Communication dans un congrès
hal-02751750v1
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Water in freeze-dried lactic acid bacteria: Friend or FoeEuroFoodWater, Mar 2010, Reims, France
Communication dans un congrès
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Stabilization of lactic acid bacteria : relevance of physical properties on formulation and process efficiencyX. Congreso Latinoamericano de Microbiologia et Hygiena de los Alimentos, Oct 2009, Punta del Este, Uruguay
Communication dans un congrès
hal-02750465v1
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Freezing : a critical step for freeze-drying cycle development and product stability2008 ISPE Conference : Lyophilisation: Scientific Issues of the Process and Introduction to a Risk-Based Approach, Dec 2008, Barcelona, Spain
Communication dans un congrès
hal-02750962v1
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Stabilisation of lactic acid bacteria: relevance of physical properties on formulation efficiency1. Int. DOM Symposium on Microbial Formulation, 2007, Uppsala, Sweden
Communication dans un congrès
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Mapping membrane fluidity by fluorescence anisotropy to better understand bacterial toloerance to osmotic and cold stresses encountered during freezing52. Annual Meeting of the Society for Cryobiology, Jul 2015, Ostrava, Czech Republic, Czech Republic. Elsevier Ltd, Cryobiology, 71, pp.549, 2015, Cryobiology. ⟨10.1016/j.cryobiol.2015.10.052⟩
Poster de conférence
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Freeze-drying of bacteria : state of the art and new perspectives7. International Conference of Lyophilization and Freeze-Drying, Jul 2015, Barcelona, Spain. 2015
Poster de conférence
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Towards a better understanding of cryotolerance mechanisms in bacteria52. Annual Meeting of the Society for Cryobiology, Jul 2015, Ostrava, Czech Republic. Academic Press - Elsevier, Cryobiology, 71 (3), pp.548, 2015, Cryobiology
Poster de conférence
hal-01536531v1
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Towards the in situ study of bacterial single cells following freeze-drying using synchrotron radiation6. International Conference of Lyophilization and Freeze-Drying, Oct 2013, Sao Paulo, Brazil. 2013
Poster de conférence
hal-01628107v1
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Towards the measurement of membrane fluidity at subzero temperatures for improving cell cryopreservationEuropean Conference on the Spectroscopy of Biological Molecules (ECSBM 15), Aug 2013, Oxford, United Kingdom. Biomedical Spectroscopy and Imaging, 3(3), 2013, Biomedical Spectroscopy and Imaging
Poster de conférence
hal-01628117v1
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Freeze-drying of lactic acid bacteriaCryopreservation and Freeze-Drying Protocols, 1257, Humana Press Inc., 12 p., 2015, Methods in Molecular Biology, 978-1-4939-2192-8. ⟨10.1007/978-1-4939-2193-5_24⟩
Chapitre d'ouvrage
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