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35

Felix Rico's profile


Felix Rico is Associate Professor in the department of Physics of Aix-Marseille University since 2013. His research is developed at the joint laboratory Aix-Marseille University, CNRS & Inserm, LAI. He studied Physics at the University Autonoma of Barcelona and received his PhD in Biophysics from the University of Barcelona. Before moving to Marseille, he was postdoc at the University of Miami Miller School of Medicine (Miami, FL) and then at the Laboratoire Physico-Chimie Curie UMR168 at Institut Curie (Paris).

He has been working in force measurements with atomic force microscopy (AFM) since 2001. His research track is focused on the mechanics and adhesion properties of biological systems. He has developed various AFM based approaches to investigate the mechanical response of single molecules, membranes and cells. Recently, he adapted high speed AFM (HS-AFM) to work as a force spectroscopy tool, probing the mechanics and dynamics of single biomolecules and living cells at microsecond timescales.


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Journal articles30 documents

  • Ignacio Casuso, Lorena Redondo-Morata, Felix Rico. Biological physics by high-speed atomic force microscopy. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, Royal Society, The, 2020, 378 (2186), pp.20190604. ⟨10.1098/rsta.2019.0604⟩. ⟨hal-03027169⟩
  • Cheng Zhang, Romain A Grossier, Leda Lacaria, Felix Rico, Nadine A Candoni, et al.. A microfluidic method generating monodispersed microparticles with controllable sizes and mechanical properties. Chemical Engineering Science, Elsevier, 2020, 211, pp.115322. ⟨10.1016/j.ces.2019.115322⟩. ⟨hal-02179400v3⟩
  • Leda Lacaria, Janina R Lange, Wolfgang H Goldmann, Felix Rico, José Luis Alonso. αvβ3 integrin expression increases elasticity in human melanoma cells. Biochemical and Biophysical Research Communications, Elsevier, In press, ⟨10.1016/j.bbrc.2020.02.156⟩. ⟨hal-02505792⟩
  • Fidan Sumbul, Nahid Hassanpour, Jorge Rodriguez-Ramos, Felix Rico. One-Step Calibration of AFM in Liquid. Frontiers in Physics, Frontiers, 2020, 8, ⟨10.3389/fphy.2020.00301⟩. ⟨hal-03140309⟩
  • Felix Rico, Andreas Russek, Laura Gonzalez, Helmut Grubmüller, Simon Scheuring. Heterogeneous and rate-dependent streptavidin–biotin unbinding revealed by high-speed force spectroscopy and atomistic simulations. Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (14), pp.6594-6601. ⟨10.1073/pnas.1816909116⟩. ⟨hal-02106342⟩
  • Claire Valotteau, Fidan Sumbul, Felix Rico. High-speed force spectroscopy: microsecond force measurements using ultrashort cantilevers. Biophysical Reviews, Springer, 2019, 11 (5), pp.689-699. ⟨10.1007/s12551-019-00585-4⟩. ⟨hal-02457576⟩
  • Marianthi Karageorgi, Simon Groen, Fidan Sumbul, Julianne Pelaez, Kirsten Verster, et al.. Genome editing retraces the evolution of toxin resistance in the monarch butterfly. Nature, Nature Publishing Group, 2019, 574 (7778), pp.409-412. ⟨10.1038/s41586-019-1610-8⟩. ⟨hal-02457580⟩
  • Fidan Sumbul, Arin Marchesi, Hirohide Takahashi, Simon Scheuring, Felix Rico. High-Speed Force Spectroscopy for Single Protein Unfolding. Methods in Molecular Biology, Humana Press/Springer Imprint, 2018, pp.243-264. ⟨10.1007/978-1-4939-8591-3_15⟩. ⟨hal-01838371⟩
  • Fidan Sumbul, Arin Marchesi, Felix Rico. History, rare and multiple events of mechanical unfolding of repeat proteins. Journal of Chemical Physics, American Institute of Physics, 2018, 148 (12), ⟨10.1063/1.5013259⟩. ⟨hal-01792492⟩
  • Isaline Herrada, Philippe Barthe, Marisa Vanheusden, Karine Deguillen, Léa Mammri, et al.. Monitoring Unfolding of Titin I27 Single and Bi Domain with High-Pressure NMR Spectroscopy. Biophysical Journal, Biophysical Society, 2018, 115 (2), pp.341 - 352. ⟨10.1016/j.bpj.2018.06.010⟩. ⟨hal-01842448⟩
  • Hirohide Takahashi, Felix Rico, Christophe Chipot, Simon Scheuring. α-Helix Unwinding as Force Buffer in Spectrins. ACS Nano, American Chemical Society, 2018, 12 (3), pp.2719-2727. ⟨10.1021/acsnano.7b08973⟩. ⟨hal-02106340⟩
  • Jean-Luc Pellequer, Pierre Parot, Daniel Navajas, Sanjay Kumar, Vesna Svetličić, et al.. Fifteen years of Servitude et Grandeur to the application of a biophysical technique in medicine: The tale of AFMBioMed. Journal of Molecular Recognition, Wiley, 2018, pp.e2773. ⟨10.1002/jmr.2773⟩. ⟨hal-02009736⟩
  • Catherine Even, Gilles Abramovici, Florence Delort, Anna F. Rigato, Virginie Bailleux, et al.. Mutation in the Core Structure of Desmin Intermediate Filaments Affects Myoblast Elasticity. Biophysical Journal, Biophysical Society, 2017, 113 (3), pp.627-636. ⟨10.1016/j.bpj.2017.06.020⟩. ⟨hal-01765097⟩
  • Hermann Schillers, Carmela Rianna, Jens Schäpe, Tomas Luque, Holger Doschke, et al.. Standardized Nanomechanical Atomic Force Microscopy Procedure (SNAP) for Measuring Soft and Biological Samples. Scientific Reports, Nature Publishing Group, 2017, 7 (1), pp.5117. ⟨10.1038/s41598-017-05383-0⟩. ⟨hal-01575563⟩
  • Ignacio Munguira, Ignacio Casuso, Hirohide Takahashi, Felix Rico, Mohamed Chami, et al.. Glass-LikeMembrane Protein Diffusion in a Crowded Membrane. ACS Nano, American Chemical Society, 2016, ⟨10.1021/acsnano.5b07595⟩. ⟨inserm-01285787⟩
  • Annafrancesca Rigato, Felix Rico, Frédéric Eghiaian, Mathieu Piel, Simon Scheuring. Atomic Force Microscopy Mechanical Mapping of Micropatterned Cells Shows Adhesion Geometry-Dependent Mechanical Response on Local and Global Scales.. ACS Nano, American Chemical Society, 2015, pp.11. ⟨10.1021/acsnano.5b00430⟩. ⟨inserm-01159354⟩
  • Alexandre B. Roland, Ana Ricobaraza, Damien Carrel, Benjamin M. Jordan, Felix Rico, et al.. Cannabinoid-induced actomyosin contractility shapes neuronal morphology and growth. eLife, eLife Sciences Publication, 2014, 3, pp.e03159. ⟨10.7554/eLife.03159.026⟩. ⟨inserm-01356874⟩
  • Frédéric Eghiaian, Felix Rico, Adai Colom, Ignacio Casuso, Simon Scheuring. High-speed atomic force microscopy: Imaging and force spectroscopy. FEBS Letters, Wiley, 2014, 588 pp.3631-3638. ⟨10.1016/j.febslet.2014.06.028⟩. ⟨inserm-01360861⟩
  • Laura Picas, Felix Rico, Maxime Déforet, Simon Scheuring. Structural and Mechanical Heterogeneity of the Erythrocyte Membrane Reveals Hallmarks of Membrane Stability. ACS Nano, American Chemical Society, 2013, 7 (2), pp.1054-1063. ⟨10.1021/nn303824j⟩. ⟨hal-02289092⟩
  • Kévin Alessandri, Bibdu Ranjan Sinha, Vasily Valérïevitsch Gurchenkov, Bidisha Sinha, Tobias Reinhold Kiessling, et al.. Cellular capsules as a tool for multicellular spheroid production and for investigating the mechanics of tumor progression in vitro. Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2013, 110 (37), pp.14843-8. ⟨10.1073/pnas.1309482110⟩. ⟨inserm-01356886⟩
  • Calvin Chu, Emrah Celik, Felix Rico, Vincent T Moy. Elongated membrane tethers, individually anchored by high affinity α4β1/VCAM-1 complexes, are the quantal units of monocyte arrests.. PLoS ONE, Public Library of Science, 2013, 8 (5), pp.e64187. ⟨10.1371/journal.pone.0064187⟩. ⟨inserm-01363143⟩
  • Adai Colom, Ignacio Casuso, Felix Rico, Simon Scheuring. A hybrid high-speed atomic force–optical microscope for visualizing single membrane proteins on eukaryotic cells. Nature Communications, Nature Publishing Group, 2013, 4, pp.2155. ⟨10.1038/ncomms3155⟩. ⟨inserm-01357292⟩
  • Laura Picas, Felix Rico, Maxime Deforet, Simon Scheuring. Structural and Mechanical Heterogeneity of the Erythrocyte Membrane Reveals Hallmarks of Membrane Stability. ACS Nano, American Chemical Society, 2013, 7 (2), pp.1054-1063. ⟨10.1021/nn303824j⟩. ⟨inserm-01309087⟩
  • Felix Rico, Annafrancesca Rigato, Laura Picas, Simon Scheuring. Mechanics of proteins with a focus on atomic force microscopy. Journal of Nanobiotechnology, BioMed Central, 2013, 11 (Suppl 1), pp.S3. ⟨10.1186/1477-3155-11-S1-S3⟩. ⟨inserm-00916507⟩
  • Felix Rico, Laura Gonzalez, Ignacio Casuso, Manel Puig-Vidal, Simon Scheuring. High-speed force spectroscopy unfolds titin at the velocity of molecular dynamics simulations.: Experiment meets simulation: HS-FS. Science, American Association for the Advancement of Science (AAAS), 2013, 342 (6159), pp.741-3. ⟨10.1126/science.1239764⟩. ⟨inserm-01309044⟩
  • Laura Picas, Felix Rico, Simon Scheuring. Direct Measurement of the Mechanical Properties of Lipid Phases in Supported Bilayers. Biophysical Journal, Biophysical Society, 2012, 102 (1), pp.L01-L03. ⟨10.1016/j.bpj.2011.11.4001⟩. ⟨hal-02289090⟩
  • Amela Hozic, Felix Rico, Adai Colom, Nikolay Buzhynskyy, Simon Scheuring. Nanomechanical Characterization of the Stiffness of Eye Lens Cells: A Pilot Study. Investigative Ophthalmology & Visual Science, Association for Research in Vision and Ophthalmology, 2012, 53 ((4)), pp.2151-6. ⟨10.1167/iovs.11-8676⟩. ⟨inserm-01363257⟩
  • Laura Picas, Felix Rico, Simon Scheuring. Direct Measurement of the Mechanical Properties of Lipid Phases in Supported Bilayers. Biophysical Journal, Biophysical Society, 2012, 102 ((1)), pp.L01-3. ⟨10.1016/j.bpj.2011.11.4001⟩. ⟨inserm-01363280⟩
  • Ignacio Casuso, Felix Rico, Simon Scheuring. High-speed atomic force microscopy: Structure and dynamics of single proteins This review comes from a themed issue on Analytical Techniques Edited. Current Opinion in Chemical Biology, Elsevier, 2011, 15 ((5)), pp.704-9. ⟨10.1016/j.cbpa.2011.05.007⟩. ⟨inserm-01363295⟩
  • Richard Brun, Pierre Cornillon, J. Peyriere, F. Rico. Fertilisation de la tomate en culture sous abri. Comparaison de deux modes d'apport de la fumure phospho-potassique. PHM Revue Horticole, 1986, pp.49-54. ⟨hal-02724465⟩

Book sections1 document

  • Fidan Sumbul, Felix Rico. Single-Molecule Force Spectroscopy: Experiments, Analysis, and Simulations. Atomic Force Microscopy, Methods in Molecular Biology, pp.163-189, 2019. ⟨hal-02272098⟩

Other publications1 document

Preprints, Working Papers, ...2 documents

  • M. Majnooni, P. Lasaygues, V. Long, J.-C. Scimeca, D. Momier, et al.. Monitoring of in-vitro ultrasonic stimulation of cells by numerical modeling. 2022. ⟨hal-03629272⟩
  • Carla Silva Martins, Cyntia Taveneau, Gerard Castro-Linares, Mikhail Baibakov, Nicolas Buzhinsky, et al.. Human septins in cells organize as octamer-based filaments mediating actin-membrane anchoring. 2022. ⟨hal-03588456⟩

Conference papers1 document

  • P. Pécaut, C. Foury, F. Rico, F. Martin. Bilan d'un premier cycle de selection de varietes d'artichaut a semer. 3. Congresso, Nov 1979, Bari, Italie. ⟨hal-02783110⟩