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Federica Calevro

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Présentation

**Federica Calevro-Eisenlohr** ORCID: 0000-0001-7856-9617 IdHAL: federica-calevro ### **Positions** Since Sept. 2020 INRAE Research Director (DR2), BF2i Unit (INRAE – INSA Lyon) Lyon, France 2004-2020 Associate Professor, Department of Biosciences (INSA Lyon) and BF2i Unit, Lyon, France 2001-2004 Temporary Lecturer and Research Assistant, Department of Biosciences (INSA Lyon) and BF2i Unit, Lyon, France **Other appointments or responsabilities** Since Jan. 2021 INSA Lyon Directors’ Board Since Jan. 2021 Head of the BF2i Unit, Lyon, France Since Jan. 2021 Member (elected) of the scientific advisory board of the INRAE Plant Health and Environment (SPE) Division 2018-present Member of the pedagogic and orientation advisory board of the E2M2 (Evolution, Ecosystems, Microbiology &amp; Modeling) Doctoral School, University of Lyon 2017-present Co-coordinator of the French Aphid research network (BAPOA, more than 230 members in France, Belgium and Switzerland) of the INRAE SPE Division 2015-present Leader of the Trophic Symbioses team (SymT), BF2i Unit, Lyon 2015-2020 Deputy Head of the BF2i Unit, Lyon 2012-2020 Director of the Biology teaching service and member of the Executive Committe of the Department of Biosciences, INSA Lyon ### **Education and Training** 2018 Accreditation to supervise research (French HDR), INSA Lyon and University of Lyon 2000-2001 Postdoctoral Fellow, Pasteur Institute of Lille, Lille, France 1999-2000 Postdoctoral Fellow WHO, International Agency of Research on Cancer (IARC), Lyon, France 1995-1998 PhD, Biology (Cell and Developmental Biology) and Research Assistant, Department of Physiology and Biochemistry, University of Pisa, Italy 1998 Visiting Scientist, Brain Research Institute, University of Bremen, Germany 1997 Visiting Scientist, Department of Biochemistry, University of Bremen, Germany 1996 Professional Qualification (Biologist), University of Pisa, Italy, summa cum laude (50/50 cum laude) 1995 Diploma of Laurea, Molecular and Developmental Biology, University of Pisa, Italy, summa cum laude (110/110 cum laude) ### **Awards** 2000-2001 Director’s Fellow from the Pasteur Institute of Lille (Post-doc position) 1999-2000 WHO Fellowship (Post-doc position at IARC) 1998 Brain Research Institute Fellowship (visit to Bremen University, G. Roth lab) 1997 EMBO Short term Fellowship (visit to Bremen University, D. Beyersmann lab) 1997 Doctoral Mobility Fellowship from the University of Pisa (visit to Bremen University) 1995-1998 Doctoral Fellowship from the Italian National Agency for new technologies, Energy and sustainable Economic development (ENEA) 1994-1995 Pre-Graduate Fellowship from University of Pisa (1-year laboratory training) ### **Supervision of graduate students and post-doc fellows** ### Since 1995: ### 7 Postdocs ### 7 PhD students (degrees obtained in 2004, 2008, 2010, 2011, 2016, 2020, 2021) 6 have been recruited as Scientists (5 permanent positions/1 post-doc). 2 PhD projects are ongoing. ### 20 Master Students (11 M2 level and 9 M1 level). ### 3 students from University Institutes (*e.g.* IUT). ### **Teaching** ### Since 2020: INSA-Lyon, 12 h/year: Molecular genetics. ### 2001-2020: INSA-Lyon. 200-220 h/year: Anatomy, Biotechnology, Cell biology, Molecular genetics. ### 1995-1998: University of Pisa. 50 h/year: Molecular biology, Molecular toxicology, Comparative anatomy. **Fundings** 43 funded research projects: 2 International, 4 European, 2 IDEX and 6 ANR Programs, 1 France-Génomique grant, 1 Agropolis Foundation grant, 1 SPE-INRAE grant, 4 regional grants, 4 INSA Bonus, 4 INSA Invited Professorships, 4 FR BioEEnViS grants, 4 Investment Programs, 6 projects with industry (including 1 ANR). ### **Scientific Impact and other scientific output** ***Publications:*** 50 original publications, 2 invited reviews, 6 invited contributions to book chapters, 2323 citations, H-index 24, i10-index 33. ***Metabolic databases for arthropod genomes (most recent):*** 1) **DakvicCyc**, <http://arthropodacyc.cycadsys.org/DAKVI/>, *Daktulosphaira vitifoliae*, doi: 10.1186/s12915-020-00820-5 ; 2) **OruabCyc** et **AthroCyc**, <http://arthropodacyc.cycadsys.org/ORUAB/> et <http://arthropodacyc.cycadsys.org/ATHRO/>, *Orussus abietinus* et *Athalia rosae*, doi: 10.1093/gbe/**,** 3) **SitorCyc**, <http://arthropodacyc.cycadsys.org/SITOR/>, *Sitophilus oryzae*, doi: 10.1186/s12915-021-01158-2; **ArtSymbioCyc** (<http://artsymbiocyc.cycadsys.org/>) project containing the reconstruction of the integrated symbiotic metabolism between arthropods and their symbiotic or mutualistic bacteria, private. ***Tools (most recent):*** GReNaDIne: Data-Driven Approaches to Infer Gene Regulatory Networks in Python. <https://grenadine.readthedocs.io/en/latest/> ***Organization of meetings (most important*):** Joint 10th International Symbiosis Society &amp; 3rd International Conference on Holobionts (Lyon, July 2022); Annual Entomophagous meeting (2017, Lyon); Annual meetings of the Aphid French Network: 2010 and 2012 (Lyon), 2018 (Rennes) and 2022 (Nice); Colloque de Biologie de l’Insecte (16th edition, 2010, Lyon); Lyon’s International Multidisciplinary Meeting on Post-Genomics (5 editions, from 2006 to 2010, Lyon). ***Organization of practical courses:*** « Insect cell cultures », Aphid French Network (Bordeaux, October 2019); « Isolation of aphid bacteriocytes as a platform for transcriptomic analyses », HMicMac ANR grant (May 2017, Lyon); « RNAi in aphids: feeding and injection techniques », Aphid French Network (March 2008, Lyon). ***Ad hoc reviewer for Grant Organizations.*** Western University (Canada); FWO (Belgium); HRZZ (Croatian Science Foundation); CNR (Italy); ANR (France); FranceAgriMer (France); INRAE SPE research grants (France); Research Federation BioEEnViS University of Lyon (France); BQR (Bonus Qualité Recherche) INSA Lyon (France). ***Ad hoc reviewer for journals.*** Apoptosis, Arch. Insect Biochem. Physiol., BMC Biol., BMC Genomics, Cell Death Differ., Cell Rep., Current Biol., Cytom. Part A, Entomol. Exp. Appl., Environ. Microbiome, Eur. J. Entomol., FEMS Microbiol. Ecol., Insect Biochem. Mol. Biol., Insect Mol. Biol., Insect Sci., Insects, Int. J. Mol. Sci., iScience, J. Pest Sci., Microbiome, Microbiol. Spectr., Mol. Ecol., PNAS, Peptides, PlosOne, Sci. Rep., ISME J. ***Member of University selection committees (France).* INSA Lyon**: « Physiology » in 2012, « Insect symbiosis » in 2013, President of the jury « Insect Genomics » in 2015, « Symbiotic network modeling » in 2018, Coordinator of the jury « Microbes and Adaptation » in 2021, « Developmental genetics » in 2021. **University Claude Bernard Lyon1**: « Environmental and molecular microbiology » in 2012, « Plant physiology » in 2017. **University of Dijon:** « Invertebrate physiology » in 2015, **University of Nice**: « Host-Microbes interactions » in 2010 and 2012.

Publications

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Bacteriocyte reprogramming to cope with nutritional stress in a phloem sap feeding hemipteran, the pea aphid Acyrthosiphon pisum

Nicolas Parisot , Stefano Colella , Mélanie Ribeiro Lopes , Karen Gaget , Marie-Gabrielle Duport
International Partner Days, Oct 2018, Villeurbanne (INSA-Lyon), France
Communication dans un congrès hal-03514034v1

Rôle clé du bactériocyte dans la résilience du puceron aux stress nutritionnels

Federica Calevro , Nicolas Parisot , Mélanie Ribeiro Lopes , Stefano Colella , Karen Gaget
11ème Réunion du Réseau Français de Biologie Adaptative des Pucerons et Organismes Associés (BAPOA), Nov 2018, Rennes, France
Communication dans un congrès hal-03514026v1

Life history traits and tissue-specific gene expression changes underlying the symbiotic pea aphid resilience to a tyrosine and phenylalanine depleted diet

Nicolas Parisot , Pierre Simonet , Karen Gaget , Marie-Gabrielle Duport , Patrice Baa-Puyoulet
9. Réunion du Réseau Français de Biologie Adaptative des Pucerons et Organismes Associés (BAPOA), Nov 2016, Amiens, France
Communication dans un congrès hal-03506796v1
Image document

From SymbAphidBase to SymbAphidCyc: two companion databases to study and compare aphid symbionts from genomes to metabolic pathways

Patrice Baa-Puyoulet , Mathieu Labernardiere , Nicolas Parisot , Jean-Pierre Gauthier , Gérard Febvay
JOBIM 2015 - Journées Ouvertes Biologie Informatique Mathématiques, Université d'Auvergne - Clermont-Ferrand I (UdA). FRA., Jul 2015, Clermont-Ferrand, France. 1 p
Communication dans un congrès hal-01208786v1

SymbAphidBase : une base de données nouvelle dédiée aux symbiotes de pucerons pour stocker et visualiser les génomes séquencés en standardisant leurs annotations

Mathieu Labernardiere , Patrice Baa-Puyoulet , Jean-Pierre Gauthier , Gérard Febvay , Federica Calevro
7. Rencontres du réseau Biologie Adaptative des Pucerons et Organismes Associés (BAPOA), Réseau Biologie Adaptative des Pucerons et des Organismes Associés (BAPOA). Le Rheu, FRA., Nov 2014, Avignon, France. 1 p
Communication dans un congrès hal-01208785v1

Symbiose puceron – Buchnera : approche métabolomique chez Acyrthosiphon pisum

Marjolaine Rey , Floriant Bellvert , Marie-Gabrielle Duport , Patrice Baa-Puyoulet , Federica Calevro
6èmes journées du Réseau BAPOA (Biologie Adaptative des Pucerons et Organismes Associés, Oct 2013, Montpellier, France
Communication dans un congrès hal-03506758v1

Analyse métabolomique de la symbiose entre le puceron Acyrthosiphon pisum et la bactérie Buchnera aphidicola

Marjolaine Rey , Floriant Bellvert , Marie-Gabrielle Duport , Patrice Baa-Puyoulet , Federica Calevro
7èmes Journées Scientifiques du Réseau Français de Métabolomique et Fluxomique, Jun 2013, Amiens, France
Communication dans un congrès hal-03506751v1

Integration of metabolic pathways and host regulation in symbiosis: tyrosine and cuticular protein biosynthesis during the pea aphid embryonic development

Andréane Rabatel , Gérard Febvay , Karen Gaget , Gabrielle Duport , Nadia Bendridi
Sixth International Symposium on Molecular Insect Science, 2011, Amsterdam, Netherlands
Communication dans un congrès hal-00748785v1

Exploration génomique et fonctionnelle des insectes et de leurs partenaires symbiotiques

Hubert Charles , Stefano Colella , Federica Calevro , Gérard Febvay , Yvan Rahbé
Journée Sciences Croisées "Modélisation et Sciences Numériques : nouveaux instruments et opportunités", Institut National des Sciences Appliquées de Lyon (INSA Lyon). Conseil Scientifique de l'INSA, Villeurbanne, FRA., Oct 2010, Villeurbanne, France. n. p
Communication dans un congrès hal-02804281v1

CycADS: an annotation management system for the development and update of BioCyc metabolic network databases

A. Vellozo , Patrice Baa-Puyoulet , A. Veron , Jaime Huerta-Cepas , Ludovic Cottret
1st International Workshop on Information Systems for Insect Pests, Rennes, FRANCE, 2009, France
Communication dans un congrès hal-00496032v1

Bacteriocyte reprogramming to maintain organismal homeostasis under nutritional stress in aphid symbiosis

Nicolas Parisot , Stefano Colella , Pierre Simonet , Karen Gaget , Marie-Gabrielle Duport
UK-France joint Meeting Aphid Special Interest Group – BAPOA, Apr 2019, Rothamsted, United Kingdom
Poster de conférence hal-03513048v1

Evaluating the essentiality of the primary endosymbiont of the rice weevil Sitophilus oryzae through genome analysis

Carlos Vargas-Chavez , Nicolas Parisot , C. Goubert , Patrice Baa-Puyoulet , Severine Balmand
VI Meeting of the Spanish Society for Evolutionary Biology (SESBE), Jan 2018, Palma de Mallorca, Spain
Poster de conférence hal-03514015v1

Bacteriocyte reprogramming to maintain organismal homeostasis under nutritional stress in aphid symbiosis

Nicolas Parisot , Stefano Colella , Pierre Simonet , Karen Gaget , Marie-Gabrielle Duport
XIth European Congress of Entomology, Jul 2018, Naples, Italy
Poster de conférence hal-03509885v1

The draft genome sequence of the rice weevil Sitophilus oryzae as a model to explore the host-symbiont interactions in a nascent stage of endosymbiosis

Carlos Vargas-Chavez , Nicolas Parisot , Clément Goubert , Patrice Baa-Puyoulet , Severine Balmand
Journées Ouvertes Biologie Informatique Mathématiques (JOBIM), Jun 2016, Lyon, France
Poster de conférence hal-03506786v1
Image document

SymbAphidBase: a new database dedicated to aphid symbionts to store novel sequenced genomes and standardize their annotations

Mathieu Labernardiere , Patrice Baa-Puyoulet , Jean-Pierre Gauthier , Gérard Febvay , Federica Calevro
13. European Conference on Computational Biology (ECCB), Sep 2014, Strasbourg, France. , 1 p., 2014
Poster de conférence hal-02798649v1
Image document

Annotating arthropods genome to study and compare their metabolism: the ArthropodaCyc collection of Cyc databases powered by CycADS

Patrice Baa-Puyoulet , Augusto Vellozo , Jaime Huerta-Cepas , Gérard Febvay , Federica Calevro
13. European Conference on Computational Biology (ECCB), Sep 2014, Strasbourg, France. , 1 p., 2014
Poster de conférence hal-02798101v1

The CycADS annotation database system to support the development and update of enriched BioCyc databases: development of ad hoc BioCyc DB (AcypiCyc, ArthropodaCyc

Patrice Baa-Puyoulet , Augusto Vellozo , Jaime Huerta-Cepas , Gérard Febvay , Federica Calevro
8. Meeting of the International Aphid Genomics Consortium, Jan 2013, Harpenden, United Kingdom
Poster de conférence hal-03506707v1

« ArthropodaCyc » : une collection de bases de données enrichies à l’aide de CycADS pour étudier et comparer le métabolisme des arthropodes.

Patrice Baa-Puyoulet , Stefano Colella , Augusto Vellozo , Jaime Huerta-Cepas , Gérard Febvay
17. Colloque de Biologie de l’Insecte - CBI-2013, Oct 2013, Montpellier, France
Poster de conférence hal-03506713v1

Integration of metabolic pathways and host regulation in symbiosis: tyrosine and cuticular protein biosynthesis during the pea aphid embryonic development

Andréane Rabatel , Gérard Febvay , Karen Gaget , Marie-Gabrielle Duport , Nadia Bendridi
6. International Symposium on Molecular Insect Science, Oct 2011, Amsterdam, Netherlands. Elsevier, 2011,  
Poster de conférence hal-02747829v1

Integration of metabolic pathways and host regulation in symbiosis: tyrosine and cuticular protein biosynthesis during the pea aphid embryonic development

Andréane Rabatel , Gérard Febvay , Karen Gaget , Marie-Gabrielle Duport , Nadia Bendridi
4. Réunion Réseau BAPOA, Nov 2011, Paris, France. 1 p., 2011
Poster de conférence hal-02805925v1

Using the “CycADS” annotation management system to develop a BioCyc metabolic network database for sequenced arthropods genomes: first steps towards “ArthropodsCyc”

Augusto Vellozo , Patrice Baa-Puyoulet , Jaime Huerta-Cepas , Gérard Febvay , Federica Calevro
4. Annual Arthropod Genomics Symposium on “Arthropod Genomics: New Approaches and Outcomes”, Jun 2010, Kansas City, United States. 45 p., 2010, Fourth Annual Arthropod Genomics Symposium
Poster de conférence hal-02753908v1