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Keywords

Immunomodulation Regeneration Immunosuppression Macrophages Mesenchymal stem cell Macrophage Chondrocyte Cardioprotection Inflammation Reperfusion injury Mesenchymal Stem Cells Cartilage Myocardial infarction Osteoarthritis Apoptosis Mesenchymal stem cells MRL mouse Chondroprotection Chondrogenesis Aging
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Number of documents

54

Dr Farida DJOUAD

  •           EDUCATION

2012                      “Habilitation à diriger des recherches” (HDR), Université de Montpellier, France

2006                      Ph.D. Biology and Health, University of Montpellier, France.

2002                      Master’s Degree (DEA) in Biology and Health, University of Montpellier, France

2001                      Master’s Degree (maîtrise), in Biochemistry, University of Montpellier, France

 

  •           POSITIONS HELD

2013-              Staff Scientist (Chargée de Recherche, CR1 INSERM), Group Leader

Institute for Regenerative Medicine & Biotherapy (IRMB), Montpellier, France

2009-              Staff Scientist (Chargée de Recherche, CR2 INSERM)

Institute of Neurosciences of Montpellier (INM), Montpellier, France

2006-2008      Post-doctoral fellow in the laboratory of Rocky Tuan,

NIAMS, NIH, Bethesda, USA

Journal articles43 documents

  • Charlotte Sarre, Rafael Contreras-Lopez, Nitirut Nernpermpisooth, Christian Barrère, Sarah Bahraoui, et al.. PPARβ/δ priming enhances the anti-apoptotic and therapeutic properties of mesenchymal stromal cells in myocardial ischemia–reperfusion injury. Current Stem Cell Research & Therapy, Bentham Science Publishers Ltd, 2022, 13 (1), pp.167. ⟨10.1186/s13287-022-02840-0⟩. ⟨hal-03653227⟩
  • Gautier Tejedor, Patricia Luz-Crawford, Audrey Barthelaix, Karine Toupet, Sébastien Roudières, et al.. MANF Produced by MRL Mouse-Derived Mesenchymal Stem Cells Is Pro-regenerative and Protects From Osteoarthritis. Frontiers in Cell and Developmental Biology, Frontiers media, 2021, 9, pp.579951. ⟨10.3389/fcell.2021.579951⟩. ⟨hal-03670111⟩
  • Béryl Laplace-Builhé, Audrey Barthelaix, Said Assou, Candice Bohaud, Marine Pratlong, et al.. NRG1/ErbB signalling controls the dialogue between macrophages and neural crest-derived cells during zebrafish fin regeneration. Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.6336. ⟨10.1038/s41467-021-26422-5⟩. ⟨hal-03646943⟩
  • Candice Bohaud, Rafael Contreras-Lopez, Jholy de La Cruz, Claudia Terraza-Aguirre, Mingxing Wei, et al.. Pro-regenerative Dialogue Between Macrophages and Mesenchymal Stem/Stromal Cells in Osteoarthritis. Frontiers in Cell and Developmental Biology, Frontiers media, 2021, 9, pp.718938. ⟨10.3389/fcell.2021.718938⟩. ⟨hal-03646573⟩
  • Candice Bohaud, Matt D Johansen, Christian Jorgensen, Natacha Ipseiz, Laurent Kremer, et al.. The Role of Macrophages During Zebrafish Injury and Tissue Regeneration Under Infectious and Non-Infectious Conditions. Frontiers in Immunology, Frontiers, 2021, 12, pp.707824. ⟨10.3389/fimmu.2021.707824⟩. ⟨inserm-03381914⟩
  • Sébastien Riquier, Marc Mathieu, Chloé Bessiere, Anthony Boureux, Florence Rufflé, et al.. Long non-coding RNA exploration for mesenchymal stem cell characterisation. BMC Genomics, BioMed Central, 2021, 22 (1), pp.412. ⟨10.1186/s12864-020-07289-0⟩. ⟨inserm-03251471⟩
  • Candice Bohaud, Matt D Johansen, Christian Jorgensen, Laurent Kremer, Natacha Ipseiz, et al.. The Role of Macrophages During Mammalian Tissue Remodeling and Regeneration Under Infectious and Non-Infectious Conditions. Frontiers in Immunology, Frontiers, 2021, 12, pp.707856. ⟨10.3389/fimmu.2021.707856⟩. ⟨inserm-03381916⟩
  • Nitirut Nernpermpisooth, Charlotte Sarre, Christian Barrere, Rafaël Contreras, Patricia Luz-Crawford, et al.. PPARβ/δ Is Required for Mesenchymal Stem Cell Cardioprotective Effects Independently of Their Anti-inflammatory Properties in Myocardial Ischemia-Reperfusion Injury. Frontiers in Cardiovascular Medicine, Frontiers Media, 2021, 8, pp.681002. ⟨10.3389/fcvm.2021.681002⟩. ⟨hal-03644844⟩
  • Gautier Tejedor, Rafael Contreras-Lopez, Audrey Barthelaix, Maxime Ruiz, Danièle Noël, et al.. Pyrroline-5-Carboxylate Reductase 1 Directs the Cartilage Protective and Regenerative Potential of Murphy Roths Large Mouse Mesenchymal Stem Cells. Frontiers in Cell and Developmental Biology, Frontiers media, 2021, 9, pp.604756. ⟨10.3389/fcell.2021.604756⟩. ⟨hal-03653004⟩
  • Dorothea I H Müller, Cornelia Stoll, Katrin Palumbo-Zerr, Christina Böhm, Brenda Krishnacoumar, et al.. PPARδ-mediated mitochondrial rewiring of osteoblasts determines bone mass. Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.8428. ⟨10.1038/s41598-020-65305-5⟩. ⟨inserm-02869506⟩
  • Mónica Kurte, Ana María Vega-Letter, Patricia Luz-Crawford, Farida Djouad, Danièle Noël, et al.. Time-dependent LPS exposure commands MSC immunoplasticity through TLR4 activation leading to opposite therapeutic outcome in EAE. Current Stem Cell Research & Therapy, Bentham Science Publishers Ltd, 2020, 11, pp.416. ⟨10.1186/s13287-020-01840-2⟩. ⟨hal-02961469⟩
  • Elodie Sanchez, Béryl Laplace-Builhé, Frédéric Tran Mau-Them, Eric Richard, Alice Goldenberg, et al.. POLR1B and neural crest cell anomalies in Treacher Collins syndrome type 4. Genetics in Medicine, Nature Publishing Group, 2020, 22 (3), pp.547-556. ⟨10.1038/s41436-019-0669-9⟩. ⟨hal-02549940⟩
  • Rafael A Contreras-Lopez, Roberto Elizondo-Vega, Maria J Torres, Ana M Vega-Letter, Noymar Luque-Campos, et al.. PPARβ/δ-dependent MSC metabolism determines their immunoregulatory properties. Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.11423. ⟨10.1038/s41598-020-68347-x⟩. ⟨inserm-02925972⟩
  • Mai Nguyen-Chi, Patricia Luz-Crawford, Laurence Balas, Tamara Sipka, Rafael Contreras-López, et al.. Pro‐resolving mediator protectin D1 promotes epimorphic regeneration by controlling immune cell function in vertebrates. British Journal of Pharmacology, Wiley, 2020, 177 (17), pp.4055-4073. ⟨10.1111/bph.15156⟩. ⟨hal-02993375⟩
  • Gautier Tejedor, Béryl Laplace-Builhé, Patricia Luz-Crawford, Said Assou, Audrey Barthelaix, et al.. Whole embryo culture, transcriptomics and RNA interference identify TBX1 and FGF11 as novel regulators of limb development in the mouse. Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.3597. ⟨10.1038/s41598-020-60217-w⟩. ⟨inserm-02498306⟩
  • Claudia Terraza-Aguirre, Mauricio Campos-Mora, Roberto Elizondo-Vega, Rafael Contreras-López, Patricia Luz-Crawford, et al.. Mechanisms behind the Immunoregulatory Dialogue between Mesenchymal Stem Cells and Th17 Cells. Cells, MDPI, 2020, 9 (7), pp.1660. ⟨10.3390/cells9071660⟩. ⟨hal-03594110⟩
  • Noymar Luque-Campos, Rafael Contreras-López, María Jose Paredes-Martínez, Maria Jose Torres, Sarah Bahraoui, et al.. Mesenchymal Stem Cells Improve Rheumatoid Arthritis Progression by Controlling Memory T Cell Response. Frontiers in Immunology, Frontiers, 2019, 10, pp.Front. Immunol. 10:798. ⟨10.3389/fimmu.2019.00798⟩. ⟨hal-03076689⟩
  • C. Sarre, G. Tejedor, P. Gonzalez, S. Bahraoui, Christian Barrère, et al.. Comparative regenerative properties of mesenchymal stem cells isolated from MRL (Murphy Roths Large) versus C57Bl6 mice. Archives of Cardiovascular Diseases Supplements, Elsevier/French Society of Cardiology, 2019, 11 (2), pp.244-245. ⟨10.1016/j.acvdsp.2019.02.137⟩. ⟨hal-02404686⟩
  • Vincent Hyenne, Shima Ghoroghi, Mayeul Collot, Joanna Bons, Gautier Follain, et al.. Studying the Fate of Tumor Extracellular Vesicles at High Spatiotemporal Resolution Using the Zebrafish Embryo. Developmental Cell, Elsevier, 2019, 48 (4), pp.554-572.e7. ⟨10.1016/j.devcel.2019.01.014⟩. ⟨hal-02274251⟩
  • Patricia Luz-Crawford, Javier Hernandez, Farida Djouad, Noymar Luque-Campos, Andrès Caicedo, et al.. Mesenchymal stem cell repression of Th17 cells is triggered by mitochondrial transfer. Current Stem Cell Research & Therapy, Bentham Science Publishers Ltd, 2019, 10 (1), pp.232. ⟨10.1186/s13287-019-1307-9⟩. ⟨inserm-02376241⟩
  • Jean-Marc Brondello, Farida Djouad, Christian Jorgensen. Where to Stand with Stromal Cells and Chronic Synovitis in Rheumatoid Arthritis?. Cells, MDPI, 2019, 8 (10), pp.1257. ⟨10.3390/cells8101257⟩. ⟨hal-02555388⟩
  • Paul Chuchana, Anne-Laure Mausset-Bonnefont, Marc Mathieu, Francisco Espinoza, Marisa Teigell, et al.. Secreted α-Klotho maintains cartilage tissue homeostasis by repressing NOS2 and ZIP8-MMP13 catabolic axis.. Aging, Impact Journals, 2018, 10 (6), pp.1442-1453. ⟨10.18632/aging.101481⟩. ⟨hal-01834060⟩
  • Patricia Luz-Crawford, Gabriel Espinosa-Carrasco, Natacha Ipseiz, Rafael Contreras, Gautier Tejedor, et al.. Gilz-Activin A as a Novel Signaling Axis Orchestrating Mesenchymal Stem Cell and Th17 Cell Interplay. Theranostics, Ivyspring International Publisher, 2018, 8 (3), pp.846 - 859. ⟨10.7150/thno.21793⟩. ⟨hal-01834084⟩
  • Monica Kurte, Patricia Luz-Crawford, Ana María Vega-Letter, Rafael Contreras, Gautier Tejedor, et al.. IL17/IL17RA as a Novel Signaling Axis Driving Mesenchymal Stem Cell Therapeutic Function in Experimental Autoimmune Encephalomyelitis. Frontiers in Immunology, Frontiers, 2018, 9, ⟨10.3389/fimmu.2018.00802⟩. ⟨hal-01833410⟩
  • Mai Nguyen-Chi, Béryl Laplace-Builhé, Jana Travnickova, Patricia Luz-Crawford, Gautier Tejedor, et al.. TNF signaling and macrophages govern fin regeneration in zebrafish larvae. Cell Death and Disease, Nature Publishing Group, 2017, 8, pp.e2979. ⟨10.1038/cddis.2017.374⟩. ⟨hal-02086729⟩
  • Patricia Luz-Crawford, Christian Jorgensen, Farida Djouad. Mesenchymal Stem Cells Direct the Immunological Fate of Macrophages.. Results and Problems in Cell Differentiation, Springer-verlag Berlin Heidelberg, 2017, pp.61-72. ⟨10.1007/978-3-319-54090-0_4⟩. ⟨hal-01834124⟩
  • Farida Djouad, Natacha Ipseiz, Patricia Luz-Crawford, Carina Scholtysek, Gerhard Krönke, et al.. PPARβ/δ: A master regulator of mesenchymal stem cell functions. Biochimie, Elsevier, 2017, 136, pp.55 - 58. ⟨10.1016/j.biochi.2016.11.011⟩. ⟨hal-01798137⟩
  • C Luz-Crawford, N Ipseiz, G Espinosa-Carrasco, C Caicedo, G Tejedor, et al.. PPARβ/δ directs the therapeutic potential of mesenchymal stem cells in arthritis. Annals of the Rheumatic Diseases, BMJ Publishing Group, 2016, 75 (12), pp.2166 - 2174. ⟨10.1136/annrheumdis-2015-208696⟩. ⟨hal-01834105⟩
  • R. Contreras, F. Figueroa, Farida Djouad, P. Luz-Crawford. Mesenchymal Stem Cells Regulate the Innate and Adaptive Immune Responses Dampening Arthritis Progression. Stem Cells International, Hindawi Publishing Corporation, 2016, 2016, pp.3162743. ⟨10.1155/2016/3162743⟩. ⟨hal-01834064⟩
  • Patricia Luz-Crawford, Farida Djouad, Karine Toupet, Claire Bony, Marcella Franquesa, et al.. Mesenchymal Stem Cell-Derived Interleukin 1 Receptor Antagonist Promotes Macrophage Polarization and Inhibits B Cell Differentiation. STEM CELLS, AlphaMed Press, 2016, 34 (2), pp.483 - 492. ⟨10.1002/stem.2254⟩. ⟨hal-01834077⟩
  • Nguyen-Chi Mai, Laplace-Builhé Béryl, Jorgensen Christian, Farida Djouad. Deciphering the complexity of macrophage biology and function with the zebrafish model. Macrophage, Smart Science & Technology, 2016, 3, ⟨10.14800/Macrophage.1260⟩. ⟨hal-02097516⟩
  • Patricia Luz-Crawford, María Torres, Danièle Noël, Ainoa Fernandez, Karine Toupet, et al.. The immunosuppressive signature of menstrual blood mesenchymal stem cells entails opposite effects on experimental arthritis and graft versus host diseases. STEM CELLS, AlphaMed Press, 2016, 34 (2), pp.456 - 469. ⟨10.1002/stem.2244⟩. ⟨hal-01834145⟩
  • Mai Nguyen-Chi, Béryl Laplace-Builhé, Jana Travnickova, Patricia Luz-Crawford, Gautier Tejedor, et al.. Identification of polarized macrophage subsets in zebrafish. eLife, eLife Sciences Publication, 2015, 4, ⟨10.7554/eLife.07288⟩. ⟨hal-01834168v2⟩
  • P. Luz-Crawford, G. Tejedor, Anne-Laure Mausset-Bonnefont, E. Beaulieu, F. Morand, et al.. Glucocorticoid-Induced Leucine Zipper Governs the Therapeutic Potential of Mesenchymal Stem Cells by Inducing a Switch From Pathogenic to Regulatory Th17 Cells in a Mouse Model of Collagen-Induced Arthritis. Arthritis & rheumatology, Wiley, 2015, 67 (6), pp.1514 - 1524. ⟨10.1002/art.39069⟩. ⟨hal-01834130⟩
  • Lars Rackwitz, Farida Djouad, Sasa Janjanin, Ulrich Nöth, Rocky S. Tuan. Functional cartilage repair capacity of de-differentiated, chondrocyte- and mesenchymal stem cell-laden hydrogels in vitro. Osteoarthritis and Cartilage, Elsevier, 2014, 22 (8), pp.1148-1157. ⟨10.1016/j.joca.2014.05.019⟩. ⟨hal-03109221⟩
  • Marc Mathieu, Mathieu Iampietro, Paul Chuchana, David Guérit, Farida Djouad, et al.. Involvement of Angiopoietin-like 4 in Matrix Remodeling during Chondrogenic Differentiation of Mesenchymal Stem Cells. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2014, 289 (12), pp.8402-8412. ⟨10.1074/jbc.M113.539825⟩. ⟨hal-03116030⟩
  • Farida Djouad, Gautier Tejedor, Karine Toupet, Marie Maumus, Claire Bony, et al.. Promyelocytic leukemia zinc-finger induction signs mesenchymal stem cell commitment: identification of a key marker for stemness maintenance?. Stem Cell Research and Therapy, BioMed Central, 2014, 5 (1), pp.27. ⟨10.1186/scrt416⟩. ⟨inserm-00976578⟩
  • Patricia Luz-Crawford, Monica Kurte, Javiera Bravo-Alegría, Rafael Contreras, Estefania Nova-Lamperti, et al.. Mesenchymal stem cells generate a CD4+CD25+Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells.. Stem Cell Research and Therapy, BioMed Central, 2013, 4 (3), pp.65. ⟨10.1186/scrt216⟩. ⟨inserm-00836318⟩
  • Wesley Jackson, Thomas Lozito, Farida Djouad, Nastaran Kuhn, Leon Nesti, et al.. Differentiation and regeneration potential of mesenchymal progenitor cells derived from traumatized muscle tissue. Journal of Cellular and Molecular Medicine, Wiley Open Access, 2011, 15 (11), pp.2377 - 2388. ⟨10.1111/j.1582-4934.2010.01225.x⟩. ⟨hal-01878048⟩
  • Soufiane Ghannam, Carine Bouffi, Farida Djouad, Christian Jorgensen, Danièle Noël. Immunosuppression by mesenchymal stem cells: mechanisms and clinical applications. Current Stem Cell Research & Therapy, Bentham Science Publishers Ltd, 2010, 1 (1), ⟨10.1186/scrt2⟩. ⟨inserm-01878105⟩
  • Farida Djouad, Wesley Jackson, Brent Bobick, Sasa Janjanin, Yingjie Song, et al.. Activin A expression regulates multipotency of mesenchymal progenitor cells.. Stem Cell Research and Therapy, BioMed Central, 2010, 1 (2), pp.11. ⟨10.1186/scrt11⟩. ⟨inserm-00622572⟩
  • Farida Djouad, Claire Bony, François Canovas, Olivia Fromigue, Thierry Rème, et al.. Transcriptomic Analysis Identifies Foxo3A as a Novel Transcription Factor Regulating Mesenchymal Stem Cell Chrondrogenic Differentiation. Cloning and Stem Cells, Mary Ann Liebert, 2009, 11 (3), pp.407 - 416. ⟨10.1089/clo.2009.0013⟩. ⟨inserm-01878108⟩
  • Farida Djouad, Claire Bony, Thomas Häupl, Gilles Uzé, Najiba Lahlou, et al.. Transcriptional profiles discriminate bone marrow-derived and synovium-derived mesenchymal stem cells.. Arthritis Research and Therapy, BioMed Central, 2005, 7, pp.R1304-15. ⟨10.1186/ar1827⟩. ⟨inserm-00089978⟩

Conference papers6 documents

  • Marine Charrier, Judith Lorant, Rafael Contreras-López, Christophe Blanquart, Blandine Lieubeau, et al.. Demonstration of Immunomodulatory properties for the human MuStem cell population, a promising candidate for cell therapy of muscular dystrophies. Forum Bioregate, Dec 2018, Nantes, France. ⟨hal-01959647⟩
  • M. Maumus, K. Toupet, Farida Djouad, J.-P. David, C. Jorgensen, et al.. Protective effect of thrombospondin-4 expressing mesenchymal stem cells in osteoarthritis. World Congress of the Osteoarthritis-Research-Society-International (OARSI) on Osteoarthritis, Mar 2016, Amsterdam, Netherlands. ⟨10.1016/j.joca.2016.01.926⟩. ⟨hal-01834285⟩
  • M Maumus, K Toupet, Farida Djouad, D David, C Jorgensen, et al.. Protective effect of thrombospondin-4 expressing mesenchymal stem cells in osteoarthritis. 36th European Workshop for Rheumatology Research (EWRR), Feb 2016, York, United Kingdom. pp.A56.2 - A56, ⟨10.1136/annrheumdis-2016-209124.133⟩. ⟨hal-01834281⟩
  • Mai Nguyen-Chi, B Laplace-Builhe, J Travnickova, C Luz-Crawford, G. Tejedor, et al.. Identification of macrophage subsets in zebrafish larvae. ANNALS OF THE RHEUMATIC DISEASES, Mar 2015, London, United Kingdom. pp.A8.2 - A8, ⟨10.1136/annrheumdis-2015-207259.19⟩. ⟨hal-01834463⟩
  • C Luz-Crawford, N Ipseiz, C Caicedo, C Scholtysek, C Stoll, et al.. PPARβ/δ expression orchestrates the immunosuppressive effect of mesenchymal stem cells via NF-κB signalling. ANNALS OF THE RHEUMATIC DISEASES, Mar 2015, London, United Kingdom. pp.A91.1 - A91, ⟨10.1136/annrheumdis-2015-207259.209⟩. ⟨hal-01834517⟩
  • B Laplace-Builhe, Mai Nguyen-Chi, J Travnickova, C Luz-Crawford, G. Tejedor, et al.. Pro-inflammatory macrophages mediated TNF-alpha signalling is required for caudal fin regenerationin zebrafish larvae. ANNALS OF THE RHEUMATIC DISEASES, Mar 2015, London, United Kingdom. pp.A16.1 - A16, ⟨10.1136/annrheumdis-2015-207259.37⟩. ⟨hal-01834525⟩

Poster communications3 documents

  • C. Sarre, N. Nernpermpisooth, Christian Barrère, P. Luz-Crawford, G. Tejedor, et al.. PPARβ/δ is involved in the cardioprotective effect of mesenchymal stem cells. ECongrès le Printemps de la Cardiologie, Oct 2020, grenoble, France. 12 (2-4), pp.230, 2020, ⟨10.1016/j.acvdsp.2020.03.077⟩. ⟨hal-03429725⟩
  • Marine Charrier, Judith Lorant, Rafael Contreras Lopez, Christophe Blanquart, Blandine Lieubeau-Teillet, et al.. Demonstration of immunomodulatory properties for the human MuStem cell population, a promising candidate for cell therapy of muscular dystrophies. 6eme congrès international de Myologie, Mar 2019, Bordeaux, France. 2019. ⟨hal-02083276⟩
  • Marine Charrier, Judith Lorant, Rafael Contreras Lopez, Christophe Blanquart, Blandine Lieubeau-Teillet, et al.. Demonstration of immunomodulatory properties for the human MuStem cell population, a promising candidate for cell therapy of muscular dystrophies. 2nd annual meeting of French Society for Stem Cell Research, Dec 2018, Nantes, France. 2018. ⟨hal-01959646⟩

Preprints, Working Papers, ...1 document

  • Jana Travnickova, Sandra Nhim, Naoill Abdellaoui, Farida Djouad, Mai Nguyen-Chi, et al.. Macrophage plasticity is Rac signalling and MMP9 dependant. 2019. ⟨hal-02106150⟩

Theses1 document

  • Farida Djouad. Les personnes handicapées vieillissantes : enjeux socio-économiques, organisationnels, et diagnostics : le cas du syndrome de Down. Sciences cognitives. Université de Bordeaux, 2015. Français. ⟨tel-03151154⟩