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From biodiversity to the synthesis of anti-apoptotic proteins inhibitors

 Sandy Desrat , Shelly Gapil Tiamas , Khalijah Awang , Alma Abou Samra , Camille Remeur , et al.
8ème Rencontres de Chimie Organique et Bioorganique (RECOB), Mar 2022, Aussois, France.
Poster de conférence hal-04400541v1
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Bio-inspired synthesis and profiling of a potent antiviral flavonol targeting the lipid exchanger OSBP

 Gwenaëlle Jézéquel , Zoé Grimanelli , Carole Guimard , Joëlle Bigay , Juliano Haddad , et al.
2024
Pré-publication, Document de travail hal-04513014v1
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Structural revision of the Mcl-1 inhibitor MIM1: synthesis and biological studies on ovarian cancer cells with evaluation of designed analogues

 Hippolyte Paysant , Siham Hedir , Frédéric Justaud , Louis Bastien Weiswald , Assaad Nasr El Dine , et al.
Organic & Biomolecular Chemistry, 2021, 19 (41), pp.8968-8987. ⟨10.1039/d1ob01521d⟩
Article dans une revue hal-03414007v1

Design of chemical probes derived from schweinfurthins to hijack OSBP, implicated in cholesterol homeostasis

 Clément Grisel , Ophélie Bento , Isabel Ramon Martinez , Laurie Azkenatzis , Jérôme Bignon , et al.
27th EFMC International Symposium on Medicinal Chemistry, Sep 2022, Nice, France.
Poster de conférence hal-04400602v1

Plant specialized metabolites as a source of inspiration in medicinal chemistry

 Fanny Roussi
2023
Autre publication scientifique hal-04404867v1

Design of chemical probes derived from schweinfurthins to hijack OSBP, implicated in cholesterol homeostasis

 Clément Grisel , Ophélie Bento , Isabel Ramon Martinez , Laurie Azkenatzis , Jérome Bignon , et al.
Journées de Chimie Organique (JCO) 2022, Nov 2022, Palaiseau, France.
Poster de conférence hal-04400652v1

Targeting OSBP degradation by PROTACs derived from schweinfurthin for cancer therapy

 Carole Guimard , Gwenaëlle Jézéquel , Laurie Askenatzis , Jérome Bignon , Sandy Desrat , et al.
27th EFMC International Symposium on Medicinal Chemistry, Sep 2022, Nice, France.
Poster de conférence hal-04400614v1

Conception of Natural-Inspired Small-Molecule Inhibitors of Bcl-2 Family Proteins

 Fanny Roussi
SYMPOSIUM PIRAMID, Sep 2021, Nantes (44000), France
Communication dans un congrès hal-04397585v1

Substances naturelles, chimie et cibles du cancer

 Fanny Roussi
Journées de l'Ecole Doctorale, Jul 2019, Caen, France
Communication dans un congrès hal-04397622v1

MetGem Software for the Generation of Molecular Networks Based on the t-SNE Algorithm

 Nicolas Elie , Florent Olivon , Gwendal Grelier , Fanny Roussi , Marc Litaudon , et al.
RFMF 2019, May 2019, Clermont-Ferrand, France
Communication dans un congrès hal-04428142v1
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Dual Beam Depth Profiling and Imaging with Argon and Bismuth Clusters of Prenylated Stilbenes on Glandular Trichomes of Macaranga vedeliana

 Tiphaine Péresse , Nicolas Elie , David Touboul , Van-Cuong Pham , Vincent Dumontet , et al.
Analytical Chemistry, 2017, 89 (17), pp.9247-9252. ⟨10.1021/acs.analchem.7b02020⟩
Article dans une revue hal-03176647v1

From ICSN chemical library to a chemical lead for treatment of glioblastoma

 Fanny Roussi
i-npchem virtual meeting, Oct 2021, Virtuel- Européen, France
Communication dans un congrès hal-04404885v1

Methylaluminoxane (MAO)-Assisted Direct Amidation of Esters

 Sandy Desrat , Aline Ducousso , Shelly Gapil , Camille Remeur , Fanny Roussi
SYNLETT, 2015, 26 (03), pp.385-387. ⟨10.1055/s-0034-1378927⟩
Article dans une revue hal-01142881v1

Asymmetric Total Synthesis and Biological Evaluation of Proapoptotic Natural Myrcene-Derived Cyclohexenyl Chalcones

 Shelly Gapil Tiamas , Florian Audet , Alma Abou Samra , Jerome Bignon , Marc Litaudon , et al.
European Journal of Organic Chemistry, 2018, 2018 (42), pp.5830-5835. ⟨10.1002/ejoc.201800262⟩
Article dans une revue hal-02355166v1
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Molecular and cellular dissection of the oxysterol-binding protein cycle through a fluorescent inhibitor

 Tiphaine Peresse , Davidi Kovacs , Mélody Subra , Joelle Bigay , Meng-Chen Tsai , et al.
Journal of Biological Chemistry, 2020, ⟨10.1074/jbc.RA119.012012⟩
Article dans une revue hal-02733227v1
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Drimane derivatives as the first examples of covalent BH3-mimetics that target MCL-1

 Florian Daressy , Florian Malard , Line Seguy , Vincent Guérineau , Cécile Apel , et al.
ChemMedChem, 2021, 16 (11), pp.1789-1798. ⟨10.1002/cmdc.202100011⟩
Article dans une revue hal-03279424v1
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In vitro evaluation of NA1-115-7-loaded nanoemulsions, an MCL-1-specific inhibitor of natural origin, intended to treat B-cell lymphoproliferative disorders after oral administration

 Line Séguy , Florian Daressy , Sophia Lahlil , Sophie Corvaisier , Vincent Dumontet , et al.
International Journal of Pharmaceutics, 2023, 630, pp.122433. ⟨10.1016/j.ijpharm.2022.122433⟩
Article dans une revue hal-04127315v1
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NA1—115—7, from Zygogynum pancheri, is a new selective MCL-1 inhibitor inducing the apoptosis of hematological cancer cells but non-toxic to normal blood cells or cardiomyocytes

 Florian Daressy , Line Séguy , Loëtitia Favre , Sophie Corvaisier , Cécile Apel , et al.
Biomedicine and Pharmacotherapy, 2022, 154, pp.113546. ⟨10.1016/j.biopha.2022.113546⟩
Article dans une revue hal-03777709v1

Dual inhibitors of the pro-survival proteins Bcl-2 and Mcl-1 derived from natural compound meiogynin A

 Alma Abou Samra , Aude Robert , Crystal Gov , Loëtitia Favre , Laure Eloy , et al.
European Journal of Medicinal Chemistry, 2018, 148, pp.26-38. ⟨10.1016/j.ejmech.2018.01.100⟩
Article dans une revue hal-02343193v1

Fast & easy preparation of 3D scaffolds from methyl benzoate by a diversity oriented synthesis strategy based on Diels–Alder and ene-reactions

 Dominique Brossard , Pascal Retailleau , Vincent Dumontet , Philippe Breton , Sandy Desrat , et al.
Organic & Biomolecular Chemistry, 2017, 15 (26), pp.5585-5592. ⟨10.1039/C7OB01236E⟩
Article dans une revue hal-02355151v1
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Structure-Based Design of a Lead Compound Derived from Natural Schweinfurthins with Antitumor Properties That Target Oxysterol-Binding Protein

 Gwenaëlle Jézéquel , Céline Rampal , Carole Guimard , David Kovacs , Joël Polidori , et al.
Journal of Medicinal Chemistry, 2023, 66 (20), pp.14208-14220. ⟨10.1021/acs.jmedchem.3c01298⟩
Article dans une revue hal-04297926v1
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Synthesis and Anti-Leishmanial Properties of Quinolones Derived from Zanthosimuline

 Gwenaëlle Jézéquel , Laura Nogueira de Faria Cardoso , Florent Olivon , Indi Dennemont , Cécile Apel , et al.
Molecules, 2022, 27 (22), pp.7892. ⟨10.3390/molecules27227892⟩
Article dans une revue hal-03853782v1

Selectivity in the Intermolecular Diels-Alder Reaction of Conjugated Trienes: Experimental and Theoretical Approaches

 Camille Remeur , Sandy Desrat , Vincent Gandon , Fanny Roussi
European Journal of Organic Chemistry, 2018, 2018 (42), pp.5869-5877. ⟨10.1002/ejoc.201800472⟩
Article dans une revue hal-02355162v1
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MetGem Software for the Generation of Molecular Networks Based on the t-SNE Algorithm

 Nicolas Elie , Florent Olivon , Gwendal Grelier , Fanny Roussi , Marc Litaudon , et al.
12émes journées du RFMF ( Réseau Français de Métabolomique et Fluxomique ) 2019, May 2019, Clermont-Ferrand, France. 2018
Poster de conférence hal-04427165v1
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Pro-apoptotic meiogynin A derivatives that target Bcl-xL and Mcl-1.

 Sandy Desrat , Anaïs Pujals , Claire Colas , Jérémy Dardenne , Loëtitia Favre , et al.
Bioorganic and Medicinal Chemistry Letters, 2014, 24 (21), pp.5086-5088. ⟨10.1016/j.bmcl.2014.09.004⟩
Article dans une revue hal-01077156v1

Development of an efficient route toward meiogynin A-inspired dual inhibitors of Bcl-xL and Mcl-1 anti-apoptotic proteins

 Sandy Desrat , Camille Remeur , Fanny Roussi
Organic & Biomolecular Chemistry, 2015, 13 (19), pp.5520-5531. ⟨10.1039/c5ob00354g⟩
Article dans une revue hal-01152801v1
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Anti-diabetic and lipid-lowering effects of drimane sesquiterpenoids isolated from Zygogynum pancheri

 Sahla Belhadj , Henda Keskes , Cécile Apel , Fanny Roussi , Marc Litaudon , et al.
Chemico-Biological Interactions, 2020, ⟨10.1016/j.cbi.2020.109167⟩
Article dans une revue hal-03007353v1

Targeting OSBP degradation by PROTACs derived from schweinfurthin for cancer therapy

 Carole Guimard , Gwenaëlle Jézéquel , Laurie Askenatzis , Jérome Bignon , Sandy Desrat , et al.
Journée de l’école doctorale Innovation Thérapeutique: du Fondamental à l'Appliqué, Jun 2022, Chatenay-Malabry, France
Poster de conférence hal-04400585v1

Cytotoxic lignans from fruits of Cleistanthus tonkinensis

 Lam Hong Nguyen , van Nam Vu , Dao Phi Thi , Viet Hung Tran , Marc Litaudon , et al.
Fitoterapia, 2020, 140, pp.104432. ⟨10.1016/j.fitote.2019.104432⟩
Article dans une revue hal-03007684v1
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Environmentally Friendly Procedure Based on Supercritical Fluid Chromatography and Tandem Mass Spectrometry Molecular Networking for the Discovery of Potent Antiviral Compounds from Euphorbia semiperfoliata

 Louis-Félix Nothias , Stéphanie Boutet-Mercey , Xavier Cachet , Erick de la Torre , Laurent Laboureur , et al.
Journal of Natural Products, 2017, 80 (10), pp.2620-2629. ⟨10.1021/acs.jnatprod.7b00113⟩
Article dans une revue hal-03977037v1
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