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Fabrice Leclerc

CNRS senior scientist in the field of RNA bioinformatics at the University Paris Saclay. I develop and apply modeling approaches to understand the structure/function relationships of RNAs (sequence, 2D, and 3D structure). My research interests include RNomics (identification and characterization of non-coding RNA genes), computational enzymology (elucidate the catalysis by self-cleaving ribozymes), docking (model and predict RNA/protein interactions), and and fragment-based design of oligonucleotides.

Journal articles9 documents

  • Roy González-Alemán, Nicolas Chevrollier, Manuel Simoes, Luis Montero-Cabrera, Fabrice Leclerc. MCSS-based Predictions of Binding Mode and Selectivity of Nucleotide Ligands. Journal of Chemical Theory and Computation, American Chemical Society, 2021, ⟨10.1021/acs.jctc.0c01339⟩. ⟨hal-03174156⟩
  • Marie-Christine Maurel, Fabrice Leclerc, Jacques Vergne, Giuseppe Zaccai. RNA Back and Forth: Looking through Ribozyme and Viroid Motifs. Viruses, MDPI, 2019, 11 (3), pp.283. ⟨10.3390/v11030283⟩. ⟨hal-02104510⟩
  • Marie Christine Maurel, Fabrice Leclerc, Guy Hervé. Ribozyme Chemistry: to be or not to be under high pressure. Chemical Reviews, American Chemical Society, 2019, 120 (11), pp.4898-4918. ⟨10.1021/acs.chemrev.9b00457⟩. ⟨hal-02317015v2⟩
  • Fabrice Leclerc, Giuseppe Zaccai, Jacques Vergne, Martina Řìhovà, Anne Martel, et al.. Self-assembly Controls Self-cleavage of HHR from ASBVd (−): a Combined SANS and Modeling Study. Scientific Reports, Nature Publishing Group, 2016, 6 (30287), ⟨10.1038/srep30287⟩. ⟨hal-01357443⟩
  • Marie-Christine Maurel, Fabrice Leclerc. From Foundation Stones to Life: Concepts and Results. Elements, GeoScienceWorld, 2016, 12 (6), pp.407 - 412. ⟨10.2113/gselements.12.6.407⟩. ⟨hal-01489685⟩
  • Claire Toffano-Nioche, Daniel Gautheret, Fabrice Leclerc. Revisiting the structure/function relationships of H/ACA(-like) RNAs: a unified model for Euryarchaea and Crenarchaea.. Nucleic Acids Research, Oxford University Press, 2015, pp.7744-61. ⟨10.1093/nar/gkv756⟩. ⟨hal-01464539⟩
  • Claire Toffano-Nioche, Alban Ott, Estelle Crozat, an N Nguyen, Matthias Zytnicki, et al.. RNA at 92 °C: The non-coding transcriptome of the hyperthermophilic archaeon Pyrococcus abyssi.. RNA Biology, Taylor & Francis, 2013, 10 (7), pp.1211-20. ⟨10.4161/rna.25567⟩. ⟨hal-00863721⟩
  • Jean-Baptiste Fourmann, Anne-Sophie Tillault, Magali Blaud, Fabrice Leclerc, Christiane Branlant, et al.. Comparative Study of Two Box H/ACA Ribonucleoprotein Pseudouridine-Synthases: Relation between Conformational Dynamics of the Guide RNA, Enzyme Assembly and Activity. PLoS ONE, Public Library of Science, 2013, 8 (7), pp.e70313. ⟨10.1371/journal.pone.0070313⟩. ⟨hal-01452159⟩
  • Julien Allali, Cédric Saule, Cedric Chauve, Yves d'Aubenton-Carafa, Alain Denise, et al.. BRASERO: A resource for benchmarking RNA secondary structure comparison algorithms. Advances in Bioinformatics, Hindawi Publishing Corporation, 2012, 2012, pp.1-5. ⟨10.1155/2012/893048⟩. ⟨hal-00647725⟩

Conference papers7 documents

  • Fabrice Leclerc. Modified oligonucleotides as RNA-based drugs (biosensors): prerequisites and opportunities for in silico methods within the framework of fragment-based approaches. GDR RNA: 1st Scientific Meeting, Nov 2020, Nice (en ligne), France. ⟨hal-03313276⟩
  • Fabrice Leclerc. Design of oligonucleotides as RNA-based drugs: prerequisites and opportunities for in silico methods within the framework of fragment-based approaches. Mini-symposium@JOBIM 2020 - RNA structure, design and interactions with proteins, Jul 2020, Montpellier (en ligne), France. ⟨hal-03313254⟩
  • Fabrice Leclerc. MCSS with hybrid solvent models: qualitative docking & screening powers of nucleotidic ligands. CHARMM Meeting 2020, Jul 2020, Cambridge, MA, United States. ⟨hal-03313271⟩
  • Fabrice Leclerc. MCSS Update biomolecular fragments solvent models, scoring functions, … and application examples to oligonucleotides. Charmm-Tinker meeting (2019), Jul 2019, Paris, France. ⟨hal-02324203⟩
  • Fabrice Leclerc, Yoanna Ginarte. Integrative Model of Rhodanine Derivatives as Tau- aggregation inhibitors in AD: ligand-based (QSAR) and structure-based (docking, MD) approaches. 7th International Chemistry Symposium SIQ - SEADIM / 12th Molecular Design and Bioinformatics Symposium, Jun 2019, Cayo Santa María, Cuba. ⟨hal-02324217⟩
  • Julien Allali, Yves d'Aubenton-Carafa, Cedric Chauve, Alain Denise, Christine Drevet, et al.. Benchmarking RNA secondary structure comparison algorithms. JOBIM'08, 2008, Lille, France. pp.67-68. ⟨hal-00375710⟩
  • Emmanuel Gothié, Yann Guermeur, Fabrice Leclerc, Christiane Branlant, Alexander Bockmayr. Analyse des Séquences InterORF chez les Levures - Application à la Recherche des petits ARN. Structure, Intégration, Fonction et Réactivité des ARN - SIFRARN, Oct 2002, Nancy, France. ⟨inria-00101006⟩

Poster communications1 document

  • Yoanna Álvarez-Ginarte, Elena Moreno-Castillo, Luis A Montero-Cabrera, Alberto Bencomo-Martínez, Roy González-Alemán, et al.. INTEGRATIVE MODEL OF RHODANINE DERIVATIVES AS TAU AGGREGATION INHIBITORS IN ALZHEIMER'S DISEASE. BIOInfOMICs2019 IX International Meeting on Bioinformatics and OMICs, Oct 2019, Cayo Santa María, Cuba. ⟨hal-02318289v3⟩

Book sections1 document

  • Yann Ponty, Fabrice Leclerc. Drawing and Editing the Secondary Structure(s) of RNA.. Ernesto Picardi. RNA Bioinformatics, 1269, Springer New York, pp.63-100, 2015, Methods in Molecular Biology, 978-1-4939-2290-1. ⟨10.1007/978-1-4939-2291-8_5⟩. ⟨hal-01079893⟩

Preprints, Working Papers, ...1 document

  • Roy Gonzalez-Aleman, Nicolas Chevrollier, Manuel Simoes, Luis Montero-Cabrera, Fabrice Leclerc. MCSS-based Predictions of Binding Mode and Selectivity of Nucleotide Ligands. 2021. ⟨hal-02116374v2⟩

Reports1 document

  • Fabrice Leclerc, Carine Tisné. L’histoire du vivant: Des viroïdes et virus à l’homme, dans les traces du « RNA World ». [Autre] Institut de Biologie Intégrative de la Cellule. 2017. ⟨hal-01627909⟩

Lectures3 documents

  • Fabrice Leclerc. RNA-based drugs: discovery and design, From aptamers to oligonucleotides: a perspective for in silico approaches. Doctoral. France. 2020. ⟨hal-03313797⟩
  • Fabrice Leclerc. Analyse et Visualisation de structures 2D d’ARN. Master. Paris, France. 2020. ⟨hal-03313812⟩
  • Fabrice Leclerc. Viroids & the RNA World: from genomic scale (RNA) to atomic scale (ribozyme). Master. BGA Biochimie et Génétique des ARN, Paris, France. 2020. ⟨hal-03313809⟩