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Fabien GOSSELET

112
Documents

Publications

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Enhancing Oral Delivery of Biologics: A Non-Competitive and Cross-Reactive Anti-Leptin Receptor Nanofitin Demonstrates a Gut-Crossing Capacity in an Ex Vivo Porcine Intestinal Model

Solene Masloh , Anne Chevrel , Maxime Culot , Anaëlle Perrocheau , Yogeshvar N Kalia
Pharmaceutics, 2024, 16 (1), pp.116. ⟨10.3390/pharmaceutics16010116⟩
Article dans une revue hal-04413366v1
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Impact of Pesticide Residues on the Gut-Microbiota–Blood–Brain Barrier Axis: A Narrative Review

Maria Abou Diwan , Marwa Lahimer , Véronique Bach , Fabien Gosselet , Hafida Khorsi-Cauet
International Journal of Molecular Sciences, 2023, 24 (7), ⟨10.3390/ijms24076147⟩
Article dans une revue hal-04068149v1
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Vesicular Trafficking, a Mechanism Controlled by Cascade Activation of Rab Proteins: Focus on Rab27

Camille Menaceur , Océane Dusailly , Fabien Gosselet , Laurence Fenart , Julien Saint-Pol
Article dans une revue hal-04363886v1
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High levels of endothelial ICAM-1 prohibit natalizumab mediated abrogation of  CD4+ T cell arrest on the inflamed BBB under flow in vitro

Sasha Soldati , Alexander Bär , Mykhailo Vladymyrov , Dale Glavin , James L Mcgrath
Journal of Neuroinflammation, 2023, ⟨10.1186/s12974-023-02797-8⟩
Article dans une revue hal-04104383v1
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TNFα Activates the Liver X Receptor Signaling Pathway and Promotes Cholesterol Efflux from Human Brain Pericytes Independently of ABCA1

Shiraz Dib , Rodrigo Azevedo Loiola , Emmanuel Sevin , Julien Saint-Pol , Fumitaka Shimizu
International Journal of Molecular Sciences, 2023, 24 (6), ⟨10.3390/ijms24065992⟩
Article dans une revue hal-04053087v1
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BrainBike peptidomimetic enables efficient transport of proteins across brain endothelium

Maria C Lucana , Roberta Lucchi , Fabien Gosselet , Cristina Díaz-Perlas , Benjamí Oller-Salvia
RSC Chemical Biology, 2023, 5, pp.7 - 11. ⟨10.1039/d3cb00194f⟩
Article dans une revue hal-04375262v1
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ProNGF promotes brain metastasis through TrkA/EphA2 induced Src activation in triple negative breast cancer cells

Julien Cicero , Sarah Trouvilliez , Martine Palma , Gaetan Ternier , Laurine Decoster
Experimental Hematology & Oncology, 2023, 12 (1), pp.104. ⟨10.1186/s40164-023-00463-6⟩
Article dans une revue hal-04334490v1
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Highlighting In Vitro the Role of Brain-like Endothelial Cells on the Maturation and Metabolism of Brain Pericytes by SWATH Proteomics

Camille Menaceur , Johan Hachani , Shiraz Dib , Sophie Duban-Deweer , Yannis Karamanos
Article dans une revue hal-04068135v1

Discovery, Structure–Activity Relationships, and In Vivo Activity of Dihydropyridone Agonists of the Bile Acid Receptor TGR5

Sylvain Picon , Rajaa Boulahjar , Vanessa Hoguet , Morgane Baron , Isabelle Duplan
Journal of Medicinal Chemistry, 2023, ⟨10.1021/acs.jmedchem.2c01881⟩
Article dans une revue hal-04192205v1
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25-hydroxycholesterol in health and diseases

Cindy Nguyen , Julien Saint-Pol , Shiraz Dib , Caroline Pot , Fabien Gosselet
Journal of Lipid Research, 2023, ⟨10.1016/j.jlr.2023.100486⟩
Article dans une revue hal-04352365v1
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Challenges and Opportunities in the Oral Delivery of Recombinant Biologics

Solene Masloh , Maxime Culot , Fabien Gosselet , Anne Chevrel , Leonardo Scapozza
Pharmaceutics, 2023, 15 (5), ⟨10.3390/pharmaceutics15051415⟩
Article dans une revue hal-04108844v1
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Differential Blood–Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro

Erik Melander , Camilla Eriksson , Sara Wellens , Kimia Hosseini , Robert Fredriksson
Pharmaceutics, 2023, 15, ⟨10.3390/pharmaceutics15051507⟩
Article dans une revue hal-04108846v1
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Interaction of surfactant coated PLGA nanoparticles with in vitro human brain-like endothelial cells

Elisa L.J. Moya , Sonia Lombardo , Elodie Vandenhaute , Marc Schneider , Caroline Mysiorek
International Journal of Pharmaceutics, 2022, 621, pp.121780. ⟨10.1016/j.ijpharm.2022.121780⟩
Article dans une revue hal-03707013v1
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A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning

Ophélie da Silva , Nicolas Probst , Christophe Landry , Anne-Sophie Hanak , Pierre Warnault
Journal of Medicinal Chemistry, 2022, 65 (6), pp.4649-4666. ⟨10.1021/acs.jmedchem.1c01748⟩
Article dans une revue hal-03706969v1
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TNF-α and IL-1β Modulate Blood-Brain Barrier Permeability and Decrease Amyloid-β Peptide Efflux in a Human Blood-Brain Barrier Model

Romain Versele , Emmanuel Sevin , Fabien Gosselet , Laurence Tilloy-Fenart , Pietra Candela
International Journal of Molecular Sciences, 2022, 23 (18), pp.10235. ⟨10.3390/ijms231810235⟩
Article dans une revue hal-03786823v1
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Quantitative Targeted Absolute Proteomics for Better Characterization of an In Vitro Human Blood–Brain Barrier Model Derived from Hematopoietic Stem Cells

Marie-Pierre Dehouck , Masanori Tachikawa , Yutaro Hoshi , Kotaro Omori , Claude-Alain Maurage
Cells, 2022, 11 (24), pp.3963. ⟨10.3390/cells11243963⟩
Article dans une revue hal-03893240v1
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Challenges and opportunities in the use of transcriptomics characterization for human iPSC-derived BBB models

Sara Wellens , Fabien Gosselet , Maxime Culot
Toxicology in Vitro, inPress, ⟨10.1016/j.tiv.2022.105424⟩
Article dans une revue hal-03708257v2
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The Blood–Brain Barrier, an Evolving Concept Based on Technological Advances and Cell–Cell Communications

Camille Menaceur , Fabien Gosselet , Laurence Fenart , Julien Saint-Pol
Cells, 2022, 11 (1), pp.133. ⟨10.3390/cells11010133⟩
Article dans une revue hal-03706905v1
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Pioglitazone Attenuates the Effects of Peripheral Inflammation in a Human In Vitro Blood–Brain Barrier Model

Gustavo Henrique Oliveira da Rocha , Rodrigo Azevedo Loiola , Marina de Paula-Silva , Fumitaka Shimizu , Takashi Kanda
International Journal of Molecular Sciences, 2022, 23, ⟨10.3390/ijms232112781⟩
Article dans une revue hal-03851672v1
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Discovery of pyrazolo-thieno[3,2-d]pyrimidinylamino-phenyl acetamides as type-II pan-tropomyosin receptor kinase (TRK) inhibitors: Design, synthesis, and biological evaluation

Wei Yan , Lingtian Zhang , Fengping Lv , Marialuisa Moccia , Francesca Carlomagno
European Journal of Medicinal Chemistry, 2021, 216, pp.113265. ⟨10.1016/j.ejmech.2021.113265⟩
Article dans une revue hal-03185627v1

Antimalarial drug discovery: from quinine to the most recent promising clinical drug candidates

Camille Tisnerat , Alexandra Dassonville-Klimpt , Fabien Gosselet , Pascal Sonnet
Current Medicinal Chemistry, 2021, 28, ⟨10.2174/0929867328666210803152419⟩
Article dans une revue hal-03472321v1
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Miniaturization and Automation of a Human In Vitro Blood–Brain Barrier Model for the High-Throughput Screening of Compounds in the Early Stage of Drug Discovery

Elisa Moya , Elodie Vandenhaute , Eleonora Rizzi , Marie-Christine Boucau , Johan Hachani
Pharmaceutics, 2021, 13 (6), pp.892. ⟨10.3390/pharmaceutics13060892⟩
Article dans une revue hal-03472477v1
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Endothelial Iron Homeostasis Regulates Blood-Brain Barrier Integrity via the HIF2α—Ve-Cadherin Pathway

Daniel Rand , Orly Ravid , Dana Atrakchi , Hila Israelov , Yael Bresler
Pharmaceutics, 2021, 13 (3), pp.311. ⟨10.3390/pharmaceutics13030311⟩
Article dans une revue hal-03185677v1
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Secretome of endothelial progenitor cells from stroke patients promotes endothelial barrier tightness and protects against hypoxia-induced vascular leakage

Rodrigo Azevedo Loiola , Miguel García-Gabilondo , Alba Grayston , Paulina Bugno , Agnieszka Kowalska
Current Stem Cell Research & Therapy, 2021, 12 (1), ⟨10.1186/s13287-021-02608-y⟩
Article dans une revue hal-03472260v1
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Transport study of interleukin-1 inhibitors using a human in vitro model of the blood-brain barrier

Elisabet Sjöström , Maxime Culot , Lisa Leickt , Mikael Åstrand , Erik Nordling
Brain, Behavior & Immunity - Health, 2021, 16, pp.100307. ⟨10.1016/j.bbih.2021.100307⟩
Article dans une revue hal-03472272v1
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Time-Dependent Internalization of Polymer-Coated Silica Nanoparticles in Brain Endothelial Cells and Morphological and Functional Effects on the Blood-Brain Barrier

Aniela Bittner , Fabien Gosselet , Emmanuel Sevin , Lucie Dehouck , Angélique Ducray
International Journal of Molecular Sciences, 2021, 22 (4), pp.1657. ⟨10.3390/ijms22041657⟩
Article dans une revue hal-03185554v1

Beyond the Rule of 5: Impact of PEGylation with Various Polymer Sizes on Pharmacokinetic Properties, Structure–Properties Relationships of mPEGylated Small Agonists of TGR5 Receptor

Vanessa Hoguet , Manuel Lasalle , Mathieu Maingot , Geoffroy Dequirez , Rajaa Boulahjar
Journal of Medicinal Chemistry, 2021, 64 (3), pp.1593-1610. ⟨10.1021/acs.jmedchem.0c01774⟩
Article dans une revue hal-03185533v1
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Central nervous system delivery of molecules across the blood-brain barrier

Fabien Gosselet , Rodrigo Azevedo Loiola , Anna Roig , Anna Rosell , Maxime Culot
Neurochemistry International, 2021, 144, ⟨10.1016/j.neuint.2020.104952⟩
Article dans une revue hal-03282235v1
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Differential neurovirulence of Usutu viruslineages in mice and neuronal cells

Marion Clé , Orianne Constant , Jonathan Barthelemy , Caroline Desmetz , Marie France Martin
Journal of Neuroinflammation, 2021, 18 (1), pp.59. ⟨10.1186/s12974-021-02109-y⟩
Article dans une revue hal-03678372v1

Potential neurotoxicity of titanium implants: Prospective, in-vivo and in-vitro study

Shahar Shelly , Sigal Liraz Zaltsman , Ofir Ben-Gal , Avraham Dayan , Ithamar Ganmore
Biomaterials, 2021, 276, pp.121039. ⟨10.1016/j.biomaterials.2021.121039⟩
Article dans une revue hal-03472462v1
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Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound

Sara Wellens , Lucie Dehouck , Vidya Chandrasekaran , Pranika Singh , Rodrigo Azevedo Loiola
Toxicology in Vitro, 2021, 73, pp.105112. ⟨10.1016/j.tiv.2021.105112⟩
Article dans une revue hal-03185595v1
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SARS-CoV-2 Poorly Replicates in Cells of the Human Blood-Brain Barrier Without Associated Deleterious Effects

Orianne Constant , Jonathan Barthelemy , Karine Bolloré , Edouard Tuaillon , Fabien Gosselet
Frontiers in Immunology, 2021, 12, pp.697329. ⟨10.3389/fimmu.2021.697329⟩
Article dans une revue hal-03455730v1
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Flow induces barrier and glycocalyx-related genes and negative surface charge in a lab-on-a-chip human blood-brain barrier model

Ana R Santa-Maria , Fruzsina R Walter , Ricardo Figueiredo , András Kincses , Judith Vigh
Journal of Cerebral Blood Flow and Metabolism, 2021, 41 (9), pp.2201-2215. ⟨10.1177/0271678X21992638⟩
Article dans une revue hal-03185580v1
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Role of ABCA7 in Human Health and in Alzheimer’s Disease

Shiraz Dib , Jens Pahnke , Fabien Gosselet
International Journal of Molecular Sciences, 2021, 22 (9), pp.4603. ⟨10.3390/ijms22094603⟩
Article dans une revue hal-03472487v1
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A Triple Culture Cell System Modeling the Human Blood-Brain Barrier

Eleonora Rizzi , Clémence Deligne , Lucie Dehouck , Roberta Bilardo , Yasuteru Sano
Journal of visualized experiments : JoVE, 2021, 177, ⟨10.3791/63134⟩
Article dans une revue hal-03706896v1
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Differential neurovirulence of Usutu virus lineages in mice and neuronal cells

Marion Clé , Orianne Constant , Jonathan Barthelemy , Caroline Desmetz , Marie France Martin
Journal of Neuroinflammation, 2021, 18 (1), pp.11. ⟨10.1186/s12974-020-02060-4⟩
Article dans une revue hal-03126852v1
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Ketone Bodies Promote Amyloid-β1–40 Clearance in a Human in Vitro Blood–Brain Barrier Model

Romain Versele , Mariangela Corsi , Andrea Fuso , Emmanuel Sevin , Rita Businaro
International Journal of Molecular Sciences, 2020, 21 (3), pp.934. ⟨10.3390/ijms21030934⟩
Article dans une revue hal-02538226v1
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Contribution of brain pericytes in blood–brain barrier formation and maintenance: a transcriptomic study of cocultured human endothelial cells derived from hematopoietic stem cells

Marjolein Heymans , Ricardo Figueiredo , Lucie Dehouck , David Francisco , Yasuteru Sano
Fluids and Barriers of the CNS, 2020, 17 (1), ⟨10.1186/s12987-020-00208-1⟩
Article dans une revue hal-03127036v1
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Serum-derived factors of breast cancer patients with brain metastases alter permeability of a human blood–brain barrier model

Carolin Curtaz , Constanze Schmitt , Saskia-Laureen Herbert , Jonas Feldheim , Nicolas Schlegel
Fluids and Barriers of the CNS, 2020, 17, pp.31. ⟨10.1186/s12987-020-00192-6⟩
Article dans une revue hal-03127441v1
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Homology Modeling of the Human P-glycoprotein (ABCB1) and Insights into Ligand Binding through Molecular Docking Studies

Liadys Mora Lagares , Nikola Minovski , Ana Yisel Caballero Alfonso , Emilio Benfenati , Sara Wellens
International Journal of Molecular Sciences, 2020, 21 (11), pp.4058. ⟨10.3390/ijms21114058⟩
Article dans une revue hal-03127238v1
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Caspase-1 has a critical role in blood-brain barrier injury and its inhibition contributes to multifaceted repair

Hila Israelov , Orly Ravid , Dana Atrakchi , Daniel Rand , Shirin Elhaik
Journal of Neuroinflammation, 2020, 17 (1), ⟨10.1186/s12974-020-01927-w⟩
Article dans une revue hal-03126925v1
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Chemoselective Hydrogenation of 6‐Alkynyl‐3‐fluoro‐2‐pyridinaldoximes: Access to First‐in‐Class 6‐Alkyl‐3‐Fluoro‐2‐pyridinaldoxime Scaffolds as New Reactivators of Sarin‐Inhibited Human Acetylcholinesterase with Increased Blood–Brain Barrier Permeability

Jagadeesh Yerri , José Dias , Mallikajurna Reddy Nimmakayala , Franck Razafindrainibe , Charlotte Courageux
Chemistry - A European Journal, 2020, 26 (65), pp.15035-15044. ⟨10.1002/chem.202002012⟩
Article dans une revue hal-03127205v1
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Advancing human induced pluripotent stem cell‐derived blood‐brain barrier models for studying immune cell interactions

Hideaki Nishihara , Benjamin Gastfriend , Sasha Soldati , Sylvain Perriot , Amandine Mathias
FASEB Journal, 2020, 34 (12), pp.16693-16715. ⟨10.1096/fj.202001507RR⟩
Article dans une revue hal-03126912v1
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Study of Usutu virus neuropathogenicity in mice and human cellular models

Marion Clé , Jonathan Barthelemy , Caroline Desmetz , Vincent Foulongne , Lina Lapeyre
PLoS Neglected Tropical Diseases, 2020, 14 (4), pp.e0008223. ⟨10.1371/journal.pntd.0008223⟩
Article dans une revue hal-02886700v1
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Development of a human in vitro blood–brain tumor barrier model of diffuse intrinsic pontine glioma to better understand the chemoresistance

Clémence Deligne , Johan Hachani , Sophie Duban-Deweer , Samuel Meignan , Pierre Leblond
Fluids and Barriers of the CNS, 2020, 17, pp.37. ⟨10.1186/s12987-020-00198-0⟩
Article dans une revue hal-04461924v1
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The Effect of Sodium Bicarbonate, a Beneficial Adjuvant Molecule in Cystic Fibrosis, on Bronchial Epithelial Cells Expressing a Wild-Type or Mutant CFTR Channel

Ilona Gróf , Alexandra Bocsik , András Harazin , Ana Raquel Santa-Maria , Gaszton Vizsnyiczai
International Journal of Molecular Sciences, 2020, 21 (11), pp.4024. ⟨10.3390/ijms21114024⟩
Article dans une revue hal-03127314v1
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Human CD4+ T cell subsets differ in their abilities to cross endothelial and epithelial brain barriers in vitro

Hideaki Nishihara , Sasha Soldati , Adrien Mossu , Maria Rosito , Henriette Rudolph
Fluids and Barriers of the CNS, 2020, 17, pp.3. ⟨10.1186/s12987-019-0165-2⟩
Article dans une revue hal-02505269v1
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New Lipidyl-Cyclodextrins Obtained by Ring Opening of Methyl Oleate Epoxide Using Ball Milling

Estefania Oliva , David Mathiron , Sébastien Rigaud , Eric Monflier , Emmanuel Sevin
Biomolecules, 2020, Perspectives of Cyclodextrins, 10 (2), pp.1-18/339
Article dans une revue hal-02486048v1
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Targeting and Crossing the Blood-Brain Barrier with Extracellular Vesicles

Julien Saint-Pol , Fabien Gosselet , Sophie Duban-Deweer , Gwënaël Pottiez , Yannis Karamanos
Cells, 2020, 9 (4), pp.851. ⟨10.3390/cells9040851⟩
Article dans une revue hal-02538286v1
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Zika Virus Infection Promotes Local Inflammation, Cell Adhesion Molecule Upregulation, and Leukocyte Recruitment at the Blood-Brain Barrier

Marion Clé , Caroline Desmetz , Jonathan Barthelemy , Marie-France Martin , Orianne Constant
mBio, 2020, 11 (4), ⟨10.1128/mBio.01183-20⟩
Article dans une revue hal-02914994v1
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Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime

André-Guilhem Calas , Anne-Sophie Hanak , Nina Jaffré , Aurélie Nervo , José Dias
Biomolecules, 2020, 10 (6), pp.858. ⟨10.3390/biom10060858⟩
Article dans une revue hal-03127255v1
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PLGA protein nanocarriers with tailor-made fluorescence/MRI/PET imaging modalities

Yajie Zhang , Miguel García-Gabilondo , Alba Grayston , Irene Feiner , Irene Anton-Sales
Nanoscale, 2020, 12 (8), pp.4988-5002. ⟨10.1039/c9nr10620k⟩
Article dans une revue hal-02538272v1
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Naphthoquinone–Dopamine Hybrids Inhibit α‐Synuclein Aggregation, Disrupt Preformed Fibrils, and Attenuate Aggregate‐Induced Toxicity

Ashim Paul , Adi Huber , Daniel Rand , Fabien Gosselet , Itzik Cooper
Chemistry - A European Journal, 2020, 26 (69), pp.16486-16496. ⟨10.1002/chem.202003374⟩
Article dans une revue hal-03126960v1
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A High Output Method to Isolate Cerebral Pericytes from Mouse

Anupriya Mehra , Lucie Dehouck , Elodie Vandenhaute , Marc Fatar , Laurence Fenart
Journal of visualized experiments : JoVE, 2020, 155, ⟨10.3791/60588⟩
Article dans une revue hal-02535814v1
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GM1 Oligosaccharide Crosses the Human Blood–Brain Barrier In Vitro by a Paracellular Route

Erika Di Biase , Giulia Lunghi , Margherita Maggioni , Maria Fazzari , Diego Yuri Pomè
International Journal of Molecular Sciences, 2020, 21 (8), pp.2858. ⟨10.3390/ijms21082858⟩
Article dans une revue hal-03127393v1
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Nonionotropic Action of Endothelial NMDA Receptors on Blood–Brain Barrier Permeability via Rho/ROCK-Mediated Phosphorylation of Myosin

Anupriya Mehra , Sylvaine Guérit , Richard Macrez , Fabien Gosselet , Emmanuel Sevin
Journal of Neuroscience, 2020, 40 (8), pp.1778-1787. ⟨10.1523/JNEUROSCI.0969-19.2019⟩
Article dans une revue hal-02535778v1
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First step to the improvement of the blood brain barrier passage of atazanavir encapsulated in sustainable bioorganic vesicles

Florian Nolay , Emmanuel Sevin , Mathieu Létévé , Abed Bil , Fabien Gosselet
International Journal of Pharmaceutics, 2020, 587, pp.119604. ⟨10.1016/j.ijpharm.2020.119604⟩
Article dans une revue hal-02980826v1
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A Miniaturized Pump Out Method for Characterizing Molecule Interaction with ABC Transporters

Emmanuel Sevin , Lucie Dehouck , Romain Versele , Maxime Culot , Fabien Gosselet
International Journal of Molecular Sciences, 2019, 20, ⟨10.3390/ijms20225529⟩
Article dans une revue hal-03282234v1
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Oxysterols and the NeuroVascular Unit (NVU): A far true love with bright and dark sides

Julien Saint-Pol , Fabien Gosselet
Journal of Steroid Biochemistry and Molecular Biology, 2019, 191 (105368), ⟨10.1016/j.jsbmb.2019.04.017⟩
Article dans une revue hal-02505516v1

Purpurin modulates Tau-derived VQIVYK fibrillization and ameliorates Alzheimer’s disease-like symptoms in animal model

Guru Krishnakumar Viswanathan , Dana Shwartz , Yelena Losev , Elad Arad , Chen Shemesh
Cellular and Molecular Life Sciences, 2019, ⟨10.1007/s00018-019-03312-0⟩
Article dans une revue hal-02505419v1
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Transient blood–brain barrier disruption is induced by low pulsed electrical fields in vitro: an analysis of permeability and trans-endothelial electric resistivity

Shirley Sharabi , Yael Bresler , Orly Ravid , Chen Shemesh , Dana Atrakchi
Drug Delivery, 2019, 26 (1), pp.459-469. ⟨10.1080/10717544.2019.1571123⟩
Article dans une revue hal-02505306v1
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PECAM-1 Stabilizes Blood-Brain Barrier Integrity and Favors Paracellular T-Cell Diapedesis Across the Blood-Brain Barrier During Neuroinflammation

Britta Engelhardt , Isabella Wimmer , Silvia Tietz , Hideaki Nishihara , Urban Deutsch
Frontiers in Immunology, 2019, 10, pp.711. ⟨10.3389/fimmu.2019.00711⟩
Article dans une revue hal-02505535v1
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Petits mais costauds: Les exosomes neuronaux contrôlent l’intégrité vasculaire cérébrale

Julien Saint-Pol , Fabien Gosselet
Médecine/Sciences, 2018, 34 (4), pp.303-306. ⟨10.1051/medsci/20183404008⟩
Article dans une revue hal-02504238v1
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Mimicking brain tissue binding in an in vitro model of the blood-brain barrier illustrates differences between in vitro and in vivo methods for assessing the rate of brain penetration

Marjolein Heymans , Emmanuel Sevin , Fabien Gosselet , Stefan Lundquist , Maxime Culot
European Journal of Pharmaceutics and Biopharmaceutics, 2018, 127, pp.453-461. ⟨10.1016/j.ejpb.2018.03.007⟩
Article dans une revue hal-02506299v1
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ABCA7 Downregulation Modifies Cellular Cholesterol Homeostasis and Decreases Amyloid-β Peptide Efflux in an in vitro Model of the Blood-Brain Barrier

Yordenca Lamartinière , Marie-Christine Boucau , Lucie Dehouck , Markus Krohn , Jens Pahnke
Journal of Alzheimer's Disease, 2018, 64 (4), pp.1195-1211. ⟨10.3233/JAD-170883⟩
Article dans une revue hal-02506137v1
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Food-Derived Hemorphins Cross Intestinal and Blood–Brain Barriers In Vitro

Dorothee Domenger , Benoît Cudennec , Mostafa Kouach , Véronique Touche , Christophe Landry
Frontiers in Endocrinology, 2018, 9, pp.159. ⟨10.3389/fendo.2018.00159⟩
Article dans une revue hal-02506264v1
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Receptor-mediated PLGA nanoparticles for glioblastoma multiforme treatment

M.J. Ramalho , Emmanuel Sevin , F. Gosselet , J. Lima , M.A.N. Coelho
International Journal of Pharmaceutics, 2018, 545 (1-2), pp.84-92. ⟨10.1016/j.ijpharm.2018.04.062⟩
Article dans une revue hal-02506188v1
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A silicon nanomembrane platform for the visualization of immune cell trafficking across the human blood–brain barrier under flow

Adrien Mossu , Maria Rosito , Tejas Khire , Hung Li Chung , Hideaki Nishihara
Journal of Cerebral Blood Flow and Metabolism, 2018, 39 (3), pp.395-410. ⟨10.1177/0271678X18820584⟩
Article dans une revue hal-02505603v1
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Blood-Brain Barrier Cellular Responses Toward Organophosphates: Natural Compensatory Processes and Exogenous Interventions to Rescue Barrier Properties

Orly Ravid , Shirin Elhaik Goldman , David Macheto , Yael Bresler , Raquel Ines de Oliveira
Frontiers in Cellular Neuroscience, 2018, 12 (359), ⟨10.3389/fncel.2018.00359⟩
Article dans une revue hal-02505618v1
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HIV Neuroinfection and Alzheimer’s Disease: Similarities and Potential Links?

Geoffrey Canet , Chloé Dias , Audrey Gabelle , Yannick Simonin , Fabien Gosselet
Frontiers in Cellular Neuroscience, 2018, 12, ⟨10.3389/fncel.2018.00307⟩
Article dans une revue hal-02130334v1

Sodium Transporters Are Involved in Lithium Influx in Brain Endothelial Cells

Huilong Luo , Matthieu Gauthier , Xi Tan , Christophe Landry , Joël Poupon
Molecular Pharmaceutics, 2018, 15 (7), pp.2528-2538. ⟨10.1021/acs.molpharmaceut.8b00018⟩
Article dans une revue hal-02506165v1
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ALCAM (CD166) is involved in extravasation of monocytes rather than T cells across the blood–brain barrier

Ruth Lyck , Marc-André Lécuyer , Michael Abadier , Christof Wyss , Christoph Matti
Journal of Cerebral Blood Flow and Metabolism, 2017, 37 (8), pp.2894-2909. ⟨10.1177/0271678X16678639⟩
Article dans une revue hal-02506628v1
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Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance

Manuel Lasalle , Vanessa Hoguet , Nathalie Hennuyer , Florence Leroux , Catherine Piveteau
Journal of Medicinal Chemistry, 2017, 60 (10), pp.4185-4211. ⟨10.1021/acs.jmedchem.6b01873⟩
Article dans une revue inserm-02115415v1
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Disease-Induced Alterations in Brain Drug Transporters in Animal Models of Alzheimer’s Disease

Kati-Sisko Vellonen , Jouni Ihalainen , Marie-Christine Boucau , Fabien Gosselet , Théo Picardat
Pharmaceutical Research, 2017, 34 (12), pp.2652-2662. ⟨10.1007/s11095-017-2263-7⟩
Article dans une revue hal-02506588v1
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Modélisation in vitro de la barrière hémato-encéphalique

Fabien Gosselet
Médecine/Sciences, 2017, 33 (4), pp.423-431. ⟨10.1051/medsci/20173304013⟩
Article dans une revue hal-00543630v1
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Resveratrol and Grape Extract-loaded Solid Lipid Nanoparticles for the Treatment of Alzheimer’s Disease

Joana Loureiro , Stephanie Andrade , Ana Duarte , Ana Neves , Joana Queiroz
Molecules, 2017, 22 (2), pp.277. ⟨10.3390/molecules22020277⟩
Article dans une revue hal-02506654v1
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Adapting co-culture in vitro models of the blood–brain barrier for use in cancer research: maintaining an appropriate endothelial monolayer for the assessment of transendothelial migration

Elodie Vandenhaute , Aurore Drolez , Emmanuel Sevin , Fabien Gosselet , Caroline Mysiorek
Laboratory Investigation, 2016, 96 (5), pp.588-598. ⟨10.1038/labinvest.2016.35⟩
Article dans une revue hal-02510335v1
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Cyclodextrins as Emerging Therapeutic Tools in the Treatment of Cholesterol-Associated Vascular and Neurodegenerative Diseases

Caroline Coisne , Sébastien Tilloy , Eric Monflier , Daniel Wils , Laurence Fenart
Molecules, 2016, 21 (12), pp.1748. ⟨10.3390/molecules21121748⟩
Article dans une revue hal-01681349v1

Efficient Docosahexaenoic Acid Uptake by the Brain from a Structured Phospholipid

M. Hachem , A. Geloen , A. L. Van , B. Foumaux , L. Fenart
Molecular Neurobiology, 2016, 53 (5), pp.3205-3215. ⟨10.1007/s12035-015-9228-9⟩
Article dans une revue hal-01850313v1
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Modulation of Amyloid-β1–40 Transport by ApoA1 and ApoJ Across an in vitro Model of the Blood-Brain Barrier

Cristina Merino-Zamorano , Sofía Fernández-de Retana , Alex Montañola , Aina Batlle , Julien Saint-Pol
Journal of Alzheimer's Disease, 2016, 53 (2), pp.677-691. ⟨10.3233/JAD-150976⟩
Article dans une revue hal-02506917v1
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In vitro blood–brain barrier permeability predictions for GABAA receptor modulating piperine analogs

Daniela Elisabeth Eigenmann , Carmen Dürig , Evelyn Andrea Jähne , Martin Smieško , Maxime Culot
European Journal of Pharmaceutics and Biopharmaceutics, 2016, 103, pp.118-126. ⟨10.1016/j.ejpb.2016.03.029⟩
Article dans une revue hal-02510088v1

Pharmacokinetics and In Vitro Blood-Brain Barrier Screening of the Plant-Derived Alkaloid Tryptanthrin

Evelyn Jähne , Daniela Eigenmann , Chethan Sampath , Veronika Butterweck , Maxime Culot
Planta Medica, 2016, 82 (11/12), pp.1021-1029. ⟨10.1055/s-0042-105295⟩
Article dans une revue hal-02506889v1
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Evaluation of drug-induced neurotoxicity based on metabolomics, proteomics and electrical activity measurements in complementary CNS in vitro models

Luise Schultz , Marie-Gabrielle Zurich , Maxime Culot , Anaelle da Costa , Christophe Landry
Toxicology in Vitro, 2015, 30 (1), pp.138-165. ⟨10.1016/j.tiv.2015.05.016⟩
Article dans une revue hal-02513335v1

In vitro discrimination of the role of LRP1 at the BBB cellular level: Focus on brain capillary endothelial cells and brain pericytes

Pietra Candela , Julien Saint-Pol , Mélanie Kuntz , Marie-Christine Boucau , Yordenca Lamartinière
Brain Research, 2015, 1594, pp.15-26. ⟨10.1016/j.brainres.2014.10.047⟩
Article dans une revue hal-02513373v1
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Bexarotene Promotes Cholesterol Efflux and Restricts Apical-to-Basolateral Transport of Amyloid-β Peptides in an In Vitro Model of the Human Blood-Brain Barrier

Mélanie Kuntz , Pietra Candela , Julien Saint-Pol , Yordenca Lamartinière , Marie-Christine Boucau
Journal of Alzheimer's Disease, 2015, 48 (3), pp.849-862. ⟨10.3233/JAD-150469⟩
Article dans une revue hal-02513306v1
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ST6GALNAC5 Expression Decreases the Interactions between Breast Cancer Cells and the Human Blood-Brain Barrier.

Aurore Drolez , Elodie Vandenhaute , Clément Philippe Delannoy , Justine Hélène Dewald , Fabien Gosselet
International Journal of Molecular Sciences, 2015, 17 (8), pp.1309. ⟨10.3390/ijms17081309⟩
Article dans une revue hal-01358166v1
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Selection of a Relevant In Vitro Blood-Brain Barrier Model to Investigate Pro-Metastatic Features of Human Breast Cancer Cell Lines.

Aurore Drolez , Elodie Vandenhaute , Sylvain Julien , Fabien Gosselet , Joy Burchell
PLoS ONE, 2015, 11 (3), pp.e0151155. ⟨10.1371/journal.pone.0151155⟩
Article dans une revue hal-01286618v1
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Blood–Brain Barrier Proteomics: Towards the Understanding of Neurodegenerative Diseases

Yannis Karamanos , Fabien Gosselet , Marie-Pierre Dehouck , Roméo Cecchelli
Archives of Medical Research, 2014, 45 (8), pp.730-737. ⟨10.1016/j.arcmed.2014.11.008⟩
Article dans une revue hal-02515225v1
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Effects of oxysterols on the blood–brain barrier: Implications for Alzheimer’s disease

Fabien Gosselet , Julien Saint-Pol , Laurence Fenart
Biochemical and Biophysical Research Communications, 2014, 446 (3), pp.687-691. ⟨10.1016/j.bbrc.2013.11.059⟩
Article dans une revue hal-02515251v1

The LXR/RXR Approaches in Alzheimer’s Disease: Is the Blood-Bra in Barrier the Forgotten Partner?

Julien Saint-Pol , Pietra Candela , Laurence Fenart , Fabien Gosselet
Journal of Alzheimer’s Disease & Parkinsonism, 2013, 03 (04), ⟨10.4172/2161-0460.1000e131⟩
Article dans une revue hal-02515301v1
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Oxysterols decrease apical-to-basolateral transport of Aß peptides via an ABCB1-mediated process in an in vitro Blood-brain barrier model constituted of bovine brain capillary endothelial cells

Julien Saint-Pol , Pietra Candela , Marie-Christine Boucau , Laurence Fenart , Fabien Gosselet
Brain Research, 2013, 1517, pp.1-15. ⟨10.1016/j.brainres.2013.04.008⟩
Article dans une revue hal-02515669v1
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Truncated thioredoxin (Trx-80) promotes pro-inflammatory macrophages of the M1 phenotype and enhances atherosclerosis

Dler Faieeq Darweesh Mahmood , Amna Abderrazak , Dominique Couchie , Oleg Lunov , Vimala Diderot
Journal of Cellular Physiology, 2013, 228 (7), pp.1577-1583. ⟨10.1002/jcp.24319⟩
Article dans une revue hal-01544063v1
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Brain pericytes from stress-susceptible pigs increase blood-brain barrier permeability in vitro.

Elodie Vandenhaute , Maxime Culot , Fabien Gosselet , Lucie Dehouck , Catherine Godfraind
Fluids and Barriers of the CNS, 2012, 9 (1), pp.11. ⟨10.1186/2045-8118-9-11⟩
Article dans une revue inserm-00714318v1
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Transcriptional profiles of receptors and transporters involved in brain cholesterol homeostasis at the blood-brain barrier: Use of an in vitro model

Fabien Gosselet , Pietra Candela , Emmanuel Sevin , Vincent Berezowski , Roméo Cecchelli
Brain Research, 2009, 1249, p. 34-42
Article dans une revue hal-00543674v1
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Physiological pathway for low density lipoproteins across the blood-brain barrier: transcytosis through brain capillary endothelial cells in vitro

Pietra Candela , Fabien Gosselet , Florence Miller , Valérie Buée-Scherrer , Gérard Torpier
Endothelium, 2008, p. 254-264
Article dans une revue hal-00543686v1

Impact de la co-exposition chronique d’un pesticide et du régime obésogène en supplémentation à un prébiotique sur l’axe microbiote-intestin-cerveau chez les rats femelles et leur progéniture

Maria Abou Diwan , Narimane Djekkoun , Aurélie Corona , Marie-Christine Boucau , Lucie Dehouck
8ème Journée Amiénoise de Recherche en Santé, UPJV - CHU d'Amiens, Jan 2023, Amiens, France
Communication dans un congrès hal-04329941v1

Approche intégrée in vitro pour étudier l’impact des pesticides sur l’axe microbiote-intestin-cerveau

Maria Abou Diwan , Stéphane Delanaud , Emmanuel Sevin , Aurélie Corona , Fabien Gosselet
Colloque commun ARET-SFTG-STCM : Exposome en Toxicologie : du concept à la stratégie d’évaluation des risques, ARET, SFTG et STCM, Oct 2023, Paris, France
Communication dans un congrès hal-04330230v1

Alimentation et microbiote en liens avec pesticides et prébiotiques

Maria Abou Diwan , Narimane Djekkoun , Claire Joly Condette , Stéphane Delanaud , Emmanuel Sevin
Quels systèmes alimentaires pour concilier santé, climat et biodiversité ?, Fondation Evertea – SFSE et le CIRC, Oct 2023, Lyon, France
Communication dans un congrès hal-04330236v1

Etude de l’effet d’une co-exposition à un pesticide et aux lipides saturés sur le microbiote intestinal et les propriétés de la barrière hémato-encéphalique

Maria Abou Diwan , Narimane Djekkoun , Aurélie Corona , Marie-Christine Boucau , Lucie Dehouck
2ème Journée Diabète et Obésité des Hauts-de-France, Association Copeppi, May 2023, Amiens, France
Communication dans un congrès hal-04330204v1

Blood-brain barrier in CNS drug delivery and neurodegenerative diseases

Fabien Gosselet
Virtual 2nd Symposium on Alzheimer’s Disease: An Update on Pathology and Therapeutics,, Feb 2023, Porto, Portugal
Communication dans un congrès hal-04335489v1

L'exposition chronique péri-gestationnelle au chlorpyrifos ± au régime obésogène entraîne des perturbations du microbiote intestinal et des propriétés de la BHE chez les rats femelles et leur progéniture

Maria Abou Diwan , Narimane Djekkoun , Marie-Christine Boucau , Aurélie Corona , Lucie Dehouck
Journée annuelle de la Société Cerveau et Maladies cérébrovasculaires (SCMC), Société Cerveau et Maladies cérébrovasculaires (SCMC), Jun 2022, Paris, France
Communication dans un congrès hal-04329794v1

L’exposition des rates gestantes au pesticide Chlorpyrifos seul ou en co-exposition avec un régime obésogène module les propriétés de la barrière hémato-encéphalique chez la progéniture

Maria Abou Diwan , Lucie Dehouck , Marie-Christine Boucau , Fabien Gosselet , Véronique Bach
Exposition précoces aux facteurs environnementaux - Comprendre les impacts et agir sur les écosystèmes et la santé humaine, Société Francophone de Santé et Environnement et Fondation Evertea, Nov 2022, Valence, France
Communication dans un congrès hal-04329916v1

Neurotrophins promotes brain metastasis of triple negative breast cancer through Src kinase family activation

Julien Cicero , Sarah Trouvilliez , Martine Palma , Gaetan Ternier , Laurine Decoster
1st ONCOLille days 2022, Nov 2022, Lille, France
Communication dans un congrès hal-03853963v1

Secretome of endothelial-progenitor cells from stroke patients promotes endothelial barrier tightness and protects against hypoxia-induced vascular damage

Fabien Gosselet
Virtual Symposium "Signal Transduction at the Blood-Brain Barriers", Sep 2021, Bari, Italy
Communication dans un congrès hal-04335494v1

Modelling the blood-brain barrier to investigate amyloid transport in Alzheimer’s disease

Fabien Gosselet
Victor Babes Meeting 2020, Neuroscience Session, Nov 2020, Bucarest, Romania
Communication dans un congrès hal-04335497v1

«Nano-réacteurs à base de cyclodextrines amphiphiles pour la catalyse et la vectorisation»

E. Oliva , D. Mathiron , V. Bonnet , S. Pillard , A. Cocq
5ème Séminaire de recherche PIVERT, 2017, Bordeaux, France
Communication dans un congrès hal-01726466v1

«Nano-réacteurs à base de cyclodextrines amphiphiles pour la catalyse et la vectorisation»

E. Oliva , D. Mathiron , V. Bonnet , S. Pilard , A. Cocq
17èmes Journées Cyclodextrines, 2016, Nancy, France
Communication dans un congrès hal-01726583v1

EFFECTS OF PESTICIDES ON THE GUT-MICROBIOTA-BRAIN AXIS ASSESSED BY AN INTEGRATED HUMAN IN VITRO APPROACH

Maria Abou Diwan , Avénie Huet , Stéphane Delanaud , Emmanuel Sevin , Aurélie Corona
11th International Conference on Nutrition & Growth, Feb 2024, Lisbon (Portugal), Portugal.
Poster de conférence hal-04475612v1

Impact de la co-exposition chronique périnatale au pesticide Chlorpyrifos et à un régime obésogène sur l'axe microbiote-intestin-cerveau chez la rate gestante et la progéniture

Maria Abou Diwan , Narimane Djekkoun , Aurélie Corona , Marie-Christine Boucau , Lucie Dehouck
Les 10 ans de la Fondation Rovaltain, Jun 2023, Valence, France
Poster de conférence hal-04330257v1
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Combinaison de modèles in vivo et in vitro pour étudier la co-exposition des effets chroniques des pesticides et du régime obésogène en supplémentation d’un prébiotique (inuline) sur le microbiote intestinal et sur la barrière hémato-encéphalique chez des populations sensibles

Maria Abou Diwan , Narimane Djekkoun , Marie-Christine Boucau , Aurélie Corona , Lucie Dehouck
DOCTORIALES, Jun 2022, Belle Dune, Fort-Mahon, France
Poster de conférence hal-04330252v1
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Interaction of enterovirus A71 with the human blood-brain barrier: an in vitro study

Léa Gaume , Hélène Chabrolles , Isabelle Simon , Lucie Dehouck , Fabien Gosselet
Société d'études des interfaces Sang Cerveau - SEISC, Nov 2022, Paris, France.
Poster de conférence hal-03877075v1

Effect of chronic peri-gestational exposure to chlorpyrifos, alone or in co-exposure with an obesogenic diet on the gut microbiota and the blood-brain barrier

Pietra Candela , Maria Abou Diwan , Narimane Djekkoun , Marie-Christine Boucau , Aurélie Corona
Journée Scientifique de la Société d’Etudes des Interfaces Sang-Cerveau (SEISC), Nov 2022, Paris, France
Poster de conférence hal-04330253v1