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Researcher identifiers

Number of documents

89

CV

 

Etienne Dague, PhD-HDR, PharmD LAAS-CNRS

CNRS Research Fellow 7 avenue du Colonel Roche

ORCID ID: 0000-0003-3290-9166 31400 Toulouse, France

Born on 08/10/1978 +33 5 61 33 78 41 

Married, 2 childs, edague@laas.fr

 

 

CURRENT POSITION

-        CNRS Research Director: Systems Analysis and Architecture Laboratory, Engineering for Life Sciences team (ELIA), Toulouse, France

-        Adjunct Professor: University of Regina, Canada. Faculty of Graduate Studies and Research

 

ACADEMIC BACKGROUND

2011:          Habilitation to Lead Research, University of Toulouse, France

2006:          Doctorate in Sciences, University of Lorraine, France

2003:          State Diploma of Doctorate in Pharmacy, University of Lorraine, France

2003:          MSc: Water Chemistry and Microbiology, University of Lorraine-University of Poitiers, France

2001:          Master's degree in Biological and Medical Sciences, University of Lorraine, France

 

PREVIOUS POSITIONS

2007-2021: CNRS Researcher Systems Analysis and Architecture Laboratory, Engineering for Life          Sciences team (ELIA), Toulouse, France

2011-2016: Head of the team " Nanocardiology and Biophysics of Cancer Cells (NBC) " at ITAV-CNRS (Institut des Technologies Avancées en Sciences du Vivant), Toulouse, France

2002-2007: Army pharmacist-chemist under commitment to serve in the operational reserve, 1st medical regiment of Metz, France

2006-2007: Post-doctoral researcher, Catholic University of Louvain, Louvain-la-Neuve, Belgium

2003-2006: PhD student on the subject "Physico-chemistry of bacterial-aqueous solution interfaces", thesis under the supervision of Dr. Gaboriaud, Prof. Jorand and Prof. Block, University of Lorraine, France

2001-2002: External in pharmacy, Neufchâteau regional hospital, France

 

BIBLIOMETRY

I am the author of 69 articles, 12 journals or book chapters published in international peer-reviewed scientific journals, and 3 patents. I have an H-index of 36, my work has been cited more than 3200 times. I have been invited to 19 international conferences, presented 42 oral communications and 47 posters in 67 international scientific conferences. I have edited more than 110 papers for PlosOne as an academic editor.

 

RESEARCH FUNDING

2019-2020: MITACS global link, an exchange program between France and Canada, obtaining a scholarship for a year's thesis in France of Easter Ndlovu

2018-2021: ANR PRC GRAPHICS, 350 k€. Project entitled " Characterization of the architecture of GPCRs on the surface of living cells by Atomic Force Microscopy in single molecule force spectroscopy mode ", selected by Evaluation Committee 11 (Biochemistry, Biophysics, Molecular and Structural Biology)

2017:          AURORA exchange program between France and Norway, funded by Campus France, on the project entitled "Elucidating interaction capacities of micoorganisms using sensitive force probes".

2016-2022: Industrial contract with the company Lallemand, 201 k€. Project entitled "LallWall, Understanding the architecture of industrial yeasts by integrating biochemical, molecular and biophysical approaches".

2016 :          Åsgard exchange program between France and Norway, financed by the French Embassy in Norway.

2015-2019: ECOS-North France-Mexico cooperation program, financing of 8 missions, on the project entitled "NanoPalpation for medical diagnosis".

2015-2017: Initiatives of Excellencies IDEX Toulouse Transversality, 50 k€. Project entitled "SMiRCH: Force spectroscopy for Single Molecule ResearCH at the surface of living cells".

2014-2016: Funding of the FRM (Foundation for Medical Research), 90 k€. Project entitled "Atomic Force Microscopy on living cardiomyocytes".

2013-2016: Cofinancing of a thesis by the PRES of Toulouse and the Midi-Pyrénnées Region, 130 k€. Project entitled "MIFACARD: Atomic Force Microscopy for CARDiology".

2013-2015: Laboratory-company research operation, funded by the Midi-Pyrénnées Region, 28 k€. Project entitled "BACT'EAU: transfer mechanisms of deformable bacteria in membrane filtration processes used in water production". Project carried out in collaboration with the company Polymem.

2012-2015: ANR JCJC AFMYST, 182 k€. Project entitled "Biophysical, biochemical and biomolecular study of the yeast wall", selected by the Evaluation Committee SVSE5 (Physique-Chimie du Vivant et Innovation Biotechnologique).

2010-2013: CNRS interdisciplinary program CNRS physics-chemistry-biology interface, support for risk taking, 50 k€. Project entitled "THERMOBIOAFM: protein unfolding at controlled temperature by AFM force spectroscopy".

2010-2012: Inter-regional scientific project funded by ANR NanoInnov C'Nano Grand Sud Ouest, 20 k€. Project entitled "APTATIPS: antibody-aptamers comparison for single molecule force spectroscopy experiments".

 

AWARDS AND GRANTS

2014:          ICNano Mexico travel grant to give a plenary lecture at ICNano 2014 (International Congress on Application of Nanotechnology), Mexico City, Mexico.

2013:          George McCracken Infectious Disease Travel Fellowship from the American Society of Microbiology (ASM) to present my work at the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC).

2011:          Travel grant from JPK Instruments, obtained to give a lecture at the NanoBioView congress: Scanning probe microscopy and optical tweezers in life sciences, Berlin, Germany

2010:          Travel grant from the Centre Franco-Indien de la Promotion de la Recherche Avancée to give a lecture at the Hope in Red (Host pathogen interaction in respiratory infectious diseases) conference, Bengalore, India.

2008:          Thesis Prize of the National Academy of Pharmacy, obtained for presenting the best thesis in Pharmaceutical Sciences, Paris, France

2007:          Thesis Prize of the Academy of Sciences of Lorraine, Nancy, France

2007:          Dissertation prize from the University of Lorraine, Nancy, France

2004:          IHP (Improving the Human Potential) travel grant to attend the BIO- IMED II (Biofilms in industry, medicine and environmental biotechnology) congress, Galway, Ireland.

 

 

SCIENTIFIC EXPERTISE ACTIVITIES

2019:          Member of the editorial board of the scientific journal “The cell surface” (Elsevier)

2018:          Project evaluator for Flanders Fundation Research, Belgium

2014-2016: Evaluator of 3 projects for the Scientific Council of the Ile-de-France region, and one project for the Scientific Council of the Franche-Comté region

2012 :          PlosOne Academic Editor, edition of 110 articles

2010- :         Reviewing articles (˃100) for the following journals: Physical chemistry chemical physics, Journal of Molecular Recognition, Journal of Structural Biology, Biophysical Journal, Biomacromolecules, Biofouling, Biomaterials, JACS, Future medicine: nanomedicine, Micron, BBA biomembrane, BBA GS, PlosOne, Nanoscale, Trends in Microbiology, Soft Matter, M Sphere, Micromachines, etc...

2010-2019: Evaluator of more than 20 projects for the FNRS (National Fund for Scientific Research), Belgium

2010 :          Evaluator of a project at ANR at Evaluation Committee 10 (Nanosciences)

2009:          Evaluator of 3 projects at the ANR in the P3N program (Nanosciences, Nanotechnologies, Nanosystems Program)

 

ORGANIZATION OF SCIENTIFIC CONFERENCES

2020:          Organizer of a Symposium (Fabrication and applications of BioMEMS-NEMS, Labs-on-a-chip and Organs-on-a-chip), held during the 29th IMRC (International Material Research Conference), Cancun, Mexico CANCELLED

2020:          Member of the scientific committee of the 3rd NanoInBio (Advances for life and material sciences) congress, organized in Gosier, Guadeloupe, France; Postponed October 2020

2020:          Organizer of the plenary days of the GDR B2I (Bio Engineering of Interfaces), Toulouse, France; CANCELLED, Postpone in 2021

2019:          Organizer of the C2 Symposium (Fabrication and applications of BioMEMS-NEMS, Labs-on-a-chip and Organs-on-a-chip), held during the 28th IMRC (International Material Research Conference), Cancun, Mexico

2018:          Member of the organizing committee and the scientific committee of the 2nd NanoInBio (Advances for life and material sciences) congress, organized in Gosier, Guadeloupe, France.

2018:          Organizer and member of the scientific committee of the BioPhysAdh congress (International conference on the Biophysics of the microbial adhesion), Toulouse, France

2018:          Organizer of a dedicated session (Dimensional metrology of nanoparticles) that took place during the Nanotech France 2018 congress, Paris, France

2016-2019: Member of the scientific committee of the annual ICONAN (International Conference on Nanomedicine and Nanobiotechnology) congress

2016:          Member of the organizing committee and the scientific committee of the 1st NanoInBio (Advances for life and material sciences) congress, organized in Gosier, Guadeloupe, France.

2014:          Member of the organizing committee of the forum of Local Probe Microscopy, Montauban, France

2013:          Organizer of an INSERM workshop entitled "Cellular and molecular Nanomechanics as probed by Atomic Force Microscopy", Paris, France

2013:          Organization of a thematic day entitled "Atomic Force Microscopy: Themes and Variations", within the FERMAT Research Federation, Toulouse, France

 

MENTORING ACTIVITIES: PhD supervision

2019-2022: Co-supervision of a thesis funded by ANR, carried out by Irem Demir, on the subject: Nano-investigation of bubble-microorganisms interactions.

2019-2022: Co-supervision of a thesis in international cooperation with Canada, Univeristy of Regina, carried out by Easter Ndvolu on the topic “C. albicans interactions with cnacerous cells”.

2017-2020: Co-direction of a ministerial thesis (MEGEP doctoral school), directed by Ibrahima Dramé, on the subject "Role of pills in the adhesion of Lacotococcus lactis".

2017-2020: Supervision of a 6-month stay of a thesis student in Portugal, Mafalda Cavalheiro, on the topic "From nanoscale to genome-wide uncovering of the master regulators of C. glabrata surface adhesion and biofilm formation".

2016-2020: Co-direction of a thesis in international co-supervision with Mexico, financed by CONACYT Mexico, carried out by Sergio Proa, on the subject "Automation of measurements by Atomic Force Microscopy".

2013-2016: Direction of a PRES Toulouse - Région Midi-Pyrénnées thesis, carried out by Véronique Lachaize, on the subject "Nanotechnologies for the study of nanomechanical properties and the micro-organisation of interfaces of living cardiomyocytes".

2012-2015: Supervision of a thesis student on the BACT'EAU project, Arthur Gaveau, on the subject "Study of the transfer mechanisms of deformable bacteria in frontal microfiltration".

2012-2014: Direction of a thesis co-funded by ANR and the French Defence Procurement Agency (DGA), carried out by Cécile Formosa, on the subject "Understanding the action targets of new antibacterial molecules using bionanotechnologies".

2011-2014: Co-direction of a CIFRE thesis with the Lallemand company, carried out by Marion Schiavone on the subject "Characterization of the molecular architecture and biophysical properties of yeast walls".

2010-2013: Co-director of a DGA thesis, directed by Louise Chopinet, on the subject "Study of the mechanism of electrotransfer of molecules in cells and tissues by advanced microscopy techniques".

2009-2012: Co-director of a PRES thesis in Toulouse, directed by Eric Jauvert, on the subject "Nanotechnologies for biology, application to bacterial-bacteriophage interactions".

2008-2011: Co-direction of an INRA thesis, directed by Doan Thanh Lam Le, on the subject "Identification of the physico-chemical and biological determinants involved in the adhesion of Lactococcus lactis to the intestinal mucosa".

 

MENTORING ACTIVITIES: Post-doctoral researchers

2017-2018: Postdoc ANR GRAPHICS, Rosie Dawaliby, on the subject "Characterization of GPCR architecture on the surface of living cells by Atomic Force Microscopy".

2015-201 :   Postdoc financed by the Lallemand company, directed by Marion Schiavone, on the subject "LallWall, Understanding the architecture of industrial yeasts by integrating biochemical, molecular and biophysical approaches".

2014-2016: Postdoc Fondation Recherche Médicale, by Georges Smolyakov, on the subject "Multiparametric AFM of living cardiomyocytes".

2014-2018: Multi-support post-doc, by Flavien Pillet, on the subject of "Eradication of bacteria by electroporation".

2013:          ANR AFMYST post-doc, by Flavien Pillet, on the subject "Biophysical, biochemical and biomolecular study of the yeast wall".

2012:          Post-doc ANR AFMYST, by Sébastien Gauthier, on the subject "Biophysical, biochemical and biomolecular study of the yeast wall".

 

SCIENTIFIC COLLABORATIONS

International collaborations

-    Dr. Adrian Martinez-Rivas, Instituto Polytechnico Nacional, Mexico (2015-pending) / 1 patent, 2 publications, 1 PhD thesis cosupervised and defended (february 2020)

-    Prof. Marit Sletmoen, Norwegian University of Sciences and Technology (NTNU), Norway (2015-ongoing) / 1 publication, exchange of masters and doctoral students

-    Dr. Martina Baum, Univeristy of Kiel, Germany (2018-ongoing) / 1 publication submitted, exchange of a master student

-    Prof. Tanya Dahms, University of Regina, Canada (2018-in-progress) / 1 book chapter, 1 publication submitted, thesis exchange student, Sabbatical hosting.

-    Prof. Miguel Texeira, University of Lisboa, Portugal (2018-ongoing) / 1 publication submitted, exchange of a thesis student

-    Prof. Alistair Brown and Prof. Carol Munro, University of Aberdeen, UK (2014-2018) / 3 publications

-    Prof. Nadica Ivosevic DeNardis, Ruder Boskovic Institute, Zagreb, Croatia (2018-ongoing) / 1 publication

-    Prof. Marcos De Morais Jr, Universidad Federal de Pernambuco, Brazil (2016-ongoing) / 1 publication

 

 

National collaborations

-    Prof. Juan Pelta and Prof. Sid Labdi, LAMBE, University of Evry, France (2014-2016) / 1 publication

-    Prof. Jean-Paul Latgé, Institut Pasteur, Paris (2006-2013) / 4 publications

-    Dr. M. Lavie-Richard, Institut Micalis, INRA Jouy-en-Josas (2012-2015) / 1 publication

-    Prof. Raphaël Duval, SRSMC, University of Lorraine, France (2011-2015) / 11 publications

-    Prof. Christophe D'Enfert, Pasteur Institute, Paris (2014-2018) / 3 publications

-    Dr. Mickaël Desvaux, University of Clermont-Auvergne (2018-2019) / 1 publication

 

Local collaborations (outside the laboratory)

-    Pr. Clémence Coetsier, LGC, University of Toulouse (2019-ongoing)

-    Dr. Emmanuel Flahaut, CIRIMAT, University of Toulouse (2019-ongoing)

-    Prof. Eric Oswald, CHU of Toulouse (2017-in progress)

-    Prof. Marie-Pierre Rols, IPBS, University of Toulouse (2011-ongoing) / 8 publications

-    Prof. Laurence Ressier, LPCNO, INSA of Toulouse, France (2009-2012) / 5 publications

-    Prof. Jean-Marie François and Dr. Hélène Martin-Yken, TBI, INSA de Toulouse, France (2008-ongoing) / 10 publications

-    Prof. Christel Causserand, LGC, University of Toulouse (2012-2015) / 1 publication

-    Dr. Muriel Mercier-Bonin, Toxalim, University of Toulouse (2008-2011) / 4 publications

-    Dr. Céline Galès and Dr. Constandina Arvanitis, I2MC, University of Toulouse (2011-ongoing) / 5 publications

-    Dr. Mickaël Castelain, TBI, INSA of Toulouse, France (2015-ongoing) / 2 publications

-    Dr. Mathieu Castex, Société Lallemand, Toulouse (2011-ongoing) / 3 publications

 

 

Fait à Toulouse le 5 juin 2020

 

 

Journal articles67 documents

  • Karen Dunker, Sol de la Torre Canny, Catherine Nordgård, Etienne Dague, Cécile Formosa-Dague, et al.. Elucidating bacterial adhesion to mucosal surface by an original AFM approach. BMC Microbiology, BioMed Central, 2021, 21 (1), ⟨10.1186/s12866-021-02303-1⟩. ⟨hal-03347159⟩
  • Irem Demir, Ines Lüchtefeld, Claude Lemen, Etienne Dague, Pascal Guiraud, et al.. Probing the interactions between air bubbles and (bio)interfaces at the nanoscale using FluidFM technology. Journal of Colloid and Interface Science, Elsevier, 2021, 604, pp.785-797. ⟨10.1016/j.jcis.2021.07.036⟩. ⟨hal-03423284⟩
  • Childérick Séverac, Sergio Proa-Coronado, Adrian Martinez-Rivas, Cécile Formosa-Dague, Etienne Dague. Automation of Bio-Atomic Force Microscope Measurements on Hundreds of C. albicans Cells. Journal of visualized experiments : JoVE, JoVE, 2021, 170, ⟨10.3791/61315⟩. ⟨hal-03025337⟩
  • Mafalda Cavalheiro, Diana Pereira, Cécile Formosa-Dague, Carolina Leitão, Pedro Pais, et al.. From the first touch to biofilm establishment by the human pathogen Candida glabrata: a genome-wide to nanoscale view. Communications Biology, Nature Publishing Group, 2021, 4 (1), ⟨10.1038/s42003-021-02412-7⟩. ⟨hal-03328637⟩
  • Sophie Klemm, Martina Baum, Haoyi Qiu, Zibin Nan, Mafalda Cavalheiro, et al.. Development of Polythiourethane/ZnO-Based Anti-Fouling Materials and Evaluation of the Adhesion of Staphylococcus aureus and Candida glabrata Using Single-Cell Force Spectroscopy. Nanomaterials, MDPI, 2021, 11 (2), pp.271. ⟨10.3390/nano11020271⟩. ⟨hal-03136104⟩
  • Ibrahima Drame, Christine Lafforgue, Cécile Formosa-Dague, Marie-Pierre Chapot-Chartier, Jean-Christophe Piard, et al.. Pili and other surface proteins influence the structure and the nanomechanical properties of Lactococcus lactis biofilms. Scientific Reports, Nature Publishing Group, 2021, 11 (1), ⟨10.1038/s41598-021-84030-1⟩. ⟨hal-03163203⟩
  • Clara Bouyx, Marion Schiavone, Marie-Ange Teste, Etienne Dague, Nathalie Sieczkowski, et al.. The dual role of amyloid-β-sheet sequences in the cell surface properties of FLO11-encoded flocculins in Saccharomyces cerevisiae. eLife, eLife Sciences Publication, 2021, 10, pp.e68592. ⟨10.7554/eLife.68592⟩. ⟨hal-03434693⟩
  • Juan Carlos Camacho-Fernández, Génesis Karendash González Quijano, Childerick Severac, Etienne Dague, Véronique Gigoux, et al.. Nanobiomechanical behavior of Fe3O4@SiO2 and Fe3O4@SiO2-NH2 nanoparticles over HeLa cells interfaces. Nanotechnology, Institute of Physics, In press, ⟨10.1088/1361-6528/ac0a13⟩. ⟨hal-03260468⟩
  • S. Proa-Coronado, Childérick Séverac, A. Martinez-Rivas, Etienne Dague. Beyond the paradigm of nanomechanical measurements on cells using AFM: an automated methodology to rapidly analyse thousands of cells. Nanoscale Horizons, Royal Society of Chemistry, 2020, 5 (1), pp.131-138. ⟨10.1039/C9NH00438F⟩. ⟨hal-03025101⟩
  • Irem Demir, Jonas Blockx, Etienne Dague, Pascal Guiraud, Wim Thielemans, et al.. Nanoscale Evidence Unravels Microalgae Flocculation Mechanism Induced by Chitosan. ACS Applied Bio Materials, ACS Publications, 2020, 3 (12), pp.8446-8459. ⟨10.1021/acsabm.0c00772⟩. ⟨hal-03025212⟩
  • Ibrahima Dramé, Cécile Formosa-Dague, Marie-Pierre Chapot-Chartier, Jean-Christophe Piard, Mickaël Castelain, et al.. Analysis of Homotypic Interactions of Lactococcus lactis Pili Using Single-Cell Force Spectroscopy. ACS Applied Materials & Interfaces, Washington, D.C. : American Chemical Society, 2020, 12 (19), pp.21411-21423. ⟨10.1021/acsami.0c03069⟩. ⟨hal-02860018⟩
  • Flavien Pillet, Etienne Dague, Jadranka Pečar Ilić, Ivica Ružić, Marie-Pierre Rols, et al.. Changes in nanomechanical properties and adhesion dynamics of algal cells during their growth. Bioelectrochemistry, Elsevier, 2019, 127, pp.154-162. ⟨10.1016/j.bioelechem.2019.02.011⟩. ⟨hal-02321318⟩
  • Marion Schiavone, Nathalie Sieczkowski, Mathieu Castex, Emmanuelle Trévisiol, Etienne Dague, et al.. AFM dendritips functionalized with molecular probes specific to cell wall polysaccharides as a tool to investigate cell surface structure and organization. The Cell Surface, Elsevier, 2019, 5, pp.100027. ⟨10.1016/j.tcsw.2019.100027⟩. ⟨hal-02295500⟩
  • Valentin Ageorges, Marion Schiavone, Grégory Jubelin, Nelly Caccia, Philippe Ruiz, et al.. Differential homotypic and heterotypic interactions of antigen 43 (Ag43) variants in autotransporter-mediated bacterial autoaggregation. Scientific Reports, Nature Publishing Group, 2019, 9 (1), pp.11100. ⟨10.1038/s41598-019-47608-4⟩. ⟨hal-02335796⟩
  • Celine Guilbeau-Frugier, Marie Cauquil, Clement Karsenty, Camille Dambrin, Bruno Payre, et al.. Structural evidence for a new elaborate 3D-organization of the cardiomyocyte lateral membrane in adult mammalian cardiac tissues. Cardiovascular Research, Oxford University Press (OUP), 2019, 115 (6), pp.1078-1091. ⟨10.1093/cvr/cvy256⟩. ⟨hal-02321816⟩
  • Georgiy Smolyakov, Etienne Dague, Clément Roux, M. H Seguelas, C. Galés, et al.. Nanoscale structural mapping as a measure of maturation in the murine frontal cortex. Brain Structure and Function, Springer Verlag, 2018, 223 (1), pp.255-265. ⟨10.1007/s00429-017-1486-z⟩. ⟨hal-01907682⟩
  • Camille Lamarche, Charlotte da Silva, Gauthier Demol, Etienne Dague, Marie-Pierre Rols, et al.. Electrical discharges in water induce spores' DNA damage. PLoS ONE, Public Library of Science, 2018, ⟨10.1371/journal.pone.0201448⟩. ⟨hal-01907680⟩
  • Hélène Martin-Yken, Tina Bedekovic, Alexandra Brand, Mathias Richard, Sadri Znaidi, et al.. A conserved fungal hub protein involved in adhesion and drug resistance in the human pathogen Candida albicans. The Cell Surface, Elsevier, 2018, 4, pp.10-19. ⟨10.1016/j.tcsw.2018.10.002⟩. ⟨hal-02091662⟩
  • Cécile Formosa-Dague, Mickaël Castelain, Hélène Martin-Yken, Karen Dunker, Etienne Dague, et al.. The Role of Glycans in Bacterial Adhesion to Mucosal Surfaces: How Can Single-Molecule Techniques Advance Our Understanding?. Microorganisms, MDPI, 2018, 6 (2), 26 p. ⟨10.3390/microorganisms6020039⟩. ⟨hal-01907666⟩
  • Cécile Formosa-Dague, Raphael Duval, Etienne Dague. Cell biology of microbes and pharmacology of antimicrobial drugs explored by Atomic Force Microscopy. Seminars in Cell and Developmental Biology, Elsevier, 2018, 73, pp.165 - 176. ⟨10.1016/j.semcdb.2017.06.022⟩. ⟨hal-01907671⟩
  • Georges Smolyakov, Marie Cauquil, Childérick Séverac, Véronique Lachaize, Céline Guilbeau-Frugier, et al.. Biophysical properties of cardiomyocyte surface explored by multiparametric AFM. Journal of Structural Biology, Elsevier, 2017, 198 (1), pp.28-37. ⟨10.1016/j.jsb.2017.03.001⟩. ⟨hal-01907685⟩
  • Flavien Pillet, Laure Gibot, Moinecha Madi, Marie-Pierre Rols, Etienne Dague. Importance of endogenous extracellular matrix in biomechanical properties of human skin model. Biofabrication, IOP Publishing, 2017, 9 (2), pp.025017. ⟨10.1088/1758-5090/aa6ed5⟩. ⟨hal-01698349⟩
  • Arthur Gaveau, Clémence Coetsier, Christine Roques, Patrice Bacchin, Etienne Dague, et al.. Bacteria transfer by deformation through microfiltration membrane. Journal of Membrane Science, Elsevier, 2017, 523, pp.446-455. ⟨10.1016/j.memsci.2016.10.023⟩. ⟨hal-01451400⟩
  • Marion Schiavone, Sébastien Dejean, Nathalie Sieczkowski, Mathieu Castex, Etienne Dague, et al.. Integration of Biochemical, Biophysical and Transcriptomics Data for Investigating the Structural and Nanomechanical Properties of the Yeast Cell Wall. Frontiers in Microbiology, Frontiers Media, 2017, 8, pp.1806 ⟨10.3389/fmicb.2017.01806⟩. ⟨hal-01698344⟩
  • Adrian Martinez-Rivas, Génesis González-Quijano, Sergio Proa-Coronado, Childérick Séverac, Etienne Dague. Methods of Micropatterning and Manipulation of Cells for Biomedical Applications. Micromachines, MDPI, 2017, 8 (12), pp.347. ⟨10.3390/mi8120347⟩. ⟨hal-01907683⟩
  • Georges Smolyakov, Bénédicte Thiebot, Clément Campillo, Sid Labdi, Childérick Séverac, et al.. Elasticity, Adhesion, and Tether Extrusion on Breast Cancer Cells Provide a Signature of Their Invasive Potential. ACS Applied Materials & Interfaces, Washington, D.C. : American Chemical Society, 2016, 8 (41), pp.27426 - 27431. ⟨10.1021/acsami.6b07698⟩. ⟨hal-01552762⟩
  • Flavien Pillet, Cécile Formosa-Dague, Houda Baaziz, Etienne Dague, Marie-Pierre Rols. Cell wall as a target for bacteria inactivation by pulsed electric fields. Scientific Reports, Nature Publishing Group, 2016, 6, pp.19778. ⟨10.1038/srep19778⟩. ⟨hal-01552815⟩
  • Marion Schiavone, Cécile Formosa-Dague, Carolina Elsztein, Marie-Ange Teste, Helene Martin-Yken, et al.. Evidence for a Role for the Plasma Membrane in the Nanomechanical Properties of the Cell Wall as Revealed by an Atomic Force Microscopy Study of the Response of Saccharomyces cerevisiae to Ethanol Stress. Applied and Environmental Microbiology, American Society for Microbiology, 2016, 82 (15), pp.4789 - 4801. ⟨10.1128/AEM.01213-16⟩. ⟨hal-01552795⟩
  • Georges Smolyakov, Cécile Formosa-Dague, Childérick Séverac, Raphael Duval, Etienne Dague. High speed indentation measures by FV, QI and QNM introduce a new understanding of bionanomechanical experiments. Micron, Elsevier, 2016, 85, pp.8-14. ⟨10.1016/j.micron.2016.03.002⟩. ⟨hal-01552823⟩
  • Iuliana V. Ene, Louise Brown, Marion Schiavone, Keunsook Lee, Hélène Martin-Yken, et al.. Cell Wall Remodeling Enzymes Modulate Fungal Cell Wall Elasticity and Osmotic Stress Resistance. mBio, American Society for Microbiology, 2015, 6 (4), pp.e00986-15. ⟨10.1128/mBio.00986-15⟩. ⟨hal-01269162v2⟩
  • Marion Schiavone, Nathalie Sieczkowski, Mathieu Castex, Etienne Dague, Jean Marie François. Effects of the strain background and autolysis process on the composition and biophysical properties of the cell wall from two different industrial yeasts. FEMS Yeast Research, Oxford University Press (OUP), 2015, 15 (2), pp.12. ⟨10.1093/femsyr/fou012⟩. ⟨hal-01553141⟩
  • Ran Liu, Cécile Formosa-Dague, Adilia Dagkessamanskaia, Etienne Dague, Jean Marie François, et al.. Combining atomic force microscopy and genetics to investigate the role of KNR4 in Saccharomyces Cerevisiae sensitivity to K9 killer toxin. Letters in Applied NanoBioScience, 2015, 4 (4), pp.306-315. ⟨hal-01553082⟩
  • Cécile Formosa-Dague, Marion Schiavone, Anita Boisrame, Mathias Richard, Raphael Duval, et al.. Multiparametric imaging of adhesive nanodomains at the surface of Candida albicans by atomic force microscopy. Nanomedicine: Nanotechnology, Biology and Medicine, Elsevier, 2015, 11 (1), pp.57-65. ⟨10.1016/j.nano.2014.07.008⟩. ⟨hal-01553144⟩
  • Cécile Formosa-Dague, Véronique Lachaize, C Galés, M P Rols, Hélène Martin-Yken, et al.. Mapping HA-tagged protein at the surface of living cells by atomic force microscopy. Journal of Molecular Recognition, Wiley, 2015, 28 (1), pp.1-9. ⟨10.1002/jmr.2407⟩. ⟨hal-01169622⟩
  • Cécile Formosa-Dague, Flavien Pillet, Marion Schiavone, Raphaël E. Duval, Laurence Ressier, et al.. Generation of living cell arrays for atomic force microscopy studies. Nature Protocols, Nature Publishing Group, 2015, 10 (1), pp.199-204. ⟨10.1038/nprot.2015.004⟩. ⟨hal-01495201⟩
  • Helene Yken, Ran Liu, Cécile Formosa-Dague, Marion Schiavone, Etienne Dague, et al.. Combining Atomic Force Microscopy and genetics to investigate the role of Knr4 in Saccharomyces cerevisiae sensitivity to K9 Killer toxin. Letters in Applied NanoBioScience, 2015, 4 (4), pp.306-315. ⟨hal-01269076⟩
  • Cécile Formosa-Dague, M. Herold, C Vidaillac, R. E. Duval, Etienne Dague. Unravelling of a mechanism of resistance to colistin in Klebsiella pneumoniae using atomic force microscopy. Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2015, 70 (8), pp.2261-2270. ⟨10.1093/jac/dkv118⟩. ⟨hal-01553126⟩
  • Véronique Lachaize, Cécile Formosa-Dague, Georgiy Smolyakov, Celine Guilbeau-Frugier, Céline Galés, et al.. Atomic Force Microscopy: an innovative technology to explore cardiomyocyte cell surface in cardiac physio/pathophysiology. Letters in Applied NanoBioScience, 2015, 4 (4), pp.321-324. ⟨hal-01552834⟩
  • Eric Jauvert, Etienne Palleau, Etienne Dague, Laurence Ressier. Directed assembly of living Pseudomonas aeruginosa on PEI patterns fabricated by nanoxerography for statistical AFM bio-experiments. ACS Applied Materials & Interfaces, Washington, D.C. : American Chemical Society, 2014, 6 (23), pp.21230-21236. ⟨10.1021/am506241n⟩. ⟨hal-02049093⟩
  • Vitor Cabral, Sadri Znaidi, Louise A. Walker, Hélène Martin-Yken, Etienne Dague, et al.. Targeted changes of the cell wall proteome influence [i]Candida albican[/i]s ability to form single- and multi-strain biofilms. PLoS Pathogens, Public Library of Science, 2014, 10 (12), pp.e1004542. ⟨10.1371/journal.ppat.1004542⟩. ⟨hal-01204415⟩
  • Stéphanie da Silva, Catherine Robbe-Masselot, Afifa Ait-Belgnaoui, Alessandro Mancuso, Myriam Mercade-Loubière, et al.. Stress disrupts intestinal mucus barrier in rats via mucin O-glycosylation shift: prevention by a probiotic treatment. AJP - Gastrointestinal and Liver Physiology, American Physiological Society, 2014, 307 (4), pp.G420 - G429. ⟨10.1152/ajpgi.00290.2013⟩. ⟨hal-02636997⟩
  • Etienne Dague, Gaël Genet, Véronique Lachaize, Céline Guilbeau-Frugier, J. Fauconnier, et al.. Atomic force and electron microscopic-based study of sarcolemmal surface of living cardiomyocytes unveils unexpected mitochondrial shift in heart failure.. Journal of Molecular and Cellular Cardiology, Elsevier, 2014, 74C, pp.162-172. ⟨10.1016/j.yjmcc.2014.05.006⟩. ⟨inserm-01016102⟩
  • Marion Schiavone, Amélie Vax, Cécile Formosa, Hélène Martin-Yken, Etienne Dague, et al.. A combined chemical and enzymatic method to determine quantitatively the polysaccharide components in the cell wall of yeasts. FEMS Yeast Research, Oxford University Press (OUP), 2014, 14 (6), pp.933 - 947. ⟨10.1111/1567-1364.12182⟩. ⟨hal-02638140⟩
  • Flavien Pillet, Stéphane Lemonier, Marion Schiavone, Cécile Formosa, Hélène Martin-Yken, et al.. Uncovering by Atomic Force Microscopy of an original circular structure at the yeast cell surface in response to heat shock. BMC Biology, BioMed Central, 2014, 12 (6), 20p. ⟨10.1186/1741-7007-12-6⟩. ⟨hal-02639992⟩
  • Doan Le, Thi-Ly Tran, Marie-Pierre Duviau, Mickael Meyrand, Yann Guerardel, et al.. Unraveling the role of surface mucus-binding protein and pili in muco-adhesion of lactococcus lactis. PLoS ONE, Public Library of Science, 2013, 8 (11), ⟨10.1371/journal.pone.0079850⟩. ⟨hal-01204286⟩
  • Louise Chopinet-Mayeux, C. Formosa, M. P. Rols, R. E. Duval, Etienne Dague. Imaging living cells surface and quantifying its properties at high resolution using AFM in QI (TM) mode. Micron, Elsevier, 2013, 48, pp.26-33. ⟨10.1016/j.micron.2013.02.003⟩. ⟨hal-01493934⟩
  • Jean Marie François, Cécile Formosa-Dague, Marion Schiavone, Flavien Pillet, Helene Yken, et al.. Use of atomic force microscopy (AFM) to explore cell wall properties and response to stress in the yeast Saccharomyces cerevisiae. Current Genetics, Springer Verlag, 2013, 59 (4), pp.187 - 196. ⟨10.1007/s00294-013-0411-0⟩. ⟨hal-01268470⟩
  • Anne Beauvais, Silvia Bozza, Olaf Kniemeyer, Cécile Formosa-Dague, Viviane Balloy, et al.. Deletion of the α-(1,3)-glucan synthase genes induces a restructuring of the conidial cell wall responsible for the avirulence of Aspergillus fumigatus.. PLoS Pathogens, Public Library of Science, 2013, 9 (11), pp.e1003716. ⟨10.1371/journal.ppat.1003716⟩. ⟨pasteur-01450713⟩
  • Cécile Formosa-Dague, Marion Schiavone, Hélène Martin-Yken, J.M. François, Raphael Duval, et al.. Nanoscale Effects of Caspofungin against Two Yeast Species, Saccharomyces cerevisiae and Candida albicans. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2013, 57 (8), pp.3498 - 3506. ⟨10.1128/AAC.00105-13⟩. ⟨hal-01268080⟩
  • - Doan Thanh Lam Le, Sandrine Zanna, Isabelle Frateur, Philippe Marcus, Pascal Loubière, et al.. Real-time investigation of the muco-adhesive properties of Lactococcus lactis using a quartz crystal microbalance with dissipation monitoring. Biofouling, Taylor & Francis, 2012, 28 (5), pp.479 - 490. ⟨10.1080/08927014.2012.688103⟩. ⟨hal-02648937⟩
  • Gaël Genet, Céline Guilbeau-Frugier, Benjamin Honton, Etienne Dague, Michael Schneider, et al.. Ephrin-B1 is a novel specific component of the lateral membrane of the cardiomyocyte and is essential for the stability of cardiac tissue architecture cohesion.. Circulation Research, American Heart Association, 2012, 110 (5), pp.688-700. ⟨10.1161/CIRCRESAHA.111.262451⟩. ⟨inserm-00755171⟩
  • C. Formosa, M. Grare, E. Jauvert, A. Coutable, J. B. Regnouf-De-Vains, et al.. Nanoscale analysis of the effects of antibiotics and CX1 on a Pseudomonas aeruginosa multidrug-resistant strain. Scientific Reports, Nature Publishing Group, 2012, 2 (1), ⟨10.1038/srep00575⟩. ⟨hal-01650390⟩
  • Cécile Formosa-Dague, Marion Grare, Raphaël E. Duval, Etienne Dague. Nanoscale effects of antibiotics on P. aeruginosa. Nanomedicine: Nanotechnology, Biology and Medicine, Elsevier, 2012, 8 (1), pp.12 - 16. ⟨10.1016/j.nano.2011.09.009⟩. ⟨hal-01650395⟩
  • Eric Jauvert, Etienne Dague, Marjorie Severac, Laurence Ressier, Anne-Marie Caminade, et al.. Probing single molecule interactions by AFM using bio-functionalized dendritips. Sensors and Actuators B: Chemical, Elsevier, 2012, 168, pp.436 - 441. ⟨10.1016/j.snb.2012.04.048⟩. ⟨hal-01268327⟩
  • Yann Guerardel, Pascal Loubière, Muriel Mercier-Bonin, Etienne Dague. Measuring kinetic dissociation/association constants between lactococcus lactis bacteria and mucins using living cell probes. Biophysical Journal, Biophysical Society, 2011, 101 (11), pp.2843 - 2853. ⟨10.1016/j.bpj.2011.10.034⟩. ⟨hal-02644455⟩
  • Etienne Dague, Eric Jauvert, Loïc Laplatine, B. Viallet, Christophe Thibault, et al.. Assembly of live micro-organisms on microstructured PDMS stamps by convective/capillary deposition for AFM bio-experiments. Nanotechnology, Institute of Physics, 2011, 22 (39), pp.395102. ⟨10.1088/0957-4484/22/39/395102⟩. ⟨hal-01767584⟩
  • Etienne Dague, Rajaa Bitar, Hubert Ranchon, Fabien Durand, Hélène Martin-Yken, et al.. An atomic force microscopy analysis of yeast mutants defective in cell wall architecture. Yeast, Wiley, 2010, 27 (8), pp.673-684. ⟨10.1002/yea.1801⟩. ⟨hal-02937501⟩
  • Hélène Lalo, Cédric Ayela, Etienne Dague, Christophe Vieu, Karsten Haupt. Nanopatterning molecularly imprinted polymers by soft lithography: a hierarchical approach. Lab on a Chip, Royal Society of Chemistry, 2010, issue 10, pp. 1316 - 1318,. ⟨10.1039/b924315a⟩. ⟨hal-00493035⟩
  • Aline Cerf, Jean Christophe Cau, Christophe Vieu, Etienne Dague. Nanomechanical Properties of Dead or Alive Single-Patterned Bacteria. Langmuir, American Chemical Society, 2009, 25 (10), pp.5731-5736. ⟨10.1021/la9004642⟩. ⟨hal-02061192⟩
  • Christophe Thibault, Franck Carcenac, Etienne Dague, Jerôme Chalmeau, Christophe Vieu. Porous silicon membrane, with an integrated aqueous supply, for two chamber AFM. Microelectronic Engineering, Elsevier, 2009, 86 (4-6), pp.1393 - 1395. ⟨10.1016/j.mee.2008.11.068⟩. ⟨hal-01767624⟩
  • Josiane-Aurore Tatchou-Nyamsi-König, Etienne Dague, Martine Mullet, Jérôme F.L. Duval, Fabien Gaboriaud, et al.. Adhesion of Campylobacter jejuni and Mycobacterium avium onto polyethylene terephtalate (PET) used for bottled waters. Water Research, IWA Publishing, 2008, 42 (19), pp.4751-4760. ⟨10.1016/j.watres.2008.09.009⟩. ⟨hal-02059714⟩
  • M. Grare, Etienne Dague, M. Mourer, J.-B. Regnouf-De-Vains, C. Finance, et al.. Microelectrophoresis and atomic force microscopy: new tools to explore mechanism of action of antibacterial compounds. Pathologie Biologie, Elsevier Masson, 2007, 55 (10), pp.465 - 471. ⟨10.1016/j.patbio.2007.08.001⟩. ⟨hal-01651226⟩
  • Robert Karreman, Etienne Dague, Fabien Gaboriaud, Fabienne Quilès, Jérôme F.L. Duval, et al.. The stress response protein Hsp12p increases the flexibility of the yeast Saccharomyces cerevisiae cell wall. Biochimica et Biophysica Acta Proteins and Proteomics, Elsevier, 2007, 1774 (1), pp.131 - 137. ⟨10.1016/j.bbapap.2006.10.009⟩. ⟨hal-01848650⟩
  • David Alsteens, Etienne Dague, Claire Verbelen, Guillaume Andre, Gregory Francius, et al.. Nanomicrobiology. Nanoscale Research Letters, SpringerOpen, 2007, 2 (8), pp.365-372. ⟨10.1007/s11671-007-9077-1⟩. ⟨hal-02086905⟩
  • Fabien Gaboriaud, Sidney Bailet, Etienne Dague, Frédéric Jorand. Probing the modifications of polystyrene surface properties after incubation with theShewanella putrefaciens bacteria at two pH values (4, 10) by atomic force microscopy. Surface and Interface Analysis, Wiley-Blackwell, 2007, 39 (7), pp.648 - 652. ⟨10.1002/sia.2570⟩. ⟨hal-01848863⟩
  • Etienne Dague, Fabien Gaboriaud, Jérôme Duval, Frédéric Jorand, Fabien Thomas. Probing surface structures of Shewanella spp. by microelectrophoresis. Biophysical Journal, Biophysical Society, 2006, 90, pp.2612. ⟨10.1529/biophysj.105.068205⟩. ⟨hal-00090765⟩
  • Fabien Gaboriaud, Etienne Dague, Sidney Bailet, Frédéric Jorand, Jérôme Duval, et al.. Multiscale dynamics of the cell envelope of Shewanella putrefaciens as a response to pH change. Colloids and Surfaces, Elsevier, 2006, 52 (2), pp.108 - 116. ⟨10.1016/j.colsurfb.2006.04.017⟩. ⟨hal-00112240⟩

Conference papers14 documents

  • Etienne Dague. Biomedical Applications of Atomic Force Microscopy. MSC-SMC-2021, microscopical society of Canada, Jun 2021, Hamilton (online), Canada. ⟨hal-03260476⟩
  • Irem Demir, Ines Lüchtefeld, Claude Lemen, Etienne Dague, Pascal Guiraud, et al.. Probing the interactions between air bubbles and (bio)-interfaces at the molecular scale using FluidFM technology. Colloque de la Société française des Microscopies (Sfµ), Jul 2021, Reims (Virtuel), France. ⟨hal-03430090⟩
  • Irem Demir-Yilmaz, Jonas Blockx, Etienne Dague, Pascal Guiraud, Koenraad Muylaert, et al.. Understanding chitosan-induced flocculation mechanism in C. vulgaris using atomic force microscopy (AFM). International confenrence on Biomass, Bioproducts and Biofuels (AlgalBBB 2021), Jun 2021, Virtuel, United Kingdom. ⟨hal-03430080⟩
  • Irem Demir, Ines Lüchtefeld, Claude Lemen, Pascal Guiraud, Etienne Dague, et al.. Fluidic force microscopy to access the interactions between gaz/liquid and biological interfaces. Microbe-on-chip, Oct 2020, Toulouse (on line), France. ⟨hal-03428273⟩
  • Hélène Martin-Yken, M Chinain, Emmanuelle Trévisiol, Etienne Dague. New biosensors to detect ciguatoxins and characterization of their binding on mammalian neuronal cell by single molecule force spectroscopy Supprimé: strategies in the detection. Mycotoxins-Phytotoxins Gordon Research Conference, Jun 2019, Boston, United States. ⟨hal-02322858⟩
  • Tanya E S Dahms, André Körning, Esther Ndlovu, Hélène Martin-Yken, Etienne Dague. Deconstructing and reconstructing the yeast cell wall: A top-down, bottom-up approach. Nano in Bio Nanotechnologies for Life and Materials, Apr 2018, Le Gosier, France. ⟨hal-02950644⟩
  • Hélène Martin-Yken, Camille Gironde, Hélène Taiana Darius, Christophe Furger, Mireille Chinain, et al.. New strategies in the fight against Ciguatera. Nano In Bio 2018 Nanosciences for Life and Materials, May 2018, Le Gosier, France. ⟨hal-02950613⟩
  • Hélène Martin-Yken, Cécile Formosa-Dague, Marion Schiavone, Etienne Dague. The Dark Side of the Wall: Atomic Force Microscopy Revelations on Drug Resistance and Adhesion. Fungal Cell wall 2017 Conference, Pr; Mritxell Riquelme, Oct 2017, Ensenada, Mexico. ⟨hal-02944890⟩
  • Hélène Martin-Yken, C Formosa-Dague, M Schiavone, Jean Marie François, Etienne Dague. Stress, Drug Resistance, Adhesion: the dark side of the wall. Nano In Bio : Advances for Life and Material sciences, May 2016, Le Gosier, France. ⟨hal-02949505⟩
  • Hélène Martin-Yken, Cécile Formosa, Marion Schiavone, Jean Marie François, Etienne Dague. Drug resistance and adhesion: a closer look into the dark side of the wall.. Human Fungal Pathogens 2015, May 2015, La Colle sur Loup, France. ⟨hal-02950986⟩
  • Hélène Martin-Yken, Cécile Formosa, Etienne Dague, J.M. François, Marion Schiavone. Drug Resistance and Adhesion: a Closer Look at the Dark Side of the Wall.. 27. International Conference on Yeast Genetics and Molecular Biology (ICYGMB), Sep 2015, Levico Terme, Italy. ⟨hal-02949429⟩
  • Hélène Yken, Cécile Formosa-Dague, Marion Schiavone, Jean Marie François, Etienne Dague. Drug resistance and adhesion: a closer look at the dark side of the wall. 27. International Conference on Yeast Genetics and Molecular Biology (ICYGMB), Fondazione Edmund Mach. San Michele All'adige, ITA., Sep 2015, Levico Trente, Italy. 2 p. ⟨hal-01269495⟩
  • Stéphanie da Silva, Catherine Robbe Masselot, Afifa Ait-Belgnaoui, Allesandro Mancuso, Myriam Mercade Loubière, et al.. Stress disrupts the intestinal mucus barrier in rats via mucin O-glycosylation shift: prevention by probiotic treatment. 26. Meeting of European Intestinal Transport Group (EITG), European Intestinal Transport Group (EITG). INT., Oct 2014, Marstrand, Sweden. 2 p. ⟨hal-02742282⟩
  • Hélène Lalo, Etienne Dague, Christophe Vieu, Karsten Haupt, Cédric Ayela. Biomimetic nanopatterns achieved by combining Molecularly Imprinted Polymers with Soft Lithography. MRS Fall meeting 2009, Nov 2009, Boston, United States. 1 page. ⟨hal-00493038⟩

Poster communications4 documents

  • Irem Demir-Yilmaz, Ines Lüchtefeld, Claude Lemen, Etienne Dague, Pascal Guiraud, et al.. Probing the interactions between bubbles (gas / liquid) and (bio)interfaces at the molecular scale using FluidFM technology. Journées plénières du GDR Bioingénierie des Interfaces (B2I), Sep 2021, Toulouse, France. ⟨hal-03429997⟩
  • Helene Yken, Cécile Formosa-Dague, Marion Schiavone, Etienne Dague. The dark side of the wall: atomic force microscopy revelations on drug resistance and adhesion. FEBS Advanced Lecture Course on "Human Fungal Pathogens - Molecular Mechanisms of Host-Pathogen Interactions and Virulence", May 2017, La Colle sur Loup, France. 2017. ⟨hal-01608703⟩
  • Helene Yken, Cécile Formosa-Dague, Marion Schiavone, Etienne Dague. Stress, Drug Resistance, Adhesion: the dark side of the wall.. NanoInBio Advances for life and materials science, May 2016, Le Gosier, France. 2016. ⟨hal-01604110⟩
  • Hélène Martin-Yken, Cécile Formosa, Marion Schiavone, Jean Marie François, Etienne Dague. Stress, Drug resistance and Adhesion: a closer look at the dark side of the wall. Fungal Cell Wall Meeting, Oct 2015, Paris, France. ⟨hal-02951445⟩

Book sections1 document

Other publications1 document

  • Hélène Martin-Yken, Etienne Dague, Christophe Furger, H. T. Darius, M. Chinain. From the Yeast cell wall to new strategies in the fight against Ciguatera. 2018. ⟨hal-02951948⟩

Preprints, Working Papers, ...1 document

  • Baptiste Alric, Cécile Formosa-Dague, Etienne Dague, Liam Holt, Morgan Delarue. Macromolecular crowding limits growth under pressure. 2021. ⟨hal-03428857⟩

Theses1 document