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Coupe le cordon, vole de tes propres ailes !

Erwan Mortier , Fella Tamzalit , Yannick Jacques , Sébastien Morisseau
Médecine/Sciences, 2014, 30 (10), pp.836. ⟨10.1051/medsci/20143010006⟩
Article dans une revue inserm-02437321v1
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NK Cell Hyporesponsiveness: More Is Not Always Better

Marie Frutoso , Erwan Mortier
International Journal of Molecular Sciences, 2019, 20 (18), pp.4514. ⟨10.3390/ijms20184514⟩
Article dans une revue inserm-02289319v1
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Natural, Proteolytic Release of a Soluble Form of Human IL-15 Receptor a-Chain That Behaves as a Specific, High Affinity IL-15 Antagonist

Erwan Mortier , Jerome Bernard , Ariane Plet , Yannick Jacques
Journal of Immunology, 2004, 173, pp.1681 - 1688
Article dans une revue inserm-02437358v1
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Editorial: Modulating Cytokines as Treatment for Autoimmune Diseases and Cancer

Erwan Mortier , Averil Ma , Barbara A Malynn , Markus F Neurath
Frontiers in Immunology, 2020, ⟨10.3389/fimmu.2020.608636⟩
Article dans une revue inserm-02971041v1
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Macrophage-and Dendritic-Cell-Derived Interleukin-15 Receptor Alpha Supports Homeostasis of Distinct CD8+ T Cell Subsets

Erwan Mortier , Rommel Advincula , Leesun Kim , Stephen Chmura , Julio Barrera , et al.
Immunity, 2009, 31 (5), pp.811. ⟨10.1016/j.immuni.2009.09.017⟩
Article dans une revue inserm-02442545v1
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Le renouveau de l'interleukine 2 : Modèle revisité et nouvelles applications thérapeutiques

Yannick Jacques , Erwan Mortier
Médecine/Sciences, 2016, 32 ((6-7)), pp.612-618. ⟨10.1051/medsci/20163206025⟩
Article dans une revue inserm-01419855v1
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The Exon-3-Encoded Domain of IL-15Rα Contributes to IL-15 High-Affinity Binding and Is Crucial for the IL-15 Antagonistic Effect of Soluble IL-15Rα

Grégory Bouchaud , Laure Garrigue-Antar , Véronique Solé , Agnès Quéméner , Yvan Boublik , et al.
Journal of Molecular Biology, 2008, 382 (1), pp.1 - 12. ⟨10.1016/j.jmb.2008.07.019⟩
Article dans une revue istex inserm-02533457v1

Reversible DNA Hypermethylation of the Interleukin-15 (IL-15) Promoter Induces IL-15 Expression, Drives the Pathogenesis of T-Cell Large Granular Lymphocytic Leukemia and Provides a Potential Therapeutic Approach Using 5-Azacitidine

Jonathan Brammer , Amy Boles , Anthony Mansour , Aharon Freud , Monique Mathé-Allainmat , et al.
61th ASH Annual Meeting, Dec 2019, Orlando, Florida, United States. pp.3776-3776, ⟨10.1182/blood-2019-131174⟩
Communication dans un congrès inserm-02991752v1

Homeostatic MyD88-dependent signals cause lethal inflammation in the absence of A20

Emre E Turer , Rita M Tavares , Erwan Mortier , Osamu Hitotsumatsu , Rommel Advincula , et al.
Journal of Experimental Medicine, 2008, 205 (2), pp.451. ⟨10.1084/jem.20071108⟩
Article dans une revue inserm-02442492v1
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Syndecan-1 regulates the biological activities of interleukin-34

Aude Segaliny , Régis Brion , Erwan Mortier , Mike Maillasson , Michel Chérel , et al.
BBA - Biochimica et Biophysica Acta, 2015, 1853 (5), pp.1010 - 1021. ⟨10.1016/j.bbamcr.2015.01.023⟩
Article dans une revue inserm-01644783v1
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Cutting Edge: Differential Fine-Tuning of IL-2- and IL-15- Dependent Functions by targeting their Common IL-2/15Rβ/γc Receptor

Dihia Meghnem , Sébastien Morisseau , Marie Frutoso , Kilian Trillet , Mike Maillasson , et al.
Journal of Immunology, 2017, 198 (12), pp.4563-4568. ⟨10.4049/jimmunol.1700046⟩
Article dans une revue inserm-01524397v1
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Interleukin-15 and Its Soluble Receptor Mediate the Response to Infliximab in Patients With Crohn's Disease

Grégory Bouchaud , Erwan Mortier , Mathurin Flamant , Isabelle Barbieux , Ariane Plet , et al.
Gastroenterology, 2010, 138 (7), pp.2378-2387. ⟨10.1053/j.gastro.2010.02.044⟩
Article dans une revue inserm-02442031v1
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Editorial: Modulating cytokines as treatment for autoimmune diseases and cancer: volume II

Gaby Palmer , Sheela Ramanathan , Erwan Mortier
Frontiers in Immunology, 2023, 14, pp.1225699. ⟨10.3389/fimmu.2023.1225699⟩
Article dans une revue inserm-04116740v1
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IL-15.IL-15Rα complex shedding following trans-presentation is essential for the survival of IL-15 responding NK and T cells

Fella Tamzalit , Isabelle Barbieux , Ariane Plet , Julie Heim , Steven Nedellec , et al.
Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (23), pp.8565. ⟨10.1073/pnas.1405514111⟩
Article dans une revue inserm-02437298v1
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Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering

Ana I Romero , Nathalie Chaput , Vichnou Poirier-Colame , Sylvie Rusakiewicz , Nicolas Jacquelot , et al.
Cancer Research, 2014, 74 (1), pp.68. ⟨10.1158/0008-5472.CAN-13-1186⟩
Article dans une revue inserm-02442721v1
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Different dynamics of IL-15R activation following IL-15 cis-or trans-presentation

Harmonie Perdreau , Erwan Mortier , Grégory Bouchaud , Véronique Sole , Yvan Boublik , et al.
European Cytokine Network, 2010, 21 (4), pp.297. ⟨10.1684/ecn.2010.0207⟩
Article dans une revue inserm-02437096v1
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Emergence of NK Cell Hyporesponsiveness after Two IL-15 Stimulation Cycles

Marie Frutoso , Sébastien Morisseau , Fella Tamzalit , Agnès Quéméner , Dihia Meghnem , et al.
Journal of Immunology, 2018, Epub ahead of print. ⟨10.4049/jimmunol.1800086⟩
Article dans une revue inserm-01805185v1
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IL-15Rα chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation

Erwan Mortier , Tammy Woo , Rommel Advincula , Sara Gozalo , Averil Ma
Journal of Experimental Medicine, 2008, 205 (5), pp.1213. ⟨10.1084/jem.20071913⟩
Article dans une revue inserm-02442464v1
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IL-15 trans-presentation promotes human NK cell development and differentiation in vivo

Nicholas D Huntington , Nicolas Legrand , Nuno L. Alves , Barbara Jaron , Kees Weijer , et al.
Journal of Experimental Medicine, 2009, 206 (1), pp.25-34. ⟨10.1084/jem.20082013⟩
Article dans une revue inserm-02442774v1
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Counteracting Interleukin-15 to Elucidate Its Modes of Action in Physiology and Pathology

Erwan Mortier , Mike Maillasson , Agnès Quéméner
Journal of Interferon and Cytokine Research, 2023, 43 (1), pp.2 - 22. ⟨10.1089/jir.2022.0198⟩
Article dans une revue inserm-03948405v1
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Identification of an Interleukin-15 α Receptor-binding Site on Human Interleukin-15

Jérôme Bernard , Catherine Harb , Erwan Mortier , Agnès Quéméner , Rob H Meloen , et al.
Journal of Biological Chemistry, 2004, 279 (23), pp.24313. ⟨10.1074/jbc.M312458200⟩
Article dans une revue inserm-02442410v1
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IL-15Rα membrane-anchorage either in cis or in trans is required for stabilization of IL-15 and optimal signaling

Agnès Quéméner , Sébastien Morisseau , Rui P Sousa , Kilian Trillet , Mike Maillasson , et al.
Journal of Cell Science, 2019, Epub ahead of print. ⟨10.1242/jcs.236802⟩
Article dans une revue inserm-02345095v1
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Discovery of a Small-Molecule Inhibitor of Interleukin 15: Pharmacophore-Based Virtual Screening and Hit Optimization

Agnès Quéméner , Mike Maillasson , Laurence Arzel , Benoit Sicard , Romy Vomiandry , et al.
Journal of Medicinal Chemistry, 2017, 60 (14), pp.6249-6272. ⟨10.1021/acs.jmedchem.7b00485⟩
Article dans une revue inserm-01550121v1

BTN2A, a New Immune-Checkpoint Targeting Vg9Vd2 T Cell Cytotoxicity

Carla Cano , Christine Pasero , Aude de Gassart , René Hoet , Emmanuel Scotet , et al.
61th ASH Annual Meeting, Dec 2019, Orlando, Florida, United States. pp.1044-1044, ⟨10.1182/blood-2019-128658⟩
Communication dans un congrès inserm-02991780v1
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Interleukin-15 and cancer: some solved and many unsolved questions

Piera Filomena Fiore , Sabina Di Matteo , Nicola Tumino , Francesca Romana Mariotti , Gabriella Pietra , et al.
Journal for Immunotherapy of Cancer, 2020
Article dans une revue inserm-03013809v1
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MODULATING CYTOKINES AS TREATMENT FOR AUTOIMMUNE DISEASES AND CANCER

Erwan Mortier , Averil Ma , Barbara A Malynn , Markus F Neurath
11, pp.608636, 2020, ⟨10.3389/fimmu.2020.608636⟩
Ouvrages inserm-03079706v1
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The Soluble α Chain of Interleukin-15 Receptor: A Proinflammatory Molecule Associated with Tumor Progression in Head and Neck Cancer

Cécile Badoual , Grégory Bouchaud , Nour El Houda Agueznay , Erwan Mortier , Stéphane Hans , et al.
Cancer Research, 2008, 68 (10), pp.3907 - 3921. ⟨10.1158/0008-5472.CAN-07-6842⟩
Article dans une revue inserm-02442631v1
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Docking of Human Interleukin-15 to its Specific Receptor α Chain: Correlation Between Molecular Modeling and Mutagenesis Experimental Data

Agnès Quéméner , Jérôme Bernard , Erwan Mortier , Ariane Plet , Yannick Jacques , et al.
Proteins - Structure, Function and Bioinformatics, 2006, 65 (3), pp.623
Article dans une revue inserm-02442432v1
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Mechanistic and Structural Insights on the IL-15 System through Molecular Dynamics Simulations

Rui P Sousa , Adèle Laurent , Agnès Quéméner , Erwan Mortier , Jean-Yves Le Questel
Molecules, 2019, 24 (18), pp.3261. ⟨10.3390/molecules24183261⟩
Article dans une revue inserm-02289307v1

MUTATED INTERLEUKIN-34 (IL-34) POLYPEPTIDES AND USES THEREOF IN THERAPY

Carole Guillonneau , Ignacio Anegon , Erwan Mortier , Agnès Quéméner
France, Patent n° : WO2020148338. 2020
Brevet inserm-02991886v1