Nombre de documents

42

ERIC GUEDON


Biography:

I obtained my PhD in microbiology and molecular biology at Paris XI University in 2000. My PhD work, carried under the supervision of P. Renault, focused on the regulation of the proteolytic system of Lactococcus lactisby CodY, a pleiotropic transcriptional factor. In March 2000, I joined the group of Tarek Msadek at Pasteur Institute (Paris) to study the mechanisms of transcriptional regulation by two-component systems in Bacillus subtilis.  In September 2001, I was appointed as permanent INRA research scientist in the Génétique Microbienne lab headed by S.D. Ehrlich (INRA, Jouy-en-Josas) where I joined the BAC team to work on the molecular mechanisms of adaptation, including genetic and genomic modifications, of Streptococci to environmental changes. In 2010, I joined the Micalis institute (INRA, Jouy-en-Josas) to work on commensal bacteria of the human gut microbiota in the frame of the MetaHit EU project. In 2015, I moved to UMR1253 STLO (INRA-Agrocampus Ouest, Rennes) to develop works on intercellular communication and bacterial extracellular vesicles and to lead the Microbio team. In January 2017, I was promoted INRA Senior Researcher (Directeur de Recherches INRA).

 

Research topic:

From my PhD to now, the main focus of my research has always been the study of interactions and adaptation to environment of Gram-positive bacteria in order to gain a better understanding of how bacterial cell function. I have developed an expertise in microbiology, molecular genetics, genomic and post-genomic through works on the mechanisms of gene expression control, analysis of bacterial functions, genome evolution and bacterial-host interactions. My background reflects my curiosity and my interest for original, collaborative and multidisciplinary projects related to food and human health. Initially centering on lactic acid bacteria to improve the quality of fermented foods, my research activity evolved towards the study of commensal bacteria to unravel the mechanisms of their beneficial effects on human health and wellness. I participated to the pioneer works on the human intestinal microbiota at the UMR Micalis (INRA, Jouy-en-Josas). To further explore the relations between fermented foods, microbiota and host health, I joined the UMR STLO in 2015, in which I currently lead the MicroBio team. Our team shares a common ambition: to better understand the functioning of bacterial communities in relation with food and mammals in order to provide knowledge for their management and functionalization. For my part, I initiated studies on intra- and inter-species interactions and mechanisms of dialogue. In particular, my main interest now resides on extracellular vesicles (i.e. exosomes, EVs), nanoparticles produced by bacteria, and their role as mediators in communication with other bacteria, the microbiota and the host.

Contact:

E-mail: eric.guedon@inra.fr

Tel : +33 2 23 48 53 37

https://orcid.org/0000-0002-0901-4447

www.rennes.inra.fr/stlo

www.rennes.inra.fr/stlo_eng/RESEARCH/Research-Teams/Microbiology-of-Milk-and-Egg-Sectors

 


Article dans une revue28 documents

  • Blandine David, Marie-Clémence Duchêne, Gabrielle Laurie Haustenne, Daniel Perez Nunez, Marie-Pierre Chapot-Chartier, et al.. PBP2b plays a key role in both peripheral growth and septum positioning in Lactococcus lactis. PLoS ONE, Public Library of Science, 2018, 13 (5), pp.e0198014. 〈10.1371/journal.pone.0198014〉. 〈hal-01806302〉
  • Natayme Rocha Tartaglia, Koen Breyne, Evelyne Meyer, Chantal Cauty, Julien Jardin, et al.. Staphylococcus aureus Extracellular Vesicles Elicit an Immunostimulatory Response in vivo on the Murine Mammary Gland. Frontiers in Cellular and Infection Microbiology, Frontiers Media, 2018, 8 (277), pp.277. 〈10.3389/fcimb.2018.00277〉. 〈hal-01860012〉
  • Benoit Couvigny, Saulius Kulakauskas, Nicolas Pons, Benoit Quinquis, Anne-Laure Abraham, et al.. Identification of New Factors Modulating Adhesion Abilities of the Pioneer Commensal Bacterium Streptococcus salivarius. Frontiers in Microbiology, Frontiers Media, 2018, 9 ( article 273), 〈10.3389/fmicb.2018.00273〉. 〈hal-01713777〉
  • Benoit Couvigny, Nicolas Lapaque, Lionel Rigottier-Gois, Alain Guillot, Sophie Chat, et al.. Three glycosylated serine-rich repeat proteins play a pivotal role in adhesion and colonization of the pioneer commensal bacterium, Streptococcus salivarius. Environmental Microbiology, Wiley-Blackwell, 2017, 19 (9), pp.3579-3594. 〈10.1111/1462-2920.13853〉. 〈hal-01608428〉
  • Leticia Hernandez Galan, Thomas Cattenoz, Steven Le Feunteun, Alexis Canette, Romain Briandet, et al.. Effect of dairy matrices on the survival of Streptococcus thermophilus, Brevibacterium aurantiacum and Hafnia alvei during digestion. Food Research International, Elsevier, 2017, 100 (1), pp.477-488. 〈10.1016/j.foodres.2017.07.044〉. 〈hal-01607632〉
  • Narimane Dahmane, Virginie Libante, Florence Charron-Bourgoin, Eric Guedon, Gérard Guédon, et al.. Diversity of Integrative and Conjugative Elements of Streptococcus salivarius and Their Intra- and Interspecies Transfer. Applied and Environmental Microbiology, American Society for Microbiology, 2017, 83 (13), pp.e00337-17. 〈10.1128/AEM.00337-17〉. 〈hal-01543490〉
  • Narimane Dahmane, Emilie Robert, Julien Deschamps, Thierry Meylheuc, Christine Delorme, et al.. Impact of cell surface molecules on conjugative transfer of the integrative and conjugative element ICESt3 of Streptococcus thermophilus. Applied and Environmental Microbiology, American Society for Microbiology, 2017, pp.AEM.02109-17. 〈10.1128/AEM.02109-17〉. 〈hal-01678088〉
  • Helle Krogh Pedersen, Valborg Gudmundsdottir, Henrik Bjørn Nielsen, Tuulia Hyotylainen, Trine Nielsen, et al.. Human gut microbes impact host serum metabolome and insulin sensitivity. Nature, Nature Publishing Group, 2016, 535 (7612), pp.376-381. 〈10.1038/nature18646〉. 〈hal-01594855〉
  • Benoit Couvigny, Claire Thérial, Céline Gautier, Pierre Renault, Romain Briandet, et al.. Streptococcus thermophilus Biofilm Formation: A Remnant Trait of Ancestral Commensal Life?. PLoS ONE, Public Library of Science, 2015, 10 (6), pp.e0128099. 〈10.1371/journal.pone.0128099〉. 〈hal-01204465〉
  • Eric Dugat-Bony, Cecile Straub, Aurélie Teissandier, Djamila Onesime, Valentin Loux, et al.. Overview of a surface-ripened cheese community functioning by meta-omics analyses. PLoS ONE, Public Library of Science, 2015, 10 (4), pp.e0124360. 〈10.1371/journal.pone.0124360〉. 〈hal-01195505〉
  • Benoit Couvigny, Tomas De Wouters, Ghalia Kaci, Elsa Jacouton, Christine Delorme, et al.. Commensal [i]Streptococcus salivarius[/i] modulates PPARγ transcriptional activity in human intestinal epithelial cells. PLoS ONE, Public Library of Science, 2015, 10 (5), 〈10.1371/journal.pone.0125371〉. 〈hal-01204466〉
  • H Bjørn Nielsen, Mathieu Almeida, Agnieszka Sierakowska Juncker, Simon Rasmussen, Junhua Li, et al.. Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes. Nature Biotechnology, Nature Publishing Group, 2014, 32, pp.822-828. 〈10.1038/nbt.2939〉. 〈hal-01195477〉
  • Junhua Li, Huijue Jia, Xianghang Cai, Huanzi Zhong, Qiang Feng, et al.. An integrated catalog of reference genes in the human gut microbiome. Nature Biotechnology, Nature Publishing Group, 2014, 32, pp.834-841. 〈10.1038/nbt.2942〉. 〈hal-01195478〉
  • Christine Delorme, Anne-Laure Abraham, Pierre Renault, Eric Guedon. Genomics of Streptococcus salivarius, a major human commensal. Infection, Genetics and Evolution, Elsevier, 2014, 〈10.1016/j.meegid.2014.10.001〉. 〈hal-01154007〉
  • Emmanuelle Le Chatelier, Trine Nielsen, Junjie Qin, Edi Prifti, Falk Hildebrand, et al.. Richness of human gut microbiome correlates with metabolic markers. Nature, Nature Publishing Group, 2013, 500 (7464), pp.541-546. 〈10.1038/nature12506〉. 〈hal-01190602〉
  • Bjorn Vergauwen, Kenneth Verstraete, Dilani B. Senadheera, Ann Dansercoer, Dennis G. Cvitkovitch, et al.. Molecular and structural basis of glutathione import in Gram-positive bacteria via GshT and the cystine ABC importer TcyBC of Streptococcus mutans. Molecular Microbiology, Wiley, 2013, 89 (2), pp.288 - 303. 〈10.1111/mmi.12274〉. 〈hal-01004454〉
  • Donald A. Morrison, Eric Guedon, Pierre Renault. Competence for Natural Genetic Transformation in the Streptococcus bovis Group Streptococci S. infantarius and S. macedonicus. Journal of Bacteriology, American Society for Microbiology, 2013, 195 (11), pp.2612 - 2620. 〈10.1128/JB.00230-13〉. 〈hal-01001520〉
  • Olivier Delumeau, Francois Lecointe, Jan Muntel, Alain Guillot, Eric Guedon, et al.. The dynamic protein partnership of RNA polymerase in Bacillus subtilis. Proteomics, Wiley-VCH Verlag, 2011, 11 (15), pp.2992 - 3001. 〈10.1002/pmic.201000790〉. 〈hal-01000647〉
  • Daniel Perez Nunez, Romain Briandet, Blandine David, Celine Gautier, Pierre Renault, et al.. A new morphogenesis pathway in bacteria: unbalanced activity of cell wall synthesis machineries leads to coccus-to-rod transition and filamentation in ovococci. Molecular Microbiology, Wiley, 2011, 79 (3), pp.759-771. 〈10.1111/j.1365-2958.2010.07483.x〉. 〈hal-01001253〉
  • Christine Delorme, Eric Guédon, Nicolas Pons, Corine Cruaud, Arnaud Couloux, et al.. Complete genome sequence of the clinical Streptococcus salivarius strain CCHSS3. Journal of Bacteriology, American Society for Microbiology, 2011, 193 (18), pp.5041-5042. 〈10.1128/JB.05416-11〉. 〈hal-01000176〉
  • Eric Guedon, Christine Delorme, Nicolas Pons, Corinne Cruaud, Valentin Loux, et al.. Complete genome sequence of the commensal Streptococcus salivarius strain JIM8777. Journal of Bacteriology, American Society for Microbiology, 2011, 193 (18), pp.5024-5025. 〈10.1128/JB.05390-11〉. 〈hal-01019305〉
  • Christine Delorme, Claire Bartholini, Mélanie Luraschi, Nicolas Pons, Valentin Loux, et al.. Complete genome sequence of the pigmented Streptococcus thermophilus strain JIM8232. Journal of Bacteriology, American Society for Microbiology, 2011, 193 (19), pp.5581-5582. 〈10.1128/JB.05404-11〉. 〈hal-01000180〉
  • Brice Sperandio, Celine Gautier, Nicolas Pons, Stanislav Ehrlich, Pierre Renault, et al.. Three paralogous LysR-type transcriptional regulators control sulfur amino acid supply in Streptococcus mutans. Journal of bacteriology, 2010, 192 (13), pp.3464-3473. 〈10.1128/JB.00119-10〉. 〈hal-01204450〉
  • Pascal Hols, Frédéric Hancy, Laetitia Fontaine, Benoît Grossiord, Deborah Prozzi, et al.. New insights in the molecular biology and physiology of revealed by comparative genomics. FEMS Microbiology Reviews, Wiley-Blackwell, 2005, 29 (3), pp.435 - 463. 〈10.1016/j.femsre.2005.04.008〉. 〈hal-01631250〉
  • Brice Sperandio, P. Polard, Dusko S Ehrlich, Pierre Renault, Eric Guédon. Sulfur Amino Acid Metabolism and Its Control in Lactococcus lactis IL1403. Journal of Bacteriology, American Society for Microbiology, 2005, 187 (11), pp.3762 - 3778. 〈10.1128/jb.187.11.3762-3778.2005〉. 〈hal-01895330〉
  • Eric Guédon, Cécile Martin, François-Xavier Gobert, S. Dusko Ehrlich, Pierre Renault, et al.. Réseau de régulation de la transcription des gènes du système protéolytique de lactococcus lactis. Le Lait, INRA Editions, 2001, 81 (1-2), pp.65-74. 〈10.1051/lait:2001112〉. 〈hal-00895460〉
  • Eric Guédon, Pierre Renault, S. Dusko Ehrlich, Christine Delorme. Transcriptional Pattern of Genes Coding for the Proteolytic System of Lactococcus lactis and Evidence for Coordinated Regulation of Key Enzymes by Peptide Supply. Journal of Bacteriology, American Society for Microbiology, 2001, 183 (12), pp.3614 - 3622. 〈10.1128/jb.183.12.3614-3622.2001〉. 〈hal-01895319〉
  • Pierre Renault, Sébastien Calero, Christine Delorme, Sophie Drouault, Nathalie Goupil-Feuillerat, et al.. Du génome à l'application. Le Lait, INRA Editions, 1998, 78 (1), pp.39-52. 〈hal-00929583〉

Communication dans un congrès3 documents

  • Eric Guedon. Exploration des interactions fonctionnelles entre les bactéries de l'aliment fermenté et le microbiote. Séminaire Aliment-Microbiote, Dec 2016, Paris, France. 2016. 〈hal-01432625〉
  • Eric Guedon. L'Homme et ses microbes. 15.rencontre G-RREMI, Oct 2013, Lyon, France. 2013. 〈hal-01454651〉
  • Eric Guedon. Données de (Meta)-génomiques et de (Meta)-transcriptomiques. Journées d'Animation MEM , Jan 2012, Valpré, France. 2012. 〈hal-01454650〉

Poster11 documents

  • Yves Le Loir, Eric Guedon, Natayme Rocha Tartaglia, Koen Breyne, Evelyne Meyer, et al.. Staphylococcus aureus extracellular vesicles elicit an immunostimulatory response in vivo on the murine mammary gland. 14.congrès national de la Société Française de Microbiologie (SFM), Oct 2018, Paris, France. 2018. 〈hal-01889276〉
  • Natayme Rocha Tartaglia, Koene Breyne, Kristel Demeyere, Julien Jardin, Chantal Cauty, et al.. Staphylococcus aureus-derived extracellular vesicles induce an inflammatory response in murine model of mastitis. Congrès FSEV 2017, Nov 2017, Paris, France. 2017. 〈hal-01645112〉
  • Sylvie Lortal, Eric Guedon. Biodiversité microbienne de la chaîne alimentaire: Les écosystèmes fromagers.. 20. Edition du Club des Bactéries Lactiques, Jun 2015, Lille, France. 2015. 〈hal-01174822〉
  • Benoit Couvigny, Romain Briandet, Celine Gautier, Lionel Rigottier-Gois, Manfred Rohde, et al.. The three Serine rich Proteins encoded in the secA2Y2 system of the human commensal bacterium Streptococcus salivarius promotes binding to different targets of the host. 7th international conference on Gram-positive microorganisms, Jun 2013, Montecatini Italy. 2013. 〈hal-01454649〉
  • Donald Morrison, Eric Guedon, Pierre Renault. Robust and widespread competence for natural genetic transformation in the S. bovid group [i]streptococci, S. infantarius[/i] and [i]S. macedonicus[/i]. 7th international conference on Gram-positive microorganisms, Jun 2013, Montecatini, Italy. 2013. 〈hal-01359144〉
  • Benoit Couvigny, Claire Therial, Celine Gautier, Pierre Renault, Romain Briandet, et al.. [i]Streptococcus thermopilus[/i] biofilm lifestyle : A remnant of commensal ancestral life?. 7th international conference on Gram-positive microorganisms, Jun 2013, Montecatini, Italy. 2013. 〈hal-01359145〉
  • Benoit Couvigny, Tomas De Wouters, Ghalia Kaci, Christine Delorme, Joel Dore, et al.. The commensal bacterium [i]Streptococcus salivarius[/i] inhibits PPARg activity and its target genes in human intestinal epithelial cells. IHMC, International Human Microbiome Congress : Paris 2012, Sep 2012, Paris, France. 2012. 〈hal-01359134〉
  • Séverine Layec, Alain Guillot, Florence Levenez, Eric Guedon, Joel Dore, et al.. Impact of surface-exposed proteins on the commensal life in [i]Streptococcus salivarius[/i]. IHMC, International Human Microbiome Congress : Paris 2012, Mar 2012, Paris, France. 2012. 〈hal-01359142〉
  • Mathieu Almeida, Emmanuelle Le Chatelier, Nicolas Pons, Emna Achouri, Séverine Layec, et al.. Prevalence of streptococci in the intestinal flora. IHMC, International Human Microbiome Congress : Paris 2012, Mar 2012, Paris, France. 2012. 〈hal-01359143〉
  • Eric Guedon, Benoit Couvigny, Romain Briandet, Celine Gautier, Séverine Layec, et al.. Relationship between self-aggregation property of the human commensal bacterium [i]Streptococcus salivarius[/i] and its ability to interact with intestinal epithelial cells. IHMC, International Human Microbiome Congress : Paris 2012, Mar 2012, Paris, France. 2012. 〈hal-01359136〉
  • Claire Therial, Julien Deschamps, Romain Briandet, Pierre Renault, Eric Guédon. Identification des gènes impliqués dans la formation de biofilm chez une souche atypique de Streptococcus thermophilus. 16ème colloque du Club des Bactéries Lactiques, 2009, Toulouse, France. 〈hal-01944202〉