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Coupling of D2R Short but not D2R Long receptor isoform to the Rho/ROCK signaling pathway renders striatal neurons vulnerable to mutant huntingtin

Jocelyne Caboche , Galan-Rodriguez Beatriz , Martin Elodie , Emmanuel ; Déglon , Betuing Sandrine , et al.
European Journal of Neuroscience, 2017, 45 (1), pp.198-206. ⟨10.1111/ejn.13415⟩
Article dans une revue hal-03365878v1

Impaired brain energy metabolism in the BACHD mouse model of Huntington's disease: critical role of astrocyte-neuron interactions

Lydie Boussicault , Anne-Sophie Herard , Noel Calingasan , Fanny Petit , Carole Malgorn , et al.
Journal of Cerebral Blood Flow and Metabolism, 2014, 34 (9), pp.1500-1510. ⟨10.1038/jcbfm.2014.110⟩
Article dans une revue hal-01545792v1
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Calpain is a major cell death effector in selective striatal degeneration induced $in\ vivo$ by 3-nitropropionate: implications for Huntington's disease.

Nicolas Bizat , Jean-Michel Hermel , Frédéric Boyer , Carine Jacquard , Christophe Créminon , et al.
Journal of Neuroscience, 2003, 23 (12), pp.5020-30
Article dans une revue cea-02290630v1
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Time-Course of Alterations in the Endocannabinoid System after Viral-Mediated Overexpression of α-Synuclein in the Rat Brain

Rachel Kelly , Alexis-Pierre Bemelmans , Charlène Joséphine , Emmanuel Brouillet , Declan P Mckernan , et al.
Molecules, 2022, 27 (2), pp.507. ⟨10.3390/molecules27020507⟩
Article dans une revue hal-04419946v1
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Diffusion-weighted magnetic resonance spectroscopy enables cell-specific monitoring of astrocyte reactivity $in\ vivo$

Clémence Ligneul , Marco Palombo , Edwin Hernández-Garzón , Maria-Angeles Carrillo-de Sauvage , Julien Flament , et al.
NeuroImage, 2019, 191, pp.457-469. ⟨10.1016/j.neuroimage.2019.02.046⟩
Article dans une revue cea-02155405v1

CA150 expression delays striatal cell death in overexpression and knock-in conditions for mutant huntingtin neurotoxicity

Margarita Arango , Sébastien Holbert , Dania Zala , Emmanuel Brouillet , James Pearson , et al.
Journal of Neuroscience, 2006, 26 (17), pp.4649 - 4659. ⟨10.1523/JNEUROSCI.5409-05.2006⟩
Article dans une revue hal-02666883v1

Mitochondria in Huntington's disease

Maria Damiano , Laurie Galvan , Nicole Déglon , Emmanuel Brouillet
Biochimica et Biophysica Acta - Molecular Basis of Disease, 2010, 1802 (1), pp.52-61. ⟨10.1016/j.bbadis.2009.07.012⟩
Article dans une revue hal-02459756v1
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Imaging and spectroscopic approaches to probe brain energy metabolism dysregulation in neurodegenerative diseases

Gilles Bonvento , Julien Valette , Julien Flament , Fanny Mochel , Emmanuel Brouillet
Journal of Cerebral Blood Flow and Metabolism, 2017, 37 (6), pp.1927-1943. ⟨10.1177/0271678X17697989⟩
Article dans une revue hal-01539753v1
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$In\ Vivo$ Calpain/Caspase Cross-talk during 3-Nitropropionic Acid-induced Striatal Degeneration

Nicolas Bizat , Jean-Michel Hermel , Sandrine Humbert , Carine Jacquard , Christophe Créminon , et al.
Journal of Biological Chemistry, 2003, 278 (44), pp.43245-43253. ⟨10.1074/jbc.M305057200⟩
Article dans une revue cea-02290633v1

Energy defects in Huntington's disease: Why “in vivo” evidence matters

Géraldine Liot , Julien Valette , Jérémy Pépin , Julien Flament , Emmanuel Brouillet
Biochemical and Biophysical Research Communications, 2017, 483 (4), pp.1084-1095. ⟨10.1016/j.bbrc.2016.09.065⟩
Article dans une revue hal-04476989v1
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Possible involvement of self-defense mechanisms in the preferential vulnerability of the striatum in Huntington's disease

Laetitia Francelle , Laurie Galvan , Emmanuel Brouillet
Frontiers in Cellular Neuroscience, 2014, ⟨10.3389/fncel.2014.00295⟩
Article dans une revue hal-02459873v1

Striatal long noncoding RNA Abhd11os is neuroprotective against an N-terminal fragment of mutant huntingtin in vivo.

Laetitia Francelle , Laurie Galvan , Marie-Claude Gaillard , Fanny Petit , Benoît Bernay , et al.
Neurobiology of Aging, 2015, pp.1601.e7-16. ⟨10.1016/j.neurobiolaging.2014.11.014⟩
Article dans une revue hal-01465910v1

SET translocation is associated with increase in caspase cleaved amyloid precursor protein in CA1 of Alzheimer and Down syndrome patients.

Patricia Facchinetti , Emilie Dorard , Vincent Contremoulins , Marie-Claude Gaillard , Nicole Déglon , et al.
Neurobiol Aging, 2014, 35 (5), pp.958-68. ⟨10.1016/j.neurobiolaging.2013.08.039⟩
Article dans une revue hal-00946234v1

The C-Terminal Domain of LRRK2 with the G2019S Substitution Increases Mutant A53T α-Synuclein Toxicity in Dopaminergic Neurons In Vivo

Noémie Cresto , Camille Gardier , Marie-Claude Gaillard , Francesco Gubinelli , Pauline Roost , et al.
International Journal of Molecular Sciences, 2021, 22 (13), pp.6760. ⟨10.3390/ijms22136760⟩
Article dans une revue hal-03452142v1
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What is gained or ‘lost in translation’ in Huntington’s disease

Emmanuel Brouillet , Karine Merienne
Brain - A Journal of Neurology , 2019, 142 (10), pp.2900-2902. ⟨10.1093/brain/awz274⟩
Article dans une revue hal-03058364v1
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Corticostriatopallidal Neuroprotection by Adenovirus-Mediated Ciliary Neurotrophic Factor Gene Transfer in a Rat Model of Progressive Striatal Degeneration

Vincent Mittoux , Stephane Ouary , Christelle Monville , Fabrice Lisovoski , Thomas Poyot , et al.
Journal of Neuroscience, 2002, 22 (11), pp.4478-86
Article dans une revue cea-02290628v1

Perseverative behavior underlying attentional set-shifting deficits in rats chronically treated with the neurotoxin 3-nitropropionic acid.

Nicole El Massioui , Stéphane Ouary , Fabrice Chéruel , Philippe Hantraye , Emmanuel Brouillet
Experimental Neurology, 2001, 172 (1), pp.172-81. ⟨10.1006/exnr.2001.7766⟩
Article dans une revue istex hal-01467542v1

A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin

Maria Damiano , Elsa Diguet , Carole Malgorn , Marilena d'Aurelio , Laurie Galvan , et al.
Human Molecular Genetics, 2013, 22 (19), pp.3869-3882. ⟨10.1093/hmg/ddt242⟩
Article dans une revue hal-02459752v1

The Mitochondrial Toxin 3-Nitropropionic Acid Induces Striatal Neurodegeneration via a c-Jun N-Terminal Kinase/c-Jun Module

Marta Garcia , Peter Vanhoutte , Christiane Pagès , Marie-Jo Besson , Emmanuel Brouillet , et al.
Journal of Neuroscience, 2002, 22 (6), pp.2174-2184. ⟨10.1523/JNEUROSCI.22-06-02174.2002⟩
Article dans une revue hal-02372666v1

Ectosomes: a new mechanism for non-exosomal secretion of tau protein.

Simon Dujardin , Séverine Bégard , Raphaëlle Caillierez , Cédrick Lachaud , Lucie Delattre , et al.
PLoS ONE, 2013, 9 (6), pp.e100760. ⟨10.1371/journal.pone.0100760⟩
Article dans une revue hal-01181185v1

Discovering new bioactive neuropeptides in the striatum secretome using in vivo microdialysis and versatile proteomics.

Benoît Bernay , Marie-Claude Gaillard , Vilém Guryca , Anouk Emadali , Lauriane Kuhn , et al.
Molecular and Cellular Proteomics, 2009, 8 (5), pp.946-58. ⟨10.1074/mcp.M800501-MCP200⟩
Article dans une revue inserm-00410894v1

Contribution of Neuroepigenetics to Huntington’s Disease

Laetitia Francelle , Caroline Lotz , Tiago Outeiro , Emmanuel Brouillet , Karine Merienne
Frontiers in Human Neuroscience, 2017, 11, ⟨10.3389/fnhum.2017.00017⟩
Article dans une revue hal-03060269v1

Contribution of Neuroepigenetics to Huntington’s Disease

Laetitia Francelle , Caroline Lotz , Tiago Outeiro , Emmanuel Brouillet , Karine Merienne
Frontiers in Human Neuroscience, 2017, 11, ⟨10.3389/fnhum.2017.00017⟩
Article dans une revue cea-01751739v1
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Activation of Astrocytes by CNTF Induces Metabolic Plasticity and Increases Resistance to Metabolic Insults

Carole Escartin , Karin Pierre , Angélique Colin , Emmanuel Brouillet , Thierry Delzescaux , et al.
Journal of Neuroscience, 2007, 27 (27), pp.7094-7104. ⟨10.1523/JNEUROSCI.0174-07.2007⟩
Article dans une revue cea-02290623v1
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The Neuroprotective Agent CNTF Decreases Neuronal Metabolites in the Rat Striatum: An $in\ Vivo$ Multimodal Magnetic Resonance Imaging Study

Maria-Angeles Carrillo-de Sauvage , Julien Flament , Yann Bramoullé , Lucile Ben Haim , Martine Guillermier , et al.
Journal of Cerebral Blood Flow and Metabolism, 2015, 35 (6), pp.917-921. ⟨10.1038/jcbfm.2015.48⟩
Article dans une revue cea-02168367v1
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The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin

Laurie Galvan , Laetitia Francelle , Marie-Claude Gaillard , Lucie de Longprez , Maria-Angeles Carrillo-de Sauvage , et al.
Brain - A Journal of Neurology , 2018, 141 (5), pp.1434-1454. ⟨10.1093/brain/awy057⟩
Article dans une revue hal-02074093v1
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THY-Tau22 mouse model accumulates more tauopathy at late stage of the disease in response to microglia deactivation through TREM2 deficiency

Audrey Vautheny , Charlotte Duwat , Gwennaëlle Aurégan , Charlène Joséphine , Anne-Sophie Hérard , et al.
Neurobiology of Disease, 2021, 155, pp.105398. ⟨10.1016/j.nbd.2021.105398⟩
Article dans une revue inserm-03366724v1
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Mitochondria in Huntington's disease

Maria Damiano , Laurie Galvan , Nicole Déglon , Emmanuel Brouillet
Biochimica et Biophysica Acta - Molecular Basis of Disease, 2009, 1802 (1), pp.52. ⟨10.1016/j.bbadis.2009.07.012⟩
Article dans une revue hal-00543005v1

Extreme conservation of the poly-glutamine tract in huntingtin is related to neurodevelopmental functions: the “better” may become the “enemy of the good” in the course of evolution

Emmanuel Brouillet
Cell Death and Differentiation, 2022, 29 (2), pp.266-268. ⟨10.1038/s41418-021-00927-4⟩
Article dans une revue hal-04312713v1

Energy defects in Huntington's disease: Why “in vivo” evidence matters

Géraldine Liot , Julien Valette , Jérémy Pépin , Julien Flament , Emmanuel Brouillet
Biochemical and Biophysical Research Communications, 2017, 483, pp.1084 - 1095. ⟨10.1016/j.bbrc.2016.09.065⟩
Article dans une revue cea-01752431v1