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Massive Cell Vacuolization Induced by Organic Amines Such as Procainamide

Emmanuel Moreau , G. Morissette
Journal of Pharmacology and Experimental Therapeutics, 2004, 310 (1), pp.395 - 406. ⟨10.1124/jpet.104.066084⟩
Article dans une revue hal-01677592v1

Novel imidazo[1,2-a]naphthyridinic systems (part 1): Synthesis, antiproliferative and DNA-intercalating activities

Emmanuel Moreau , Mounir Andaloussi , Nicolas Masurier , Jacques Lacroix , René C Gaudreault , et al.
European Journal of Medicinal Chemistry, 2008, 43 (11), pp.2505 - 2517. ⟨10.1016/j.ejmech.2008.02.017⟩
Article dans une revue istex hal-01677576v1
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Intramolecular Cyclization of N-phenyl N'(2-chloroethyl)ureas leads to Active N-phenyl-4,5-dihydrooxazol-2-amines Alkylating β-Tubulin Glu198 and Prohibitin Asp40

Anna Trzeciakiewicz , Sébastien Fortin , Emmanuel Moreau , René C. Gaudreault , Jacques Lacroix , et al.
Biochemical Pharmacology, 2011, 81 (9), pp.1116- 1123. ⟨10.1016/j.bcp.2011.02.014⟩
Article dans une revue hal-00685075v1

Plasticizers exposure in nicu: is it an issue for the patients?

Lise Bernard , Morgane Masse , Benoît Boeuf , Philip Chennell , Bertrand Décaudin , et al.
European society of clinical pharmacy - Spring Workshop 2022 (ESCP 2022), Apr 2022, Zürich, Switzerland. Springer, International Journal of Clinical Pharmacy, 44, pp.823, 2022, ⟨10.1007/s11096-022-01432-5⟩
Poster de conférence hal-04027067v1
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Development of a new radiofluorinated quinoline analog for PET imaging of phosphodiesterase 5 (PDE5) in brain

Jianrong Liu , Barbara Wenzel , Sladjana Dukic-Stefanovic , Rodrigo Teodoro , Friedrich-Alexander Ludwig , et al.
Pharmaceuticals, 2016, 9 (2), pp.22. ⟨10.3390/ph9020022⟩
Article dans une revue hal-01677542v1

Selective C-Acylation of 2-Aminoimidazo[1,2- a ]pyridine: Application to the Synthesis of Imidazopyridine-Fused [1,3]Diazepinones

Nicolas Masurier , Roberta Aruta , Vincent Gaumet , Séverine Denoyelle , Emmanuel Moreau , et al.
Journal of Organic Chemistry, 2012, 77 (7), pp.3679 - 3685. ⟨10.1021/jo300364d⟩
Article dans une revue hal-01677551v1
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Comparative Effects of Di-(2-ethylhexyl)phthalate and Di-(2-ethylhexyl)terephthalate Metabolites on Thyroid Receptors: In Vitro and In Silico Studies

Nicolas Kambia , Isabelle Séverin , Amaury Farce , Laurence Dahbi , Thierry Dine , et al.
Metabolites, 2021, 11 (2), pp.94. ⟨10.3390/metabo11020094⟩
Article dans une revue hal-03141182v1

A convenient synthesis of linear pyridinoimidazo[1,2-a]pyridine and pyrroloimidazo[1,2-a]pyridine cores

Emmanuel Moreau , Mounir Andaloussi , Olivier Chavignon , Jean C. Teulade
Tetrahedron Letters, 2007, 48 (47), pp.8392 - 8395. ⟨10.1016/j.tetlet.2007.07.223⟩
Article dans une revue istex hal-01677644v1
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Quick and Simple Detection Technique to Assess the Binding of Antimicrotubule Agents to the Colchicine-Binding Site

Sébastien Fortin , Jacques Lacroix , Marie-France Côté , Emmanuel Moreau , Éric Petitclerc , et al.
Biological Procedures Online, 2010, 12 (1), pp.113-117. ⟨10.1007/s12575-010-9029-5⟩
Article dans une revue hal-01677569v1

Simple and convenient conversion of acridones into 9-unsubstituted acridines via acridanes using borane tetrahydrofuran complex

Nicolas Desbois , Anna Szollosi , Aurélie Maisonial , Valérie Weber , Emmanuel Moreau , et al.
Tetrahedron Letters, 2009, 50 (49), pp.6894 - 6896. ⟨10.1016/j.tetlet.2009.09.141⟩
Article dans une revue istex hal-01677641v1

Homologation of the Alkyl Side Chain of Antimitotic Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonate Prodrugs Selectively Targeting CYP1A1-Expressing Breast Cancers Improves Their Stability in Rodent Liver Microsomes

Atziri Corin Chavez Alvarez , Chahrazed Bouzriba , Emmanuel Moreau , Philippe Auzeloux , Sophie Besse , et al.
Journal of Medicinal Chemistry, 2023, 66 (4), pp.2477-2497. ⟨10.1021/acs.jmedchem.2c01268⟩
Article dans une revue hal-04205850v1

Melanoma-targeted delivery system (part 2): Synthesis, radioiodination and biological evaluation in B16F0 bearing mice

Emmanuel Moreau , Radhia El Aissi , Imen Miladi , Jean-Michel J.-M. Chezal , Olivier Chavignon , et al.
European Journal of Medicinal Chemistry, 2016, 120, pp.304 - 312. ⟨10.1016/j.ejmech.2016.05.019⟩
Article dans une revue hal-01677545v1

N-Phenyl-N′-(2-chloroethyl)ureas (CEUs) as potential antineoplastic agents. Part 3: Role of carbonyl groups in the covalent binding to the colchicine-binding site

Emmanuel Moreau , Sébastien Fortin , Jacques Lacroix , Alexandre Patenaude , Jean L C Rousseau , et al.
Bioorganic and Medicinal Chemistry, 2008, 16 (3), pp.1206 - 1217. ⟨10.1016/j.bmc.2007.10.078⟩
Article dans une revue hal-01677581v1

Efficient synthesis of imidazopyridodiazepines from peri annulation in imidazo[1,2-a]pyridine

Emmanuel Moreau , C. Dechambre , Jean M. Chezal , François Estour , B. Combourieu , et al.
Tetrahedron Letters, 2002, 43 (50), pp.9119-9123. ⟨10.1016/S0040-4039(02)02239-6⟩
Article dans une revue istex hal-01677657v1

Short and efficient access to imidazo[1,2-a]pyrrolo[3,2-c]pyridine derivatives

Emmanuel Moreau , Vincent Gaumet , Abbass Taleb , Fernand Leal , Johan Neyts , et al.
Tetrahedron Letters, 2010, 51 (47), pp.6082 - 6085. ⟨10.1016/j.tetlet.2010.09.056⟩
Article dans une revue istex hal-01677637v1

Preliminary Study of Palladium Catalyzed Iminoannulation in an Imidazo[1,2-a]pyridine Series

Emmanuel Moreau , Olivier Chavignon , Mounir Andaloussi , Jean M. Chezal , Claire Lartigue , et al.
Heterocycles, 2005, 65 (5), ⟨10.3987/COM-05-10340⟩
Article dans une revue hal-01677675v1

Heterocyclization of functionalized vinylic derivatives of imidazo.

Emmanuel Moreau , C Chezal , G Delmas , G Gueiffier , Y. Blache , et al.
Journal of Organic Chemistry, 2001, pp.6576-84
Article dans une revue hal-01677594v1

Aminoimidazo[1,2-a]pyridines: regioselective synthesis of substituted imidazonaphthyridines, azacarbolines and cyclazines

Emmanuel Moreau , Jean Chezal , Olivier Chavignon , Vincent Gaumet , Jacques Métin , et al.
Tetrahedron, 2002, 58 (2), pp.295 - 307. ⟨10.1016/S0040-4020(01)01141-3⟩
Article dans une revue istex hal-01677662v1

Heterocyclization of Functionalized Vinylic Derivatives of Imidazo[1,2- a ]pyridines

Emmanuel Moreau , Jean Chezal , Gregory Delmas , Alain Gueiffier , Yves Blache , et al.
Journal of Organic Chemistry, 2001, 66 (20), pp.6576 - 6584. ⟨10.1021/jo015582x⟩
Article dans une revue istex hal-01677665v1
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New SPE-LC-MS/MS method for the simultaneous determination in urine of 22 metabolites of DEHP and alternative plasticizers from PVC medical devices

Jérémy Pinguet , Nicolas Kerckhove , Teuta Eljezi , Celine Lambert , Emmanuel Moreau , et al.
Talanta, 2019, 198, pp.377-389. ⟨10.1016/j.talanta.2019.01.115⟩
Article dans une revue hal-02194877v1

Characterization of the Covalent Binding of N-Phenyl-N'-(2-chloroethyl)ureas to -Tubulin: Importance of Glu198 in Microtubule Stability

Emmanuel Moreau , S. Fortin , B. Bouchon , C. Chambon , J. Lacroix , et al.
Journal of Pharmacology and Experimental Therapeutics, 2011, 336 (2), pp.460 - 467. ⟨10.1124/jpet.110.171082⟩
Article dans une revue hal-01677562v1

N-Substituted 4-aminobenzamides (procainamide analogs): an assessment of multiple cellular effects vis-a-vis ion trapping

Emmanuel Moreau , G. Morissette
Molecular Pharmacology, 2008, ⟨10.1124/mol.105.016527⟩
Article dans une revue hal-01677587v1

Optimized N-phenyl-N′-(2-chloroethyl)ureas as potential antineoplastic agents: Synthesis and growth inhibition activity

Emmanuel Moreau , Sébastien Fortin , Michel Desjardins , Jean L C Rousseau , Eric Petitclerc , et al.
Bioorganic and Medicinal Chemistry, 2005, 13 (24), pp.6703 - 6712. ⟨10.1016/j.bmc.2005.07.048⟩
Article dans une revue hal-01677590v1
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In vitro cytotoxic effects of secondary metabolites of DEHP and its alternative plasticizers DINCH and DINP on a L929 cell line

Teuta Eljezi , Pierre Pinta , Fabien Nativel , Damien Richard Richard , Jérémy Pinguet , et al.
International Journal of Hygiene and Environmental Health, 2019, 222 (3), pp.583-589. ⟨10.1016/j.ijheh.2019.03.005⟩
Article dans une revue hal-02385535v1

Synthesis of Polyfused Heterocycle Derivatives Containing the Dipyridoimidazole Core by Friedländer’s Reaction: Access to Analogs of Ellipticine

Emmanuel Moreau , Jean-Claude Teulade , Nicolas Desbois , Jean-Michel J.-M. Chezal , Florence Fauvelle , et al.
Heterocycles, 2005, 65 (5), ⟨10.3987/COM-05-10354⟩
Article dans une revue hal-01677674v1

Mechanism of action of N-phenyl-N′-(2-chloroethyl)ureas in the colchicine-binding site at the interface between α- and β-tubulin

Emmanuel Moreau , Sébastien Fortin , Lianhu Wei , Philippe Labrie , Éric Petitclerc , et al.
Bioorganic and Medicinal Chemistry, 2009, 17 (10), pp.3690 - 3697. ⟨10.1016/j.bmc.2009.03.056⟩
Article dans une revue hal-01677570v1

A comparative molecular field and comparative molecular similarity indices analyses (CoMFA and CoMSIA) of N-phenyl-N′-(2-chloroethyl)ureas targeting the colchicine-binding site as anticancer agents

Emmanuel Moreau , Sébastien Fortin , Philippe Labrie , Lianhu Wei , Lakshmi P Kotra , et al.
Bioorganic and Medicinal Chemistry, 2008, 16 (4), pp.1914 - 1926. ⟨10.1016/j.bmc.2007.11.004⟩
Article dans une revue hal-01677579v1

N-Phenyl-N′-(2-chloroethyl)ureas (CEU) as potential antineoplastic agents. Part 2: Role of ω-hydroxyl group in the covalent binding to β-tubulin

Emmanuel Moreau , Sébastien Fortin , Alexandre Patenaude , Michel Desjardins , Jacques Lacroix , et al.
Bioorganic and Medicinal Chemistry, 2007, 15 (3), pp.1430 - 1438. ⟨10.1016/j.bmc.2006.11.005⟩
Article dans une revue hal-01677583v1

Design, Synthesis, Biological Evaluation, and Structure–Activity Relationships of Substituted Phenyl 4-(2-Oxoimidazolidin-1-yl)benzenesulfonates as New Tubulin Inhibitors Mimicking Combretastatin A-4

Emmanuel Moreau , Sébastien Fortin , Lianhu Wei , Jacques Lacroix , Marie-France Côté , et al.
Journal of Medicinal Chemistry, 2011, 54 (13), pp.4559 - 4580. ⟨10.1021/jm200488a⟩
Article dans une revue hal-01677554v1

Synthesis and Biological Evaluation of New Quinoxaline Derivatives of ICF01012 as Melanoma-Targeting Probes

Emmanuel Moreau , Radhia El Aissi , Jianrong Liu , Sophie Besse , Damien Canitrot , et al.
ACS Medicinal Chemistry Letters, 2014, 5 (5), pp.468 - 473. ⟨10.1021/ml400468x⟩
Article dans une revue hal-01677548v1