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Elsa Bazellières CV

Bazellières Elsa

20/01/1981

elsa.bazellieres@univ-amu.fr  

                                    

SITUATION PROFESSIONNELLE ACTUELLE

Nomination CRCN au 1er Octobre 2017

 

 LABORATOIRES PRECEDENTS

Post Doctorat à l’IBDM

1er  Décembre 2016- 30 Septembre 2017: Contrat AMU Aix Marseille (financement LabeX)

1er Décembre 2014- 30 Novembre 2016 : Contrat CNRS (financement propre Ligue Nationale Contre Cancer)

 

Post Doctorat à IBEC laboratoire de Xavier Trepat

1er Janvier 2011- 10 Octobre 2014 : Contrat IBEC

1er-Juin 2010- 31 Décembre 2010 : Contrat Fundacio Bosch i Gimpera

 

Post Doctorat à l IBDM

1er Décembre 2009- 30 Mai 2010 : Contrat CNRS

 

Thèse à l’IBDM. Superviseur André Le Bivic

1er Octobre 2008- 30 Septembre 2009: Contrat CNRS

1er Octobre 2005- 30 Septembre 2008 : Contrat Doctoral Université Aix Marseille

 

PUBLICATIONS

·         2019 :

1.       Le Borgne-Rochet M, Angevin L, Bazellières E, Comunale F, Denisov EV, Tashireva LA, Perelmuter VM, Bièche I, Vacher S, Plutoni C, Bodin S, Gauthier-Rouvière C, P-cadherin-induced collagen fiber alignment is required for directional collective cell migration, J Cell Sci : 132(21).

2.Pérez-González C, Alert R, C Blanch-Mercader C, Gómez-González M, Kolodziej T, Bazellières E, Casademunt J, Trepat X, Active wetting of epithelial tissues, Nature Physics (15) :79-88

·         2018 :

1.       Mire E, Hocine M, Bazellières E, Jungas T, Davy A, Chauvet S, Mann F.Developmental Upregulation of Ephrin-B1 Silences Sema3C/Neuropilin-1 Signaling during Post-crossing Navigation of Corpus Callosum Axons. Curr Biol. 2018 Jun ;28(11):1768-1782.e4.

·         2017 :

1.       Bazellières E, Aksenova V, Barthélémy-Requin M, Massey-Harroche D, Le Bivic A. Role of the crumbs proteins in ciliogenesis, cell migration and actin organization. Semin Cell Dev Biol. 2017. pii: S1084-9521(16)30333-0. Review.

2.       Salis P, Payre F, Valenti P, Bazellieres E, Le Bivic A, Mottola G. Crumbs,Moesin and Yurt regulate junctional stability and dynamics for a proper morphogenesis of the Drosophila pupal wing epithelium. Sci Rep. 2017 Dec1;7(1):16778

3.       González-Tarragó V, Elosegui-Artola A, Bazellières E, Oria R, Pérez-González C, Roca-Cusachs P.Binding of ZO-1 to α5β1 integrins regulates the mechanical properties of α5β1-fibronectin links.Mol Biol Cell. 7;28(14):1847-1852.

4.       Blanch-Mercader C, Vincent R, Bazelllières E, Serra-Picamal X, Trepat X, Casademunt J.Effective viscosity and dynamics of spreading epithelia: a solvable model.Soft Matter. 8;13(6):1235-1243.

·         2016:

1.       Pallesi-Pocachard E, Bazellières E, Viallat-Lieutaud A, Delgrossi MH, Barthélémy-requin Magali, Le Bivic A, Massey-Harroche D.  Hook2, a microtubule-binding protein, interacts with Par6α  and controls centrosome orientation during polarized cell migration. Sci Rep 14;6:33259

2.       Plutoni C, Bazellières E, Gauthier-Rouvière C. Pcadherin mediated Rho GTPase regulation during collective cell migration. Small GTPases 2;7(3):156-63

3.       Plutoni C, Bazellières E, Le Borgne-Rochet M, Comunale F, Brugues A, Seveno M, Planchon D, Thuault S, Morin N, Bodin S, Trépat X, Gauthier-Rouvière C. P-cadherin promotes collective cell migration via a Cdc42-mediated increase in mechanical forces.J Cell Biol 18;212(2):199-217

·         2015:

1.       Vincent R, Bazellières E, Pérez-González C, Uroz M, Serra-Picamal X, Trepat X. Active Tensile Modulus of an Epithelial Monolayer. Phys Rev Lett 115 : 248103

2.       Perrault CM, Brugues A, Bazellières E, Ricco P, Lacroix D, Trepat X. Traction Forces of Endothelial Cells under Slow Shear Flow. Biophys J 109: 1533-1536

3.       Bazellières E, Conte V, Elosegui-Artola A, Serra-Picamal X, Bintanel-Morcillo M, Roca-Cusachs P, Muñoz JJ, Sales-Pardo M,Guimera R, Trepat X. Control of cell-cell forces and collective cell dynamics by the intercellular adhesome. Nat. Cell Biol. 17 (4), 409 -420.

4.       Mrkonjić S, Garcia-Elias A, Pardo-Pastor C, Bazellières E, Trepat X, Vriens J, Ghosh D, Voets T, Vicente R, Valverde MA.TRPV4 participates in the establishment of trailing adhesions and directional persistence of migrating cells. Pflugers Arch 467(10):2107-19

·         2014 :

1.       Elosegui-Artola A, Bazellières E, Allen M, Andreu I, Oria R, Sunyer R, Marshall J,Jones L, Trepat X, Roca-Cusachs P, Rigidity sensing and adaptation through regulation of integrin types, Nat Mater 13 :631-637. News and Views in Nat Mater 13:539-540 : Cellular mechanotransduction : Sensing rigidity

2.       Vacca B, Bazellières E, Nouar R, Harada A, Massey-Harroche D, Le Bivic A. DrebrinE depletion in human intestinal epithelial cells mimics Rab8a loss of function, Hum Mol Genet, Jan 12.

·         2012 :

1.       Serra-Picamal X,Conte V, Vincent R, Añon E, Tambe D, Bazellières E, Butler J, Fredberg J, Trepat X, Mechanical waves during tissue expansion, Nature Physics, 8 : 628-634.

2.       Bazellières, E., Massey-Harroche, D., M. Barthélémy, Richard, F., Arsanto, J.P. & Le Bivic, A. Apico-basal elongation requires a drebrin-E-EB3 complex in columnar human epithelial cells. J Cell Sci 125(Pt 4):919-31. Highlighted in J Cell Sci 125, e405: Making cells longer with Drebrin E.

·         2009:

1.       Bazellières E et al. Crumbs proteins in epithelial morphogenesis. Review. Front Biosci.2009 Jan1; 14:2149-69.

·         2008 :

1.       Assémat E; Bazellières E et al. Polarity complex proteins. Review. Biochim Biophys Acta.2008 Mar; 1778(3):614-30.

 

MANUSCRIPTS EN PREPARATION

Bazellières E, Conte V, Massey-Harroche D, Le Bivic A. Crb3 master regulator of the initial step of collective cell migration

Bazellières E, André Le Bivic , review Mechanoregulation of PDZ proteins, an emerging function

 

in the serie 'In-depth mining of PDZ interactions and functions'. Methods Mol Biol

 

GRANTS

·      2019 : Centuri, PhD Fellowship 3 years

·      2017 : AmideX « Interdisciplinarity » call for projects – 2016 Project: CapoStromEx

·         2014 : Allocations de Recherche PostDoctorale, Ligue Nationale Contre le Cancer

 

 

REVIEWING

·   2020  Chemical Science (1 manuscrit),

·   2019 Soft Matter (1 manuscrit), FEBS letter (1 manuscrit)

 

COMMUNICATIONS ORALES

·         2019 Seminaire au Centuri Day, Marseille

·         2016 : Séminaire au French Cell Adhesion Club Symposium sur invitation, Montpellier.

·         2014 : Séminaire au CRBM, Montpellier sur invitation de Cécile Gauthier-Rouvière. Titre: Control of cell-cell forces and collective cell dynamics by the intercellular adhesome.

·       2006-2009: European consortium Crumbs Insight

·       2007: Workshop AMAXA, American Society of Cell Biology, Washington DC.

·       2007: Canceropôle ACI, Institut Paoli Calmettes, Marseille

DOMAINES DE COMPETENCES

Bio-physique : Particle Image Velocimetry, Traction Force Microscopy, Monolayer Stress Microscopy, Segmentation et Analyse d’image, Pinces Magnétiques, Ablation Laser

Microscopie : Microscopie Optique et à Fluorescence, Video Microscopie, Microscopie Confocale,  Microsopie Electronique à Balayage et à Transmission

Biologie Cellulaire : Patterning cellulaire, Culture en 2D et 3D sur substrat mou, Transfection et Clonage Cellulaire, Calcium Switch Assay, Mesure de Résistance Transépithéliale

Biochimie: GST pull-down, Co-Immunoprecipitation, extraction de proteines et purifications, Western blot, Biotinylation de surface

Biologie moléculaire: RT-PCR, PCR, clonage ADN, screen double hybride

Informatique : Matlab, Metamorph, ImageQuant TL, ImageJ, LSM Browse, Axiovision, Endnote, Adobe Photoshop/Illustrator, Word, Excel, Power Point.

 

ACTIVITES ADMINISTRATIVES/ENCADREMENTS

2019-2022 : Co-direction Thèse Niels Gouirand

2020 : Membre du CORES Centuri

2019-2020 : Membre du bureau GDR Approche Quantitative du Vivant

2009, 2013, 2014, 2018 : Encadrements d’étudiants en Master1 Roqyia Nouar, Victor Gonzalez Tarrago, Amina Dali et Master2 (Carlos Perez-Gonzalez, Roxane Benoit)

2005-2009 : Représentante élue des étudiants en thèse à l’IBDM

2006-2008, 2019 : Intervention dans des écoles dans le cadre de la « Semaine du Cerveau »

Journal articles31 documents

  • Maïlys Le Borgne-Rochet, Lucie Angevin, Elsa Bazellières, Laura Ordas, Franck Comunale, et al.. P-cadherin-induced decorin secretion is required for collagen fiber alignment and directional collective cell migration. Journal of Cell Science, Company of Biologists, 2019, pp.jcs.233189. ⟨10.1242/jcs.233189⟩. ⟨hal-02339510⟩
  • Carlos Pérez-González, Ricard Alert, Carles Blanch-Mercader, Manuel Gómez-González, Tomasz Kolodziej, et al.. Active wetting of epithelial tissues. Nature Physics, Nature Publishing Group, 2019, 15 (1), pp.79-88. ⟨10.1038/s41567-018-0279-5⟩. ⟨hal-02406488⟩
  • Maïlys Le Borgne-Rochet, Lucie Angevin, Elsa Bazellieres, Laura Ordas, Franck Comunale, et al.. P-cadherin-induced decorin secretion is required for collagen fiber alignment and directional collective cell migration. Journal of Cell Science, Company of Biologists, 2019, 132 (21), pp.jcs233189. ⟨10.1242/jcs.233189⟩. ⟨hal-03064511⟩
  • Fanny Mann, Elsa Bazellieres, Mélanie Hocine, Sophie Chauvet, Thomas Jungas, et al.. Developmental Upregulation of Ephrin-B1 Silences Sema3C/Neuropilin-1 Signaling during Post-crossing Navigation of Corpus Callosum Axons. Current Biology - CB, Elsevier, 2018, 28 (11), pp.1768-1782.e4. ⟨10.1016/j.cub.2018.04.026⟩. ⟨hal-01989172⟩
  • Elsa Bazellieres, Veronika Aksenova, Magali Barthélémy-Requin, Dominique Massey-Harroche, André Le Bivic. Role of the Crumbs proteins in ciliogenesis, cell migration and actin organization. Seminars in Cell & Developmental Biology, 2018, 81, pp.13-20. ⟨10.1016/j.semcdb.2017.10.018⟩. ⟨hal-03064493⟩
  • Erik Mire, Mélanie Hocine, Elsa Bazellieres, Thomas Jungas, Alice Davy, et al.. Developmental Upregulation of Ephrin-B1 Silences Sema3C/Neuropilin-1 Signaling during Post-crossing Navigation of Corpus Callosum Axons. Current Biology - CB, Elsevier, 2018, 28 (11), pp.1768-1782.e4. ⟨10.1016/j.cub.2018.04.026⟩. ⟨hal-03064483⟩
  • Víctor González-Tarragó, Alberto Elosegui-Artola, Elsa Bazellières, Roger Oria, Carlos Pérez-González, et al.. Binding of ZO-1 to α5β1 integrins regulates the mechanical properties of α5β1–fibronectin links. Molecular Biology of the Cell, American Society for Cell Biology, 2017, 28 (14), pp.1847 - 1852. ⟨10.1091/mbc.E17-01-0006⟩. ⟨hal-01691510⟩
  • Pauline Salis, François Payre, Philippe Valenti, Elsa Bazellières, André Le Bivic, et al.. Crumbs, Moesin and Yurt regulate junctional stability and dynamics for a proper morphogenesis of the Drosophila pupal wing epithelium. Scientific Reports, Nature Publishing Group, 2017, 7 (1), pp.16778. ⟨10.1038/s41598-017-15272-1⟩. ⟨hal-01796116v2⟩
  • C. Blanch-Mercader, R. Vincent, Elsa Bazellières, X. Serra-Picamal, X. Trepat, et al.. Effective viscosity and dynamics of spreading epithelia: a solvable model. Soft Matter, Royal Society of Chemistry, 2017, 13 (6), pp.1235-1243. ⟨10.1039/c6sm02188c⟩. ⟨hal-02406558⟩
  • Víctor González-Tarragó, Alberto Elosegui-Artola, Elsa Bazellieres, Roger Oria, Carlos Pérez-González, et al.. Binding of ZO-1 to α5β1 integrins regulates the mechanical properties of α5β1–fibronectin links. Molecular Biology of the Cell, American Society for Cell Biology, 2017, 28 (14), pp.1847-1852. ⟨10.1091/mbc.E17-01-0006⟩. ⟨hal-03064506⟩
  • Pauline Salis, Francois Payre, Philippe Valenti, Elsa Bazellieres, André Le Bivic, et al.. Crumbs, Moesin and Yurt regulate junctional stability and dynamics for a proper morphogenesis of the Drosophila pupal wing epithelium. Scientific Reports, Nature Publishing Group, 2017, 7 (1), ⟨10.1038/s41598-017-15272-1⟩. ⟨hal-03064499⟩
  • Elsa Bazellières, Veronika Aksenova, Magali Barthélémy-Requin, Dominique Massey-Harroche, André Le Bivic. Role of the crumbs proteins in ciliogenesis, cell migration and actin organization. Seminars in Cell and Developmental Biology, Elsevier, 2017, ⟨10.1016/j.semcdb.2017.10.018⟩. ⟨hal-01692596⟩
  • E. Pallesi-Pocachard, E. Bazellieres, A. Viallat-Lieutaud, M.H. Delgrossi, M. Barthelemy-Requin, et al.. Hook2, a microtubule-binding protein, interacts with Par6α and controls centrosome orientation during polarized cell migration. Scientific Reports, Nature Publishing Group, 2016, pp.33259. ⟨10.1038/srep33259.⟩. ⟨hal-01445270⟩
  • Cédric Plutoni, Elsa Bazellieres, Maïlys Le Borgne-Rochet, Franck Comunale, Agusti Brugues, et al.. P-cadherin promotes collective cell migration via a Cdc42-mediated increase in mechanical forces. Journal of Cell Biology, Rockefeller University Press, 2016, 212 (2), pp.199--217. ⟨10.1083/jcb.201505105⟩. ⟨hal-01878038⟩
  • Emilie Pallesi-Pocachard, Elsa Bazellieres, Annelise Viallat-Lieutaud, Marie-Hélène Delgrossi, Magali Barthelemy-Requin, et al.. Hook2, a microtubule-binding protein, interacts with Par6α and controls centrosome orientation during polarized cell migration. Scientific Reports, Nature Publishing Group, 2016, 6 (1), ⟨10.1038/srep33259⟩. ⟨hal-03064449⟩
  • Cédric Plutoni, Elsa Bazellieres, Cécile Gauthier-Rouvière. P-cadherin-mediated Rho GTPase regulation during collective cell migration. Small GTPases, Taylor & Francis, 2016, 7 (3), pp.156-163. ⟨10.1080/21541248.2016.1173772⟩. ⟨hal-03064437⟩
  • Cédric Plutoni, Elsa Bazellieres, Maïlys Le Borgne-Rochet, Franck Comunale, Agusti Brugues, et al.. P-cadherin promotes collective cell migration via a Cdc42-mediated increase in mechanical forces. Journal of Cell Biology, Rockefeller University Press, 2016, 212 (2), pp.199-217. ⟨10.1083/jcb.201505105⟩. ⟨hal-03064445⟩
  • Cédric Plutoni, Elsa Bazellières, Cécile Gauthier-Rouvière. P-cadherin-mediated Rho GTPase regulation during collective cell migration. Small GTPases, Taylor & Francis, 2016, 7 (3), pp.156--163. ⟨10.1080/21541248.2016.1173772⟩. ⟨hal-01878043⟩
  • Sanela Mrkonjić, Anna Garcia-Elias, Carlos Pardo-Pastor, Elsa Bazellières, Xavier Trepat, et al.. TRPV4 participates in the establishment of trailing adhesions and directional persistence of migrating cells. Pflügers Archiv European Journal of Physiology, Springer Verlag, 2015, 467 (10), pp.2107-2119. ⟨10.1007/s00424-014-1679-8⟩. ⟨hal-02406582⟩
  • Romaric Vincent, Elsa Bazellières, Carlos Pérez-González, Marina Uroz, Xavier Serra-Picamal, et al.. Active Tensile Modulus of an Epithelial Monolayer. Physical Review Letters, American Physical Society, 2015, 115 (24), ⟨10.1103/PhysRevLett.115.248103⟩. ⟨hal-02406565⟩
  • Cecile m. Perrault, Agusti Brugues, Elsa Bazellières, Pierre Ricco, Damien Lacroix, et al.. Traction Forces of Endothelial Cells under Slow Shear Flow. Biophysical Journal, Biophysical Society, 2015, 109 (8), pp.1533-1536. ⟨10.1016/j.bpj.2015.08.036⟩. ⟨hal-02406574⟩
  • Elsa Bazellières, Vito Conte, Alberto Elosegui-Artola, Xavier Serra-Picamal, María Bintanel-Morcillo, et al.. Control of cell–cell forces and collective cell dynamics by the intercellular adhesome. Nature Cell Biology, Nature Publishing Group, 2015, 17 (4), pp.409-420. ⟨10.1038/ncb3135⟩. ⟨hal-02406578⟩
  • Barbara Vacca, Elsa Bazellieres, Roqiya Nouar, Akihiro Harada, Dominique Massey-Harroche, et al.. Drebrin E depletion in human intestinal epithelial cells mimics Rab8a loss of function. Human Molecular Genetics, Oxford University Press (OUP), 2014, 23 (11), pp.2834-2846. ⟨10.1093/hmg/ddt670⟩. ⟨hal-03064457⟩
  • B. Vacca, E. Bazellieres, R. Nouar, A. Harada, D. Massey-Harroche, et al.. Drebrin E depletion in human intestinal epithelial cells mimics Rab8a loss of function. Human Molecular Genetics, Oxford University Press (OUP), 2014, 23 (11), pp.2834-46. ⟨10.1093/hmg/ddt670⟩. ⟨hal-01134798⟩
  • Alberto Elosegui-Artola, Elsa Bazellières, Michael Allen, Ion Andreu, Roger Oria, et al.. Rigidity sensing and adaptation through regulation of integrin types. Nature Materials, Nature Publishing Group, 2014, 13 (6), pp.631-637. ⟨10.1038/nmat3960⟩. ⟨hal-02406591⟩
  • Xavier Serra-Picamal, Vito Conte, Romaric Vincent, Ester Anon, Dhananjay Tambe, et al.. Mechanical waves during tissue expansion. Nature Physics, Nature Publishing Group, 2012, 8 (8), pp.628-634. ⟨10.1038/nphys2355⟩. ⟨hal-03064520⟩
  • Elsa Bazellières, Dominique Massey-Harroche, Magali Barthélémy-Requin, Fabrice Richard, Jean-Pierre Arsanto, et al.. Apico-basal elongation requires a drebrin-E-EB3 complex in columnar human epithelial cells.. Journal of Cell Science, Company of Biologists, 2012, 125 (Pt 4), pp.919-31. ⟨10.1242/jcs.092676⟩. ⟨hal-00843390⟩
  • Elsa Bazellieres. Crumbs proteins in epithelial morphogenesis. Frontiers in Bioscience, Frontiers in Bioscience, 2009, Volume (14), pp.2149. ⟨10.2741/3368⟩. ⟨hal-03064476⟩
  • E. Bazellières, E. Assemat, J.P. Arsanto, A. Le Bivic, D. Massey-Harroche. Crumbs proteins in epithelial morphogenesis. Frontiers in bioscience : a journal and virtual library, 2009, 14, pp.2149-69. ⟨hal-00428878⟩
  • Emeline Assémat, Emilie Pallesi-Pocachard, André Le Bivic, Dominique Massey-Harroche, Romaric Vincent, et al.. Polarity complex proteins. Biochimica et Biophysica Acta:Biomembranes, Elsevier, 2008, 1778 (3), pp.614-630. ⟨10.1016/j.bbamem.2007.08.029⟩. ⟨hal-03064016⟩
  • E. Assemat, E. Bazellieres, E. Pallesi-Pocachard, A. Le Bivic, D. Massey-Harroche. Polarity complex proteins. Biochimica et Biophysica Acta:Biomembranes, Elsevier, 2008, 1778, pp.614-630. ⟨hal-00306189⟩