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Elsa Bazellières

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Présentation

**Bazellières Elsa** 20/01/1981 <elsa.bazellieres@univ-amu.f>r **SITUATION PROFESSIONNELLE ACTUELLE** Nomination CRCN au 1er Octobre 2017 **LABORATOIRES PRECEDENTS** **Post Doctorat à l’IBDM** **1er Décembre 2016- 30 Septembre 2017:** Contrat AMU Aix Marseille (financement LabeX) **1er Décembre 2014- 30 Novembre 2016 :** Contrat CNRS (financement propre Ligue Nationale Contre Cancer) **Post Doctorat à IBEC laboratoire de Xavier Trepat** **1er Janvier 2011- 10 Octobre 2014 :** Contrat IBEC **1er-Juin 2010- 31 Décembre 2010 :** Contrat Fundacio Bosch i Gimpera **Post Doctorat à l IBDM** **1er Décembre 2009- 30 Mai 2010** : Contrat CNRS **Thèse à l’IBDM. Superviseur André Le Bivic** **1er Octobre 2008- 30 Septembre 2009**: Contrat CNRS **1er Octobre 2005- 30 Septembre 2008** : Contrat Doctoral Université Aix Marseille **PUBLICATIONS** · **2019 :** 1\. Le Borgne-Rochet M, Angevin L, **Bazellières E**, Comunale F, Denisov EV, Tashireva LA, Perelmuter VM, Bièche I, Vacher S, Plutoni C, Bodin S, Gauthier-Rouvière C, *P-cadherin-induced collagen fiber alignment is required for directional collective cell migration,* J Cell Sci : 132(21). 2.Pérez-González C, Alert R, C Blanch-Mercader C, Gómez-González M, Kolodziej T, **Bazellières E**, Casademunt J, Trepat X, *Active wetting of epithelial tissues,* Nature Physics (15) :79-88 · **2018 :** 1\. Mire E, Hocine M, **Bazellières E,** Jungas T, Davy A, Chauvet S, Mann F.*Developmental Upregulation of Ephrin-B1 Silences Sema3C/Neuropilin-1 Signaling during Post-crossing Navigation of Corpus Callosum Axons*. Curr Biol. 2018 Jun ;28(11):1768-1782.e4. · **2017 :** 1\. **Bazellières E**, Aksenova V, Barthélémy-Requin M, Massey-Harroche D, Le Bivic A. *Role of the crumbs proteins in ciliogenesis, cell migration and actin organization. Semin Cell Dev Biol. 2017. pii: S1084-9521(16)30333-0. Review.* 2\. Salis P, Payre F, Valenti P, Bazellieres E, Le Bivic A, Mottola G*. Crumbs,Moesin and Yurt regulate junctional stability and dynamics for a proper morphogenesis of the Drosophila pupal wing epithelium. Sci Rep. 2017 Dec1;7(1):16778* 3\. González-Tarragó V, Elosegui-Artola A, **Bazellières E**, Oria R, Pérez-González C, Roca-Cusachs P.*Binding of ZO-1 to α5β1 integrins regulates the mechanical properties of α5β1-fibronectin links.*Mol Biol Cell. 7;28(14):1847-1852. 4\. Blanch-Mercader C, Vincent R, **Bazelllières E**, Serra-Picamal X, Trepat X, Casademunt J.*Effective viscosity and dynamics of spreading epithelia: a solvable model.*Soft Matter. 8;13(6):1235-1243. · **2016:** 1\. Pallesi-Pocachard E, **Bazellières E**, Viallat-Lieutaud A, Delgrossi MH, Barthélémy-requin Magali, Le Bivic A, Massey-Harroche D. *Hook2, a microtubule-binding protein, interacts with Par6α and controls centrosome orientation during polarized cell migration.* Sci Rep 14;6:33259 2\. Plutoni C, **Bazellières E**, Gauthier-Rouvière C. *Pcadherin mediated Rho GTPase regulation during collective cell migration.* Small GTPases 2;7(3):156-63 3\. Plutoni C, **Bazellières E**, Le Borgne-Rochet M, Comunale F, Brugues A, Seveno M, Planchon D, Thuault S, Morin N, Bodin S, Trépat X, Gauthier-Rouvière C. *P-cadherin promotes collective cell migration via a Cdc42-mediated increase in mechanical forces.*J Cell Biol 18;212(2):199-217 · **2015:** 1\. Vincent R, **Bazellières E**, Pérez-González C, Uroz M, Serra-Picamal X, Trepat X. *Active Tensile Modulus of an Epithelial Monolayer*. Phys Rev Lett 115 : 248103 2\. Perrault CM, Brugues A, **Bazellières E**, Ricco P, Lacroix D, Trepat X. *Traction Forces of Endothelial Cells under Slow Shear Flow.* Biophys J 109: 1533-1536 3\. **Bazellières E**, Conte V, Elosegui-Artola A, Serra-Picamal X, Bintanel-Morcillo M, Roca-Cusachs P, Muñoz JJ, Sales-Pardo M,Guimera R, Trepat X. Control of cell-cell forces and collective cell dynamics by the intercellular adhesome. Nat. Cell Biol. 17 (4), 409 -420. 4\. Mrkonjić S, Garcia-Elias A, Pardo-Pastor C, **Bazellières E**, Trepat X, Vriens J, Ghosh D, Voets T, Vicente R, Valverde MA.*TRPV4 participates in the establishment of trailing adhesions and directional persistence of migrating cells*. Pflugers Arch 467(10):2107-19 · **2014 :** 1\. Elosegui-Artola A, **Bazellières E**, Allen M, Andreu I, Oria R, Sunyer R, Marshall J,Jones L, Trepat X, Roca-Cusachs P, *Rigidity sensing and adaptation through regulation of integrin types,* Nat Mater 13 :631-637. News and Views in Nat Mater 13:539-540 : *Cellular mechanotransduction : Sensing rigidity* 2\. Vacca B, **Bazellières E**, Nouar R, Harada A, Massey-Harroche D, Le Bivic A. *DrebrinE depletion in human intestinal epithelial cells mimics Rab8a loss of function*, Hum Mol Genet, Jan 12. · **2012 :** 1\. Serra-Picamal X,Conte V, Vincent R, Añon E, Tambe D, **Bazellières E**, Butler J, Fredberg J, Trepat X, *Mechanical waves during tissue expansion*, Nature Physics, 8 : 628-634. 2\. **Bazellières, E**., Massey-Harroche, D., M. Barthélémy, Richard, F., Arsanto, J.P. &amp; Le Bivic, A. *Apico-basal elongation requires a drebrin-E-EB3 complex in columnar human epithelial cells*. J Cell Sci 125(Pt 4):919-31. Highlighted in J Cell Sci 125, e405: *Making cells longer with Drebrin E.* · **2009:** 1\. **Bazellières E** et al. *Crumbs proteins in epithelial morphogenesis.* Review. Front Biosci.2009 Jan1; 14:2149-69. · **2008** : 1\. Assémat E; **Bazellières E** et al. *Polarity complex proteins.* Review. Biochim Biophys Acta.2008 Mar; 1778(3):614-30. **MANUSCRIPTS EN PREPARATION** **Bazellières E**, Conte V, Massey-Harroche D, Le Bivic A. *Crb3 master regulator of the initial step of collective cell migration* **Bazellières E,** André Le Bivic , review *Mechanoregulation of PDZ proteins, an emerging function* in the serie 'In-depth mining of PDZ interactions and functions'. Methods Mol Biol **GRANTS** · **2019** : Centuri, PhD Fellowship 3 years · **2017 :** AmideX « Interdisciplinarity » call for projects – 2016 Project: CapoStromEx · **2014 :** Allocations de Recherche PostDoctorale, Ligue Nationale Contre le Cancer **REVIEWING** · **2020** Chemical Science (1 manuscrit), · **2019** Soft Matter (1 manuscrit), FEBS letter (1 manuscrit) **COMMUNICATIONS ORALES** · **2019** Seminaire au Centuri Day, Marseille · **2016 :** Séminaire au French Cell Adhesion Club Symposium sur invitation, Montpellier. · **2014 :** Séminaire au CRBM, Montpellier sur invitation de Cécile Gauthier-Rouvière. Titre: Control of cell-cell forces and collective cell dynamics by the intercellular adhesome. · **2006-2009:** European consortium Crumbs Insight · **2007**: Workshop AMAXA, American Society of Cell Biology, Washington DC. · 2007**: Canceropôle ACI, Institut Paoli Calmettes, Marseille **DOMAINES DE COMPETENCES** **Bio-physique :** Particle Image Velocimetry, Traction Force Microscopy, Monolayer Stress Microscopy, Segmentation et Analyse d’image, Pinces Magnétiques, Ablation Laser **Microscopie :** Microscopie Optique et à Fluorescence, Video Microscopie, Microscopie Confocale, Microsopie Electronique à Balayage et à Transmission **Biologie Cellulaire :** Patterning cellulaire, Culture en 2D et 3D sur substrat mou, Transfection et Clonage Cellulaire, Calcium Switch Assay, Mesure de Résistance Transépithéliale **Biochimie:** GST pull-down, Co-Immunoprecipitation, extraction de proteines et purifications, Western blot, Biotinylation de surface **Biologie moléculaire:** RT-PCR, PCR, clonage ADN, screen double hybride **Informatique :** Matlab, Metamorph, ImageQuant TL, ImageJ, LSM Browse, Axiovision, Endnote, Adobe Photoshop/Illustrator, Word, Excel, Power Point. **ACTIVITES ADMINISTRATIVES/ENCADREMENTS** 2019-2022 : Co-direction Thèse Niels Gouirand 2020 : Membre du CORES Centuri 2019-2020 : Membre du bureau GDR Approche Quantitative du Vivant 2009, 2013, 2014, 2018 : Encadrements d’étudiants en Master1 Roqyia Nouar, Victor Gonzalez Tarrago, Amina Dali et Master2 (Carlos Perez-Gonzalez, Roxane Benoit) 2005-2009 : Représentante élue des étudiants en thèse à l’IBDM 2006-2008, 2019 : Intervention dans des écoles dans le cadre de la « Semaine du Cerveau »

Publications

P-cadherin-induced decorin secretion is required for collagen fiber alignment and directional collective cell migration

Maïlys Le Borgne-Rochet , Lucie Angevin , Elsa Bazellieres , Laura Ordas , Franck Comunale
Journal of Cell Science, 2019, 132 (21), pp.jcs233189. ⟨10.1242/jcs.233189⟩
Article dans une revue hal-03064511v1

Active wetting of epithelial tissues

Carlos Pérez-González , Ricard Alert , Carles Blanch-Mercader , Manuel Gómez-González , Tomasz Kolodziej
Nature Physics, 2019, 15 (1), pp.79-88. ⟨10.1038/s41567-018-0279-5⟩
Article dans une revue hal-02406488v1
Image document

P-cadherin-induced decorin secretion is required for collagen fiber alignment and directional collective cell migration

Maïlys Le Borgne-Rochet , Lucie Angevin , Elsa Bazellières , Laura Ordas , Franck Comunale
Journal of Cell Science, 2019, pp.jcs.233189. ⟨10.1242/jcs.233189⟩
Article dans une revue hal-02339510v1

Role of the Crumbs proteins in ciliogenesis, cell migration and actin organization

Elsa Bazellieres , Veronika Aksenova , Magali Barthélémy-Requin , Dominique Massey-Harroche , André Le Bivic
Seminars in Cell & Developmental Biology, 2018, 81, pp.13-20. ⟨10.1016/j.semcdb.2017.10.018⟩
Article dans une revue hal-03064493v1

Developmental Upregulation of Ephrin-B1 Silences Sema3C/Neuropilin-1 Signaling during Post-crossing Navigation of Corpus Callosum Axons

Fanny Mann , Elsa Bazellieres , Mélanie Hocine , Sophie Chauvet , Thomas Jungas
Current Biology - CB, 2018, 28 (11), pp.1768-1782.e4. ⟨10.1016/j.cub.2018.04.026⟩
Article dans une revue hal-01989172v1

Developmental Upregulation of Ephrin-B1 Silences Sema3C/Neuropilin-1 Signaling during Post-crossing Navigation of Corpus Callosum Axons

Erik Mire , Mélanie Hocine , Elsa Bazellieres , Thomas Jungas , Alice Davy
Current Biology - CB, 2018, 28 (11), pp.1768-1782.e4. ⟨10.1016/j.cub.2018.04.026⟩
Article dans une revue hal-03064483v1

Binding of ZO-1 to α5β1 integrins regulates the mechanical properties of α5β1–fibronectin links

Víctor González-Tarragó , Alberto Elosegui-Artola , Elsa Bazellières , Roger Oria , Carlos Pérez-González
Molecular Biology of the Cell, 2017, 28 (14), pp.1847 - 1852. ⟨10.1091/mbc.E17-01-0006⟩
Article dans une revue hal-01691510v1

Role of the crumbs proteins in ciliogenesis, cell migration and actin organization

Elsa Bazellières , Veronika Aksenova , Magali Barthélémy-Requin , Dominique Massey-Harroche , André Le Bivic
Seminars in Cell and Developmental Biology, 2017, ⟨10.1016/j.semcdb.2017.10.018⟩
Article dans une revue hal-01692596v1

Binding of ZO-1 to α5β1 integrins regulates the mechanical properties of α5β1–fibronectin links

Víctor González-Tarragó , Alberto Elosegui-Artola , Elsa Bazellieres , Roger Oria , Carlos Pérez-González
Molecular Biology of the Cell, 2017, 28 (14), pp.1847-1852. ⟨10.1091/mbc.E17-01-0006⟩
Article dans une revue hal-03064506v1
Image document

Crumbs, Moesin and Yurt regulate junctional stability and dynamics for a proper morphogenesis of the Drosophila pupal wing epithelium

Pauline Salis , François Payre , Philippe Valenti , Elsa Bazellières , André Le Bivic
Scientific Reports, 2017, 7 (1), pp.16778. ⟨10.1038/s41598-017-15272-1⟩
Article dans une revue hal-01796116v2

Crumbs, Moesin and Yurt regulate junctional stability and dynamics for a proper morphogenesis of the Drosophila pupal wing epithelium

Pauline Salis , Francois Payre , Philippe Valenti , Elsa Bazellieres , André Le Bivic
Scientific Reports, 2017, 7 (1), ⟨10.1038/s41598-017-15272-1⟩
Article dans une revue hal-03064499v1

Effective viscosity and dynamics of spreading epithelia: a solvable model

C. Blanch-Mercader , R. Vincent , Elsa Bazellières , X. Serra-Picamal , X. Trepat
Soft Matter, 2017, 13 (6), pp.1235-1243. ⟨10.1039/c6sm02188c⟩
Article dans une revue hal-02406558v1

Hook2, a microtubule-binding protein, interacts with Par6α and controls centrosome orientation during polarized cell migration

E. Pallesi-Pocachard , E. Bazellieres , A. Viallat-Lieutaud , M.H. Delgrossi , M. Barthelemy-Requin
Scientific Reports, 2016, 6, pp.33259. ⟨10.1038/srep33259⟩
Article dans une revue hal-01445270v1

P-cadherin-mediated Rho GTPase regulation during collective cell migration

Cédric Plutoni , Elsa Bazellieres , Cécile Gauthier-Rouvière
Small GTPases, 2016, 7 (3), pp.156-163. ⟨10.1080/21541248.2016.1173772⟩
Article dans une revue hal-03064437v1

P-cadherin-mediated Rho GTPase regulation during collective cell migration

Cédric Plutoni , Elsa Bazellières , Cécile Gauthier-Rouvière
Small GTPases, 2016, 7 (3), pp.156--163. ⟨10.1080/21541248.2016.1173772⟩
Article dans une revue hal-01878043v1

P-cadherin promotes collective cell migration via a Cdc42-mediated increase in mechanical forces

Cédric Plutoni , Elsa Bazellieres , Maïlys Le Borgne-Rochet , Franck Comunale , Agusti Brugues
Journal of Cell Biology, 2016, 212 (2), pp.199-217. ⟨10.1083/jcb.201505105⟩
Article dans une revue hal-03064445v1

Hook2, a microtubule-binding protein, interacts with Par6α and controls centrosome orientation during polarized cell migration

Emilie Pallesi-Pocachard , Elsa Bazellieres , Annelise Viallat-Lieutaud , Marie-Hélène Delgrossi , Magali Barthelemy-Requin
Scientific Reports, 2016, 6 (1), ⟨10.1038/srep33259⟩
Article dans une revue hal-03064449v1
Image document

P-cadherin promotes collective cell migration via a Cdc42-mediated increase in mechanical forces

Cédric Plutoni , Elsa Bazellieres , Maïlys Le Borgne-Rochet , Franck Comunale , Agusti Brugues
Journal of Cell Biology, 2016, 212 (2), pp.199--217. ⟨10.1083/jcb.201505105⟩
Article dans une revue hal-01878038v1

Traction Forces of Endothelial Cells under Slow Shear Flow

Cecile m. Perrault , Agusti Brugues , Elsa Bazellières , Pierre Ricco , Damien Lacroix
Biophysical Journal, 2015, 109 (8), pp.1533-1536. ⟨10.1016/j.bpj.2015.08.036⟩
Article dans une revue hal-02406574v1

TRPV4 participates in the establishment of trailing adhesions and directional persistence of migrating cells

Sanela Mrkonjić , Anna Garcia-Elias , Carlos Pardo-Pastor , Elsa Bazellières , Xavier Trepat
Pflügers Archiv European Journal of Physiology, 2015, 467 (10), pp.2107-2119. ⟨10.1007/s00424-014-1679-8⟩
Article dans une revue hal-02406582v1

Active Tensile Modulus of an Epithelial Monolayer

Romaric Vincent , Elsa Bazellières , Carlos Pérez-González , Marina Uroz , Xavier Serra-Picamal
Physical Review Letters, 2015, 115 (24), ⟨10.1103/PhysRevLett.115.248103⟩
Article dans une revue hal-02406565v1

Control of cell–cell forces and collective cell dynamics by the intercellular adhesome

Elsa Bazellières , Vito Conte , Alberto Elosegui-Artola , Xavier Serra-Picamal , María Bintanel-Morcillo
Nature Cell Biology, 2015, 17 (4), pp.409-420. ⟨10.1038/ncb3135⟩
Article dans une revue hal-02406578v1

Drebrin E depletion in human intestinal epithelial cells mimics Rab8a loss of function

B. Vacca , E. Bazellieres , R. Nouar , A. Harada , D. Massey-Harroche
Human Molecular Genetics, 2014, 23 (11), pp.2834-46. ⟨10.1093/hmg/ddt670⟩
Article dans une revue hal-01134798v1

Rigidity sensing and adaptation through regulation of integrin types

Alberto Elosegui-Artola , Elsa Bazellières , Michael Allen , Ion Andreu , Roger Oria
Nature Materials, 2014, 13 (6), pp.631-637. ⟨10.1038/nmat3960⟩
Article dans une revue hal-02406591v1

Drebrin E depletion in human intestinal epithelial cells mimics Rab8a loss of function

Barbara Vacca , Elsa Bazellieres , Roqiya Nouar , Akihiro Harada , Dominique Massey-Harroche
Human Molecular Genetics, 2014, 23 (11), pp.2834-2846. ⟨10.1093/hmg/ddt670⟩
Article dans une revue hal-03064457v1

Apico-basal elongation requires a drebrin-E-EB3 complex in columnar human epithelial cells.

Elsa Bazellières , Dominique Massey-Harroche , Magali Barthélémy-Requin , Fabrice Richard , Jean-Pierre Arsanto
Journal of Cell Science, 2012, 125 (Pt 4), pp.919-31. ⟨10.1242/jcs.092676⟩
Article dans une revue hal-00843390v1

Mechanical waves during tissue expansion

Xavier Serra-Picamal , Vito Conte , Romaric Vincent , Ester Anon , Dhananjay Tambe
Nature Physics, 2012, 8 (8), pp.628-634. ⟨10.1038/nphys2355⟩
Article dans une revue hal-03064520v1

Crumbs proteins in epithelial morphogenesis

E. Bazellières , E. Assemat , J.P. Arsanto , A. Le Bivic , D. Massey-Harroche
Frontiers in bioscience : a journal and virtual library, 2009, 14, pp.2149-69
Article dans une revue hal-00428878v1

Crumbs proteins in epithelial morphogenesis

Elsa Bazellieres
Frontiers in Bioscience, 2009, Volume (14), pp.2149. ⟨10.2741/3368⟩
Article dans une revue hal-03064476v1

Polarity complex proteins

Emeline Assémat , Emilie Pallesi-Pocachard , André Le Bivic , Dominique Massey-Harroche , Romaric Vincent
Biochimica et Biophysica Acta:Biomembranes, 2008, 1778 (3), pp.614-630. ⟨10.1016/j.bbamem.2007.08.029⟩
Article dans une revue hal-03064016v1

Polarity complex proteins

E. Assemat , E. Bazellieres , E. Pallesi-Pocachard , A. Le Bivic , D. Massey-Harroche
Biochimica et Biophysica Acta:Biomembranes, 2008, 1778, pp.614-630
Article dans une revue hal-00306189v1
Image document

Mechanoregulation of PDZ Proteins, An Emerging Function

Elsa Bazellières , André Le Bivic
Mechanoregulation of PDZ Proteins, An Emerging Function, pp.257 - 275, 2021, ⟨10.1007/978-1-0716-1166-1_15⟩
Chapitre d'ouvrage hal-03557734v1