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CV E. DUPREZ


Estelle DUPREZ
estelle.duprez@inserm.fr
French nationality

2 children

 

POSITION:

Directeur de Recherche, deuxième classe, DR2 CNRS

Team leader of the Team: Epigenetic factors in normal and malignant hematopoiesis, CRCM, IPC, U-1068 INSERM, UMR 7258 CNRS, Aix Marseille University.

EDUCATION:
1990- Maîtrise de Biochimie. Paris VI. Mention assez bien
1991- D.E.A. d'Endocrinologie et interactions cellulaires. Paris XI. Mention bien.

1995- Doctorat de l'université PARIS XI. Mention très honorable avec félicitations du jury
2008-HDR de Aix-Marseille Université


ACADEMIC APPOINTMENTS:
1992-1995 PhD fellow, Unité INSERM U-301 Hôpital St Louis, PARIS.
Financial support: Bourse MRT, Bourse ARC.
1996-1997 Postdoctoral fellow  Paul Freemont Lab Imperial Cancer Research Fund, London
Financial support: Bourse individuelle "Capital Humain et Mobilité" de la CE.

1998-Chargé de recherche (CR2) CNRS. INSERM U-496, Hopital Saint-Louis, Paris.
1999-2002-Détachement, Division of Hematology/ Oncology Harvard Institute of Medicine, Boston, USA, Dan Tenen Lab.

2003-2009-Chargé de recherche (CR1) Mickael Sieweke lab. Centre d’Immunologie de Marseille Luminy.

2010-2011- Chargé de recherche (CR1) CRCM IPC, U-1068 INSERM, UMR 7258 CNRS, Marseille.

2012-Now- Directeur de recherche (DR2) Group leader: Epigenetic factors in normal and malignant hematopoiesis. CRCM IPC, U-1068 INSERM, UMR 7258 CNRS, Marseille

 

SCIENTIFIC PRODUCTION:

52 Publications, 37 articles  > 2100 citations, h index=22,

1 patent, WO2015169906-A1, 1 patent in preparation

 

Expertise/consulting, grant evaluation:

Expert for Leukaemia & Lymphoma Research Foundation LRF, England (2010-13), Cancéropôle Grandouest (2011), Celgene Corporation (2011), European Hematology Association (EHA) (2012-13; 2015), INSERM Contrat Interface Hospitalier (2012-13-2015), Scientific committee of LLC IDF (2013-16), Association Laurette Fugain (2014- ), Fondation de France (2016- ), Fondation Recherche Médical (2018-2021). Member of SFH. Member of the CHO organisation (2014-2017 ; treasurer 2016-17).

Reviewer for : Journal of Experimental Medicine, PLoS Genetics, Cancer Research, Leukemia, Blood.

 

TEACHING/MENTORING:

Master Development & Immunity (3 days/year)  and Master Human Pathology (2 day/year) Aix-Marseille-University.

Member of M2 jury  (2012; 2013; 2016 ;2019). Since 2008, Member of 9 PhD thesis/HDR jury.

Mentor of 16 M1/M2 students, 2 Post-docs, Director of 7 PhD students, « Tuteur » of 2 PhD,

 

Invited conferences:

-EHA, Stokholm, 2013, Epigenetic profiling in AML

-HEMID, Milan, Juin 2012, Polycomb Repressive Complexes in hematopoiesis

-17ème congrès de CHO, Les Embiez, Septembre 2011

 -International Florence Meeting in Hematology, Florence, 2010

-EHA, Berlin, Juin 2009, PRC in APL

 

 

SELECTED PUBLICATIONS :

Zidi, B., Vincent-FabertC.,  Pouyet, L., Seillier, M., Vandevelde, A., N’guessan, P., Guittard, G., Mancini, S., Duprez, E*., Carrier, A*. TP53INP1 deficiency maintains murine B lymphopoiesis in aged bone marrow through redox controlled IL-7R/STAT5 signaling.(PNAS, in press). * Co-last and corresponding authorsKoubi, M., Poplineau M., Vernerey, J., N’Guyen L., El-Kaoutari, A., Garciaz, S., Tiberi, G., Maqbool MA, Andrau JC, Guillouf C., Saurin, A., Duprez E. Regulation of the positive transcriptional effect of PLZF through a non-canonical EZH2 activity. Nucleic Acids Res doi: 10.1093/nar/gky080. (2018) PMID: 29425303Vincent-FabertC, PlatetN., Vandevelde, A., Poplineau M., Koubi, M., Finetti., P, Tiberi, G., Imbert, AM., Bertucci, F., Duprez, E. PLZF mutation alters mouse hematopoietic stem cell function and cell cycle progression 14;127:1881-5, Blood (2016).Kuhnl A, Valk PJ, Sanders MA, Ivey A, Hills RK, Mills KI, Gale RE, Kaiser MF, Dillon R, Joannides M, Gilkes A, Haferlach T, Schnittger S, Duprez E, Linch DC, Delwel R, Lowenberg B, Baldus CD, Solomon E, Burnett AK et al. Downregulation of the Wnt inhibitor CXXC5 predicts a better prognosis in acute myeloid leukemia. Blood 125: 2985-94 (2015).Navarro, JM, Touzard, A, Pradel, L, Loosveld, M, Koubi, M, Fenouil, R, Le Noir, S, Ahmad Maqboo, M, Morgado, E,, Gregoire, C, Jaeger, S, Mamessier, E, Pignon, C, Hacein-Bey, S, Malissen, B Gut,M Gut,I, Dombret, H, Macintyre, E, Howes, S, Thrasher, A, Ifrah, N, Payet-Bornet, D, Duprez, E*, Andrau, JC*, Asnafi, V*, and Nadel,B*. Site-& allele-specific de-silencing of polycomb repressive activity by insertional oncogenesis: a new recurrent mechanism of TAL1 activation in T-ALL. Nat Commun, 23;6: 6094 (2015). * Equal contribution.Tiberi, G, Pekowska, A, Oudin, C, Ivey, A, Prebet, T, Koubi, M, Lembo, F, Mozziconacci, MJ, Bidaut, G, Autret, A, Chabannon, C, Grimwade, D, Vey, N, Spicuglia, S, Calmels, B, Duprez, E. PcG methylation of the HIST1 cluster defines an epigenetic marker of Acute Myeloid Leukemia. Leukemia,  Dec 8. doi: 10.1038/leu.2014.339 (2015).Sarrazin S, Mossadegh-Keller, N Fukao T, Mossadegh-Keller, N, Aziz, A, Mourcin, F, Vanhille L, Kelly-Modis L, Kastern P, Chan S, Duprez E, Otto C, Sieweke M. MafB restricts m-CSF dependent Myeloid committment divsions of hematopoietic stem cells. Cell, 138: 300-13 (2009).Boukarabila H, Saurin A, Batsché E, Mossadegh N, VanLohuizen M, Otte A, Pradel J, Muchardt C, Sieweke M, Duprez E. The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation. Genes Dev, 23: 1195-1206 (2009).



Journal articles15 documents

  • Estelle Duprez, Mathilde Poplineau. Mining old transcriptomes to predict HSC age. Blood, American Society of Hematology, 2021, 138 (6), pp.422-423. ⟨10.1182/blood.2021012002⟩. ⟨hal-03436319⟩
  • Léonard Hérault, Mathilde Poplineau, Adrien Mazuel, Nadine Platet, Elisabeth Remy, et al.. Single-cell RNA-seq reveals a concomitant delay in differentiation and cell cycle of aged hematopoietic stem cell. BMC Biology, BioMed Central, 2021, ⟨10.1186/s12915-021-00955-z⟩. ⟨hal-03045386⟩
  • Marielle Balzano, Maria de Grandis, Thien-Phong Vu Manh, Lionel Chasson, Florence Bardin, et al.. Nidogen-1 Contributes to the Interaction Network Involved in Pro-B Cell Retention in the Peri-sinusoidal Hematopoietic Stem Cell Niche. Cell Reports, Elsevier Inc, 2019, 26 (12), pp.3257-3271.e8. ⟨10.1016/j.celrep.2019.02.065⟩. ⟨hal-02504005⟩
  • Bochra Zidi, Christelle Vincent-Fabert, Laurent Pouyet, Marion Seillier, Amelle Vandevelde, et al.. TP53INP1 deficiency maintains murine B lymphopoiesis in aged bone marrow through redox-controlled IL-7R/STAT5 signaling. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2019, 116 (1), pp.211-216. ⟨10.1073/pnas.1809980116⟩. ⟨hal-02145737⟩
  • Sylvain Garciaz, Lia N’guyen Dasi, Pascal Finetti, Christine Chevalier, Julien Vernerey, et al.. Epigenetic down-regulation of the HIST1 locus predicts better prognosis in acute myeloid leukemia with NPM1 mutation. Clinical Epigenetics, BioMed Central, 2019, 11 (1), ⟨10.1186/s13148-019-0738-6⟩. ⟨hal-02322283⟩
  • Mathilde Poplineau, Julien Vernerey, Nadine Platet, Lia N'Guyen, Léonard Hérault, et al.. PLZF limits enhancer activity during hematopoietic progenitor aging. Nucleic Acids Research, Oxford University Press, 2019, 47 (9), pp.4509-4520. ⟨10.1093/nar/gkz174⟩. ⟨hal-02145730⟩
  • Mathilde Poplineau, Julien Vernerey, Nadine Platet, Lia N’guyen, Léonard Hérault, et al.. PLZF limits enhancer activity during hematopoietic progenitor aging. Nucleic Acids Research, Oxford University Press, 2019, 47, pp.4509 - 4520. ⟨10.1093/nar/gkz174⟩. ⟨hal-03411442⟩
  • Myriam Koubi, Mathilde Poplineau, Julien Vernerey, Lia N 'Guyen, Guillaume Tiberi, et al.. Regulation of the positive transcriptional effect of PLZF through a non-canonical EZH2 activity. Nucleic Acids Research, Oxford University Press, In press, 46 (7), pp.3339-3350. ⟨10.1093/nar/gky080⟩. ⟨hal-01765664⟩
  • Myriam Koubi, Christian Chabannon, Estelle Duprez. Au cœur d’une complexité biologique EZH2, une protéine du groupe Polycomb.. médecine/sciences, EDP Sciences, 2017, 33 (5), pp.499 - 505. ⟨10.1051/medsci/20173305013⟩. ⟨hal-01787246⟩
  • Jean-Marc Navarro, Aurore Touzart, Lydie Pradel, Marie Loosveld, Myriam Koubi, et al.. Site- and allele-specific polycomb dysregulation in T-cell leukaemia. Nature Communications, Nature Publishing Group, 2015, 6 (1), ⟨10.1038/ncomms7094⟩. ⟨hal-01765422⟩
  • Diana Ordoñez-Rueda, Friederike Jönsson, David Mancardi, Weidong Zhao, Aurélie Malzac, et al.. A hypomorphic mutation in the Gfi1 transcriptional repressor results in a novel form of neutropenia. European Journal of Immunology, Wiley-VCH Verlag, 2012, 42 (9), pp.2395-2408. ⟨10.1002/eji.201242589⟩. ⟨pasteur-02518924⟩
  • Salvatore Spicuglia, Christelle Vincent-Fabert, Touati Benoukraf, Guillaume Tibéri, Andrew J Saurin, et al.. Characterisation of Genome-Wide PLZF/RARA Target Genes. PLoS ONE, Public Library of Science, 2011, 6 (9), pp.e24176. ⟨10.1371/journal.pone.0024176⟩. ⟨hal-00674513⟩
  • Sandrine Sarrazin, Noushine Mossadegh-Keller, Taro Fukao, Athar Aziz, Frederic Mourcin, et al.. MafB restricts M-CSF-dependent myeloid commitment divisions of hematopoietic stem cells.. Cell, Elsevier, 2009, 138 (2), pp.300-13. ⟨10.1016/j.cell.2009.04.057⟩. ⟨inserm-00420157⟩
  • Hanane Boukarabila, Andrew J Saurin, Eric Batsché, Noushine Mossadegh, Maarten van Lohuizen, et al.. The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation.. Genes and Development, Cold Spring Harbor Laboratory Press, 2009, 23 (10), pp.1195-206. ⟨10.1101/gad.512009⟩. ⟨hal-00408483⟩
  • Hiromi Iwasaki, Chamorro Somoza, Hirokazu Shigematsu, Estelle A Duprez, Junko Iwasaki-Arai, et al.. Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation.. Blood, American Society of Hematology, 2005, 106 (5), pp.1590-600. ⟨10.1182/blood-2005-03-0860⟩. ⟨hal-00187635⟩

Conference papers2 documents

  • Léonard Hérault, Mathilde Poplineau, Adrien Mazuel, Nadine Platet, Élisabeth Remy, et al.. 3014 – ORAL PRESENTATION: SINGLE-CELL RNA-SEQ REVEALS A CONCOMITANT DELAY IN DIFFERENTIATION AND CELL CYCLE OF AGED HEMATOPOIETIC STEM CELL. ISEH, Aug 2020, New york, United States. pp.S42, ⟨10.1016/j.exphem.2020.09.035⟩. ⟨hal-03436489⟩
  • Mathilde Poplineau, Nadine Platet, Lia N'Guyen, Shuhei Koide, Julien Vernerey, et al.. New Insights into PLZF/Rara Mechanism during APL Onset: EZH2 on the Road. 61st Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Oct 2019, Orlando, United States. pp.3761-3761, ⟨10.1182/blood-2019-125509⟩. ⟨hal-03436495⟩