DF
Dimitri Fayolle
7
Documents
Affiliations actuelles
- 1089283
Identifiants chercheurs
- dimitri-fayolle
- 0000-0002-1543-136X
Présentation
Dr Dimitri Fayolle is a physical chemist applying analytical tools to drug discovery, mostly through the determination of druggability parameters. He is a Research Engineer and the principal scientist of the Drug Innovation and Design platform (DruiD) at the CERMN laboratory (University of Caen, FR).
After a BSc in physical chemistry (2015, Montpellier, FR) and a MSc in organic synthesis (2017, Lyon, FR), he defended in 2020 a PhD thesis in bioorganic chemistry under the supervision of Prof. Peter Strazewski in Lyon, FR, studying the formation of complex mixtures of small amphiphilic biomolecules under conditions mimicking the origins of life, and the anchoring of such molecules to cell-like membranes. A large part of this research revolved around LC/MS and liquid-state NMR.
He was then recruited in early 2022 as a postdoctoral researcher in magnetic resonance at the University of Caen, developing new technologies for 129Xe magnetic resonance imaging in preclinical research, before becoming a permanent Research Engineer at the CERMN laboratory of the University of Caen in 2023. He is now in charge of the newly-founded Drug Innovation and Design platform of the lab. The platform offers its expertise in medicinal chemistry, biological activity screeining (enzymology, receptor binding...), drugability profiling (solubility, lipophilicity, permeation) and galenics, and is open to collaboration with academics and pharmaceutical companies. Dr Fayolle's research currently focuses on the determination of the lipophilicity of drugs, including emergent classes such as macromolecules.
Domaines de recherche
Chimie analytique
Chimie organique
Chimie thérapeutique
Médicaments
Compétences
Druggability
HPLC
NMR
ITC
Mass spectrometry