CV Accueil - Archive ouverte HAL

	Overcoming the Challenges Imposed by Humoral Immunity to AAV Vectors to Achieve Safe and Efficient Gene Transfer in Seropositive Patients David-Alexandre Gross , Novella Tedesco , Christian Leborgne , Giuseppe Ronzitti Frontiers in Immunology, 2022, 13, ⟨10.3389/fimmu.2022.857276⟩ Article dans une revue hal-03640310v1
	Neuropilin-1 cooperates with PD-1 in CD8+ T cells predicting outcomes in melanoma patients treated with anti-PD1 Julien Rossignol , Zakia Belaid , Guillemette Fouquet , Flavia Guillem , Rachel Rignault iScience, 2022, 25 (6), pp.104353. ⟨10.1016/j.isci.2022.104353⟩ Article dans une revue hal-03842485v1
	Hepatic expression of GAA results in enhanced enzyme bioavailability in mice and non-human primates Helena Costa-Verdera , Fanny Collaud , Christopher Riling , Pauline Sellier , Jayme Nordin Nature Communications, 2021, 12 (1), pp.6393. ⟨10.1038/s41467-021-26744-4⟩ Article dans une revue hal-04324265v1
	Hepatic expression of GAA results in enhanced enzyme bioavailability in mice and non-human primates Helena Costa-Verdera , Fanny Collaud , Christopher R Riling , Pauline Sellier , Jayme M L Nordin Nature Communications, 2021, 12 (1), pp.6393. ⟨10.1038/s41467-021-26744-4⟩ Article dans une revue hal-03449262v1
	A combination of cyclophosphamide and interleukin-2 allows CD4 1 T cells converted to Tregs to control scurfy syndrome Marianne Delville , Florence Bellier , Juliette Leon , Roman Klifa , Sabrina Lizot Blood, 2021, 137 (17), pp.2326-2336. ⟨10.1182/blood.2020009187⟩ Article dans une revue hal-04416555v1
	A combination of cyclophosphamide and interleukin-2 allows CD4+ T cells converted to Tregs to control scurfy syndrome Marianne Delville , Florence Bellier , Juliette Leon , Roman Klifa , Sabrina Lizot Blood, 2021, 137 (17), pp.2326-2336. ⟨10.1182/blood.2020009187⟩ Article dans une revue hal-03588460v1
	A combination of cyclophosphamide and interleukin-2 allows CD4 1 T cells converted to Tregs to control scurfy syndrome Marianne Delville , Florence Bellier , Juliette Leon , Roman Klifa , Sabrina Lizot Blood, 2021, 137 (17), pp.2326-2336. ⟨10.1182/blood.2020009187⟩ Article dans une revue hal-04417449v1
	Human Immune Responses to Adeno-Associated Virus (AAV) Vectors Giuseppe Ronzitti , David-Alexandre Gross , Federico Mingozzi Frontiers in Immunology, 2020, 11, ⟨10.3389/fimmu.2020.00670⟩ Article dans une revue hal-04363711v1
	IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses Irini Evnouchidou , Pascal Chappert , Samira Benadda , Andrés Ernesto Zucchetti , Mirjana Weimershaus Nature Communications, 2020, 11 (1), pp.2779. ⟨10.1038/s41467-020-16471-7⟩ Article dans une revue hal-02867476v1
	Of rAAV and Men: From Genetic Neuromuscular Disorder Efficacy and Toxicity Preclinical Studies to Clinical Trials and Back Laurine Buscara , David-Alexandre Gross , Nathalie Daniele Journal of Personalized Medicine, 2020, 10 (4), pp.258. ⟨10.3390/jpm10040258⟩ Article dans une revue hal-04363708v1
	Dual muscle-liver transduction imposes immune tolerance for muscle transgene engraftment despite preexisting immunity Laurent Bartolo , Stéphanie Li Chung Tong , Pascal Chappert , Dominique Urbain , Fanny Collaud JCI Insight, 2019, 4 (11), ⟨10.1172/jci.insight.127008⟩ Article dans une revue hal-04324422v1
	Cross-Presentation of Skin-Targeted Recombinant Adenoassociated Virus 2/1 Transgene Induces Potent Resident Memory CD8 ؉ T Cell Responses David-Alexandre Gross , Alexandre Ghenassia , Laurent Bartolo , Dominique Urbain , Sofia Benkhelifa-Ziyyat Journal of Virology, 2019, 93 (5), pp.e01334-18. ⟨10.1128/JVI.01334-18⟩ Article dans une revue hal-03827009v1
	Foxp3+ Regulatory and Conventional CD4+ T Cells Display Similarly High Frequencies of Alloantigen-Reactive Cells Mélanie Lalfer , Pascal Chappert , Maxime Carpentier , Dominique Urbain , Jean Davoust Frontiers in Immunology, 2019, 10, ⟨10.3389/fimmu.2019.00521⟩ Article dans une revue hal-02392758v1
	Dual muscle-liver transduction imposes immune tolerance for muscle transgene engraftment despite preexisting immunity Laurent Bartolo , Stéphanie Li Chung Tong , Pascal Chappert , Dominique Urbain , Fanny Collaud JCI Insight, 2019, 4 (11), pii: 127008. ⟨10.1172/jci.insight.127008⟩ Article dans une revue hal-02332827v1
	Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node Ruby Alonso , Héloïse Flament , Sébastien Lemoine , Christine Sedlik , Emanuel Bottasso Nature Communications, 2018, 9, pp.2113. ⟨10.1038/s41467-018-04524-x⟩ Article dans une revue hal-01976612v1
	Intradermal Immunization with rAAV1 Vector Induces Robust Memory CD8+ T Cell Responses Independently of Transgene Expression in DCs Alexandre Ghenassia , David-Alexandre Gross , Stéphanie Lorain , Fabiola Tros , Dominique Urbain Molecular Therapy, 2017, 25 (10), pp.2309-2322. ⟨10.1016/j.ymthe.2017.06.019⟩ Article dans une revue hal-03846034v1
	Triggering the TCR Developmental Checkpoint Activates a Therapeutically Targetable Tumor Suppressive Pathway in T-cell Leukemia Amélie Trinquand , Nuno R. Dos Santos , Christine Tran Quang , Francesca Rocchetti , Benedetta Zaniboni Cancer Discovery, 2016, 6 (9), pp.972-985. ⟨10.1158/2159-8290.CD-15-0675⟩ Article dans une revue hal-01460133v1
	Intrinsic Transgene Immunogenicity Gears CD8+ T-cell Priming After rAAV-Mediated Muscle Gene Transfer Maxime Carpentier , Stéphanie Lorain , Pascal Chappert , Mélanie Lalfer , Romain Hardet Molecular Therapy, 2015, 23 (4), pp.697-706. ⟨10.1038/mt.2014.235⟩ Article dans une revue hal-02407918v1
	Extrathymic induction of Foxp3⁺ regulatory T cells declines with age in a T-cell intrinsic manner. Maxime Carpentier , Pascal Chappert , Chantal Kuhn , Mélanie Lalfer , Héloïse Flament European Journal of Immunology, 2013, 43 (10), pp.2598-604. ⟨10.1002/eji.201343532⟩ Article dans une revue pasteur-00912507v1
	Prolonged Gene Expression in Muscle Is Achieved Without Active Immune Tolerance Using MicrorRNA 142.3p-Regulated rAAV Gene Transfer Florence Boisgérault , David-Alexandre Gross , Maxime Ferrand , Jérôme Poupiot , Sylvie Darocha Human Gene Therapy, 2013, 24 (4), pp.393-405. ⟨10.1089/hum.2012.208⟩ Article dans une revue hal-02338036v1
	Induction of multiple CD8+ T cell responses against the inducible Hsp70 employing an Hsp70 oligoepitope peptide. Olivier Faure , Stéphanie Graff-Dubois , Pedro M S Alves , Sébastien Cornet , Marie-Thérèse Duffour Oncology Reports, 2007, 17 (3), pp.679-85. ⟨10.3892/or.17.3.679⟩ Article dans une revue pasteur-00166658v1
	Foxp3+ CD25+ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage Julie Cabarrocas , Cécile Cassan , Fay Magnusson , Eliane Piaggio , Lennart T. Mars Proceedings of the National Academy of Sciences of the United States of America, 2006, 103 (22), pp.8453-8458. ⟨10.1073/pnas.0603086103⟩ Article dans une revue hal-03095902v1
	A lentiviral vector encoding the human Wiskott–Aldrich syndrome protein corrects immune and cytoskeletal defects in WASP knockout mice S Charrier , D Stockholm , K Seye , P Opolon , M Taveau Gene Therapy, 2005, 12 (7), pp.597-606. ⟨10.1038/sj.gt.3302440⟩ Article dans une revue hal-03765538v1
	Anchoring cytokines to tumor cells for the preparation of anticancer vaccines without gene transfection in mice. Philippe Nizard , David-Alexandre Gross , Aurélie Babon , Alexandre Chenal , Bruno Beaumelle Journal of Immunotherapy, 2003, 26 (1), pp.63-71. ⟨10.1097/00002371-200301000-00007⟩ Article dans une revue hal-02998464v1

David Alexandre Gross

Présentation

Publications

Overcoming the Challenges Imposed by Humoral Immunity to AAV Vectors to Achieve Safe and Efficient Gene Transfer in Seropositive Patients

Neuropilin-1 cooperates with PD-1 in CD8+ T cells predicting outcomes in melanoma patients treated with anti-PD1

Hepatic expression of GAA results in enhanced enzyme bioavailability in mice and non-human primates

Hepatic expression of GAA results in enhanced enzyme bioavailability in mice and non-human primates

A combination of cyclophosphamide and interleukin-2 allows CD4 1 T cells converted to Tregs to control scurfy syndrome

A combination of cyclophosphamide and interleukin-2 allows CD4+ T cells converted to Tregs to control scurfy syndrome

A combination of cyclophosphamide and interleukin-2 allows CD4 1 T cells converted to Tregs to control scurfy syndrome

Human Immune Responses to Adeno-Associated Virus (AAV) Vectors

IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses

Of rAAV and Men: From Genetic Neuromuscular Disorder Efficacy and Toxicity Preclinical Studies to Clinical Trials and Back

Dual muscle-liver transduction imposes immune tolerance for muscle transgene engraftment despite preexisting immunity

Cross-Presentation of Skin-Targeted Recombinant Adenoassociated Virus 2/1 Transgene Induces Potent Resident Memory CD8 ؉ T Cell Responses

Foxp3+ Regulatory and Conventional CD4+ T Cells Display Similarly High Frequencies of Alloantigen-Reactive Cells

Dual muscle-liver transduction imposes immune tolerance for muscle transgene engraftment despite preexisting immunity

Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node

Intradermal Immunization with rAAV1 Vector Induces Robust Memory CD8+ T Cell Responses Independently of Transgene Expression in DCs

Triggering the TCR Developmental Checkpoint Activates a Therapeutically Targetable Tumor Suppressive Pathway in T-cell Leukemia

Intrinsic Transgene Immunogenicity Gears CD8+ T-cell Priming After rAAV-Mediated Muscle Gene Transfer

Extrathymic induction of Foxp3⁺ regulatory T cells declines with age in a T-cell intrinsic manner.

Prolonged Gene Expression in Muscle Is Achieved Without Active Immune Tolerance Using MicrorRNA 142.3p-Regulated rAAV Gene Transfer

Induction of multiple CD8+ T cell responses against the inducible Hsp70 employing an Hsp70 oligoepitope peptide.

Foxp3+ CD25+ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage

A lentiviral vector encoding the human Wiskott–Aldrich syndrome protein corrects immune and cytoskeletal defects in WASP knockout mice

Anchoring cytokines to tumor cells for the preparation of anticancer vaccines without gene transfection in mice.