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Molecular Design in Practice: A Review of Selected Projects in a French Research Institute That Illustrates the Link between Chemical Biology and Medicinal Chemistry

Benoit Deprez , Damien Bosc , Julie Charton , Cyril Couturier , Rebecca Deprez-Poulain , et al.
Molecules, 2021, 26 (19), pp.6083. ⟨10.3390/molecules26196083⟩
Article dans une revue hal-04465890v1
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Comparative Study of the Synthesis and Structural and Physicochemical Properties of Diketopiperazines vs Aza-diketopiperazines

Pierre Regenass , Damien Bosc , Stéphanie Riché , Patrick Gizzi , Marcel Hibert , et al.
Journal of Organic Chemistry, 2017, 82 (6), pp.3239-3244. ⟨10.1021/acs.joc.6b02895⟩
Article dans une revue hal-03563479v1

Highly improved antiparasitic activity after introduction of an N-benzylimidazole moiety on protein farnesyltransferase inhibitors

Damien Bosc , Elisabeth Mouray , Sandrine Cojean , Caio Haddad Franco , Philippe M Loiseau , et al.
European Journal of Medicinal Chemistry, 2016, 109, pp.173-186
Article dans une revue mnhn-02047327v1
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Three essays on modeling the dependence between financial assets

Damien Bosc
Computational Finance [q-fin.CP]. Ecole Polytechnique X, 2012. English. ⟨NNT : ⟩
Thèse pastel-00721674v1

New protein farnesyltransferase inhibitors in the 3-arylthiophene 2-carboxylic acid series: diversification of the aryl moiety by solid-phase synthesis.

Sébastien Lethu , Damien Bosc , Elisabeth Mouray , Philippe Grellier , Joëlle Dubois
Journal of Enzyme Inhibition and Medicinal Chemistry, 2013, 28 (1), pp.163-71. ⟨10.3109/14756366.2011.643302⟩
Article dans une revue hal-00798409v1

Introduction of methionine mimics on 3-arylthiophene: influence on protein farnesyltransferase inhibition and on antiparasitic activity

D. Bosc , E. Mouray , P. Grellier , S. Cojean , P. M. Loiseau , et al.
Med. Chem. Commun, 2013, 4, pp.1034-1041. ⟨10.1039/C3MD00065F⟩
Article dans une revue hal-00857426v1
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Identification of indole-based activators of insulin degrading enzyme

Nicolas Kraupner , Chau Phi Dinh , Xiaoan Wen , Valérie Landry , Adrien Herledan , et al.
European Journal of Medicinal Chemistry, 2021, pp.113982. ⟨10.1016/j.ejmech.2021.113982⟩
Article dans une revue hal-03430475v1
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Kinetic Target-Guided Synthesis: Reaching the Age of Maturity

Damien Bosc , Virgyl Camberlein , Ronan Gealageas , Omar Castillo-Aguilera , Benoit Deprez , et al.
Journal of Medicinal Chemistry, 2019, 63 (8), pp.3817-3833. ⟨10.1021/acs.jmedchem.9b01183⟩
Article dans une revue hal-03051818v1
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Modulators of hERAP2 discovered by High-Throughput Screening

Laura Medve , Ronan Gealageas , Vy Lam Bao , Valentin Guillaume , Omar Castillo-Aguilera , et al.
European Journal of Medicinal Chemistry, 2020, 211, pp.113053. ⟨10.1016/j.ejmech.2020.113053⟩
Article dans une revue hal-03059990v1
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Controlling Plasma Stability of Hydroxamic Acids: A MedChem Toolbox

Paul Hermant , Damien Bosc , Catherine Piveteau , Ronan Gealageas , Baovy Lam , et al.
Journal of Medicinal Chemistry, 2017, 60 (21), pp.9067-9089. ⟨10.1021/acs.jmedchem.7b01444⟩
Article dans une revue hal-03054238v1
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A new quinoline-based chemical probe inhibits the autophagy-related cysteine protease ATG4B

D. Bosc , L. Vezenkov , S. Bortnik , J. An , J. Xu , et al.
Scientific Reports, 2018, 8 (1), pp.11653. ⟨10.1038/s41598-018-29900-x⟩
Article dans une revue hal-03564786v1

Integrated optical waveguide polarizer on glass with a birefringent polymer overlay

Alain Morand , C. Sanchez-Perez , P. Benech , S. Tedjini , D. Bosc
IEEE Photonics Technology Letters, 1998, 10 (11), pp.1599-1601. ⟨10.1109/68.726762⟩
Article dans une revue hal-01974487v1
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Multi-Component Reaction for the Preparation of 1,5-Disubstituted 1,2,3-Triazoles by In-Situ Generation of Azides and Nickel-Catalyzed Azide-Alkyne Cycloaddition

Virgyl Camberlein , Nicolas Kraupner , Nour Bou Karroum , Emmanuelle Lipka , Rebecca Deprez-Poulain , et al.
Tetrahedron Letters, In press, ⟨10.1016/j.tetlet.2021.153131⟩
Article dans une revue hal-03207833v1

Structure optimization of electro-optic polymer waveguides for low half-wave voltage modulators

H. Mahé , D. Bosc , N. Gayet , F. Odobel , P.A. Bonnardel , et al.
SPIE Photonics Europe 2010, Nonlinear Optics and Applications IV, 2010, Belgium. pp.77281G-1-9, ⟨10.1117/12.853595⟩
Communication dans un congrès hal-00549980v1

Discovery of a new class of protein farnesyltransferase inhibitors in the arylthiophene series.

Sébastien Lethu , Maryon Ginisty , Damien Bosc , Joëlle Dubois
Journal of Medicinal Chemistry, 2009, 52 (20), pp.6205-8. ⟨10.1021/jm901280q⟩
Article dans une revue hal-00424981v1

Comparative Study of the Synthesis and Structural and Physicochemical Properties of Diketopiperazines vs Aza-diketopiperazines

Pierre Regenass , Damien Bosc , Stéphanie Riché , Patrick Gizzi , Marcel Hibert , et al.
Journal of Organic Chemistry, 2017, 82 (6), pp.3239-3244. ⟨10.1021/acs.joc.6b02895⟩
Article dans une revue hal-02366265v1
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Extreme dependence for multivariate data

Damien Bosc , Alfred Galichon
Quantitative Finance, 2014, 14 (7), pp.1187 - 1199. ⟨10.1080/14697688.2014.886777⟩
Article dans une revue hal-03470461v1
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Extreme dependence for multivariate data

Alfred Galichon , Damien Bosc
2010
Pré-publication, Document de travail hal-03588294v1
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Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice

Rebecca Déprez-Poulain , Nathalie Hennuyer , Damien Bosc , Wenguang Liang , Emmanuelle Enée , et al.
Nature Communications, 2015, 6 (8250), ⟨10.1038/ncomms9250⟩
Article dans une revue hal-02511111v1

Improvement of the trypanocidal activity of 3-arylthiophene farnesyltransferase inhibitors by modulation of their 3-aryl group

D. Bosc , S. Lethu , E. Mouray , P. Grellier , Joëlle Dubois
MedChemComm, 2012, 3, pp.1512-1517. ⟨10.1039/c2md20197f⟩
Article dans une revue hal-00763999v1
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Synthèse et évaluation biologique d’hétérocycles à cinq chaînons, inhibiteurs de la protéine farnésyltransférase

Damien Bosc
Autre. Université Paris Sud - Paris XI, 2011. Français. ⟨NNT : 2011PA112200⟩
Thèse tel-00769930v1
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Identification of ebselen as a potent inhibitor of insulin degrading enzyme by a drug repurposing screening

Florence Leroux , Damien Bosc , Terence Beghyn , Paul Hermant , Sandrine Warenghem , et al.
European Journal of Medicinal Chemistry, 2019, 179, pp.557-566. ⟨10.1016/j.ejmech.2019.06.057⟩
Article dans une revue hal-03243182v1