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The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing

Marie Pourcelot , Naima Zemirli , Leandro Silva da Costa , Roxane Loyant , Dominique Garcin , et al.
BMC Biology, 2015, 14 (1), pp.69. ⟨10.1186/s12915-016-0292-z⟩
Article dans une revue inserm-01354365v1
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The eIF2a kinase HRI in innate immunity, proteostasis and mitochondrial stress

Stephen E Girardin , Camille Cuziol , Dana J Philpott , Damien Arnoult
FEBS Journal, In press
Article dans une revue hal-03022202v1
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MAVS ubiquitination by the E3 ligase TRIM25 and degradation by the proteasome is involved in type I Interferon production after activation of the antiviral RIG-I-Like receptors.

Céline Castanier , Naima Zemirli , Alain Portier , Dominique Garcin , Nicolas Bidère , et al.
BMC Biology, 2012, 10 (1), pp.44. ⟨10.1186/1741-7007-10-44⟩
Article dans une revue inserm-00706690v1

The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling

Mena Abdel-Nour , Leticia Carneiro , Jeffrey Downey , Jessica Tsalikis , Ahmed Outlioua , et al.
Science, 2019, 365 (6448), pp.eaaw4144. ⟨10.1126/science.aaw4144⟩
Article dans une revue hal-02372326v1

Melatonin Therapy Modulates Cerebral Metabolism and Enhances Remyelination by Increasing PDK4 in a Mouse Model of Multiple Sclerosis

Majid Ghareghani , Linda Scavo , Yahya Jand , Naser Farhadi , Hossein Sadeghi , et al.
Frontiers in Pharmacology, 2019, 10, ⟨10.3389/fphar.2019.00147⟩
Article dans une revue hal-02372331v1

Mitochondrial protein import stress regulates the LC3 lipidation step of mitophagy through NLRX1 and RRBP1

Samuel Killackey , Yuntian Bi , Fraser Soares , Ikram Hammi , Nathaniel Winsor , et al.
Molecular Cell, 2022, 82 (15), pp.2815-2831.e5. ⟨10.1016/j.molcel.2022.06.004⟩
Article dans une revue hal-04277561v1
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Gastric IL-1β, IL-8, and IL-17A expression in Moroccan patients infected with Helicobacter pylori may be a predictive signature of severe pathological stages

Ahmed Outlioua , Wafaa Badre , Christophe Desterke , Zerif Echarki , Nadira El Hammani , et al.
Cytokines, 2020
Article dans une revue hal-03008966v1
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Cytosolic retention of the mitochondrial protease HtrA2 during mitochondrial protein import stress (MPIS) triggers the DELE1-HRI pathway

Paul Y Bi , Samuel A Killackey , Linus Schweizer , Damien Arnoult , Dana J Philpott , et al.
2023
Pré-publication, Document de travail hal-04304708v1

The eIF2α kinase HRI triggers the autophagic clearance of cytosolic protein aggregates

Damien Arnoult , Tapas Mukherjee , Valeria Ramaglia , Mena Abdel-Nour , Athanasia Bianchi , et al.
Journal of Biological Chemistry, 2021, 296, pp.100050. ⟨10.1074/jbc.RA120.014415⟩
Article dans une revue hal-03430875v1

The eIF2α kinase HRI in innate immunity, proteostasis, and mitochondrial stress

Damien Arnoult , Stephen Girardin , Camille Cuziol , Dana Philpott
FEBS Journal, 2021, 288 (10), pp.3094-3107. ⟨10.1111/febs.15553⟩
Article dans une revue hal-03430878v1
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Chemical targeting of NEET proteins reveals their function in mitochondrial morphodynamics

Diana Molino , Irene Pila‐castellanos , Henri‐baptiste Marjault , Nivea Dias Amoedo , Katja Kopp , et al.
EMBO Reports, 2020, ⟨10.15252/embr.201949019⟩
Article dans une revue hal-03003196v1
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The eIF2α kinase HRI triggers the autophagic clearance of cytosolic protein aggregates

Damien Arnoult , Tapas Mukherjee , Valeria Ramaglia , Mena Abdel-Nour , Athanasia Bianchi , et al.
Journal of Biological Chemistry, 2020, pp.jbc.RA120.014415. ⟨10.1074/jbc.RA120.014415⟩
Article dans une revue hal-03001543v1
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The role of optineurin in antiviral type I interferon production

Ahmed Outlioua , Marie Pourcelot , Damien Arnoult
Frontiers in Immunology, 2018, 9, pp.1-8. ⟨10.3389/fimmu.2018.00853⟩
Article dans une revue hal-02621518v1

RNA viruses promote activation of the NLRP3 inflammasome through cytopathogenic effect-induced potassium efflux

Ahmed Outlioua , Adrienne Anginot , Khadija Akarid , Damien Arnoult
Cell Death and Disease, 2019, 10 (5), ⟨10.1038/s41419-019-1579-0⟩
Article dans une revue hal-02372327v1
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IL-1 Polymorphism and Helicobacter pylori Infection Features: Highlighting VNTR’s Potential in Predicting the Susceptibility to Infection-Associated Disease Development

Hajar El Filaly , Ahmed Outlioua , Christophe Desterke , Zerif Echarki , Wafaa Badre , et al.
Microorganisms, 2023, 11 (2), pp.353. ⟨10.3390/microorganisms11020353⟩
Article dans une revue hal-04304689v1