Cyril Goudet

Documents

Publications

	Optical activation of endogenous metabotropic glutamate receptor 4 (mGlu4) in the amygdala dynamically regulates symptoms associated with persistent inflammatory pain Charleine Zussy , X. Gomez-Santacana , Xavier Rovira , Dimitri de Bundel , S. Ferrazzo 2018, pp.489-489. ⟨10.1038/mp.2018.4⟩ Autre publication scientifique hal-02448333v1

	Optical Control of Adenosine A 2A Receptor Using Istradefylline Photosensitivity Anaëlle Dumazer , Xavier Gómez-Santacana , Fanny Malhaire , Chris Jopling , Damien Maurel ACS Chemical Neuroscience, In press, 15 (3), pp.645-655. ⟨10.1021/acschemneuro.3c00721⟩ Article dans une revue hal-04425630v1
	Photopharmacological manipulation of amygdala metabotropic glutamate receptor mGlu4 alleviates neuropathic pain Vanessa Pereira , Juri Aparicio Arias , Amadeu Llebaria , Cyril Goudet Pharmacological Research, 2023, 187, pp.106602. ⟨10.1016/j.phrs.2022.106602⟩ Article dans une revue hal-03914258v1
	Editorial: Molecular mechanisms of nociception Cyril Goudet , Fabien Marchand Frontiers in Molecular Neuroscience, 2022, 15, pp.1025230. ⟨10.3389/fnmol.2022.1025230⟩ Article dans une revue hal-03805607v1
	Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations Chady Nasrallah , Giuseppe Cannone , Julie Briot , Karine Rottier , Alice Berizzi Cell Reports, 2021, 36 (9), pp.109648. ⟨10.1016/j.celrep.2021.109648⟩ Article dans une revue hal-03340751v1
	International Union of Basic and Clinical Pharmacology. CXI. Pharmacology, Signaling, and Physiology of Metabotropic Glutamate Receptors Karen J Gregory , Cyril Goudet Pharmacological Reviews, 2021, 73 (1), pp.521-569. ⟨10.1124/pr.119.019133⟩ Article dans une revue hal-03099669v1
	Les avancées récentes dans le domaine de la biologie structurale des récepteurs couplés aux protéines G de la classe C : Le récepteur métabotropique du glutamate 5 Ludovic Berto , Anaëlle Dumazer , Fanny Malhaire , Giuseppe Cannone , Vinothkumar Kutti Biologie Aujourd'hui, 2021, 215 (3-4), pp.85-94. ⟨10.1051/jbio/2021013⟩ Article dans une revue hal-03744975v2
	THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors Stephen Alexander , Arthur Christopoulos , Anthony Davenport , Eamonn Kelly , Alistair Mathie British Journal of Pharmacology, 2021, 178 (S1), pp.e0243333. ⟨10.1111/bph.15538⟩ Article dans une revue hal-03875300v1
	Mechanistic insights into light-driven allosteric control of GPCR biological activity Maria Ricart-Ortega , Alice Berizzi , Vanessa Pereira , Fanny Malhaire , Juanlo Catena ACS Pharmacology & Translational Science, 2020, ⟨10.1021/acsptsci.0c00054⟩ Article dans une revue hal-02924800v1
	Development and validation of a mass spectrometry binding assay for mGlu5 receptor Maria Ricart-Ortega , Alice Berizzi , Juanlo Catena , Fanny Malhaire , Lourdes Muñoz Analytical and Bioanalytical Chemistry, In press, ⟨10.1007/s00216-020-02772-9⟩ Article dans une revue hal-02884945v1
	Emerging Trends in Pain Modulation by Metabotropic Glutamate Receptors Vanessa Pereira , Cyril Goudet Frontiers in Molecular Neuroscience, 2019, 11, pp.464. ⟨10.3389/fnmol.2018.00464⟩ Article dans une revue hal-02388671v1
	THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors Stephen Alexander , Arthur Christopoulos , Anthony P Davenport , Eamonn Kelly , Alistair Mathie British Journal of Pharmacology, 2019, 176 (S1), pp.S21-S141. ⟨10.1111/bph.14748⟩ Article dans une revue hal-02388696v1
	Chloride ions stabilize the glutamate-induced active state of the metabotropic glutamate receptor 3 Amélie S. Tora , Xavier Rovira , Anne-Marinette Cao , Alexandre Cabaye , Linnea Olofsson Neuropharmacology, 2018, 140, pp.275-286. ⟨10.1016/j.neuropharm.2018.08.011⟩ Article dans une revue hal-02346230v1
	Shedding light on metabotropic glutamate receptors using optogenetics and photopharmacology Cyril Goudet , Xavier Rovira , Amadeu Llebaria Current Opinion in Pharmacology, 2018, 38, pp.8-15. ⟨10.1016/j.coph.2018.01.007⟩ Article dans une revue hal-02388700v1
	Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites Chelliah Selvam , Isabelle Lemasson , Isabelle Brabet , Nadia Oueslati , Berin Karaman Journal of Medicinal Chemistry, 2018, 61 (5), pp.1969-1989. ⟨10.1021/acs.jmedchem.7b01438⟩ Article dans une revue hal-02018007v1
	Profiling of orthosteric and allosteric group-III metabotropic glutamate receptor ligands on various G protein-coupled receptors with Tag-lite® assays Abderazak Belhocine , Pietro Veglianese , Candide Hounsou , Elodie Dupuis , Francine C. Acher Neuropharmacology, 2018, 140, pp.233-245. ⟨10.1016/j.neuropharm.2018.07.032⟩ Article dans une revue hal-02388698v1
	Dynamic modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor 4 Charleine Zussy , X. Gomez-Santacana , Xavier Rovira , Dimitri de Bundel , S. Ferrazzo Molecular Psychiatry, 2018, 23 (3), pp.509-520. ⟨10.1038/mp.2016.223⟩ Article dans une revue hal-02073218v1
	Illuminating Phenylazopyridines To Photoswitch Metabotropic Glutamate Receptors: From the Flask to the Animals Xavier Gómez-Santacana , Silvia Pittolo , Xavier Rovira , Marc Lopez , Charleine Zussy ACS Central Science, 2017, 3 (1), pp.81-91. ⟨10.1021/acscentsci.6b00353⟩ Article dans une revue hal-02066097v1
	Positional isomers of bispyridine benzene derivatives induce efficacy changes on mGlu 5 negative allosteric modulation Xavier Gómez-Santacana , James Dalton , Xavier Rovira , Jean-Philippe Pin , Cyril Goudet European Journal of Medicinal Chemistry, 2017, 127, pp.567-576. ⟨10.1016/j.ejmech.2017.01.013⟩ Article dans une revue hal-02066019v1
	Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator Joan Font , Marc López-Cano , Serena Notartomaso , Pamela Scarselli , Paola Di Pietro eLife, 2017, 6, ⟨10.7554/elife.23545.001⟩ Article dans une revue hal-03549950v1
	Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer Junke Liu , Zongyong Zhang , David Moreno-Delgado , James Ar Dalton , Xavier Rovira eLife, 2017, 6, ⟨10.7554/eLife.26985⟩ Article dans une revue hal-02073040v1
	Shining Light on an mGlu5 Photoswitchable NAM: A Theoretical Perspective James Dalton , Isaias Lans , Xavier Rovira , Fanny Malhaire , Xavier Gómez-Santacana Current Neuropharmacology, 2016, 14 (5), pp.441-454. ⟨10.2174/1570159x13666150407231417⟩ Article dans une revue hal-02448289v1
	OptoGluNAM4.1, a Photoswitchable Allosteric Antagonist for Real-Time Control of mGlu4 Receptor Activity Xavier Rovira , Ana Trapero , Silvia Pittolo , Charleine Zussy , Adèle Faucherre Cell Chemical Biology, 2016, 23 (8), pp.929--34. ⟨10.1016/j.chembiol.2016.06.013⟩ Article dans une revue hal-01941168v1
	New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III Tri H. V. Huynh , Mette N. Erichsen , Amélie S. Tora , Cyril Goudet , Emmanuelle Sagot Journal of Medicinal Chemistry, 2016, 59, pp.914-924. ⟨10.1021/acs.jmedchem.5b01333⟩ Article dans une revue hal-01288609v1
	Allosteric modulation of metabotropic glutamate receptors by chloride ions Amélie S. Tora , Xavier Rovira , Ibrahima Dione , Hugues-Olivier Bertrand , Isabelle Brabet FASEB Journal, 2015, 29 (10), pp.4174-4188. ⟨10.1096/fj.14-269746⟩ Article dans une revue hal-02065116v1
	Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors Xavier Rovira , Fanny Malhaire , Pauline Scholler , Jordi Rodrigo , P. Gonzalez-Bulnes FASEB Journal, 2015, 29 (1), pp.116--30. ⟨10.1096/fj.14-257287⟩ Article dans une revue hal-01943324v1
	Determination of the absolute configuration of phosphinic analogues of glutamate Bruno Commare , Delphine Rigault , Isabelle Lemasson , Patrick Deschamps , Alain Tomas Organic & Biomolecular Chemistry, 2015, 13 (4), pp.1106-1112. ⟨10.1039/C4OB01960A⟩ Article dans une revue hal-02268872v1
	Synthesis and studies on the mGluR agonist activity of FAP4 stereoisomers Pavel Ivashkin , Gérald Lemonnier , Amélie S. Tora , Jean-Philippe Pin , Cyril Goudet Bioorganic and Medicinal Chemistry Letters, 2015, 25 (12), pp.2523-2526. ⟨10.1016/j.bmcl.2015.04.043⟩ Article dans une revue hal-01180138v1
	Therapeutic potential of group III metabotropic glutamate receptor ligands in pain Francine Acher , Cyril Goudet Current Opinion in Pharmacology, 2015, 20, pp.64-72. ⟨10.1016/j.coph.2014.11.007⟩ Article dans une revue hal-01950127v1
	An allosteric modulator to control endogenous G protein-coupled receptors with light S. Pittolo , X. Gomez-Santacana , K. Eckelt , Xavier Rovira , J. Dalton Nature Chemical Biology, 2014, 10 (10), pp.813--5. ⟨10.1038/nchembio.1612⟩ Article dans une revue hal-01942934v1
	Exploring the active conformation of cyclohexane carboxylate positive allosteric modulators of the type 4 metabotropic glutamate receptor Xavier Rovira , Youssef Harrak , Ana Trapero , Patricia Gonzalez-Bulnes , Fanny Malhaire ChemMedChem, 2014, 9 (12), pp.2685--98. ⟨10.1002/cmdc.201402190⟩ Article dans une revue hal-01943327v1
	Alleviating Pain Hypersensitivity through Activation of Type 4 Metabotropic Glutamate Receptor Bruno Vilar , Jérôme Busserolles , Bing Ling , Sophie Laffray , Lauriane Ulmann Journal of Neuroscience, 2013, 33 (48), pp.18951-18965. ⟨10.1523/JNEUROSCI.1221-13.2013⟩ Article dans une revue hal-02448295v1
	Cinnabarinic Acid, an Endogenous Metabolite of the Kynurenine Pathway, Activates Type 4 Metabotropic Glutamate Receptors F. Fazio , L. Lionetto , G. Molinaro , H. Bertrand , F. Acher Molecular Pharmacology, 2012, 81 (5), pp.643-656. ⟨10.1124/mol.111.074765⟩ Article dans une revue hal-02448364v1
	Α-amino-β-fluorocyclopropanecarboxylic acids as a new tool for drug development: synthesis of glutamic acid analogs and agonist activity towards metabotropic glutamate receptor 4. Gérald Lemonnier , Cédric Lion , Jean-Charles Quirion , Jean-Philippe Pin , Cyril Goudet Bioorganic and Medicinal Chemistry, 2012, 20 (15), pp.4716-26. ⟨10.1016/j.bmc.2012.06.006⟩ Article dans une revue hal-00996602v1
	A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential. Cyril Goudet , Bruno Vilar , Tiphanie Courtiol , Thierry Deltheil , Thomas Bessiron FASEB Journal, 2012, 26 (4), pp.1682-93. ⟨10.1096/fj.11-195941⟩ Article dans une revue hal-01182946v1
	A new Selective Metabotropic Glutamate Receptor type 4 Agonist Reveals New ways to Develop Subtype Selective Orthosteric Ligands with Potential Therapeutic Effects Cyril Goudet , Bruno Vilar , Tiphanie Courtiol , Thierry Deltheil , Thomas Bessiron Current Neuropharmacology, 2011, 9 (1), pp.26 Article dans une revue hal-01384798v1
	Is metabotropic glutamate receptor mGlu4R a good target to treat Parkinson's disease symptoms? Design and evaluation of potent and selective agonists Isabelle A. Lemasson , Chelliah Selvam , Nadia Oueslati , Isabelle Brabet , Tiphanie Courtiol Abstracts of Papers of the American Chemical Society, 2009, 238 Article dans une revue hal-01384832v1
	N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors. Yelin Chen , Cyril Goudet , Jean-Philippe Pin , P Jeffrey Conn Molecular Pharmacology, 2008, 73 (3), pp.909-18. ⟨10.1124/mol.107.040097⟩ Article dans une revue inserm-00318958v1
	LSP1-2111, a new orthosteric group III mGlur agonist with preferential activity on mGluR4, modulates the striatopallidal synapse and alleviates parkinsonian symptoms C. Beurrier , D. Revy , S. Lopez , M. Lherondel , Cyril Goudet Neuropharmacology, 2008, 55 (4), pp.587-588. ⟨10.1016/j.neuropharm.2008.06.015⟩ Article dans une revue hal-01384860v1
	Synthesis and biological evaluation of 1-amino-2-phosphonomethylcyclopropanecarboxylic acids, new group III metabotropic glutamate receptor agonists. Pauline Sibille , Sébastien Lopez , Isabelle Brabet , Ornella Valenti , Nadia Oueslati Journal of Medicinal Chemistry, 2007, 50 (15), pp.3585-95. ⟨10.1021/jm070262c⟩ Article dans une revue inserm-00318976v1
	Group III metabotropic glutamate receptors inhibit hyperalgesia in animal models of inflammation and neuropathic pain Cyril Goudet , Eric Chapuy , Abdelkrim Alloui , Francine Acher , Jean-Philippe Pin Pain, 2007, 137 (1), pp.112-124. ⟨10.1016/j.pain.2007.08.020⟩ Article dans une revue inserm-00318859v1
	Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses. Yelin Chen , Yi Nong , Cyril Goudet , Kamondanai Hemstapat , Tomas de Paulis Molecular Pharmacology, 2007, 71 (5), pp.1389-98. ⟨10.1124/mol.106.032425⟩ Article dans une revue inserm-00319012v1
	L-(+)-2-Amino-4-thiophosphonobutyric acid (L-thioAP4), a new potent agonist of group III metabotropic glutamate receptors: increased distal acidity affords enhanced potency. Chelliah Selvam , Cyril Goudet , Nadia Oueslati , Jean-Philippe Pin , Francine C. Acher Journal of Medicinal Chemistry, 2007, 50 (19), pp.4656-64. ⟨10.1021/jm070400y⟩ Article dans une revue inserm-00318965v1
	D-myo-inositol 1-phosphate as a surrogate of D-myo-inositol 1,4,5-tris phosphate to monitor G protein-coupled receptor activation. Eric Trinquet , Michel Fink , Hervé Bazin , Florence Grillet , Fabrice Maurin Analytical Biochemistry, 2006, 358 (1), pp.126-35. ⟨10.1016/j.ab.2006.08.002⟩ Article dans une revue inserm-00318996v1
	Asymmetric functioning of dimeric metabotropic glutamate receptors disclosed by positive allosteric modulators. Cyril Goudet , Julie Kniazeff , Veronika Hlavackova , Fanny Malhaire , Damien Maurel Journal of Biological Chemistry, 2005, 280 (26), pp.24380-5. ⟨10.1074/jbc.M502642200⟩ Article dans une revue inserm-00318925v1
	Allosteric functioning of dimeric class C G-protein-coupled receptors. Jean-Philippe Pin , Julie Kniazeff , Jianfeng Liu , Virginie Binet , Cyril Goudet FEBS Journal, 2005, 272, pp.2947-55. ⟨10.1111/j.1742-4658.2005.04728.x⟩ Article dans une revue inserm-00094959v1
	Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR. Veronika Hlavackova , Cyril Goudet , Julie Kniazeff , Alice Zikova , Damien Maurel EMBO Journal, 2005, 24 (3), pp.499-509. ⟨10.1038/sj.emboj.7600557⟩ Article dans une revue inserm-00318934v1
	Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors. Cyril Goudet , Florence Gaven , Julie Kniazeff , Claire Vol , Jianfeng Liu Proceedings of the National Academy of Sciences of the United States of America, 2004, 101 (1), pp.378-83. ⟨10.1073/pnas.0304699101⟩ Article dans une revue inserm-00319003v1
	Locking the dimeric GABA(B) G-protein-coupled receptor in its active state. Julie Kniazeff , Pierre-Philippe Saintot , Cyril Goudet , Jianfeng Liu , Annie Charnet Journal of Neuroscience, 2004, 24 (2), pp.370-7. ⟨10.1523/JNEUROSCI.3141-03.2004⟩ Article dans une revue hal-00319013v1
	Cluster organization and pore structure of ion channels formed by beticolin 3, a nonpeptidic fungal toxin Cyril Goudet , J.P. Benitah , M.L. Milat , Herve Sentenac , J.B. Thibaud Biophysical Journal, 1999, 77, pp.3052-3059. ⟨10.1016/S0006-3495(99)77136-5⟩ Article dans une revue hal-02689303v1
	Magnesium ions promote assembly of channel-like structures from beticolin o, a non-peptide fungal toxin purified from Cercospora beticola Cyril Goudet , Anne-Aliénor Véry , M.L. Milat , M. Ildefonse , Jean-Baptiste Thibaud Plant Journal, 1998, 14 (3), pp.359-364. ⟨10.1046/j.1365-313X.1998.00129.x⟩ Article dans une revue hal-02690441v1

	Conformational diversity in class C GPCR positive allosteric modulation Giuseppe Cannone , Ludovic Berto , Fanny Malhaire , Gavin Ferguson , Aurelien Fouillen 2023 Pré-publication, Document de travail hal-04280250v1

	Strategies and considerations of G-protein-coupled receptor photopharmacology Alice Berizzi , Cyril Goudet Christopher J. Langmead. From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors, 88, Elsevier, pp.143-172, 2020, Advances in Pharmacology, 978-0-12-820187-9. ⟨10.1016/bs.apha.2019.12.001⟩ Chapitre d'ouvrage hal-02863838v1

Cyril Goudet

Publications

Optical activation of endogenous metabotropic glutamate receptor 4 (mGlu4) in the amygdala dynamically regulates symptoms associated with persistent inflammatory pain

Optical Control of Adenosine A 2A Receptor Using Istradefylline Photosensitivity

Photopharmacological manipulation of amygdala metabotropic glutamate receptor mGlu4 alleviates neuropathic pain

Editorial: Molecular mechanisms of nociception

Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations

International Union of Basic and Clinical Pharmacology. CXI. Pharmacology, Signaling, and Physiology of Metabotropic Glutamate Receptors

Les avancées récentes dans le domaine de la biologie structurale des récepteurs couplés aux protéines G de la classe C : Le récepteur métabotropique du glutamate 5

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors

Mechanistic insights into light-driven allosteric control of GPCR biological activity

Development and validation of a mass spectrometry binding assay for mGlu5 receptor

Emerging Trends in Pain Modulation by Metabotropic Glutamate Receptors

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors

Chloride ions stabilize the glutamate-induced active state of the metabotropic glutamate receptor 3

Shedding light on metabotropic glutamate receptors using optogenetics and photopharmacology

Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites

Profiling of orthosteric and allosteric group-III metabotropic glutamate receptor ligands on various G protein-coupled receptors with Tag-lite® assays

Dynamic modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor 4

Illuminating Phenylazopyridines To Photoswitch Metabotropic Glutamate Receptors: From the Flask to the Animals

Positional isomers of bispyridine benzene derivatives induce efficacy changes on mGlu 5 negative allosteric modulation

Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator

Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer

Shining Light on an mGlu5 Photoswitchable NAM: A Theoretical Perspective

OptoGluNAM4.1, a Photoswitchable Allosteric Antagonist for Real-Time Control of mGlu4 Receptor Activity

New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III

Allosteric modulation of metabotropic glutamate receptors by chloride ions

Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors

Determination of the absolute configuration of phosphinic analogues of glutamate

Synthesis and studies on the mGluR agonist activity of FAP4 stereoisomers

Therapeutic potential of group III metabotropic glutamate receptor ligands in pain

An allosteric modulator to control endogenous G protein-coupled receptors with light

Exploring the active conformation of cyclohexane carboxylate positive allosteric modulators of the type 4 metabotropic glutamate receptor

Alleviating Pain Hypersensitivity through Activation of Type 4 Metabotropic Glutamate Receptor

Cinnabarinic Acid, an Endogenous Metabolite of the Kynurenine Pathway, Activates Type 4 Metabotropic Glutamate Receptors

Α-amino-β-fluorocyclopropanecarboxylic acids as a new tool for drug development: synthesis of glutamic acid analogs and agonist activity towards metabotropic glutamate receptor 4.

A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential.

A new Selective Metabotropic Glutamate Receptor type 4 Agonist Reveals New ways to Develop Subtype Selective Orthosteric Ligands with Potential Therapeutic Effects

Is metabotropic glutamate receptor mGlu4R a good target to treat Parkinson's disease symptoms? Design and evaluation of potent and selective agonists

N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors.

LSP1-2111, a new orthosteric group III mGlur agonist with preferential activity on mGluR4, modulates the striatopallidal synapse and alleviates parkinsonian symptoms

Synthesis and biological evaluation of 1-amino-2-phosphonomethylcyclopropanecarboxylic acids, new group III metabotropic glutamate receptor agonists.

Group III metabotropic glutamate receptors inhibit hyperalgesia in animal models of inflammation and neuropathic pain

Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses.

L-(+)-2-Amino-4-thiophosphonobutyric acid (L-thioAP4), a new potent agonist of group III metabotropic glutamate receptors: increased distal acidity affords enhanced potency.

D-myo-inositol 1-phosphate as a surrogate of D-myo-inositol 1,4,5-tris phosphate to monitor G protein-coupled receptor activation.

Asymmetric functioning of dimeric metabotropic glutamate receptors disclosed by positive allosteric modulators.

Allosteric functioning of dimeric class C G-protein-coupled receptors.

Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR.

Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors.

Locking the dimeric GABA(B) G-protein-coupled receptor in its active state.

Cluster organization and pore structure of ion channels formed by beticolin 3, a nonpeptidic fungal toxin

Magnesium ions promote assembly of channel-like structures from beticolin o, a non-peptide fungal toxin purified from Cercospora beticola

Conformational diversity in class C GPCR positive allosteric modulation

Strategies and considerations of G-protein-coupled receptor photopharmacology