Skip to Main content

Researcher identifiers

Co-authors

› Full list

Open access quantity

89 %

Number of documents

28

Dr. Clémentine Bosch-Bouju

 

I am a neuroscientist expert in the impact of nutrition on neurophysiology. I have dense knowledge and experience in studying synapse and network dysfunctions in the neurodegenerative Parkinson’s disease. I acquired expertise for ex vivo electrophysiology during my PhD and for in vivo electrophysiology & optogenetics during my postdoctoral fellows. I joined NutriNeuro lab in 2014 where I specialised in the impact of nutrition on brain function. I am lecturing in food biochemistry and physiology at Bordeaux INP since 2016, which allowed me to enlarge my network with researchers in the field of polymer chemistry. I'm currently leading 2 research projects, one investigating the role of vitamin A in the pathogenesis of Parkinson's disease and the other one developping a new neurotechnology for the remote release of bioactive molecules in the brain.

Journal articles26 documents

  • Quentin Leyrolle, Fanny Decoeur, Cyril Dejean, Marie-Galadriel Briere, Stephane Leon, et al.. N‐3 PUFA deficiency disrupts oligodendrocyte maturation and myelin integrity during brain development. Glia, Wiley, 2022, 70 (1), pp.50-70. ⟨10.1002/glia.24088⟩. ⟨hal-03347586⟩
  • Fabien Naneix, Ioannis Bakoyiannis, Marianela Santoyo-Zedillo, Clémentine Bosch-Bouju, Gustavo Pacheco-Lopez, et al.. Chemogenetic silencing of hippocampus and amygdala reveals a double dissociation in periadolescent obesogenic diet-induced memory alterations. Neurobiology of Learning and Memory, Elsevier, 2021, 178, pp.107354. ⟨10.1016/j.nlm.2020.107354⟩. ⟨hal-03312581⟩
  • Fabien Naneix, Ioannis Bakoyiannis, Marianela Santoyo-Zedillo, Clémentine Bosch-Bouju, Gustavo Pacheco-Lopez, et al.. Chemogenetic silencing of hippocampus and amygdala reveals a double dissociation in periadolescent obesogenic diet-induced memory alterations. Neurobiology of Learning and Memory, Elsevier, 2021, 178, pp.107354. ⟨10.1016/j.nlm.2020.107354⟩. ⟨hal-03419785⟩
  • Anais Marie, Morgane Darricau, Katia Touyarot, Louise C Parr-Brownlie, Clémentine Bosch-Bouju. Role and Mechanism of Vitamin A Metabolism in the Pathophysiology of Parkinson's Disease.. Journal of Parkinson's disease, Amsterdam : b : IOS Press, 2021, pp.1-22. ⟨10.3233/JPD-212671⟩. ⟨hal-03288013⟩
  • Charlotte Piette, Marie Vandecasteele, Clémentine Bosch-Bouju, Valérie Goubard, Vincent Paillé, et al.. Intracellular Properties of Deep-Layer Pyramidal Neurons in Frontal Eye Field of Macaque Monkeys. Frontiers in Synaptic Neuroscience, Frontiers Media, 2021, 13, ⟨10.3389/fnsyn.2021.725880⟩. ⟨hal-03426368⟩
  • Charlotte Piette, Marie Vandecasteele, Clémentine Bosch-Bouju, Valérie Goubard, Vincent Paillé, et al.. Intracellular Properties of Deep-Layer Pyramidal Neurons in Frontal Eye Field of Macaque Monkeys. Frontiers in Synaptic Neuroscience, Frontiers Media, 2021, 13, ⟨10.3389/fnsyn.2021.725880⟩. ⟨hal-03376047⟩
  • Mathieu Di Miceli, Clémentine Bosch-Bouju, Sophie Layé. PUFA and their derivatives in neurotransmission and synapses: a new hallmark of synaptopathies. Proceedings of the Nutrition Society, Cambridge University Press (CUP), 2020, 79 (4), pp.388-403. ⟨10.1017/S0029665120000129⟩. ⟨hal-03173011⟩
  • C. Madore, Q. Leyrolle, L. Morel, M. Rossitto, A. Greenhalgh, et al.. Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain. Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.6133. ⟨10.1038/s41467-020-19861-z⟩. ⟨hal-03047178⟩
  • Fabien Ducrocq, Roman Walle, Andrea Contini, Asma Oummadi, Baptiste Caraballo, et al.. Causal link between n-3 polyunsaturated fatty acid deficiency and motivation deficits. Cell Metabolism, Elsevier, 2020, 31 (4), pp.755-772. ⟨10.1016/j.cmet.2020.02.012⟩. ⟨hal-02550371⟩
  • Fabien Dumetz, Corinne Bure, Serge Alfos, Marc Bonneu, Emmanuel Richard, et al.. Normalization of hippocampal retinoic acid level corrects age-related memory deficits in rats. Neurobiology of Aging, Elsevier, 2020, 85, pp.1-10. ⟨10.1016/j.neurobiolaging.2019.09.016⟩. ⟨hal-02620292⟩
  • Fabien Dumetz, Rachel Ginieis, Corinne Bure, Anaïs Marie, Serge Alfos, et al.. Neuronal morphology and synaptic plasticity in the hippocampus of vitamin A deficient rats. Nutritional Neuroscience, Maney Publishing, In press, pp.1-12. ⟨10.1080/1028415X.2020.1809877⟩. ⟨hal-02950511⟩
  • Mathieu Di Miceli, Zoé Husson, Philippe Ruel, Sophie Layé, Daniela Cota, et al.. In silico hierarchical clustering of neuronal populations in the rat ventral tegmental area based on extracellular electrophysiological properties. Frontiers in Neural Circuits, Frontiers, 2020, 14, pp.51. ⟨10.3389/fncir.2020.00051⟩. ⟨hal-02941027⟩
  • Célia Fourrier, Clémentine Bosch-Bouju, Raphael Boursereau, Julie Sauvant, Agnès Aubert, et al.. Brain tumor necrosis factor-α mediates anxiety-like behavior in a mouse model of severe obesity. Brain, Behavior, and Immunity, Elsevier, 2019, online fisrt, pp.1-12. ⟨10.1016/j.bbi.2018.11.316⟩. ⟨hal-02626314⟩
  • Fabien Ducrocq, Roman Walle, Andrea Contini, Asma Oummadi, Baptiste Caraballo, et al.. Causal Link between n-3 Polyunsaturated Fatty Acid Deficiency and Motivation Deficits. Cell Metabolism, Elsevier, 2019, 31 (4), pp.755-772.e7. ⟨10.2139/ssrn.3382436⟩. ⟨hal-03347311⟩
  • Olivier Manzoni, Clémentine Bosch-Bouju, Thomas Larrieu, Louisa Linders, Olivier J. Manzoni, et al.. Endocannabinoid-Mediated Plasticity in Nucleus Accumbens Controls Vulnerability to Anxiety after Social Defeat Stress. Cell Reports, Elsevier Inc, 2016, 16 (5), pp.1237 - 1242. ⟨10.1016/j.celrep.2016.06.082⟩. ⟨hal-01826144⟩
  • Olivier Manzoni, Aurore Thomazeau, Clémentine Bosch-Bouju, Sophie Layé. Nutritional n-3 PUFA Deficiency Abolishes Endocannabinoid Gating of Hippocampal Long-Term Potentiation. Cerebral Cortex, Oxford University Press (OUP), 2016, 27 (4), pp.2571-2579. ⟨10.1093/cercor/bhw052⟩. ⟨hal-01826142⟩
  • Jean-Christophe Delpech, Aurore Thomazeau, Charlotte Madore, Clémentine Bosch-Bouju, Thomas Larrieu, et al.. Dietary n-3 PUFAs Deficiency Increases Vulnerability to Inflammation-Induced Spatial Memory Impairment. Neuropsychopharmacology, Nature Publishing Group, 2015, 40 (12), pp.2774-2787. ⟨10.1038/npp.2015.127⟩. ⟨hal-03259529⟩
  • Louise C. Parr-Brownlie, Clémentine Bosch-Bouju, Lucia Schoderboeck, Rachel J. Sizemore, Wickliffe C. Abraham, et al.. Lentiviral vectors as tools to understand central nervous system biology in mammalian model organisms. Frontiers in Molecular Neuroscience, Frontiers Media, 2015, 8, 12 p. ⟨10.3389/fnmol.2015.00014⟩. ⟨hal-02638796⟩
  • Jean-Christophe Delpech, Aurore Thomazeau, Charlotte Madore, Clémentine Bosch-Bouju, Thomas Larrieu, et al.. Dietary n-3 PUFAs deficiency increases vulnerability to inflammation-induced spatial memory impairment. Neuropsychopharmacology, Nature Publishing Group, 2015, 40 (12), pp.2774-2787. ⟨10.1038/npp.2015.127⟩. ⟨hal-02640350⟩
  • Sonja Seeger-Armbruster, Clémentine Bosch-Bouju, Shane Little, Roseanna Smither, Stephanie Hughes, et al.. Patterned, But Not Tonic, Optogenetic Stimulation in Motor Thalamus Improves Reaching in Acute Drug-Induced Parkinsonian Rats. Journal of Neuroscience, Society for Neuroscience, 2015, 35, pp.1211 - 1216. ⟨10.1523/jneurosci.3277-14.2015⟩. ⟨hal-03485799⟩
  • Clémentine Bosch-Bouju, Roseanna Smither, Brian Hyland, Louise Parr-Brownlie. Reduced Reach-Related Modulation of Motor Thalamus Neural Activity in a Rat Model of Parkinson's Disease. Journal of Neuroscience, Society for Neuroscience, 2014, 34, pp.15836 - 15850. ⟨10.1523/jneurosci.0893-14.2014⟩. ⟨hal-03485806⟩
  • Clémentine Bosch-Bouju, Brian Hyland, Louise Parr-Brownlie. Motor thalamus integration of cortical, cerebellar and basal ganglia information: implications for normal and parkinsonian conditions. Frontiers in Computational Neuroscience, Frontiers, 2013, 7, ⟨10.3389/fncom.2013.00163⟩. ⟨hal-03485810⟩
  • Matthew Nelson, Clémentine Bosch-Bouju, Laurent Venance, Pierre Pouget. Microscale Inhomogeneity of Brain Tissue Distorts Electrical Signal Propagation. Journal of Neuroscience, Society for Neuroscience, 2013, 33 (7), pp.2821-2827. ⟨10.1523/JNEUROSCI.3502-12.2013⟩. ⟨hal-02876719⟩
  • Clémentine Bosch-Bouju, P Mailly, B Degos, J-M Deniau, L Venance. Preservation of the hyperdirect pathway of basal ganglia in a rodent brain slice. Neuroscience, Elsevier - International Brain Research Organization, 2012, 215, pp.31 - 41. ⟨10.1016/j.neuroscience.2012.04.033⟩. ⟨hal-03485847⟩
  • Clémentine Bosch-Bouju, Bertrand Degos, Jean-Michel Deniau, Laurent Venance. Subthalamic nucleus high-frequency stimulation generates a concomitant synaptic excitation-inhibition in substantia nigra pars reticulata. The Journal of Physiology, Wiley, 2011, 589, pp.4189 - 4207. ⟨10.1113/jphysiol.2011.211367⟩. ⟨hal-03485906⟩
  • Clémentine Bosch-Bouju, Jesus Bertran-Gonzalez, Clémentine Bosch-Bouju, Matthieu Maroteaux, Miriam Matamales, et al.. Opposing Patterns of Signaling Activation in Dopamine D1 and D2 Receptor-Expressing Striatal Neurons in Response to Cocaine and Haloperidol. Journal of Neuroscience, Society for Neuroscience, 2008, 28, pp.5671 - 5685. ⟨10.1523/jneurosci.1039-08.2008⟩. ⟨hal-03485929⟩

Book sections2 documents

  • Clémentine Bosch-Bouju. Introductory Chapter: Feed Your Mind - How Does Nutrition Modulate Brain Function throughout Life?. Feed Your Mind - How Does Nutrition Modulate Brain Function throughout Life?, IntechOpen, 2019, ⟨10.5772/intechopen.89349⟩. ⟨hal-03485932⟩
  • Clémentine Bosch-Bouju, Sophie Layé. Dietary Omega-6/Omega-3 and Endocannabinoids: Implications for Brain Health and Diseases. Cannabinoids in Health and Disease, INTECH EUROPE, pp.32, 2016, 978-953-51-2430-6; 978-953-51-2429-0. ⟨10.5772/62498⟩. ⟨hal-02800247⟩