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Clémentine Bosch-Bouju

Dr. Clémentine Bosch-Bouju Assistant Professor (Maître des conférences) Bordeaux INP - Ensmac NutriNeuro, UMR 1286 INRAE, University of Bordeaux, Bordeaux INP
33
Documents
Identifiants chercheurs

Présentation

I am a neuroscientist expert in neurophysiology. I have dense knowledge and experience in studying synapse and network dysfunctions in the neurodegenerative Parkinson’s disease. I acquired expertise for *ex vivo* electrophysiology patch-clamp during my PhD and for *in vivo* electrophysiology with optogenetics during my postdoctoral fellows. I joined NutriNeuro lab in 2014 where I specialised in the impact of nutrition on brain function. I am lecturing in food biochemistry and physiology at Bordeaux INP since 2016, which allowed me to enlarge my network with researchers in the field of polymer chemistry and bioelectronics. I have been leading 2 research projects since 2018, one investigating the role of vitamin A in the pathogenesis of Parkinson's disease and the other one developping a new neurotechnology for the remote release of bioactive molecules in the brain.

Domaines de recherche

Neurobiologie Alimentation et Nutrition

Publications

Impact of dietary vitamin A on striatal function in adult rats

Anaïs Marie , Rémi Kinet , Jean‐christophe Helbling , Morgane Darricau , Serge Alfos
FASEB Journal, 2023, 37 (8), ⟨10.1096/fj.202300133R⟩
Article dans une revue hal-04291511v1

Memory deficits in a juvenile rat model of type 1 diabetes are due to excess 11β-HSD1 activity, which is upregulated by high glucose concentrations rather than insulin deficiency

Julie Brossaud , Clémentine Bosch-Bouju , Nathalie Marissal-Arvy , Marie-Neige Campas-Lebecque , Jean-Christophe Helbling
Diabetologia, 2023, 66 (9), pp.1735-1747. ⟨10.1007/s00125-023-05942-3⟩
Article dans une revue hal-04175051v1

Erratum to “N-3 PUFA deficiency disrupts oligodendrocyte maturation and myelin integrity during brain development”

Quentin Leyrolle , Fanny Decoeur , Cyril Dejean , Marie-Galadriel Briere , Stephane Leon
Glia, 2023, 71 (3), pp.796-796. ⟨10.1002/glia.24321⟩
Article dans une revue hal-03998738v1

Impact of dietary vitamin A on striatal function in adult rats

Anaïs Marie , Rémi Kinet , Jean‐christophe Helbling , Morgane Darricau , Serge Alfos
FASEB Journal, 2023, 37 (8), ⟨10.1096/fj.202300133R⟩
Article dans une revue hal-04181884v1

N‐3 PUFA deficiency disrupts oligodendrocyte maturation and myelin integrity during brain development

Quentin Leyrolle , Fanny Decoeur , Cyril Dejean , Marie-Galadriel Briere , Stephane Leon
Glia, 2022, 70 (1), pp.50-70. ⟨10.1002/glia.24088⟩
Article dans une revue hal-03347586v1
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Dietary Long-Chain n-3 Polyunsaturated Fatty Acid Supplementation Alters Electrophysiological Properties in the Nucleus Accumbens and Emotional Behavior in Naïve and Chronically Stressed Mice

Mathieu Di Miceli , Maud Martinat , Moïra Rossitto , Agnès Aubert , Shoug Alashmali
International Journal of Molecular Sciences, 2022, 23 (12), pp.6650. ⟨10.3390/ijms23126650⟩
Article dans une revue hal-03739678v1
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Chemogenetic silencing of hippocampus and amygdala reveals a double dissociation in periadolescent obesogenic diet-induced memory alterations

Fabien Naneix , Ioannis Bakoyiannis , Marianela Santoyo-Zedillo , Clémentine Bosch-Bouju , Gustavo Pacheco-Lopez
Neurobiology of Learning and Memory, 2021, 178, pp.107354. ⟨10.1016/j.nlm.2020.107354⟩
Article dans une revue hal-03419785v1

Role and Mechanism of Vitamin A Metabolism in the Pathophysiology of Parkinson's Disease.

Anais Marie , Morgane Darricau , Katia Touyarot , Louise C Parr-Brownlie , Clémentine Bosch-Bouju
Journal of Parkinson's disease, 2021, pp.1-22. ⟨10.3233/JPD-212671⟩
Article dans une revue hal-03288013v1

Chemogenetic silencing of hippocampus and amygdala reveals a double dissociation in periadolescent obesogenic diet-induced memory alterations

Fabien Naneix , Ioannis Bakoyiannis , Marianela Santoyo-Zedillo , Clémentine Bosch-Bouju , Gustavo Pacheco-Lopez
Neurobiology of Learning and Memory, 2021, 178, pp.107354. ⟨10.1016/j.nlm.2020.107354⟩
Article dans une revue hal-03312581v1
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Intracellular Properties of Deep-Layer Pyramidal Neurons in Frontal Eye Field of Macaque Monkeys

Charlotte Piette , Marie Vandecasteele , Clémentine Bosch-Bouju , Valérie Goubard , Vincent Paillé
Frontiers in Synaptic Neuroscience, 2021, 13, ⟨10.3389/fnsyn.2021.725880⟩
Article dans une revue hal-03376047v1
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Normalization of hippocampal retinoic acid level corrects age-related memory deficits in rats

Fabien Dumetz , Corinne Bure , Serge Alfos , Marc Bonneu , Emmanuel Richard
Neurobiology of Aging, 2020, 85, pp.1-10. ⟨10.1016/j.neurobiolaging.2019.09.016⟩
Article dans une revue hal-02620292v1
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In silico hierarchical clustering of neuronal populations in the rat ventral tegmental area based on extracellular electrophysiological properties

Mathieu Di Miceli , Zoé Husson , Philippe Ruel , Sophie Layé , Daniela Cota
Frontiers in Neural Circuits, 2020, 14, pp.51. ⟨10.3389/fncir.2020.00051⟩
Article dans une revue hal-02941027v1
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Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain

C. Madore , Q. Leyrolle , L. Morel , M. ✉ Rossitto , A. D Greenhalgh
Nature Communications, 2020, 11 (1), pp.6133. ⟨10.1038/s41467-020-19861-z⟩
Article dans une revue hal-03047178v1

PUFA and their derivatives in neurotransmission and synapses: a new hallmark of synaptopathies

Mathieu Di Miceli , Clémentine Bosch-Bouju , Sophie Layé
Proceedings of the Nutrition Society, 2020, 79 (4), pp.388-403. ⟨10.1017/S0029665120000129⟩
Article dans une revue hal-03173011v1
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Neuronal morphology and synaptic plasticity in the hippocampus of vitamin A deficient rats

Fabien Dumetz , Rachel Ginieis , Corinne Bure , Anaïs Marie , Serge Alfos
Nutritional Neuroscience, inPress, pp.1-12. ⟨10.1080/1028415X.2020.1809877⟩
Article dans une revue hal-02950511v1
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Causal link between n-3 polyunsaturated fatty acid deficiency and motivation deficits

Fabien Ducrocq , Roman Walle , Andrea Contini , Asma Oummadi , Baptiste Caraballo
Cell Metabolism, 2020, 31 (4), pp.755-772. ⟨10.1016/j.cmet.2020.02.012⟩
Article dans une revue hal-02550371v1

Causal Link between n-3 Polyunsaturated Fatty Acid Deficiency and Motivation Deficits

Fabien Ducrocq , Roman Walle , Andrea Contini , Asma Oummadi , Baptiste Caraballo
Cell Metabolism, 2019, 31 (4), pp.755-772.e7. ⟨10.2139/ssrn.3382436⟩
Article dans une revue hal-03347311v1
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Brain tumor necrosis factor-α mediates anxiety-like behavior in a mouse model of severe obesity

Célia Fourrier , Clémentine Bosch-Bouju , Raphael Boursereau , Julie Sauvant , Agnès Aubert
Brain, Behavior, and Immunity, 2019, online fisrt, pp.1-12. ⟨10.1016/j.bbi.2018.11.316⟩
Article dans une revue hal-02626314v1

Nutritional n-3 PUFA Deficiency Abolishes Endocannabinoid Gating of Hippocampal Long-Term Potentiation

Aurore Thomazeau , Clémentine Bosch-Bouju , Olivier Manzoni , Sophie Layé
Cerebral Cortex, 2017, 27 (4), pp.2571-2579. ⟨10.1093/cercor/bhw052⟩
Article dans une revue hal-03777442v1

Nutritional n-3 PUFA Deficiency Abolishes Endocannabinoid Gating of Hippocampal Long-Term Potentiation

Olivier Manzoni , Aurore Thomazeau , Clémentine Bosch-Bouju , Sophie Layé
Cerebral Cortex, 2016, 27 (4), pp.2571-2579. ⟨10.1093/cercor/bhw052⟩
Article dans une revue hal-01826142v1
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Endocannabinoid-Mediated Plasticity in Nucleus Accumbens Controls Vulnerability to Anxiety after Social Defeat Stress

Olivier Manzoni , Clémentine Bosch-Bouju , Thomas Larrieu , Louisa Linders , Olivier J. Manzoni
Cell Reports, 2016, 16 (5), pp.1237 - 1242. ⟨10.1016/j.celrep.2016.06.082⟩
Article dans une revue hal-01826144v1
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Lentiviral vectors as tools to understand central nervous system biology in mammalian model organisms

Louise C. Parr-Brownlie , Clémentine Bosch-Bouju , Lucia Schoderboeck , Rachel J. Sizemore , Wickliffe C. Abraham
Frontiers in Molecular Neuroscience, 2015, 8, 12 p. ⟨10.3389/fnmol.2015.00014⟩
Article dans une revue hal-02638796v1
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Patterned, But Not Tonic, Optogenetic Stimulation in Motor Thalamus Improves Reaching in Acute Drug-Induced Parkinsonian Rats

Sonja Seeger-Armbruster , Clémentine Bosch-Bouju , Shane T C Little , Roseanna A Smither , Stephanie M Hughes
Journal of Neuroscience, 2015, 35, pp.1211 - 1216. ⟨10.1523/jneurosci.3277-14.2015⟩
Article dans une revue hal-03485799v1

Dietary n-3 PUFAs deficiency increases vulnerability to inflammation-induced spatial memory impairment

Jean-Christophe Delpech , Aurore Thomazeau , Charlotte Madore , Clémentine Bosch-Bouju , Thomas Larrieu
Neuropsychopharmacology, 2015, 40 (12), pp.2774-2787. ⟨10.1038/npp.2015.127⟩
Article dans une revue hal-02640350v1

Dietary n-3 PUFAs Deficiency Increases Vulnerability to Inflammation-Induced Spatial Memory Impairment

Jean-Christophe Delpech , Aurore Thomazeau , Charlotte Madore , Clémentine Bosch-Bouju , Thomas Larrieu
Neuropsychopharmacology, 2015, 40 (12), pp.2774-2787. ⟨10.1038/npp.2015.127⟩
Article dans une revue hal-03259529v1
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Reduced Reach-Related Modulation of Motor Thalamus Neural Activity in a Rat Model of Parkinson's Disease

Clémentine Bosch-Bouju , Roseanna A Smither , Brian I Hyland , Louise C Parr-Brownlie
Journal of Neuroscience, 2014, 34, pp.15836 - 15850. ⟨10.1523/jneurosci.0893-14.2014⟩
Article dans une revue hal-03485806v1
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Motor thalamus integration of cortical, cerebellar and basal ganglia information: implications for normal and parkinsonian conditions

Clémentine Bosch-Bouju , Brian I Hyland , Louise C Parr-Brownlie
Frontiers in Computational Neuroscience, 2013, 7, ⟨10.3389/fncom.2013.00163⟩
Article dans une revue hal-03485810v1
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Microscale Inhomogeneity of Brain Tissue Distorts Electrical Signal Propagation

Matthew J Nelson , Clémentine Bosch-Bouju , Laurent Venance , Pierre Pouget
Journal of Neuroscience, 2013, 33 (7), pp.2821-2827. ⟨10.1523/JNEUROSCI.3502-12.2013⟩
Article dans une revue hal-02876719v1

Preservation of the hyperdirect pathway of basal ganglia in a rodent brain slice

Clémentine Bosch-Bouju , P Mailly , B Degos , J-M Deniau , L Venance
Neuroscience, 2012, 215, pp.31 - 41. ⟨10.1016/j.neuroscience.2012.04.033⟩
Article dans une revue hal-03485847v1

Subthalamic nucleus high-frequency stimulation generates a concomitant synaptic excitation-inhibition in substantia nigra pars reticulata

Clémentine Bosch-Bouju , Bertrand Degos , Jean-Michel Deniau , Laurent Venance
The Journal of Physiology, 2011, 589, pp.4189 - 4207. ⟨10.1113/jphysiol.2011.211367⟩
Article dans une revue hal-03485906v1
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Opposing Patterns of Signaling Activation in Dopamine D1 and D2 Receptor-Expressing Striatal Neurons in Response to Cocaine and Haloperidol

Clémentine Bosch-Bouju , Jesus Bertran-Gonzalez , Matthieu Maroteaux , Miriam Matamales , Denis Herve
Journal of Neuroscience, 2008, 28, pp.5671 - 5685. ⟨10.1523/jneurosci.1039-08.2008⟩
Article dans une revue hal-03485929v1
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Introductory Chapter: Feed Your Mind - How Does Nutrition Modulate Brain Function throughout Life?

Clémentine Bosch-Bouju
Feed Your Mind - How Does Nutrition Modulate Brain Function throughout Life?, IntechOpen, 2019, ⟨10.5772/intechopen.89349⟩
Chapitre d'ouvrage hal-03485932v1
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Dietary Omega-6/Omega-3 and Endocannabinoids: Implications for Brain Health and Diseases

Clémentine Bosch-Bouju , Sophie Layé
Cannabinoids in Health and Disease, INTECH EUROPE, pp.32, 2016, 978-953-51-2430-6; 978-953-51-2429-0. ⟨10.5772/62498⟩
Chapitre d'ouvrage hal-02800247v1