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Number of documents

56

Clair-Yves BOQUIEN


Chercheur en nutrition humaine

Diplômes et fonctions

1983 - Ingénieur Agronome Institut National Agronomique Paris-Grignon

1988 - Docteur en Sciences des Aliments

Chargé de Recherches Hors Classe - INRAE

Depuis 2010 - Directeur au sein du bureau de l’Association Européenne des Banques de lait (EMBA) et membre des groupes de travail (lait maternel, banques de lait)

2015 -  Directeur Centre de Recherche en Nutrition Humaine - Ouest CRNH-Ouest (depuis 2019) & directeur-adjoint (2015-2019)

2020 - Membre commission d’évaluation CE21 (« Food and Food systems ») de l’Agence Nationale de la Recherche (ANR)

2021 - Chargé de mission scientifique auprès du Haut Conseil de l'Evaluation de la Recherche et de l'Enseignement Supérieur (HCERES)

1985-93 :  Doctorat et post-docs

1985-88 : Thèse en sciences (INRA Jouy-en-Josas) - 1988-89 : Post-doc à INRA Nouzilly

1989: Chargé Recherches INRA Thiverval-Grignon

  • 1988-89 Post-doc INRAE Tours - Nouzilly
  • 1993 Post-doc à l’université CORNELL (Ithaca, NY)

Fermentation lactique et production d’arôme / texture de produits laitiers frais

1994-2004 : Disponibilité INRA

Société DANONE - Chef de projet au Centre de Recherche DANONE de Plessis-Robinson

Fermentation lactique et propriétés organoleptiques des produits laitiers frais (yoghourts et fromages frais)

Partenaire de plusieurs projets Européens (Programmes-cadres FP1 à FP3)

2005-2021 : Chargé de Recherches

UMR 1280 INRAE Université Nantes PhAN (Physio-pathologie des Adaptations Nutritionnelles)

Thématique : nutrition périnatale et programmation nutritionnelle

  • La composition nutritionnelle du lait maternel et les conséquences sur la croissance et la santé de l’enfant allaité, conformément à l’hypothèse de la programmation nutritionnelle.
  • Le flux de lait maternel de la mère à sa descendance dans des essais de supplémentation nutritonnelle dans un modèle animal

Compétences scientifiques en nutrition humaine, physiologie, et métabolisme

Compétences en recherche translationnelle, combinant les: 

-     Etudes sur cohorte, en collaboration étroite avec les cliniciens du service de Néonatologie du CHU de Nantes, (cohorte LACTACOL de nouveau-nés prématurés allaités)

-    Etudes en expérimentation animale (Utilisation du modèle animal rongeur (rat) pour expérimentations de preuve de concept).

  • Auteur de plus de 50 publications scientifiques, les plus récentes dans le domaine de la nutrition périnatale et de la composition du lait maternel
  • Partenaire de projetsindustriels (Nestlé, France Bébé Nutrition)
  •  Editeur à la revue Nutrients (décision éditoriale en pre- et post-reviewing de manuscrits)
  • Révision d'une dizaine de manuscrits par an
  • Organisateur de symposiums internationaux à Nantes et Membre du comité scientifique de plusieurs congrès internationaux sur le lait maternel & nutrition périnatale  


Journal articles54 documents

  • Thomas Sevrin, Charlène Sirvins, Agnès David, Audrey Aguesse, Alexis Gandon, et al.. Dietary Arginine Supplementation during Gestation and Lactation Increases Milk Yield and Mammary Lipogenesis in Rats. Journal of Nutrition, American Society for Nutrition, 2021, pp.1-11. ⟨10.1093/jn/nxab152⟩. ⟨hal-03264334⟩
  • Clair-Yves Boquien, Helene Billard, Laure Simon, Cecile Boscher, Arnaud Legrand, et al.. Breast milk protein content at week 3 after birth and neurodevelopmental outcome in preterm infants fed fortified breast milk. European Journal of Nutrition, Springer Verlag, 2021, pp.1-11. ⟨10.1007/s00394-021-02562-8⟩. ⟨hal-03264328⟩
  • Thomas Sevrin, Clair-Yves Boquien, Alexis Gandon, Isabelle Grit, Pierre de Coppet, et al.. Fenugreek Stimulates the Expression of Genes Involved in Milk Synthesis and Milk Flow through Modulation of Insulin/GH/IGF-1 Axis and Oxytocin Secretion. Genes, MDPI, 2020, 11 (10), ⟨10.3390/genes11101208⟩. ⟨hal-03209164⟩
  • Marie Cécile Alexandre-Gouabau, Thomas Moyon, Agnes Sochard, François Fenaille, Sophie Cholet, et al.. Correction: Alexandre-Gouabau et al. “Comprehensive Preterm Breast Milk Metabotype Associated with Optimal Infant Early Growth Pattern”, Nutrients, 2019, 11, 528. Nutrients, MDPI, 2020, 12 (1), pp.162. ⟨10.3390/nu12010162⟩. ⟨hal-02620488⟩
  • German Cano Sancho, Marie Cécile Alexandre-Gouabau, Thomas Moyon, Anne-Lise Royer, Yann Guitton, et al.. Simultaneous exploration of nutrients and pollutants in human milk and their impact on preterm infant growth: An integrative cross-platform approach. Environmental Research, Elsevier, 2020, 182, pp.109018. ⟨10.1016/j.envres.2019.109018⟩. ⟨hal-02620289⟩
  • Guido E. Moro, Claude Billeaud, Buffin Rachel, Javier Calvo, Laura Cavallarin, et al.. Processing of donor human milk: update and recommendations from the european milk bank association (EMBA). Frontiers in Pediatrics, Frontiers, 2019, 7, pp.1-10. ⟨10.3389/fped.2019.00049⟩. ⟨hal-02620274⟩
  • Gillian Weaver, Enrico Bertino, Corinna Gebauer, Anne Grovslien, Radmila Mileusnic-Milenovic, et al.. Recommendations for the establishment and operation of human milk banks in europe: A consensus statement from the european milk bank association (EMBA). Frontiers in Pediatrics, Frontiers, 2019, 7, pp.1-8. ⟨10.3389/fped.2019.00053⟩. ⟨hal-02627234⟩
  • Sertac Arslanoglu, Clair-Yves Boquien, Caroline King, Delphine Lamireau, Paola Tonetto, et al.. Fortification of human milk for preterm infants: update and recommendations of the european milk bank association (emba) working group on human milk fortification. Frontiers in Pediatrics, Frontiers, 2019, 7, ⟨10.3389/fped.2019.00076⟩. ⟨hal-02628588⟩
  • Sertac Arslanoglu, Caroline King, Clair-Yves Boquien, Delphine Lamireau, Paola Tonetto, et al.. Letter to the editor: clarifying some aspects and the terminology of individualized human milk fortification. BMC Pediatrics, BioMed Central, 2019, 19 (1), pp.135. ⟨10.1186/s12887-019-1491-x⟩. ⟨inserm-02294624⟩
  • Marie Cécile Alexandre-Gouabau, Thomas Moyon, Agnes Sochard, François Fenaille, Sophie Cholet, et al.. Comprehensive preterm breast milk metabotype associated with optimal infant early growth pattern. Nutrients, MDPI, 2019, 11 (3), pp.1-26. ⟨10.3390/nu11030528⟩. ⟨hal-02620327⟩
  • Thomas Sevrin, Marie Cécile Alexandre-Gouabau, Blandine Castellano, Audrey Aguesse, Khadija Ouguerram, et al.. Impact of Fenugreek on Milk Production in Rodent Models of Lactation Challenge. Nutrients, MDPI, 2019, 11 (11), pp.2571. ⟨10.3390/nu11112571⟩. ⟨hal-02463454⟩
  • Marie Cécile Alexandre-Gouabau, Thomas Moyon, Véronique Cariou, Jean-Philippe Antignac, El Mostafa Qannari, et al.. Breast Milk Lipidome Is Associated with Early Growth Trajectory in Preterm Infants. Nutrients, MDPI, 2018, 10 (2), pp.164. ⟨10.3390/nu10020164⟩. ⟨hal-02429557⟩
  • Clair-Yves Boquien. Le lait maternel : un aliment idéal pour la nutrition du nouveau-né (En lien avec sa croissance et son devenir neuro-moteur). Cahiers de Nutrition et de Diététique, Elsevier Masson, 2018, ⟨10.1016/j.cnd.2018.07.003⟩. ⟨hal-02625028⟩
  • Clair-Yves Boquien. Human Milk: An Ideal Food for Nutrition of Preterm Newborn. Frontiers in Pediatrics, Frontiers, 2018, 6, pp.1-9. ⟨10.3389/fped.2018.00295⟩. ⟨hal-02623706⟩
  • Thomas Sevrin, Marie Cécile Alexandre-Gouabau, Dominique Darmaun, Antoine Palvadeau, Agnès André, et al.. Use of water turnover method to measure mother's milk flow in a rat model: Application to dams receiving a low protein diet during gestation and lactation.. PLoS ONE, Public Library of Science, 2017, 12 (7), pp.e0180550. ⟨10.1371/journal.pone.0180550⟩. ⟨hal-01607230⟩
  • Nhat Thang Tran, Marie Cécile Alexandre-Gouabau, Anthony Pagniez, Khadija Ouguerram, Clair-Yves Boquien, et al.. Neonatal Citrulline Supplementation and Later Exposure to a High Fructose Diet in Rats Born with a Low Birth Weight: A Preliminary Report. Nutrients, MDPI, 2017, 9 (4), pp.1-15. ⟨10.3390/nu9040375⟩. ⟨hal-01607137⟩
  • Farid Boubred, Eloise Delamaire, Christophe Buffat, Laurent Daniel, Clair-Yves Boquien, et al.. High protein intake in neonatal period induces glomerular hypertrophy and sclerosis in adulthood in rats born with IUGR. Pediatric Research, Nature Publishing Group, 2016, 79 (1), pp.22-26. ⟨10.1038/pr.2015.176⟩. ⟨hal-02633522⟩
  • Arnaud de Luca, Regis Hankard, Marie Cécile Alexandre-Gouabau, Veronique Ferchaud Roucher, Dominique Darmaun, et al.. Higher concentrations of branched-chain amino acids in breast milk of obese mothers. Nutrition, Elsevier, 2016, 32 (11-12), pp.1295-1298. ⟨10.1016/j.nut.2016.05.013⟩. ⟨hal-01605046⟩
  • Hélène Billard, Laure Simon, Emmanuelle Desnots, Agnes Sochard, C. Boscher, et al.. Calibration Adjustment of the Mid-infrared Analyzer for an Accurate Determination of the Macronutrient Composition of Human Milk. Journal of Human Lactation, SAGE Publications, 2016, 32 (3), pp.19-27. ⟨10.1177/0890334415588513⟩. ⟨hal-01487353⟩
  • Jean-Philippe Antignac, K. M. Main, H. E. Virtanen, Clair-Yves Boquien, P. Marchand, et al.. Country-specific chemical signatures of persistent organic pollutants (POPs) in breast milk of French, Danish and Finnish women: Country-specific chemical signatures of persistent organic pollutants (POPs) in breast milk of French, Danish and Finnish women. Environmental Pollution, Elsevier, 2016, 218, pp.728-738. ⟨10.1016/j.envpol.2016.07.069⟩. ⟨hal-02637397⟩
  • Arnaud de Luca, Marine Frasquet-Darrieux, Marie-Agnes Gaud, Patricia Christin, Clair-Yves Boquien, et al.. Higher Leptin but Not Human Milk Macronutrient Concentration Distinguishes Normal-Weight from Obese Mothers at 1-Month Postpartum. PLoS ONE, Public Library of Science, 2016, 11 (12), pp.e0168568. ⟨10.1371/journal.pone.0168568⟩. ⟨hal-02141337⟩
  • Olivier Tranquet, Valerie Echasserieau-Laporte, Herve Bernard, Clair-Yves Boquien, Thomas Moyon, et al.. Projet MANOE, Maîtrise Allergène NutritiOn Enfant. Etude de la réactivité de patients allergiques à des faibles doses d'allergènes (blé, œuf, lait, arachide). Détection et quantification des allergènes présents à faibles doses dans des matrices alimentaires complexes. Innovations Agronomiques, INRAE, 2016, 52, pp.27-35. ⟨10.15454/1.513583543955866E12⟩. ⟨hal-01652907⟩
  • Ilaria Floris, Hélène Billard, Clair-Yves Boquien, Evelyne Joram-Gauvard, Laure Simon, et al.. MiRNA Analysis by Quantitative PCR in Preterm Human Breast Milk Reveals Daily Fluctuations of hsa-miR-16-5p. PLoS ONE, Public Library of Science, 2015, 10 (10), ⟨10.1371/journal.pone.0140488⟩. ⟨hal-02641551⟩
  • Aurore Martin-Agnoux, Jean-Philippe Antignac, Clair-Yves Boquien, Agnès David, Emmanuelle Desnots, et al.. Perinatal protein restriction affects milk free amino acid and fatty acid profile in lactating rats: potential role on pup growth and metabolic status. Journal of Nutritional Biochemistry, Elsevier, 2015, 26 (7), pp.784-795. ⟨10.1016/j.jnutbio.2015.02.012⟩. ⟨hal-02634633⟩
  • Yoann Deceuninck, Emmanuelle Bichon, Philippe Marchand, Clair-Yves Boquien, Arnaud Legrand, et al.. Determination of bisphenol A and related substitutes/analogues in human breast milk using gas chromatography-tandem mass spectrometry. Analytical and Bioanalytical Chemistry, Springer Verlag, 2015, 407 (9), pp.2485 - 2497. ⟨10.1007/s00216-015-8469-9⟩. ⟨hal-02637449⟩
  • Fatima Kasbi-Chadli, Clair-Yves Boquien, Gilles Simard, Lionel Ulmann, Virginie Mimouni, et al.. Maternal supplementation with n-3 long chain polyunsaturated fatty acids during perinatal period alleviates the metabolic syndrome disturbances in adult hamster pups fed a high-fat diet after weaning. Journal of Nutritional Biochemistry, Elsevier, 2014, 25 (7), pp.726-733. ⟨10.1016/j.jnutbio.2014.03.003⟩. ⟨hal-02636983⟩
  • Véronique Ferchaud Roucher, Emmanuelle Desnots, Charlotte Nael, Aurore Martin Agnoux, Marie Cécile Alexandre-Gouabau, et al.. Use of UPLC-ESI-MS/MS to quantitate free amino acid concentrations in micro-samples of mammalian milk.. SpringerPlus, SpringerOpen, 2013, 2, pp.622. ⟨10.1186/2193-1801-2-622⟩. ⟨hal-02647300⟩
  • Jean-Christophe Rozé, Dominique Darmaun, Clair-Yves Boquien, Cyril Flamant, Jean-Charles Picaud, et al.. The apparent breastfeeding paradox in very preterm infants: relationship between breast feeding, early weight gain and neurodevelopment based on results from two cohorts, EPIPAGE and LIFT. BMJ Open, BMJ Publishing Group, 2012, 2 (2), ⟨10.1136/bmjopen-2012-000834⟩. ⟨hal-02651908⟩
  • Eloise Delamaire, Patricia Parnet, Berengere Coupe, Christine Hoebler, Sophie Blat, et al.. Long term metabolic impact of high protein neonatal feeding: a preliminary study in male rat pups born with a low birth weight. Clinical Nutrition, Elsevier, 2012, 31 (5), pp.741-748. ⟨10.1016/j.clnu.2012.02.005⟩. ⟨hal-01415274⟩
  • Hanane Kadar, Bruno Veyrand, Andrea Barbarossa, Giampiero Pagliuca, Arnaud Legrand, et al.. Development of an analytical strategy based on liquidchromatography-high resolution mass spectrometry for measuringperfluorinated compounds in human breast milk: Application to thegeneration of preliminary data regarding perinatal exposure in France. Chemosphere, Elsevier, 2011, 85 (3), pp.473 - 480. ⟨10.1016/j.chemosphere.2011.07.077⟩. ⟨hal-02644361⟩
  • I. Sodini, Clair-Yves Boquien, Georges Corrieu, C. Lacroix. Microbial dynamics of co- and separately entrapped mixed cultures of mesophilic lactic acid bacteria during the continuous prefermentation of milk. Enzyme and Microbial Technology, Elsevier, 1997, 20, pp.381-388. ⟨hal-02697444⟩
  • I. Sodini, Clair-Yves Boquien, Georges Corrieu, C. Lacroix. Use of an immobilized cell bioreactor for the continuous inoculation of milk in fresh cheese manufacturing. Journal of Industrial Microbiology and Biotechnology, Springer Verlag, 1997, 18 (1), pp.56-61. ⟨10.1038/sj.jim.2900362⟩. ⟨hal-02695477⟩
  • H. Boumerdassi, M. Desmazeaud, Christophe Monnet, Clair-Yves Boquien, Georges Corrieu. Improvement of diacetyl production by Lactococcus lactis ssp. lactis CNRZ 483 through oxygen control. Journal of Dairy Science, American Dairy Science Association, 1996, 79, pp.775-781. ⟨hal-02693291⟩
  • C. Joyeux, E. Chrzavzez, Clair-Yves Boquien, D. Picque, Georges Corrieu. Reusable solid phase immunoassay for the detection of citrate lyase. Analytica Chimica Acta, Elsevier Masson, 1996, 320, pp.77-86. ⟨hal-02690813⟩
  • P.F. David, Clair-Yves Boquien, F. Nakache, N. Bassit, D. Hartley, et al.. Quantification of citrate lyase by enzyme-linked immunosorbent assay for determining the population of Lactococcus lactis subsp. lactis biovar diacetylactis in pure and mixed cultures. Applied Microbiology and Biotechnology, Springer Verlag, 1995, 44 (1-2), pp.68-74. ⟨hal-02706973⟩
  • N. Bassit, Clair-Yves Boquien, D. Picque, Georges Corrieu. Effect of temperature on diacetyl and acetoin production by Lactococcus lactis subsp. lactis biovar diacetilactis CNRZ 483. Journal of Dairy Research, Cambridge University Press (CUP), 1995, 62, pp.123-129. ⟨hal-02713704⟩
  • I. Sodini-Gallot, Georges Corrieu, Clair-Yves Boquien, Eric Latrille, C. Lacroix. Process performance of continuous inoculation and acidification of milk with immobilized lactic acid bacteria. Journal of Dairy Science, American Dairy Science Association, 1995, 78, pp.1407-1420. ⟨hal-02704994⟩
  • C. d'Angio, C. Béal, Clair-Yves Boquien, Philippe Langella, Georges Corrieu. Plasmid stability in recombinant strains of Lactococcus lactis subsp. lactis during continuous culture. FEMS Microbiology Letters, Wiley-Blackwell, 1994, 116 (1), pp.25-30. ⟨hal-02706358⟩
  • N Bassit, E Latrille, Clair-Yves Boquien, D Picque, G Corrieu. Effet combiné de l'oxygène et de la température sur l'acidification et les productions de diacétyle et d'acétoïne par Lactococcus lactis subsp lactis biovar diacetylactis. Le Lait, INRA Editions, 1994, 74 (2), pp.115-126. ⟨hal-00929382⟩
  • C. d'Angio, C. Béal, Clair-Yves Boquien, Georges Corrieu. Influence of dilution rate and cell immobilization on plasmid stability during continuous cultures of recombinant strains of Lactococcus lactis subsp. lactis. Journal of Biotechnology, Elsevier, 1994, 34 (1), pp.87-95. ⟨hal-02706891⟩
  • V. Xanthopoulos, D. Picque, N. Bassit, Clair-Yves Boquien, Georges Corrieu. Methods for the determination of aroma compounds in dairy products : a comparative study. Journal of Dairy Research, Cambridge University Press (CUP), 1994, 61 (2), pp.289-297. ⟨hal-02707272⟩
  • N. Bassit, Clair-Yves Boquien, D. Picque, Georges Corrieu. Effect of initial oxygen concentration on diacetyl and acetoin production by Lactococcus lactis subsp. lactis biovar diacetylactis. Applied and Environmental Microbiology, American Society for Microbiology, 1993, 59 (6), pp.1893-1897. ⟨hal-02711819⟩
  • Clair-Yves Boquien. L'apport de l'immunochimie en agroalimentaire. Immunoanalyse et Biologie Spécialisée, Elsevier Masson, 1993, 2, pp.81-88. ⟨hal-02710931⟩
  • P.S.T. Tan, Marie-Pierre Chapot Chartier, K.M. Pos, M. Rousseau, Clair-Yves Boquien, et al.. Localization of peptidases in lactococci. Applied and Environmental Microbiology, American Society for Microbiology, 1992, 58 (1), pp.285-290. ⟨hal-02707933⟩
  • N. El Alami, Clair-Yves Boquien, Georges Corrieu. Batch cultures of recombinant Lactococcus lactis subsp. lactis in a stirred fermentor. I. Effect of plasmid content on bacterial growth and on genetic stability in pure cultures. Applied Microbiology and Biotechnology, Springer Verlag, 1992, 37 (3), pp.358-363. ⟨hal-02703024⟩
  • N. El Alami, Clair-Yves Boquien, Georges Corrieu. Batch cultures of recombinant Lactococcus lactis subsp. lactis in a stirred fermentor. II. Plasmid transfer in mixed cultures. Applied Microbiology and Biotechnology, Springer Verlag, 1992, 37 (3), pp.364-368. ⟨hal-02703027⟩
  • Clair-Yves Boquien, F. Nakache, A. Paraf. Ultrasound treatment for harvesting an aminopeptidase from lactic acid bacteria and quantitation of the enzyme by enzyme-linked immunosorbent assays. Applied and Environmental Microbiology, American Society for Microbiology, 1991, 57 (8), pp.2211-2216. ⟨hal-02709309⟩
  • Clair-Yves Boquien, M.J. Desmazeaud, G. Corrieu. Caractérisation d'une aminopeptidase chez Streptococcus cremoris AM2 et d'une α-galactosidase chez Leuconostoc lactis CNRZ 1091. Le Lait, INRA Editions, 1989, 69 (1), pp.71-81. ⟨hal-00929150⟩
  • E. Neviani, Clair-Yves Boquien, V. Monnet, Luu Phan Thanh, J.C. Gripon. Purification and characterization of an aminopeptidase from Lactococcus lactis subsp. cremoris AM2. Applied and Environmental Microbiology, American Society for Microbiology, 1989, 55 (9), pp.2308-2314. ⟨hal-02721915⟩
  • Clair-Yves Boquien, M.J. Desmazeaud, Georges Corrieu. Caracterisation d'une aminopeptidase chez Streptococcus cremoris AM2 et d'une alpha-galactosidase chez Leuconostoc lactis CNRZ 1091. Lait, Elsevier, 1989, 69, pp.71-81. ⟨hal-02724365⟩
  • Clair-Yves Boquien, Georges Corrieu, M.J. Desmazeaud. Enzymatic methods for determining populations of Streptococcus cremoris AM2 and Leuconostoc lactis CNRZ 1091 in pure and mixed cultures. Applied Microbiology and Biotechnology, Springer Verlag, 1989, 30 (4), pp.402-407. ⟨hal-02727478⟩
  • Clair-Yves Boquien, Georges Corrieu, J. Desmazeaud. Effect of fermentation conditions on growth of Streptococcus cremoris AM2 and Leuconostoc lactis CNRZ 1091 in pure and mixed cultures. Applied and Environmental Microbiology, American Society for Microbiology, 1988, 54 (10), pp.2527-2531. ⟨hal-02722294⟩
  • V. Juillard, H.E. Spinnler, M.J. Desmazeaud, Clair-Yves Boquien. Phénomènes de coopération et d'inhibition entre les bactéries lactiques utilisées en industrie laitière. Le Lait, INRA Editions, 1987, 67 (2), pp.149-172. ⟨hal-00929090⟩
  • Vincent Juillard, Henry-Eric Spinnler, M. Desmazeaud, Clair-Yves Boquien. Phenomenes de cooperation et d'inhibition entre les bacteries lactiques utilisees en industrie laitiere. Lait, Elsevier, 1987, 67, pp.149-172. ⟨hal-02726095⟩

Theses1 document

  • Clair-Yves Boquien. Determination des populations de Streptococcus cremoris 380 et Leuconostoc lactis 1091 en cultures pures et mixtes par methode enzymatique. Sciences du Vivant [q-bio]. Institut National Agronomique, 1988. Français. ⟨tel-02857749⟩

Other publications1 document

  • Stéphanie Jolly, Marie Le, Gaëlle Boudry, Clair-Yves Boquien, Jean-Marc Goujon, et al.. Allaitement. 2018, https://www.pole-valorial.fr/success_stories/allaitement. ⟨hal-02420645⟩