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Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors

J. Senger , J. Melesina , Martin Marek , Christophe Romier , I. Oehme , et al.
Journal of Medicinal Chemistry, 2016, 59 (4), pp.1545-55. ⟨10.1021/acs.jmedchem.5b01493⟩
Article dans une revue hal-03680475v1

Design, Multicomponent Synthesis, and Anticancer Activity of a Focused Histone Deacetylase (HDAC) Inhibitor Library with Peptoid-Based Cap Groups

Viktoria Krieger , Alexandra Hamacher , Christoph Gertzen , Johanna Senger , Martijn Zwinderman , et al.
Journal of Medical Chemistry, 2017, 60 (13), pp.5493-5506. ⟨10.1021/acs.jmedchem.7b00197⟩
Article dans une revue hal-03682266v1
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Efficient CRISPR-Cas9-mediated genome editing for characterization of essential genes in Trypanosoma cruzi

Gisele Fernanda Assine Picchi-Constante , Priscila Mazzocchi Hiraiwa , Martin Marek , Vanessa Zulkievicz Rogerio , Eloise Pavão Guerra-Slompo , et al.
STAR Protocols, 2022, 3 (2), ⟨10.1016/j.xpro.2022.101324⟩
Article dans une revue hal-04219152v1

Molecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits histone deacetylase 8 (HDAC8) from the human pathogen schistosoma mansoni

D Stolfa , Martin Marek , J Lancelot , A Hauser , A Walter , et al.
Journal of Molecular Biology, 2014, 426 (20), pp.3442-3453. ⟨10.1016/j.jmb.2014.03.007⟩
Article dans une revue hal-03831455v1
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Development of Alkylated Hydrazides as Highly Potent and Selective Class I Histone Deacetylase Inhibitors with T cell Modulatory Properties

Ping Sun , Jing Wang , Khadija S. Khan , Weiqin Yang , Billy Wai-Lung Ng , et al.
Journal of Medicinal Chemistry, 2022, 65 (24), pp.16313-16337. ⟨10.1021/acs.jmedchem.2c01132⟩
Article dans une revue hal-04219149v1

Strategies for bacterial expression of protein–peptide complexes: Application to solubilization of papillomavirus E6

Abdellahi Ould M’hamed Ould Sidi , Khaled Ould Babah , Nicole Brimer , Yves Nominé , Christophe Romier , et al.
Protein Expression and Purification, 2011, 80 (1), pp.8-16. ⟨10.1016/j.pep.2011.06.013⟩
Article dans une revue hal-03406388v1

Complex Reconstitution and Characterization by Combining Co-expression Techniques in Escherichia coli with High-Throughput

Renaud Vincentelli , Christophe Romier
Vega, MC. ADVANCED TECHNOLOGIES FOR PROTEIN COMPLEX PRODUCTION AND CHARACTERIZATION, 896, pp.43-58, 2016, Advances in Experimental Medicine and Biology, 978-3-319-27216-0; 978-3-319-27214-6. ⟨10.1007/978-3-319-27216-0_4⟩
Chapitre d'ouvrage hal-01439077v1
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Characterization of the interaction between protein Snu13p/15.5K and the Rsa1p/NUFIP factor and demonstration of its functional importance for snoRNP assembly

Benjamin Rothé , Régis Back , Marc Quinternet , Jonathan Bizarro , Marie-Cécile Robert , et al.
Nucleic Acids Research, 2014, 42 (3), pp.2015-2036. ⟨10.1093/nar/gkt1091⟩
Article dans une revue hal-01452718v1
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Design, synthesis, and biological evaluation of dual targeting inhibitors of histone deacetylase 6/8 and bromodomain BRPF1

Ehab Ghazy , Patrik Zeyen , Daniel Herp , Martin Hügle , Karin Schmidtkunz , et al.
European Journal of Medicinal Chemistry, 2020, 200, pp.112338. ⟨10.1016/j.ejmech.2020.112338⟩
Article dans une revue hal-02999300v1

Characterization and Production of Protein Complexes by Co-expression in Escherichia coli

Matthias Haffke , Martin Marek , Martin Pelosse , Marie-Laure Diebold , Uwe Schlattner , et al.
Methods in Molecular Biology, 2015, Escherichia coli, 1261, pp.63-89. ⟨10.1007/978-1-4939-2230-7_4⟩
Article dans une revue hal-01953513v1
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Strategies for bacterial expression of protein–peptide complexes: Application to solubilization of papillomavirus E6

Abdellahi Ould M’hamed Ould Sidi , Khaled Ould Babah , Nicole Brimer , Yves Nominé , Christophe Romier , et al.
Protein Expression and Purification, 2011, 80 (1), pp.8-16. ⟨10.1016/j.pep.2011.06.013⟩
Article dans une revue hal-03049172v1
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TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation

Daniil Alpern , Diana Langer , Benoit Ballester , Stephanie Le Gras , Christophe Romier , et al.
eLife, 2014, 3, pp.308-312. ⟨10.7554/eLife.03613.001⟩
Article dans une revue hal-01404987v1

Alkoxyurea-based histone deacetylase inhibitors increase cisplatin potency in chemoresistant cancer cell lines

Katharina Stenzel , Alexandra Hamacher , Finn Hansen , Christoph Gertzen , Johanna Senger , et al.
Journal of Medicinal Chemistry, 2017, 60 (13), pp.5334-5348. ⟨10.1021/acs.jmedchem.6b01538⟩
Article dans une revue hal-03691179v1
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Structural Basis for the Inhibition of Histone Deacetylase 8 (HDAC8), a Key Epigenetic Player in the Blood Fluke Schistosoma mansoni

Martin Marek , Srinivasaraghavan Kannan , Alexander-Thomas Hauser , Marina Moraes Mourão , Stéphanie Caby , et al.
PLoS Pathogens, 2013, 9, ⟨10.1371/journal.ppat.1003645⟩
Article dans une revue hal-03542658v1

Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies

Margherita Brindisi , Johanna Senger , Caterina Cavella , Alessandro Grillo , Giulia Chemi , et al.
European Journal of Medicinal Chemistry, 2018, 157, pp.127-138. ⟨10.1016/j.ejmech.2018.07.069⟩
Article dans une revue hal-02391151v1
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Binding Free Energy (BFE) Calculations and Quantitative Structure-Activity Relationship (QSAR) Analysis of Schistosoma mansoni Histone Deacetylase 8 (smHDAC8) Inhibitors

Conrad V. Simoben , Ehab Ghazy , Patrick Zeyen , Salma Darwish , Matthias Schmidt , et al.
Molecules, 2021, 26 (9), ⟨10.3390/molecules26092584⟩
Article dans une revue hal-03709508v1

Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity

Tino Heimburg , Fiona Kolbinger , Patrik Zeyen , Ehab Ghazy , Daniel Herp , et al.
Journal of Medicinal Chemistry, 2017, 60 (24), pp.10188-10204. ⟨10.1021/acs.jmedchem.7b01447⟩
Article dans une revue hal-02391183v1

Dissecting the interaction network of multiprotein complexes by pairwise coexpression of subunits in E. coli11Edited by K. Nagai

Sébastien Fribourg , Christophe Romier , Sebastiaan Werten , Yann-Gaël Gangloff , Arnaud Poterszman , et al.
Journal of Molecular Biology, 2001, 306 (2), pp.363-373. ⟨10.1006/jmbi.2000.4376⟩
Article dans une revue istex hal-02126936v1

Isophthalic Acid-Based HDAC Inhibitors as Potent Inhibitors of HDAC8 from Schistosoma mansoni

Katharina Stenzel , Alokta Chakrabarti , Jelena Melesina , Finn Hansen , Julien Lancelot , et al.
Arch Pharm (Weinheim), 2017, 350 (8), ⟨10.1002/ardp.201700096⟩
Article dans une revue hal-03691172v1
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The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y

Christophe Romier , Fabienne Cocchiarella , Roberto Mantovani , Dino Moras
Journal of Biological Chemistry, 2003, 278 (2), pp.1336-1345. ⟨10.1074/jbc.M209635200⟩
Article dans une revue hal-04156290v1
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Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2

Martin Marek , Elizabeth Ramos-Morales , Gisele F A Picchi-Constante , Theresa Bayer , Carina Norström , et al.
Cell Reports, 2021, 37, ⟨10.1016/j.celrep.2021.110129⟩
Article dans une revue hal-03504175v1
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A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing

Conrad Simoben , Dina Robaa , Alokta Chakrabarti , Karin Schmidtkunz , Martin Marek , et al.
Molecules, 2018, 23 (3), pp.566. ⟨10.3390/molecules23030566⟩
Article dans une revue hal-02391176v1
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Functional Analysis of the TFIID-specific Yeast TAF4 (yTAF II 48) Reveals an Unexpected Organization of Its Histone-fold Domain

Sylvie Thuault , Yann-Gaël Gangloff , Jay Kirchner , Steven Sanders , Sebastiaan Werten , et al.
Journal of Biological Chemistry, 2002, 277 (47), pp.45510-45517. ⟨10.1074/jbc.M206556200⟩
Article dans une revue hal-02126928v1

Baculovirus VP1054 Is an Acquired Cellular PURalpha, a Nucleic Acid-Binding Protein Specific for GGN Repeats

M. Marek , C. Romier , L. Galibert , O. W. Merten , M. M. Van Oers
J Virol, 2013, 87 (15), pp.8465-80. ⟨10.1128/JVI.00068-13⟩
Article dans une revue hal-02881124v1

The TFIID Components Human TAFII140 and Drosophila BIP2 (TAFII155) Are Novel Metazoan Homologues of Yeast TAFII47 Containing a Histone Fold and a PHD Finger

Yann-Gaël Gangloff , J.-C. Pointud , S. Thuault , L. Carre , C. Romier , et al.
Molecular and Cellular Biology, 2001, 21 (15), pp.5109-5121. ⟨10.1128/MCB.21.15.5109-5121.2001⟩
Article dans une revue hal-02126930v1

Large-Scale Overproduction and Purification of Recombinant Histone Deacetylase 8 (HDAC8) from the Human-Pathogenic Flatworm Schistosoma mansoni

Martin Marek , Tajith Baba Shaik , Sylvie Duclaud , R. J. Pierce , Christophe Romier
Methods in Molecular Biology, 2016, 1436, pp.109-18. ⟨10.1007/978-1-4939-3667-0_8⟩
Article dans une revue hal-03680463v1

Chemically Diverse S. mansoni HDAC8 Inhibitors Reduce Viability in Worm Larval and Adult Stages

Beatrice Noce , Elisabetta Di Bello , Clemens Zwergel , Rossella Fioravanti , Sergio Valente , et al.
ChemMedChem, 2023, 18 (3), ⟨10.1002/cmdc.202200510⟩
Article dans une revue hal-04219183v1

Crystallization and preliminary crystallographic analysis of eukaryotic transcription and mRNA export factor Iws1 from Encephalitozoon cuniculi

Michael Koch , Marie-Laure Diebold , Jean Cavarelli , Christophe Romier
Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 2010, 66 (Pt 2), pp.207-210. ⟨10.1107/S1744309109052749⟩
Article dans une revue hal-04014328v1

Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells

Patrik Zeyen , Yanira Zeyn , Daniel Herp , Fereshteh Mahmoudi , Talha Z. Yesiloglu , et al.
European Journal of Medicinal Chemistry, 2022, 234, ⟨10.1016/j.ejmech.2022.114272⟩
Article dans une revue hal-04222050v1

Isoform-selective HDAC1/6/8 inhibitors with an imidazo-ketopiperazine cap containing stereochemical diversity

Bertrand Lecointre , Remy Narozny , Maria Teresa Borrello , Johanna Senger , Alokta Chakrabarti , et al.
Philosophical Transactions of the Royal Society B: Biological Sciences, 2018, 373 (1748), pp.20170364. ⟨10.1098/rstb.2017.0364⟩
Article dans une revue hal-02391161v1