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Development of Pleiotropic TrkB and 5-HT4 Receptor Ligands as Neuroprotective Agents
Mirjana Antonijevic
,
Despoina Charou
,
Audrey Davis
,
Thomas Curel
,
Maria Valcarcel
Article dans une revue
hal-04414817v1
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Inducing neuronal regeneration and differentiation via the BDNF/TrkB signaling pathway: a key target against neurodegenerative diseases?
Mirjana Antonijevic
,
Patrick Dallemagne
,
Christophe Rochais
Article dans une revue
hal-04414820v1
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Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation
Rim Malek
,
Alexey Simakov
,
Audrey Davis
,
Maciej Maj
,
Paul Bernard
Article dans une revue
hal-03969932v1
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Conceptual Framework of the Design of Pleiotropic Drugs against Alzheimer’s Disease
Thomas Guiselin
,
Cédric Lecoutey
,
Christophe Rochais
,
Patrick Dallemagne
Article dans une revue
hal-04414828v1
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C3-Symmetric Ligands in Drug Design: When the Target Controls the Aesthetics of the Drug
Mirjana Antonijevic
,
Christophe Rochais
,
Patrick Dallemagne
Article dans une revue
hal-03969919v1
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Advances in prodrug design for Alzheimer’s disease: the state of the art
Valentin Travers--Lesage
,
Serge Mignani
,
Patrick Dallemagne
,
Christophe Rochais
Article dans une revue
hal-03969939v1
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5-HT4R modulators: a patent landscape
Patrick Dallemagne
,
Christophe Rochais
Article dans une revue
hal-03969965v1
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Desirable drug–drug interactions or when a matter of concern becomes a renewed therapeutic strategy
Benjamin Guieu
,
Jean-Pierre Jourdan
,
Aurore Dreneau
,
Nicolas Willand
,
Christophe Rochais
Article dans une revue
hal-03969988v1
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Development of Novel Potential Pleiotropic Compounds of Interest in Alzheimer’s Disease Treatment through Rigidification Strategy
Cédric Lecoutey
,
Rémi Legay
,
Audrey Davis
,
Jana Sopková-de Oliveira Santos
,
Patrick Dallemagne
Article dans une revue
hal-03969972v1
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Aminothiaindanone as an Accessible Scaffold for a Three-Point Chemical Diversity
Pauline Zipfel
,
Julien Lalut
,
Jana Sopková-de Oliveira Santos
,
Christophe Rochais
,
Patrick Dallemagne
Article dans une revue
hal-03969969v1
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First Synthesis of Racemic Trans Propargylamino-Donepezil, a Pleiotrope Agent Able to Both Inhibit AChE and MAO-B, with Potential Interest against Alzheimer’s Disease
Benjamin Guieu
,
Cedric Lecoutey
,
Rémi Legay
,
Audrey Davis
,
Jana Sopkova de Oliveira Santos
Article dans une revue
hal-03969980v1
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Disproportionality analysis in VigiBase as a drug repositioning method for the discovery of potentially useful drugs in Alzheimer's disease
Basile Chrétien
,
Jean‐pierre Jourdan
,
Audrey Davis
,
Sophie Fedrizzi
,
Ronan Bureau
Article dans une revue
hal-03969985v1
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Pharmacotechnical Development of a Nasal Drug Delivery Composite Nanosystem Intended for Alzheimer’s Disease Treatment
Thomas Adnet
,
Anne-Claire Groo
,
Céline Picard
,
Audrey Davis
,
Sophie Corvaisier
Article dans une revue
hal-03969997v1
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Matrix metalloproteinases as new targets in Alzheimer's disease: Opportunities and Challenges
Pauline Zipfel
,
Christophe Rochais
,
Kévin Baranger
,
Santiago Rivera
,
Patrick Dallemagne
Journal of Medicinal Chemistry, 2020
Article dans une revue
hal-03461436v1
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hERG toxicity assessment: Useful guidelines for drug design
Amanda Garrido
,
Alban Lepailleur
,
Serge M. Mignani
,
Patrick Dallemagne
,
Christophe Rochais
Article dans une revue
hal-03490407v1
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Drug repositioning: a brief overview
Jean-Pierre Jourdan
,
Ronan Bureau
,
Christophe Rochais
,
Patrick Dallemagne
Article dans une revue
hal-03961788v1
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Facing the complexity of Alzheimer's disease
Patrick Dallemagne
,
Christophe Rochais
Article dans une revue
hal-03970000v1
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Donecopride, a Swiss army knife with potential interest against Alzheimer's disease
Christophe Rochais
,
Cédric Lecoutey
,
Katia Hamidouche
,
Patrizia Giannoni
,
Florence Gaven
Article dans une revue
hal-02428730v1
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Impact of T161, Y318 and S363 alanine mutations on regulation of the human delta-opioid receptor (hDOPr) induced by peptidic and alkaloid agonists
Elise Camacho
,
Nicolas Marie
,
Quentin Dupas
,
Caroline Martel
,
Marie Nowoczyn
Article dans une revue
hal-03969992v1
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Structure-activity relationships of serotonin 5-HT7 receptors ligands: A review
Sangeetha-Laura Thirumaran
,
Alban Lepailleur
,
Christophe Rochais
Article dans une revue
hal-03488662v1
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A chemical screen identifies two novel small compounds that alter Arabidopsis thaliana pollen tube growth
Ferdousse Laggoun
,
Flavien Dardelle
,
Jérémy Dehors
,
Denis Falconet
,
Azeddine Driouich
Article dans une revue
hal-02106475v1
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26th Annual GP2A Medicinal Chemistry Conference & 32nd Journées Franco-Belges de Pharmacochimie
Patrick Dallemagne
,
Christophe Rochais
,
Pascal Marchand
,
Thierry Besson
Article dans une revue
hal-02330438v1
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Novel multi target-directed ligands targeting 5-HT4 receptors with in cellulo antioxidant properties as promising leads in Alzheimer's disease
Caroline Lanthier
,
Hugo Payan
,
Irene Liparulo
,
Bérénice Hatat
,
Cédric Lecoutey
Article dans une revue
hal-02399942v1
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Modulating 5-HT 4 and 5-HT 6 receptors in Alzheimer’s disease treatment
Julien Lalut
,
Delphine Karila
,
Patrick Dallemagne
,
Christophe Rochais
Article dans une revue
hal-02043735v1
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Benzylphenylpyrrolizinones with Anti-amyloid and Radical Scavenging Effects, Potentially Useful in Alzheimer's Disease Treatment
Jean-Pierre Jourdan
,
Marc Since
,
Laïla El kihel
,
Cédric Lecoutey
,
Sophie Corvaisier
Article dans une revue
hal-02043731v1
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Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment
Jean-Pierre Jourdan
,
Marc Since
,
Laïla El Kihel
,
Cédric Lecoutey
,
Sophie Corvaisier
Article dans une revue
hal-02043765v1
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Design, synthesis, and pharmacological evaluation of multitarget-directed ligands with both serotonergic subtype 4 receptor (5-HT 4 R) partial agonist and 5-HT 6 R antagonist activities, as potential treatment of Alzheimer’s disease
Samir Yahiaoui
,
Katia Hamidouche
,
Céline Ballandonne
,
Audrey Davis
,
Jana Sopkova-de Oliveira Santos
Article dans une revue
hal-02043759v1
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3-(Dipropylamino)-5-hydroxybenzofuro[2,3-f]quinazolin-1(2H)-one (DPA-HBFQ-1) plays an inhibitory role on breast cancer cell growth and progression
Pietro Rizza
,
Michele Pellegrino
,
Anna Caruso
,
Domenico Iacopetta
,
Maria Stefania Sinicropi
Article dans une revue
hal-02043777v1
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Recent Advances in Phenanthroindolizidine and Phenanthroquinolizidine Derivatives with Anticancer Activities
Maria Fatima Pereira
,
Christophe Rochais
,
Patrick Dallemagne
Article dans une revue
hal-02043788v1
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Indenopyrazole oxime ethers: Synthesis and β1-adrenergic blocking activity
Tomaso Angelone
,
Anna Caruso
,
Christophe Rochais
,
Angela Caputa
,
Maria Cerra
Article dans une revue
hal-01116512v1
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Chronic activation of 5-HT4 receptors or blockade of 5-HT6 receptors improve memory performances
Anne Quiedeville
,
Michel Boulouard
,
Katia Hamidouche
,
Virginie da Silva Costa-Aze
,
Gerald Nee
Article dans une revue
hal-02043824v1
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Therapeutic Potential of 5-HT 6 Receptor Agonists
Delphine Karila
,
Thomas Freret
,
Valentine Bouet
,
Michel Boulouard
,
Patrick Dallemagne
Article dans une revue
hal-02043781v1
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Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment
Cédric Lecoutey
,
Damien Hedou
,
Thomas Freret
,
Patrizia Giannoni
,
Florence Gaven
Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (36), pp.E3825--30. ⟨10.1073/pnas.1410315111⟩
Article dans une revue
hal-01800439v2
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MR22388, a novel anti-cancer agent with a strong FLT-3 ITD kinase affinity.
Christophe Rochais
,
Thierry Cresteil
,
Vittoria Perri
,
Marie Jouanne
,
Aurélien Lesnard
Article dans une revue
hal-00807871v1
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Design, synthesis and biological evaluation of novel indano- and thiaindano-pyrazoles with potential interest for Alzheimer's disease.
David Genest
,
Christophe Rochais
,
Cédric Lecoutey
,
Jana Sopkova-de Oliveira Santos
,
Céline Ballandonne
MedChemComm, 2013, 4, pp.925-931
Article dans une revue
hal-00840942v1
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Tripentones: A Promising Series of Potent Anti-Cancer Agents.
Christophe Rochais
,
Sylvain Rault
,
Patrick Dallemagne
Anti-Cancer Agents in Medicinal Chemistry, 2013, 2, pp.313-343
Article dans une revue
hal-00840950v1
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An unusual boron tribromide-mediated, one-pot bromination/cyclization reaction. Application to the synthesis of a highly strained cyclopenta[1,3]cyclopropa[1,2-b]pyrrolizin-8-one.
Jean-Pierre Jourdan
,
Christophe Rochais
,
Rémi Legay
,
Jana Sopkova-de Oliveira Santos
,
Patrick Dallemagne
Tetrahedron Letters, 2013, 54 (9), pp.1133-1136
Article dans une revue
hal-00821455v1
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Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect
Elizabeth Chosson
,
Francesca Santoro
,
Christophe Rochais
,
Jana Sopkova-de Oliveira Santos
,
Rémi Legay
Article dans une revue
hal-02357753v1
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Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT4 receptor activation (RS67333) on object recognition in mice.
Thomas Freret
,
Valentine Bouet
,
Anne Quiedeville
,
Gerald Nee
,
Patrick Dallemagne
Behavioural Brain Research, 2012, 230, pp.304-308
Article dans une revue
hal-00821461v1
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Synthesis of dual AChE/5-HT4 receptor multi-target directed ligands.
Cédric Lecoutey
,
Christophe Rochais
,
David Genest
,
Sabrina Butt-Gueulle
,
Céline Ballandonne
MedChemComm, 2012, 3, pp.627-634
Article dans une revue
hal-00764795v1
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2,5-Dimethoxytetrahydrofuran, first update.
Christophe Rochais
,
Patrick Dallemagne
Encyclopedia of Reagents for Organic Synthesis, 2012, pp.2012
Article dans une revue
hal-00821463v1
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Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT(4) receptor activation (RS67333) on object recognition in mice.
Thomas Freret
,
Valentine Bouet
,
Anne Quiedeville
,
Gérald Nee
,
Patrick Dallemagne
Article dans une revue
hal-00862757v1
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One-pot synthesis of new aza- and diaza-aminopenanthrenes
Christophe Rochais
,
Rodrigue Yougnia
,
Thomas Cailly
,
Jana Sopkova-de Oliveira Santos
,
Sylvain Rault
Article dans une revue
hal-01061754v1
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First and mild synthesis of fluorene-9-malonic acid and some substituted derivatives via the intramolecular hydroarylation of 2-phenylbenzylidenemalonic acids
Elizabeth Chosson
,
Christophe Rochais
,
Rémi Legay
,
Jana Sopkova-de Oliveira Santos
,
Sylvain Rault
Article dans une revue
hal-01018072v1
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Virtual Screening Discovery of New Acetylcholinesterase Inhibitors Issued from CERMN Chemical Library
Jana Sopkova-de Oliveira Santos
,
Aurélien Lesnard
,
Jean-Hugues Agondanou
,
Nathalie Dupont
,
Anne-Marie Godard
Article dans une revue
hal-00705935v1
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Hydrogenative desulphurization of thienopyrrolizinones: An easy and selective access to (Z)-phenethylidenepyrrolizinones with in vitro cytotoxic activity
Vittoria Perri
,
Christophe Rochais
,
Jana Sopkova-de Oliveira Santos
,
Rémi Legay
,
Thierry Cresteil
Article dans une revue
hal-02045946v1
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One-pot synthesis of novel poly-substituted phenanthrenes
Rodrigue Yougnia
,
Christophe Rochais
,
Jana Sopkova-de Oliveira Santos
,
Patrick Dallemagne
,
Sylvain Rault
Article dans une revue
hal-02045958v1
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Intramolecular Cyclisation of β-Aryl-β-Amino Acids in the Design of Novel Heterocyclic Systems with Therapeutic Interest: An Unfailing Source of Diversity
Christophe Rochais
,
Sylvain Rault
,
Patrick Dallemagne
Current Medicinal Chemistry, 2010, 17 (35), pp.4342-4369
Article dans une revue
hal-02045949v1
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Synthesis, reactivity and biological evaluation of novel halogenated tripentones.
Vittoria Perri
,
Christophe Rochais
,
Thierry Cresteil
,
Patrick Dallemagne
,
Sylvain Rault
Article dans une revue
hal-00433244v1
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Synthesis of new dipyrrolo- and furopyrrolopyrazinones related to tripentones and their biological evaluation as potential kinases (CDKs1-5, GSK-3) inhibitors.
Christophe Rochais
,
Nghia Vu Duc
,
Elodie Lescot
,
Jana Sopkova-de Oliveira Santos
,
Ronan Bureau
Article dans une revue
hal-00319802v1
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