Christophe Klein

Documents

Identifiants chercheurs

christophe-klein
0000-0001-8015-287X

Présentation

Publications

	A RAD51 functional assay as a candidate test for homologous recombination deficiency in ovarian cancer Félix Blanc-Durand , Elisa Yaniz-Galende , Alba Llop-Guevara , Catherine Genestie , Violeta Serra Gynecologic Oncology, 2023, 171, pp.106-113. ⟨10.1016/j.ygyno.2023.01.026⟩ Article dans une revue hal-04210315v1
	Deep learning-based phenotyping reclassifies combined hepatocellular-cholangiocarcinoma Julien Calderaro , Narmin Ghaffari Laleh , Qinghe Zeng , Pascale Maille , Loetitia Favre Nature Communications, 2023, 14 (1), pp.8290. ⟨10.1038/s41467-023-43749-3⟩ Article dans une revue hal-04439486v1
	New hormone receptor-positive breast cancer mouse cell line mimicking the immune microenvironment of anti-PD-1 resistant mammary carcinoma Maria Perez-Lanzon , Vincent Carbonnier , Pierre Cordier , Fatima Domenica Elisa de Palma , Adriana Petrazzuolo Journal for Immunotherapy of Cancer, 2023, 11 (6), pp.e007117. ⟨10.1136/jitc-2023-007117⟩ Article dans une revue hal-04210300v1
	Periostin‐ and podoplanin‐positive cancer‐associated fibroblast subtypes cooperate to shape the inflamed tumor microenvironment in aggressive pancreatic adenocarcinoma Cindy Neuzillet , Rémy Nicolle , Jérôme Raffenne , Annemilaï Tijeras-Raballand , Alexia Brunel Journal of Pathology, 2022, 258 (4), pp.408-425. ⟨10.1002/path.6011⟩ Article dans une revue hal-04210308v1
	Artificial intelligence predicts immune and inflammatory gene signatures directly from hepatocellular carcinoma histology Qinghe Zeng , Christophe Klein , Stefano Caruso , Pascale Maille , Narmin Ghaffari Laleh Journal of Hepatology, 2022, 77 (1), pp.116-127. ⟨10.1016/j.jhep.2022.01.018⟩ Article dans une revue hal-04210277v1
	Artificial intelligence for solid tumour diagnosis in digital pathology Christophe Klein , Qinghe Zeng , Floriane Arbaretaz , Estelle Devêvre , Julien Calderaro British Journal of Pharmacology, 2021, 178 (21), pp.4291-4315. ⟨10.1111/bph.15633⟩ Article dans une revue hal-04210289v1
	Metabolic features of cancer cells impact immunosurveillance Adrien Joseph , Pan Juncheng , Michele Mondini , Nizar Labaied , Mauro Loi Journal for Immunotherapy of Cancer, 2021, 9 (6), pp.e002362. ⟨10.1136/jitc-2021-002362⟩ Article dans une revue hal-03272265v1
	Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients Marion Picard , Satoru Yonekura , Karolina Slowicka , Ioanna Petta , Conrad Rauber Cell Death and Differentiation, 2021, 28 (5), pp.1532-1547. ⟨10.1038/s41418-020-00684-w⟩ Article dans une revue hal-03682003v1
	Acidosis‐induced activation of distal nephron principal cells triggers Gdf15 secretion and adaptive proliferation of intercalated cells Lydie Cheval , Benoit Viollet , Christophe Klein , Chloé Rafael , Lucile Figueres Acta Physiologica, 2021, pp.e13661. ⟨10.1111/apha.13661⟩ Article dans une revue hal-03208550v1
	Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer Maria Paula Roberti , Satoru Yonekura , Connie Duong , Marion Picard , Gladys Ferrere Nature Medicine, 2020, 26 (6), pp.919-931. ⟨10.1038/s41591-020-0882-8⟩ Article dans une revue hal-04210282v1
	Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer Maria Paula Roberti , Satoru Yonekura , Connie P. M. Duong , Marion Picard , Gladys Ferrere Nature Medicine, 2020, 26 (6), p. 919-931. ⟨10.1038/s41591-020-0882-8⟩ Article dans une revue hal-03313676v1
	CFH exerts anti-oxidant effects on retinal pigment epithelial cells independently from protecting against membrane attack complex Céline Borras , Jérémie Canonica , Sylvie Jorieux , Toufik Abache , Mohamed El Sanharawi Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-50420-9⟩ Article dans une revue hal-02345038v1
	Polyploidy spectrum: a new marker in HCC classification Myriam Bou-Nader , Stefano Caruso , Romain Donne , Séverine Celton-Morizur , Julien Calderaro Gut, inPress, pp.gutjnl-2018-318021. ⟨10.1136/gutjnl-2018-318021⟩ Article dans une revue hal-02102441v1
	Sostdc1 is expressed in all major compartments of developing and adult mammalian eyes Maud Valensi , Gabrielle Goldman , Dominique Marchant , Loïc van den Berghe , Laurent Jonet Graefe's Archive for Clinical and Experimental Ophthalmology, 2019, 257 (11), pp.2401-2427. ⟨10.1007/s00417-019-04462-4⟩ Article dans une revue hal-02461550v1
	Metabolic enzymes expressed by cancer cells impact the immune infiltrate Gautier Stoll , Margerie Kremer , Normal Bloy , Adrien Joseph , Maria Castedo OncoImmunology, 2019, 8 (6), pp.e1571389. ⟨10.1080/2162402X.2019.1571389⟩ Article dans une revue hal-02461563v1
	Active Fluctuations of the Nuclear Envelope Shape the Transcriptional Dynamics in Oocytes Maria Almonacid , Adel Al Jord , Stephany El-Hayek , Alice Othmani , Fanny Coulpier Developmental Cell, 2019, 51 (2), pp.145-157.e10. ⟨10.1016/j.devcel.2019.09.010⟩ Article dans une revue hal-03003444v1
	Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade Nicolas Jacquelot , Takahiro Yamazaki , Maria Roberti , Connie Duong , Miles Andrews Cell Research, 2019, 29 (10), pp.846-861. ⟨10.1038/s41422-019-0224-x⟩ Article dans une revue hal-02461559v1
	Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors Bertrand Routy , Emmanuelle Le Chatelier , Lisa Derosa , Connie Duong , Maryam Tidjani Alou Science, 2018, 359 (6371), pp.91-97. ⟨10.1126/science.aan3706⟩ Article dans une revue hal-02126484v1
	Involvement of neural crest and paraxial mesoderm in oral mucosal development and healing Juliane Isaac , Ali Nassif , Audrey Asselin , Ihsène Taïhi , Hélène Fohrer-Ting Biomaterials, 2018, 172, pp.41-53. ⟨10.1016/j.biomaterials.2018.04.036⟩ Article dans une revue hal-02461579v1
	ROCK-1 mediates diabetes-induced retinal pigment epithelial and endothelial cell blebbing: Contribution to diabetic retinopathy Pierre-Raphaël Rothschild , Sawsen Salah , Marianne Berdugo , Emmanuelle Gelize , Kimberley Delaunay Scientific Reports, 2017, 7 (1), ⟨10.1038/s41598-017-07329-y⟩ Article dans une revue hal-02461587v1
	Three-dimensional Organization of pKi-67: A Comparative Fluorescence and Electron Tomography Study Using Fluoronanogold Thierry Cheutin , Marie-Françoise O'Donohue , Adrien Beorchia , Christophe Klein , Hervé H. Kaplan Journal of Histochemistry and Cytochemistry, 2016, 51 (11), pp.1411-1423. ⟨10.1177/002215540305101102⟩ Article dans une revue hal-02328305v1
	Contribution of RIP3 and MLKL to immunogenic cell death signaling in cancer chemotherapy Heng Yang , Yuting Ma , Guo Chen , Heng Zhou , Takahiro Yamazaki OncoImmunology, 2016, 5 (6), pp.e1149673. ⟨10.1080/2162402X.2016.1149673⟩ Article dans une revue hal-02461588v1
	Targeting iron-mediated retinal degeneration by local delivery of transferrin Émilie Picard , Quentin Le Rouzic , Antonin Oudar , Marianne Berdugo , Mohamed El Sanharawi Free Radical Biology and Medicine, 2015, 89, pp.1105-1121. ⟨10.1016/j.freeradbiomed.2015.08.018⟩ Article dans une revue inserm-02980617v1
	Anti-vascular endothelial growth factor acts on retinal microglia/macrophage activation in a rat model of ocular inflammation Aude Couturier , Elodie Bousquet , Min Zhao , Marie-Christine Naud , Christophe Klein Molecular Vision, 2014, 20, pp.908-920 Article dans une revue hal-01332123v1
	Protective effect of intravitreal injection of vasoactive intestinal peptide-loaded liposomes on experimental autoimmune uveoretinitis. Emmanuelle Duron , Jean-Sébastien Vidal , Benoît Funalot , Cécile Viollet , Marie-Laure Seux Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2014, 69 (8), pp.1025-1032. ⟨10.1093/gerona/glt206⟩ Article dans une revue hal-02446108v1
	DsRed-mediated oligomerization stabilizes HMGB1 on chromatin in vivo and on DNA in vitro Melanie Messmer , Christophe Klein , Rachel Boniface , Nina F. Gnaedig , Maxime Lecerf Biochimie, 2013, 95 (4), pp.962-966. ⟨10.1016/j.biochi.2012.11.001⟩ Article dans une revue hal-01546170v1
	Live-cell imaging reveals multiple interactions between Epstein-Barr virus nuclear antigen 1 and cellular chromatin during interphase and mitosis. Nathalie Jourdan , Aude Jobart-Malfait , Gabriel dos Reis , Frédérique Quignon , Tristan Piolot Journal of Virology, 2012, 86 (9), pp.5314-29. ⟨10.1128/JVI.06303-11⟩ Article dans une revue inserm-00679274v1
	Delta-like 4 inhibits choroidal neovascularization despite opposing effects on vascular endothelium and macrophages. Serge Camelo , William Raoul , Sophie Lavalette , Bertrand Calippe , Brunella Cristofaro Angiogenesis, 2012, 15 (4), pp.609-22. ⟨10.1007/s10456-012-9290-0⟩ Article dans une revue inserm-00853034v1
	Lipid droplet analysis in caveolin-deficient adipocytes: alterations in surface phospholipid composition and maturation defects Cedric M Blouin , Soazig Le Lay , Anita Eberl , Harald Köfeler , Ida Chiara Guerrera Journal of Lipid Research, 2010, 51 (5), pp.945-956. ⟨10.1194/jlr.M001016⟩ Article dans une revue hal-02450951v1
	Protective Effect of Intravitreal Injection of Vasoactive Intestinal Peptide–Loaded Liposomes on Experimental Autoimmune Uveoretinitis Serge Camelo , Laure Lajavardi , Amélie Bochot , Brigitte Goldenberg , Marie-Christine Naud Journal of Ocular Pharmacology and Therapeutics, 2009, 25 (1), pp.9-22. ⟨10.1089/jop.2008.0074⟩ Article dans une revue hal-02507538v1
	Insulin internalizes GLUT2 in the enterocytes of healthy but not insulin-resistant mice. Vanessa Tobin , Maude Le Gall , Xavier Fioramonti , Emilie Stolarzcyk , Alba G Blazquez Diabetes, 2008, 57 (3), pp.555-62. ⟨10.2337/db07-0928⟩ Article dans une revue hal-00195152v1
	NKCC2 Surface Expression in Mammalian Cells Boubacar Benziane , Sylvie Demaretz , Nadia Defontaine , Nancy Zaarour , Lydie L Cheval Journal of Biological Chemistry, 2007, 282 (46), pp.33817-33830. ⟨10.1074/jbc.M700195200⟩ Article dans une revue hal-03160997v1
	QN1/KIAA1009: a new essential protein for chromosome segregation and mitotic spindle assembly. A. Leon , Boubaker Omri , A. Gely , Christophe Klein , Patricia Crisanti Oncogene, 2006, 25 (13), pp.1887-95. ⟨10.1038/sj.onc.1209215⟩ Article dans une revue inserm-00146728v1
	Nonrandom distribution of metaphase AgNOR staining patterns on human acrocentric chromosomes. Laurent Héliot , Fabien Mongelard , Christophe Klein , Marie-Françoise O'Donohue , Jean-Marc Chassery Journal of Histochemistry and Cytochemistry / Journal of Histochemistry & Cytochemistry, 2000, 48 (1), pp.13-20. ⟨10.1177/002215540004800102⟩ Article dans une revue hal-00192550v1
	Nonrandom Distribution of Metaphase AgNOR Staining Patterns on Human Acrocentric Chromosomes Laurent Héliot , Fabien Mongelard , Christophe Klein , Marie-Françoise O'Donohue , Jean-Marc Chassery Journal of Histochemistry and Cytochemistry, 2000, 48 (1), pp.13-20. ⟨10.1177/002215540004800102⟩ Article dans une revue hal-02328338v1
	Mounting Technique Allows Observation of Immuno-Labeled Cells on Plastic Coverslips M.F. O'Donohue , T. Cheutin , C. Klein , H. Kaplan , D. Ploton Biotechniques, 1998, 24 (6), pp.910-914. ⟨10.2144/98246bm01⟩ Article dans une revue hal-02328366v1
	The Three-dimensional Study of Chromosomes and Upstream Binding Factor-immunolabeled Nucleolar Organizer Regions Demonstrates Their Nonrandom Spatial Arrangement during Mitosis Christophe Klein , Thierry Cheutin , Lawrence Rothblum , Hervé H. Kaplan , Adrien Beorchia Molecular Biology of the Cell, 1998, 9 (11), pp.3147-3159. ⟨10.1091/mbc.9.11.3147⟩ Article dans une revue hal-02328359v1
	Electron Tomography of Metaphase Nucleolar Organizer Regions: Evidence for a Twisted-Loop Organization Laurent Héliot , Hervé H. Kaplan , Laurent Lucas , Christophe Klein , Adrien Beorchia Molecular Biology of the Cell, 1997, 8 (11), pp.2199-2216. ⟨10.1091/mbc.8.11.2199⟩ Article dans une revue hal-02328373v1

	Évaluation et adaptation de réseaux VGG16 pour la détection de carcinome sur des lames d'histologie: de la résection à la biopsie Qinghe Zeng , Nicolas Loménie , Christophe Klein , Julien Calderaro ORASIS 2021, Centre National de la Recherche Scientifique [CNRS], Sep 2021, Saint Ferréol, France Communication dans un congrès hal-03339691v1

	A novel tool for detecting lysosomal membrane permeabilization by high-throughput fluorescence microscopy Karla Alvarez-Valadez , Allan Sauvat , Hélène Fohrer-Ting , Christophe Klein , Oliver Kepp Monitoring Vesicular Trafficking in Cellular Responses to Stress - Part B, 165, Elsevier, pp.1-12, 2021, Methods in Cell Biology, ⟨10.1016/bs.mcb.2020.10.004⟩ Chapitre d'ouvrage inserm-03653036v1
	Development of Tools for the Selective Visualization and Quantification of TLS-Immune Cells on Tissue Sections Christophe Klein , Priyanka Devi-Marulkar , Marie-Caroline Dieu-Nosjean , Claire Germain Tertiary Lymphoid Structures, pp.47-69, 2018, ⟨10.1007/978-1-4939-8709-2_4⟩ Chapitre d'ouvrage hal-02461576v1

	Transcriptional regulation of jaw osteoblasts: development to pathology Ali Nassif , Guilhem Lignon , Audrey Asselin , Charles Zadikian , Stephane Petit 2022 Pré-publication, Document de travail hal-03557330v1

Christophe Klein

Présentation

Publications

A RAD51 functional assay as a candidate test for homologous recombination deficiency in ovarian cancer

Deep learning-based phenotyping reclassifies combined hepatocellular-cholangiocarcinoma

New hormone receptor-positive breast cancer mouse cell line mimicking the immune microenvironment of anti-PD-1 resistant mammary carcinoma

Periostin‐ and podoplanin‐positive cancer‐associated fibroblast subtypes cooperate to shape the inflamed tumor microenvironment in aggressive pancreatic adenocarcinoma

Artificial intelligence predicts immune and inflammatory gene signatures directly from hepatocellular carcinoma histology

Artificial intelligence for solid tumour diagnosis in digital pathology

Metabolic features of cancer cells impact immunosurveillance

Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients

Acidosis‐induced activation of distal nephron principal cells triggers Gdf15 secretion and adaptive proliferation of intercalated cells

Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer

Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer

CFH exerts anti-oxidant effects on retinal pigment epithelial cells independently from protecting against membrane attack complex

Polyploidy spectrum: a new marker in HCC classification

Sostdc1 is expressed in all major compartments of developing and adult mammalian eyes

Metabolic enzymes expressed by cancer cells impact the immune infiltrate

Active Fluctuations of the Nuclear Envelope Shape the Transcriptional Dynamics in Oocytes

Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

Involvement of neural crest and paraxial mesoderm in oral mucosal development and healing

ROCK-1 mediates diabetes-induced retinal pigment epithelial and endothelial cell blebbing: Contribution to diabetic retinopathy

Three-dimensional Organization of pKi-67: A Comparative Fluorescence and Electron Tomography Study Using Fluoronanogold

Contribution of RIP3 and MLKL to immunogenic cell death signaling in cancer chemotherapy

Targeting iron-mediated retinal degeneration by local delivery of transferrin

Anti-vascular endothelial growth factor acts on retinal microglia/macrophage activation in a rat model of ocular inflammation

Protective effect of intravitreal injection of vasoactive intestinal peptide-loaded liposomes on experimental autoimmune uveoretinitis.

DsRed-mediated oligomerization stabilizes HMGB1 on chromatin in vivo and on DNA in vitro

Live-cell imaging reveals multiple interactions between Epstein-Barr virus nuclear antigen 1 and cellular chromatin during interphase and mitosis.

Delta-like 4 inhibits choroidal neovascularization despite opposing effects on vascular endothelium and macrophages.

Lipid droplet analysis in caveolin-deficient adipocytes: alterations in surface phospholipid composition and maturation defects

Protective Effect of Intravitreal Injection of Vasoactive Intestinal Peptide–Loaded Liposomes on Experimental Autoimmune Uveoretinitis

Insulin internalizes GLUT2 in the enterocytes of healthy but not insulin-resistant mice.

NKCC2 Surface Expression in Mammalian Cells

QN1/KIAA1009: a new essential protein for chromosome segregation and mitotic spindle assembly.

Nonrandom distribution of metaphase AgNOR staining patterns on human acrocentric chromosomes.

Nonrandom Distribution of Metaphase AgNOR Staining Patterns on Human Acrocentric Chromosomes

Mounting Technique Allows Observation of Immuno-Labeled Cells on Plastic Coverslips

The Three-dimensional Study of Chromosomes and Upstream Binding Factor-immunolabeled Nucleolar Organizer Regions Demonstrates Their Nonrandom Spatial Arrangement during Mitosis

Electron Tomography of Metaphase Nucleolar Organizer Regions: Evidence for a Twisted-Loop Organization

Évaluation et adaptation de réseaux VGG16 pour la détection de carcinome sur des lames d'histologie: de la résection à la biopsie

A novel tool for detecting lysosomal membrane permeabilization by high-throughput fluorescence microscopy

Development of Tools for the Selective Visualization and Quantification of TLS-Immune Cells on Tissue Sections

Transcriptional regulation of jaw osteoblasts: development to pathology