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Christophe Hirtz


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  • Nicolas Menjot de Champfleur, Aleksandra Maleska, Cecilia Marelli, Claire Hourregue, Laure-Anne Gutierrez, et al.. Cerebrospinal Fluid and Plasma Biomarkers do not Differ in the Presenile and Late-Onset Behavioral Variants of Frontotemporal Dementia. Journal of Alzheimer's Disease, IOS Press, 2020, pp.1-9. ⟨10.3233/JAD-190378⟩. ⟨hal-02505372⟩
  • Pierre-Antoine Peyron, Sylvain Lehmann, Constance Delaby, Eric Baccino, Christophe Hirtz. Biochemical markers of time since death in cerebrospinal fluid: A first step towards “Forensomics”. Critical Reviews in Clinical Laboratory Sciences, Taylor & Francis, 2019, 56 (4), pp.274-286. ⟨10.1080/10408363.2019.1619158⟩. ⟨hal-02505396⟩
  • Carmen Murall, Massilva Rahmoun, Christian Selinger, Monique Baldellou, Claire Bernat, et al.. Natural history, dynamics, and ecology of human papillomaviruses in genital infections of young women: protocol of the PAPCLEAR cohort study. BMJ Open, BMJ Publishing Group, 2019, 9 (6), pp.e025129. ⟨10.1136/bmjopen-2018-025129⟩. ⟨hal-02157154⟩
  • Charlotte Lepleux, Aurélie Marie-Brasset, Mihaela Temelie, Marion Boulanger, Émilie Brotin, et al.. Bystander effectors of chondrosarcoma cells irradiated at different LET impair proliferation of chondrocytes. Journal of Cell Communication and Signaling, Springer Verlag, 2019, 13 (3), pp.343-356. ⟨10.1007/s12079-019-00515-9⟩. ⟨inserm-02125509⟩
  • Dominique Pontier, Claire Picart, Moaine El Baidouri, François Roudier, Tao Xu, et al.. The m 6 A pathway protects the transcriptome integrity by restricting RNA chimera formation in plants. Life Science Alliance, Life Science Alliance LLC, 2019, 2 (3), pp.e201900393. ⟨10.26508/lsa.201900393⟩. ⟨hal-02505328⟩
  • Dominique Pontier, Claire Picart, Moaine El Baidouri, Francois Roudier, Tao Xu, et al.. The m 6 A pathway protects the transcriptome integrity by restricting RNA chimera formation in plants. Life Science Alliance, Life Science Alliance LLC, 2019, 2 (3), pp.e201900393. ⟨10.26508/lsa.201900393⟩. ⟨hal-02165797⟩
  • Sylvain Lehmann, Christophe Hirtz, Jérôme Vialaret, Maxence Ory, Guillaume Gras Combes, et al.. IN VIVO LARGE SCALE MAPPING OF PROTEIN TURNOVER IN THE HUMAN CEREBROSPINAL FLUID. Analytical Chemistry, American Chemical Society, 2019, ⟨10.1021/acs.analchem.9b03328⟩. ⟨hal-02368099⟩
  • Amélie Darlix, Christophe Hirtz, Simon Thèzenas, Aleksandra Maceski, Audrey Gabelle, et al.. The prognostic value of the Tau protein serum level in metastatic breast cancer patients and its correlation with brain metastases. BMC Cancer, BioMed Central, 2019, 19 (1), pp.110. ⟨10.1186/s12885-019-5287-z⟩. ⟨inserm-02050007⟩
  • Ross Paterson, Audrey Gabelle, Brendan Lucey, Nicolas Barthelemy, Claire Leckey, et al.. SILK studies — capturing the turnover of proteins linked to neurodegenerative diseases. Nature Reviews Neurology, Nature Publishing Group, 2019, 15 (7), pp.419-427. ⟨10.1038/s41582-019-0222-0⟩. ⟨hal-02505307⟩
  • Juan Fortea, María Carmona-Iragui, Bessy Benejam, Susana Fernandez, Laura Videla, et al.. Plasma and CSF biomarkers for the diagnosis of Alzheimer's disease in adults with Down syndrome: a cross-sectional study. The Lancet Neurology, Elsevier, 2018, 17 (10), pp.860-869. ⟨10.1016/S1474-4422(18)30285-0⟩. ⟨hal-02315310⟩
  • Christophe Hirtz, Pauline Bros, Cato Brede, Pierre Lescuyer, Aleksandra Maceski, et al.. Regulatory context and validation of assays for clinical mass spectrometry proteomics (cMSP) methods. Critical Reviews in Clinical Laboratory Sciences, Taylor & Francis, 2018, 55 (5), pp.346 - 358. ⟨10.1080/10408363.2018.1470159⟩. ⟨hal-01842214⟩
  • Nicolas Molinari, Stéphane Roche, Katell Peoc’h, Laurent Tiers, Martial Seveno, et al.. Sample Pooling and Inflammation Linked to the False Selection of Biomarkers for Neurodegenerative Diseases in Top–Down Proteomics: A Pilot Study. Frontiers in Molecular Neuroscience, Frontiers Media, 2018, 11, pp.477. ⟨10.3389/fnmol.2018.00477⟩. ⟨hal-02061536⟩
  • Yves Dauvilliers, Sofiene Chenini, Jérôme Vialaret, Constance Delaby, Lily Guiraud, et al.. Association between serum hepcidin level and restless legs syndrome. Movement Disorders, Wiley, 2018, 33 (4), pp.618 - 627. ⟨10.1002/mds.27287⟩. ⟨hal-01842236⟩
  • Morgane Piton, Christophe Hirtz, Caroline Desmetz, Jacqueline Milhau, Anne Dominique Lajoix, et al.. Alzheimer’s Disease: Advances in Drug Development. Journal of Alzheimer's Disease, IOS Press, 2018, 65 (1), pp.3 - 13. ⟨10.3233/JAD-180145⟩. ⟨hal-01876065⟩
  • Jérôme Vialaret, Alexia Picas, Constance Delaby, Pauline Bros, Sylvain Lehmann, et al.. Nano-flow vs standard-flow: Which is the more suitable LC/MS method for quantifying hepcidin-25 in human serum in routine clinical settings?. Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences, Elsevier, 2018, 1086, pp.110 - 117. ⟨10.1016/j.jchromb.2018.04.003⟩. ⟨hal-01842184⟩
  • Pierre-Olivier Schmit, Jérôme Vialaret, Hans J.C.T. Wessels, Alain van Gool, Sylvain Lehmann, et al.. Towards a routine application of Top-Down approaches for label-free discovery workflows. Journal of Proteomics, Elsevier, 2018, 175, pp.12 - 26. ⟨10.1016/j.jprot.2017.08.003⟩. ⟨hal-01757595⟩
  • Anne Incamps, Celia Saez-Boiteau, Svenja Lena Tiede, Pauline Rebillard, Janin Schulte, et al.. Impact of biological matrix on inflammatory protein biomarker quantification based on targeted mass spectrometry. Bioanalysis, Future Science, 2018, 10 (17), pp.1383--1399. ⟨10.4155/bio-2018-0149⟩. ⟨hal-02316826⟩
  • Jérôme Vialaret, Sophie Broutin, Célia Pugnier, Sophie Santelé, Aurore Jaffuel, et al.. What sample preparation should be chosen for targeted MS monoclonal antibody quantification in human serum?. Bioanalysis, Future Science, 2018, 10 (10), pp.723 - 735. ⟨10.4155/bio-2018-0027⟩. ⟨hal-01842189⟩
  • Brenda Mertens, Valérie Orti, Jérôme Vialaret, Philippe Gibert, Aroa Relaño-Ginès, et al.. Assessing a multiplex-targeted proteomics approach for the clinical diagnosis of periodontitis using saliva samples. Bioanalysis, Future Science, 2018, 10 (1), pp.35 - 45. ⟨10.4155/bio-2017-0218⟩. ⟨hal-01842210⟩
  • Jérôme Vialaret, Pierre-Olivier Schmit, Sylvain Lehmann, Audrey Gabelle, Jason Wood, et al.. Identification of multiple proteoforms biomarkers on clinical samples by routine Top-Down approaches. Data in Brief, Elsevier, 2018, 18, pp.1013 - 1021. ⟨10.1016/j.dib.2018.03.114⟩. ⟨hal-01842181⟩
  • Natalia Quijada Morin, François Garcia, Karen Lambert, Anne-Sophie Walker, Laurent Tiers, et al.. Strain effect on extracellular laccase activities from Botrytis cinerea. Australian Journal of Grape and Wine Research, Wiley/Australian Society of Viticulture and Oenology 2018, 24 (2), pp.241-251. ⟨10.1111/ajgw.12322⟩. ⟨hal-01837855⟩
  • Pauline Bros, Ralf Josephs, Norbert Stoppacher, Guillaume Cazals, Sylvain Lehmann, et al.. Impurity determination for hepcidin by liquid chromatography-high resolution and ion mobility mass spectrometry for the value assignment of candidate primary calibrators. Analytical and Bioanalytical Chemistry, Springer Verlag, 2017, 409 (10), pp.2559 - 2567. ⟨10.1007/s00216-017-0202-4⟩. ⟨hal-01785651⟩
  • Sylvain Lehmann, Alexia Picas, Laurent Tiers, Jérôme Vialaret, Christophe Hirtz. Clinical perspectives of dried blood spot protein quantification using mass spectrometry methods. Critical Reviews in Clinical Laboratory Sciences, Taylor & Francis, 2017, 54 (3), pp.173 - 184. ⟨10.1080/10408363.2017.1297358⟩. ⟨hal-01763080⟩
  • Dimitri Renard, Lavinia Tatu, Christophe Demattei, Christophe Hirtz, Sylvain Lehmann, et al.. Characterizing Deep White Matter Hyperintensities in Patients with Symptomatic Isolated Cortical Superficial Siderosis. Journal of Stroke and Cerebrovascular Diseases, WB Saunders, 2017, 26 (3), pp.465 - 469. ⟨10.1016/j.jstrokecerebrovasdis.2016.12.022⟩. ⟨hal-01792463⟩
  • Audrey Gabelle, Isabelle Jaussent, Christophe Hirtz, Jérôme Vialaret, Sophie Navucet, et al.. Cerebrospinal fluid levels of orexin-A and histamine, and sleep profile within the Alzheimer process. Neurobiology of Aging, Elsevier, 2017, 53, pp.59 - 66. ⟨10.1016/j.neurobiolaging.2017.01.011⟩. ⟨hal-01781465⟩
  • Sylvain Lehmann, Cato Brede, Pierre Lescuyer, José Cocho, Jérôme Vialaret, et al.. Clinical mass spectrometry proteomics (cMSP) for medical laboratory: What does the future hold?. Clinica Chimica Acta, Elsevier, 2017, 467, pp.51 - 58. ⟨10.1016/j.cca.2016.06.001⟩. ⟨hal-01842326⟩
  • Constance Delaby, Pauline Bros, Jérôme Vialaret, Amandine Moulinier, Vincent Delatour, et al.. Quantification of hepcidin-25 in human cerebrospinal fluid using LC–MS/MS. Bioanalysis, Future Science, 2017, 9 (4), pp.337 - 347. ⟨10.4155/bio-2016-0240⟩. ⟨hal-01792350⟩
  • Aleksandra Maleska, Christophe Hirtz, Elise Casteleyn, Orianne Villard, Jacques Ducos, et al.. Comparison of HbA1c detection in whole blood and dried blood spots using an automated ion-exchange HPLC system. Bioanalysis, Future Science, 2017, 9 (5), pp.427-434. ⟨10.4155/bio-2016-0278⟩. ⟨hal-01781609⟩
  • Nicolas Barthélemy, François Fenaille, Christophe Hirtz, Nicolas Sergeant, Susanna Schraen-Maschke, et al.. Tau Protein Quantification in Human Cerebrospinal Fluid by Targeted Mass Spectrometry at High Sequence Coverage Provides Insights into Its Primary Structure Heterogeneity. Journal of Proteome Research, American Chemical Society, 2016, 15 (2), pp.667 - 676. ⟨10.1021/acs.jproteome.5b01001⟩. ⟨hal-01842426⟩
  • Christophe Hirtz, Jérôme Vialaret, Audrey Gabelle, Nora Nowak, Yves Dauvilliers, et al.. From radioimmunoassay to mass spectrometry: a new method to quantify orexin-A (hypocretin-1) in cerebrospinal fluid. Scientific Reports, Nature Publishing Group, 2016, 6 (1), ⟨10.1038/srep25162⟩. ⟨hal-01842392⟩
  • Nicolas Barthélemy, Audrey Gabelle, Christophe Hirtz, François Fenaille, Nicolas Sergeant, et al.. Differential Mass Spectrometry Profiles of Tau Protein in the Cerebrospinal Fluid of Patients with Alzheimer’s Disease, Progressive Supranuclear Palsy, and Dementia with Lewy Bodies. Journal of Alzheimer's Disease, IOS Press, 2016, 51 (4), pp.1033 - 1043. ⟨10.3233/JAD-150962⟩. ⟨hal-01842422⟩
  • Dimitri Renard, Audrey Gabelle, Christophe Hirtz, Christophe Demattei, Eric Thouvenot, et al.. Cerebrospinal Fluid Alzheimer’s Disease Biomarkers in Isolated Supratentorial Cortical Superficial Siderosis. Journal of Alzheimer's Disease, IOS Press, 2016, 54 (4), pp.1291 - 1295. ⟨10.3233/JAD-160400⟩. ⟨hal-01825499⟩
  • Dimitri Renard, Anne Wacongne, Xavier Ayrignac, Mahmoud Charif, Genevieve Fourcade, et al.. Cerebrospinal Fluid Alzheimer’s Disease Biomarkers in Cerebral Amyloid Angiopathy-Related Inflammation. Journal of Alzheimer's Disease, IOS Press, 2016, 50 (3), pp.759 - 764. ⟨10.3233/JAD-150621⟩. ⟨hal-01842362⟩
  • Dina Hassan, Monique Provansal, Sylvain Lehmann, Moustafa Rizk, Pacint Moez, et al.. Proteomic profile of cerebrospinal fluid in patients with multiple sclerosis using two dimensional gel electrophoresis. British Journal of Biomedical Science, Royal Society of Medicine, 2016, 73 (3), pp.143 - 146. ⟨10.1080/09674845.2016.1186310⟩. ⟨hal-01842395⟩
  • Christophe Hirtz, Jérôme Vialaret, Georges Nouadje, Susanna Schraen, Pascal Benlian, et al.. Development of new quantitative mass spectrometry and semi-automatic isofocusing methods for the determination of Apolipoprotein E typing. Clinica Chimica Acta, Elsevier, 2016, 454, pp.33 - 38. ⟨10.1016/j.cca.2015.12.020⟩. ⟨hal-01842388⟩
  • Christophe Hirtz, Jérôme Vialaret, Nora Nowak, Audrey Gabelle, Dominique Deville de Périère, et al.. Absolute quantification of 35 plasma biomarkers in human saliva using targeted MS. Bioanalysis, Future Science, 2016, 8 (1), pp.43 - 53. ⟨10.4155/bio.15.228⟩. ⟨hal-01842381⟩
  • Sylvain Lehmann, Jérôme Vialaret, Guillaume Gras Combe, Luc Bauchet, Olivier Hanon, et al.. Stable Isotope Labeling by Amino acid in Vivo (SILAV): a new method to explore protein metabolism. Rapid Communications in Mass Spectrometry, Wiley, 2015, 29 (20), pp.1917 - 1925. ⟨10.1002/rcm.7289⟩. ⟨hal-01842452⟩
  • L. Tall, Sylvain Lehmann, E. Diouf, C. Gérard, S. Filali, et al.. Préparation injectable de leucine marquée au carbone 13 pour un programme de recherche clinique sur la maladie d’Alzheimer : contrôle pharmaceutique des matières premières et du produit fini et étude de stabilité. Annales Pharmaceutiques Françaises, Elsevier Masson, 2015, 73 (1), pp.43 - 59. ⟨10.1016/j.pharma.2014.06.002⟩. ⟨hal-01842440⟩
  • Martine Morzel, Eric Neyraud, Hélène Brignot, Patrick Ducoroy, Aline Jeannin, et al.. Multi-omics profiling reveals that eating difficulties developed consecutively to artificial nutrition in the neonatal period are associated to specific saliva composition. Journal of Proteomics, Elsevier, 2015, 128, pp.105-112. ⟨10.1016/j.jprot.2015.07.028⟩. ⟨hal-01216253v2⟩
  • Pauline Bros, Vincent Delatour, Jérôme Vialaret, Béatrice Lalere, Nicolas Barthelemy, et al.. Quantitative detection of amyloid-β peptides by mass spectrometry: state of the art and clinical applications. Clinical Chemistry and Laboratory Medicine, De Gruyter, 2015, 53 (10), pp.1483-93. ⟨10.1515/cclm-2014-1048⟩. ⟨hal-02077074⟩
  • Laurence Bissonnette, Loubna Drissennek, Yannick Antoine, Laurent Tiers, Christophe Hirtz, et al.. Human S100A10 plays a crucial role in the acquisition of the endometrial receptivity phenotype. Cell Adhesion and Migration, Taylor & Francis, 2015, 10 (3), pp.282 - 298. ⟨10.1080/19336918.2015.1128623⟩. ⟨hal-01842413⟩
  • Pauline Bros, Jérôme Vialaret, Nicolas Barthelemy, Vincent Delatour, Audrey Gabelle, et al.. Antibody-free quantification of seven tau peptides in human CSF using targeted mass spectrometry. Frontiers in Neuroscience, Frontiers, 2015, 9, ⟨10.3389/fnins.2015.00302⟩. ⟨hal-01842470⟩
  • Christophe Hirtz, Sylvain Lehmann. [Blood sampling using "dried blood spot": a clinical biology revolution underway?].. Annales de Biologie Clinique, John Libbey Eurotext, 2015, pp.25-37. ⟨10.1684/abc.2014.1007⟩. ⟨hal-01842461⟩
  • Christophe Hirtz, Sylvain Lehmann. What is the potential of dried matrix spot sampling for cerebrospinal fluid analysis?. Bioanalysis, Future Science, 2015, 7 (22), pp.2849 - 2851. ⟨10.4155/bio.15.201⟩. ⟨hal-01842456⟩
  • Amina Bouslimani, Nicole Bec, Matthias Glueckmann, Christophe Hirtz, Christian Larroque. Matrix-assisted laser desorption/ionization imaging mass spectrometry of oxaliplatin derivatives in heated intraoperative chemotherapy (HIPEC)-like treated rat kidney.. Rapid Communications in Mass Spectrometry, Wiley, 2010, 24 (4), pp.415-21. ⟨10.1002/rcm.4408⟩. ⟨inserm-00452373⟩
  • Emanuele Armaforte, Erika Curran, Thom Huppertz, C. Anthony Ryan, Maria Caboni, et al.. Proteins and proteolysis in pre-term and term human milk and possible implications for infant formulae. International Dairy Journal, Elsevier, 2010, 20 (10), pp.715-723. ⟨10.1016/j.idairyj.2010.03.008⟩. ⟨hal-02502695⟩
  • Anne Geiger, Christophe Hirtz, Thierry Becue, Eric Bellard, Delphine Centeno, et al.. Exocytosis and protein secretion in Trypanosoma. BMC Microbiology, BioMed Central, 2010, 10, pp.20. ⟨10.1186/1471-2180-10-20⟩. ⟨hal-02502942⟩
  • François Chevalier, Christophe Hirtz, Nicolas Sommerer, Alan Kelly. Use of Reducing/Nonreducing Two-Dimensional Electrophoresis for the Study of Disulfide-Mediated Interactions between Proteins in Raw and Heated Bovine Milk. Journal of Agricultural and Food Chemistry, American Chemical Society, 2009, 57 (13), pp.5948-5955. ⟨10.1021/jf900518n⟩. ⟨hal-02502451⟩
  • François Chevalier, Christophe Hirtz, Sandrine Chay, Frédéric Cuisinier, Nicolas Sommerer, et al.. Proteomic Studies of Saliva: A Proposal for a Standardized Handling of Clinical Samples. Clinical Proteomics, BioMed Central, 2007, 3 (1-4), pp.13-21. ⟨10.1007/s12014-007-9000-x⟩. ⟨hal-02502431⟩
  • François Chevalier, Christophe Hirtz, Frédéric Cuisinier, Sandrine Chay, Nicolas Sommerer, et al.. Proteomic Studies of Saliva: A Proposal for a Standardized Handling of Clinical Samples. Clinical Proteomics, BioMed Central, 2007, 3 (1-4), pp.13 - 21. ⟨10.1007/s12014-007-9000-x⟩. ⟨hal-01743573⟩
  • Christophe Hirtz, François Chevalier, Nicolas Sommerer, Isabelle Raingeard, Jacques Bringer, et al.. Salivary protein profiling in type I diabetes using two-dimensional electrophoresis and mass spectrometry. Clinical Proteomics, BioMed Central, 2006, 2 (1-2), pp.117-127. ⟨10.1385/CP:2:1:117⟩. ⟨hal-02502403⟩
  • Christophe Hirtz, François Chevalier, Delphine Centeno, Valerie Rofidal, Jean-Christophe Egea, et al.. MS characterization of multiple forms of alpha-amylase in human saliva. Proteomics, Wiley-VCH Verlag, 2005, 5 (17), pp.4597-4607. ⟨10.1002/pmic.200401316⟩. ⟨hal-02501106⟩
  • Maria E. Marin Castaño, Joost Schanstra, Christophe Hirtz, Christiane Pecher, Jean-Pierre Girolami, et al.. B2 kinin receptor upregulation by cAMP is associated with BK-induced PGE2 production in rat mesangial cells. AJP Renal Physiology, American Physiological Society, 1998, 274 (3), pp.532-540. ⟨10.1152/ajprenal.1998.274.3.F532⟩. ⟨hal-02502598⟩
  • Joost Schanstra, E Bataillé, Maria E. Marin Castaño, Yannick Barascud, Christophe Hirtz, et al.. The B1-agonist [des-Arg10 ]-kallidin Activates Transcription Factor NF-B and Induces Homologous Upregulation of the Bradykinin B1-receptor in Cultured Human Lung Fibroblasts. Journal of Clinical Investigation, American Society for Clinical Investigation, 1998, 101 (10), pp.2080-2091. ⟨10.1172/JCI1359⟩. ⟨hal-02502902⟩

Communication dans un congrès2 documents

  • Martine Morzel, Eric Neyraud, Géraldine Lucchi, Hélène Brignot, Patrick Ducoroy, et al.. Children with eating disorders secondarily to artificial nutrition in the neonatal period have specific food preferences and saliva composition. 49. annual meeting of the European society for paediatric gastroenterology, hepatology and nutrition, May 2016, Athènes, Greece. ⟨hal-01512124⟩
  • Géraldine Lucchi, Martine Morzel, Eric Neyraud, Hélène Brignot, Patrick Ducoroy, et al.. Multi-omics profiling reveals that eating difficulties developed consecutively to artificial nutrition in the neonatal period are associated to specific saliva composition. Congrès français de Spectrométrie de Masse et d'Analyse Protéomique (SMAP 2015), 2015, Ajaccio, Corse, France. ⟨hal-01595504⟩