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Biosynthesis and Roles of Phenolic Glycolipids and Related Molecules in Mycobacterium tuberculosis

 Christophe Guilhot , Christian Chalut , Mamadou Daffé
The Mycobacterial Cell Envelope, ASM Press, pp.271-289, 2014, ⟨10.1128/9781555815783.ch17⟩
Chapitre d'ouvrage hal-03199103v1
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Protein O-mannosylation deficiency increases LprG-associated lipoarabinomannan release by Mycobacterium tuberculosis and enhances the TLR2-associated inflammatory response

 Henar Alonso , Julien Parra , Wladimir Malaga , Delphine Payros , Chia-Fang Liu , et al.
Scientific Reports, 2017, 7 (1), ⟨10.1038/s41598-017-08489-7⟩
Article dans une revue hal-02323721v1

Tn611 transposon mutagenesis in Mycobacterium smegmatis using a temperature-sensitive delivery system

 Esther Pérez , Julie-Ann Gavigan , Isabel Otal , Christophe Guilhot , V. Pelicic , et al.
Mycobacteria Protocols, 101, Humana Press, pp.187-198, 1998, 978-1-59259-576-1. ⟨10.1385/0-89603-471-2:187⟩
Chapitre d'ouvrage hal-03513995v1
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The lipid virulence factors of Mycobacterium tuberculosis exert multilayered control over autophagy-related pathways in infected human macrophages

 Aïcha Bah , Merlin Sanicas , Jérôme Nigou , Christophe Guilhot , Catherine Astarie-Dequeker , et al.
eSymposia Keystone, Oct 2020, Kerry, Ireland
Poster de conférence hal-03382295v1

Molecular dissection of the biosynthetic relationship between phthiocerol and phthiodiolone dimycocerosates and their critical role in the virulence and permeability of Mycobacterium tuberculosis

 Roxane Simeone , Patricia Constant , Wladimir Malaga , Christophe Guilhot , Mamadou Daffé , et al.
FEBS Journal, 2007, 274 (8), pp.1957-1969. ⟨10.1111/j.1742-4658.2007.05740.x⟩
Article dans une revue pasteur-02862986v1
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Phthiocerol Dimycocerosates From Mycobacterium tuberculosis Increase the Membrane Activity of Bacterial Effectors and Host Receptors

 Jacques Augenstreich , Evert Haanappel , Fadel Sayes , Roxane Simeone , Valerie Guillet , et al.
Frontiers in Cellular and Infection Microbiology, 2020, 10, pp.420. ⟨10.3389/fcimb.2020.00420⟩
Article dans une revue pasteur-02873531v1
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Mycobacterial Phenolic Glycolipids Selectively Disable TRIF-Dependent TLR4 Signaling in Macrophages

 Reid Oldenburg , Véronique Mayau , Jacques Prandi , Ainhoa Arbues , Catherine Astarie-Dequeker , et al.
Frontiers in Immunology, 2018, 9, 12 p. ⟨10.3389/fimmu.2018.00002⟩
Article dans une revue hal-02323696v1
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Phthiocerol Dimycocerosates of M. tuberculosis Participate in Macrophage Invasion by Inducing Changes in the Organization of Plasma Membrane Lipids

 Catherine Astarie-Dequeker , Laurent Le Guyader , Wladimir Malaga , Fam-Ky Seaphanh , Christian Chalut , et al.
PLoS Pathogens, 2009, 5 (2), pp.e1000289. ⟨10.1371/journal.ppat.1000289⟩
Article dans une revue hal-02333313v1

Mycobacterium leprae pgl1 expression by BCG increases CR3 mediated entry into mouse myeloid cells and induces Syk/NFAT cytokine production

 Emilie Doz-Deblauwe , Florence Carreras , Aude Remot , Mathieu Epardaud , Caroline Demangel , et al.
Journées d'Animation Scientifique du Département Santé Animale, Oct 2018, Nantes, France. , 2018, Santé Animale et Santé Publique
Poster de conférence hal-02736584v1

Preclinical assessment of a new live attenuated Mycobacterium tuberculosis Beijing-based vaccine for tuberculosis

 Florence Levillain , Hongmin Kim , Kee Woong Kwon , Simon Clark , Felipe Cia , et al.
Vaccine, 2020, 38 (6), pp.1416-1423. ⟨10.1016/j.vaccine.2019.11.085⟩
Article dans une revue hal-03014488v1

Multiple deletions in the polyketide synthase gene repertoire of Mycobacterium tuberculosis reveal functional overlap of cell envelope lipids in host-pathogen interactions

 Charlotte Passemar , Ainhoa Arbués , Wladimir Malaga , Ingrid Mercier , Flavie Moreau , et al.
Cellular Microbiology, 2014, 16 (2), pp.195-213. ⟨10.1111/cmi.12214⟩
Article dans une revue hal-02325957v1

Rv3389C from Mycobacterium tuberculosis, a member of the (R)-specific hydratase/dehydratase family

 Emmanuelle Sacco , Virginie Legendre , Françoise Laval , Didier Zerbib , Henri Montrozier , et al.
Biochimica et Biophysica Acta Proteins and Proteomics, 2007, 1774 (2), pp.303 - 311. ⟨10.1016/j.bbapap.2006.11.016⟩
Article dans une revue istex hal-01883516v1

Spontaneous Phthiocerol Dimycocerosate-Deficient Variants of Mycobacterium tuberculosis Are Susceptible to Gamma Interferon-Mediated Immunity

 Meghan Kirksey , Anna Tischler , Roxane Simeone , Katherine Hisert , Swapna Uplekar , et al.
Infection and Immunity, 2011, 79 (7), pp.2829-2838. ⟨10.1128/IAI.00097-11⟩
Article dans une revue pasteur-02863001v1
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Natural mutations in the sensor kinase of the PhoPR two-component regulatory system modulate virulence of ancestor-like tuberculosis bacilli

 Wladimir Malaga , Delphine Payros , Eva Meunier , Wafa Frigui , Fadel Sayes , et al.
PLoS Pathogens, 2023, 19 (7), pp.e1011437. ⟨10.1371/journal.ppat.1011437⟩
Article dans une revue hal-04163557v1
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Trisaccharides of Phenolic Glycolipids Confer Advantages to Pathogenic Mycobacteria through Manipulation of Host-Cell Pattern-Recognition Receptors

 Ainhoa Arbués , Wladimir Malaga , Patricia Constant , Christophe Guilhot , Jacques Prandi , et al.
ACS Chemical Biology, 2016, 11 (10), pp.2865-2875. ⟨10.1021/acschembio.6b00568⟩
Article dans une revue hal-02325887v1
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The Polyketide Synthase Pks13 Catalyzes a Novel Mechanism of Lipid Transfer in Mycobacteria

 Sabine Gavalda , Fabienne Bardou , Françoise Laval , Cécile Bon , Wladimir Malaga , et al.
Chemistry and Biology, 2014, 21 (12), pp.1660 - 1669. ⟨10.1016/j.chembiol.2014.10.011⟩
Article dans une revue hal-03002982v1
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The final assembly of trehalose polyphleates takes place within the outer layer of the mycobacterial cell envelope

 Laurie Thouvenel , Gautier Prevot , Laura Chiaradia , Julien Parra , Emmanuelle Mouton-Barbosa , et al.
Journal of Biological Chemistry, 2020, 295 (32), pp.11184-11194. ⟨10.1074/jbc.RA120.013299⟩
Article dans une revue hal-02994941v1

Identification of the Missing trans-Acting Enoyl Reductase Required for Phthiocerol Dimycocerosate and Phenolglycolipid Biosynthesis in Mycobacterium tuberculosis

 Roxane Simeone , Patricia Constant , Christophe Guilhot , Mamadou Daffé , Christian Chalut
Journal of Bacteriology, 2007, 189 (13), pp.4597-4602. ⟨10.1128/JB.00169-07⟩
Article dans une revue pasteur-02862990v1
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4′-Phosphopantetheinyl Transferase PptT, a New Drug Target Required for Mycobacterium tuberculosis Growth and Persistence In Vivo

 Cécile Leblanc , Thomas Prudhomme , Guillaume Tabouret , Aurélie Ray , Sophie Burbaud , et al.
PLoS Pathogens, 2012, 8 (12), pp.e1003097. ⟨10.1371/journal.ppat.1003097⟩
Article dans une revue hal-02391857v1

From environmental bacteria to obligate human pathogen: adaptations associated with the emergence of tuberculosis bacilli

 Delphine Payros , Wladimir Malaga , Alexandre Pawlik , Serge Mazères , Céline Berrone , et al.
EMBO Workshop. Pathogen immunity and signalling., Apr 2019, Oxford, United Kingdom
Communication dans un congrès hal-02341937v1
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Playing hide-and-seek with host macrophages through the use of mycobacterial cell envelope phthiocerol dimycocerosates and phenolic glycolipids

 Ainhoa Arbues , Geancarlo Lugo-Villarino , Olivier Neyrolles , Christophe Guilhot , Catherine Astarie-Dequeker
Frontiers in Cellular and Infection Microbiology, 2014, 4, pp.173. ⟨10.3389/fcimb.2014.00173⟩
Article dans une revue hal-02325951v1
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The PhoP-Dependent ncRNA Mcr7 Modulates the TAT Secretion System in Mycobacterium tuberculosis

 Luis Solans , Jesús Gonzalo-Asensio , Claudia Sala , Andrej Benjak , Swapna Uplekar , et al.
PLoS Pathogens, 2014, 10 (5), pp.e1004183. ⟨10.1371/journal.ppat.1004183⟩
Article dans une revue hal-02325930v1
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CR3 engaged by PGL-I triggers Syk-calcineurin-NFATc to rewire the innate immune response in Leprosy.

 Emilie Doz-Deblauwe , Florence Carreras , Ainhoa Arbues , Aude Remot , Mathieu Epardaud , et al.
Frontiers in Immunology, 2019, 10, 15 p. ⟨10.3389/fimmu.2019.02913⟩
Article dans une revue hal-02624164v1

Efficient allelic exchange and transposon mutagenesis in Mycobacterium tuberculosis

 V. Pelicic , Mary Jackson , Jean-Marc Reyrat , William R. Jacobs , Brigitte Gicquel , et al.
Proceedings of the National Academy of Sciences of the United States of America, 1997, 94 (20), pp.10955-10960. ⟨10.1073/pnas.94.20.10955⟩
Article dans une revue hal-03513941v1
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The Lipid Virulence Factors of Mycobacterium tuberculosis Exert Multilayered Control over Autophagy-Related Pathways in Infected Human Macrophages

 Aïcha Bah , Merlin Sanicas , Jérôme Nigou , Christophe Guilhot , Catherine Astarie-Dequeker , et al.
Cells, 2020, 9 (3), pp.666. ⟨10.3390/cells9030666⟩
Article dans une revue hal-02650295v1
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Functional Characterisation of Three O-methyltransferases Involved in the Biosynthesis of Phenolglycolipids in Mycobacterium tuberculosis

 Roxane Simeone , Gaëlle Huet , Patricia Constant , Wladimir Malaga , Anne Lemassu , et al.
PLoS ONE, 2013, 8 (3), pp.e58954. ⟨10.1371/journal.pone.0058954⟩
Article dans une revue hal-02391855v1
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Conformational flexibility of coenzyme A and its impact on the post‐translational modification of acyl carrier proteins by 4′‐phosphopantetheinyl transferases

 Minh Chau Nguyen , Olivier Saurel , Coralie Carivenc , Sabine Gavalda , Stéphane Saitta , et al.
FEBS Journal, 2020, 287, pp.4729 - 4746. ⟨10.1111/febs.15273⟩
Article dans une revue hal-02950584v1
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Mycobacterium tuberculosis and M. bovis BCG Moreau Fumarate Reductase Operons Produce Different Polypeptides That May Be Related to Non-canonical Functions

 Marcos Gustavo Araujo Schwarz , Deborah Antunes , Paloma Rezende Corrêa , Antônio José Da Silva-Gonçalves , Wladimir Malaga , et al.
Frontiers in Microbiology, 2021, 11, pp.624121. ⟨10.3389/fmicb.2020.624121⟩
Article dans une revue hal-03109443v1
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Pks5-recombination-mediated surface remodelling in Mycobacterium tuberculosis emergence

 Eva C. Boritsch , Wafa Frigui , Alessandro Cascioferro , Wladimir Malaga , Gilles Etienne , et al.
Nature Microbiology, 2016, 1 (février 2016), ⟨10.1038/nmicrobiol.2015.19⟩
Article dans une revue pasteur-01265519v1
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Parallel in vivo experimental evolution reveals that increased stress resistance was key for the emergence of persistent tuberculosis bacilli

 Aideen C Allen , Wladimir Malaga , Cyril Gaudin , Arnaud Volle , Flavie Moreau , et al.
Nature Microbiology, 2021, 6 (8), pp.1082-1093. ⟨10.1038/s41564-021-00938-4⟩
Article dans une revue hal-03318178v1
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