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Researcher identifiers

Keywords

Growth factors Proliferation Macrophage migration inhibitory factor Pulmonary arterial hypertension Smooth muscle cell Leptin Endothelial dysfunction Pulmonary hypertension Vascular remodeling Pericytes Animal model Smooth muscle cells Survival Adhesion molecules Arterioles Endothelial cells Signal transduction Adverse drug events Pulmonary vascular remodeling Adventitial fibroblasts
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Number of documents

52

Christophe GUIGNABERT, Research Director (Professor) at INSERM / Université Paris-Saclay, Paris, France

Christophe Guignabert joined Inserm in 2009 and is now Research Director (DR2; Professor), expert in Molecular & Cellular Biology associated to Pulmonary Hypertension research – Christophe Guignabert is graduated from the University Paris-Est Créteil (UPEC) in France with a Ph.D. in Cell Biology and Cardiovascular Research.

Dr Guignabert is currently leading a Research Team entitled « Cellular and molecular bases of pulmonary endothelial dysfunction in PAH » focusing on the role of the dysfunctional pulmonary endothelial cells in PAH and on the identification of new molecular targets.

Scientific Focus: Pulmonary arterial hypertension (PAH) – Pulmonary vascular remodeling – Endothelial dysfunction – Endothelial communications – Pericyte – Endothelial cell – Growth factors – Animal models.

Specialities: Cellular and Molecular Biology - Physiology

Lab Website (UMR_S 999)

Journal articles52 documents

  • David Montani, Barbara Girerd, Xavier Jaïs, Pierantonio Laveneziana, Edmund Lau, et al.. Screening for pulmonary arterial hypertension in adults carrying a BMPR2 mutation. European Respiratory Journal, European Respiratory Society, In press, ⟨10.1183/13993003.04229-2020⟩. ⟨hal-03104056⟩
  • Laurent Savale, Satoshi Akagi, Ly Tu, Amélie Cumont, Raphaël Thuillet, et al.. Serum and Pulmonary Uric Acid in Pulmonary Arterial Hypertension. European Respiratory Journal, European Respiratory Society, 2021, pp.2000332. ⟨10.1183/13993003.00332-2020⟩. ⟨inserm-03118201⟩
  • Nicolas Ricard, Sabine Bailly, Christophe Guignabert, Michael Simons. The quiescent endothelium: signalling pathways regulating organ-specific endothelial normalcy. Nature Reviews Cardiology, Nature Publishing Group, In press, ⟨10.1038/s41569-021-00517-4⟩. ⟨inserm-03153011⟩
  • Florian Dilasser, Lindsay Rose, Dorian Hassoun, Martin Klein, Morgane Rousselle, et al.. Essential role of smooth muscle Rac1 in severe asthma-associated airway remodelling. Thorax, BMJ Publishing Group, In press, ⟨10.1136/thoraxjnl-2020-216271⟩. ⟨hal-03142499⟩
  • Gael Jalce, Christophe Guignabert. Multiple roles of macrophage migration inhibitory factor in pulmonary hypertension. American Journal of Physiology - Lung Cellular and Molecular Physiology, American Physiological Society, 2020, 318 (1), pp.L1-L9. ⟨10.1152/ajplung.00234.2019⟩. ⟨inserm-02454988⟩
  • Marie-Camille Chaumais, Mohamed Reda Amar Djessas, Raphaël Thuillet, Amélie Cumont, Ly Tu, et al.. Additive Protective Effects of Sacubitril/Valsartan and Bosentan on Vascular Remodeling in Experimental Pulmonary Hypertension. Cardiovascular Research, Oxford University Press (OUP), 2020, pp.cvaa200. ⟨10.1093/cvr/cvaa200⟩. ⟨inserm-02907132⟩
  • Jennifer Bordenave, Ly Tu, Nihel Berrebeh, Raphaël Thuillet, Amélie Cumont, et al.. Lineage Tracing Reveals the Dynamic Contribution of Pericytes to the Blood Vessel Remodeling in Pulmonary Hypertension. Arteriosclerosis, Thrombosis, and Vascular Biology, American Heart Association, 2020, 40 (3), pp.766-782. ⟨10.1161/ATVBAHA.119.313715⟩. ⟨inserm-02454982v2⟩
  • Claire Bouvard, Nafiisha Genet, Carole Phan, Baptiste Rode, Raphaël Thuillet, et al.. Connexin 43 Is a Promising Target for Pulmonary Hypertension due To Hypoxemic Lung Disease. European Respiratory Journal, European Respiratory Society, 2020, 55 (3), pp.1900169. ⟨10.1183/13993003.00169-2019⟩. ⟨hal-02430904⟩
  • Zongye Cai, Theo Klein, Laurie Geenen, Ly Tu, Siyu Tian, et al.. Lower Plasma Melatonin Levels Predict Worse Long-Term Survival in Pulmonary Arterial Hypertension. Journal of Clinical Medicine, MDPI, 2020, 9 (5), pp.1248. ⟨10.3390/jcm9051248⟩. ⟨inserm-02581568⟩
  • Christophe Guignabert, Marc Humbert. Targeting Transforming Growth Factor Beta Receptors in Pulmonary Hypertension. European Respiratory Journal, European Respiratory Society, 2020, pp.2002341. ⟨10.1183/13993003.02341-2020⟩. ⟨inserm-02918857⟩
  • Christophe Guignabert. Dendritic Cells in Pulmonary Hypertension: Foot Soldiers or Hidden Enemies?. American Journal of Respiratory Cell and Molecular Biology, American Thoracic Society, 2020, ⟨10.1165/rcmb.2020-0330ED⟩. ⟨inserm-02918859⟩
  • Kondababu Kurakula, Xiao-Qing Sun, Chris Happé, Denielli da Silva Goncalves Bos, Robert Szulcek, et al.. Prevention of progression of pulmonary hypertension by the Nur77 agonist 6-mercaptopurine: role of BMP signalling. European Respiratory Journal, European Respiratory Society, 2019, 54 (3), pp.1802400. ⟨10.1183/13993003.02400-2018⟩. ⟨inserm-02612640⟩
  • Jennifer Bordenave, Raphaël Thuillet, Ly Tu, Carole Phan, Amélie Cumont, et al.. Neutralization of CXCL12 attenuates established pulmonary hypertension in rats Short Title: CXCL12 neutraligands in severe PH in the rat. Cardiovascular Research, Oxford University Press (OUP), In press, pp.cvz153. ⟨10.1093/cvr/cvz153⟩. ⟨hal-02195697⟩
  • Alice Huertas, Ly Tu, Marc Humbert, Christophe Guignabert. Chronic Inflammation Within the Vascular Wall in Pulmonary Arterial Hypertension: More than a Spectator. Cardiovascular Research, Oxford University Press (OUP), 2019, pp.cvz308. ⟨10.1093/cvr/cvz308⟩. ⟨inserm-02454983⟩
  • Ly Tu, Agnes Desroches-Castan, Christine Mallet, Laurent Guyon, Amélie Cumont, et al.. Selective BMP-9 Inhibition Partially Protects Against Experimental Pulmonary Hypertension. Circulation Research, American Heart Association, 2019, 124 (6), pp.846-855. ⟨10.1161/CIRCRESAHA.118.313356⟩. ⟨inserm-02581297⟩
  • Marceau Quatredeniers, K Nakhleh Morad, J Dumas Sebastien, Audrey Courboulin, C Vinhas Maria, et al.. Functional interaction between PDGFβ and GluN2B-containing NMDA receptors in smooth muscle cell proliferation and migration in pulmonary arterial hypertension. American Journal of Physiology - Lung Cellular and Molecular Physiology, American Physiological Society, 2019, 316 (3), pp.L445-L455. ⟨10.1152/ajplung.00537.2017⟩. ⟨hal-02411597⟩
  • Edda Spiekerkoetter, Elena Goncharova, Christophe Guignabert, Kurt Stenmark, Grazyna Kwapiszewska, et al.. Hot topics in the mechanisms of pulmonary arterial hypertension disease: cancer-like pathobiology, the role of the adventitia, systemic involvement, and right ventricular failure. Pulmonary circulation / Pulm Circ, Publisher : Mumbai : Medknow Publications - Latest Publisher : Jan. 2017- : Thousand Oaks, CA : Sage Publishing, 2019, 9 (4), pp.204589401988977. ⟨10.1177/2045894019889775⟩. ⟨inserm-02612634⟩
  • Jennifer Bordenave, Ly Tu, Laurent Savale, Alice Huertas, Marc Humbert, et al.. Nouveau regard sur la physiopathologie de l’hypertension artérielle pulmonaire. Revue des Maladies Respiratoires, Elsevier Masson, 2019, 36 (4), pp.433-437. ⟨10.1016/j.rmr.2019.03.003⟩. ⟨inserm-02454990⟩
  • Ly Tu, Agnes Desroches-Castan, Christine Mallet, Laurent Guyon, Amélie Cumont, et al.. Selective BMP-9 Inhibition Partially Protects Against Experimental Pulmonary Hypertension. Circulation Research, American Heart Association, 2019. ⟨hal-02007505⟩
  • Marc Humbert, Christophe Guignabert, Sébastien Bonnet, Peter Dorfmüller, James Klinger, et al.. Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives. European Respiratory Journal, European Respiratory Society, 2019, 53 (1), pp.1801887. ⟨10.1183/13993003.01887-2018⟩. ⟨inserm-02612658⟩
  • Carole Phan, Etienne-Marie Jutant, Ly Tu, Raphaël Thuillet, Andrei Seferian, et al.. Dasatinib increases endothelial permeability leading to pleural effusion. European Respiratory Journal, European Respiratory Society, 2018, 51 (1), pp.1701096. ⟨10.1183/13993003.01096-2017⟩. ⟨inserm-02580192⟩
  • Christophe Guignabert, Frances de Man, Marc Lombès. ACE2 as therapy for pulmonary arterial hypertension: the good outweighs the bad. European Respiratory Journal, European Respiratory Society, 2018, 51 (6), pp.1800848. ⟨10.1183/13993003.00848-2018⟩. ⟨inserm-02582393⟩
  • Philippe Bonniaud, Aurélie Fabre, Nelly Frossard, Christophe Guignabert, Mark Inman, et al.. Optimising experimental research in respiratory diseases: an ERS statement. European Respiratory Journal, European Respiratory Society, 2018, 51 (5), pp.1702133. ⟨10.1183/13993003.02133-2017⟩. ⟨hal-01996906⟩
  • Morane Le Hiress, Bernardin Akagah, Guillaume Bernadat, Ly Tu, Raphaël Thuillet, et al.. Design, Synthesis, and Biological Activity of New N -(Phenylmethyl)-benzoxazol-2-thiones as Macrophage Migration Inhibitory Factor (MIF) Antagonists: Efficacies in Experimental Pulmonary Hypertension. Journal of Medicinal Chemistry, American Chemical Society, 2018, 61 (7), pp.2725-2736. ⟨10.1021/acs.jmedchem.7b01312⟩. ⟨inserm-02580381⟩
  • Yuichi Tamura, Carole Phan, Ly Tu, Morane Le Hiress, Raphaël Thuillet, et al.. Ectopic upregulation of membrane-bound IL6R drives vascular remodeling in pulmonary arterial hypertension. Journal of Clinical Investigation, American Society for Clinical Investigation, 2018, 128 (5), pp.1956-1970. ⟨10.1172/JCI96462⟩. ⟨inserm-02580448⟩
  • Ly Tu, Carole Phan, Marc Humbert, Christophe Guignabert. [IL6R is the key therapeutical target in pulmonary arterial hypertension]. médecine/sciences, EDP Sciences, 2018, 34 (10), pp.765-768. ⟨10.1051/medsci/2018201⟩. ⟨inserm-02580983⟩
  • Tinne Mertens, Ankit Hanmandlu, Ly Tu, Carole Phan, Scott Collum, et al.. Switching-Off Adora2b in Vascular Smooth Muscle Cells Halts the Development of Pulmonary Hypertension. Frontiers in Physiology, Frontiers, 2018, 9, pp.555. ⟨10.3389/fphys.2018.00555⟩. ⟨inserm-02580921⟩
  • Paul-Benoit Poble, Carole Phan, Timothée Quatremare, Jennifer Bordenave, Raphaël Thuillet, et al.. Therapeutic effect of pirfenidone in the sugen/hypoxia rat model of severe pulmonary hypertension. FASEB Journal, Federation of American Society of Experimental Biology, 2018, 33 (3), pp.3670-3679. ⟨10.1096/fj.201801659R⟩. ⟨inserm-02581079⟩
  • Sven Günther, Jennifer Bordenave, Thông Hua-Huy, Carole Nicco, Amélie Cumont, et al.. Macrophage Migration Inhibitory Factor (MIF) Inhibition in a Murine Model of Bleomycin-Induced Pulmonary Fibrosis. International Journal of Molecular Sciences, MDPI, 2018, 19 (12), pp.4105. ⟨10.3390/ijms19124105⟩. ⟨inserm-02612651⟩
  • Alice Huertas, Carole Phan, Jennifer Bordenave, Ly Tu, Raphaël Thuillet, et al.. Regulatory T Cell Dysfunction in Idiopathic, Heritable and Connective Tissue-Associated Pulmonary Arterial Hypertension. Chest, American College of Chest Physicians, 2016, 149 (6), pp.1482-1493. ⟨10.1016/j.chest.2016.01.004⟩. ⟨inserm-02593143⟩
  • Christophe Guignabert, Carole Phan, Andrei Seferian, Alice Huertas, Ly Tu, et al.. Dasatinib induces lung vascular toxicity and predisposes to pulmonary hypertension. Journal of Clinical Investigation, American Society for Clinical Investigation, 2016, 126 (9), pp.3207-3218. ⟨10.1172/JCI86249⟩. ⟨inserm-02579754⟩
  • Ly Tu, Maria-Rosa Ghigna, Carole Phan, Jennifer Bordenave, Morane Le Hiress, et al.. Vers de nouvelles cibles pour le traitement de l’hypertension artérielle pulmonaire : Importance des communications cellulaires. Biologie Aujourd'hui, EDP sciences, 2016, 210 (2), pp.65-78. ⟨10.1051/jbio/2016010⟩. ⟨inserm-02579962⟩
  • Mohamed Izikki, Eric Hoang, Irena Draskovic, Olaf Mercier, Florence Lecerf, et al.. Telomere Maintenance Is a Critical Determinant in the Physiopathology of Pulmonary Hypertension. Journal of the American College of Cardiology, Elsevier, 2015, 66 (17), pp.1942 - 1943. ⟨10.1016/j.jacc.2015.08.869⟩. ⟨hal-01764142⟩
  • Morane Le Hiress, Ly Tu, Nicolas Ricard, Carole Phan, Raphaël Thuillet, et al.. Proinflammatory Signature of the Dysfunctional Endothelium in Pulmonary Hypertension. Role of the Macrophage Migration Inhibitory Factor/CD74 Complex. American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 2015, 192 (8), pp.983-997. ⟨10.1164/rccm.201402-0322OC⟩. ⟨inserm-02579320⟩
  • Véronique Freund-Michel, Marcelina Cardoso dos Santos, Christophe Guignabert, David Montani, Carole Phan, et al.. Role of Nerve Growth Factor in Development and Persistence of Experimental Pulmonary Hypertension. American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 2015, 192 (3), pp.342-355. ⟨10.1164/rccm.201410-1851OC⟩. ⟨inserm-02578672⟩
  • Alice Huertas, Ly Tu, Raphaël Thuillet, Morane Le Hiress, Carole Phan, et al.. Leptin signalling system as a target for pulmonary arterial hypertension therapy. European Respiratory Journal, European Respiratory Society, 2015, 45 (4), pp.1066-1080. ⟨10.1183/09031936.00193014⟩. ⟨inserm-02578446⟩
  • Alice Huertas, Ly Tu, Raphaël Thuillet, Morane Le Hiress, Carole Phan, et al.. Leptin signalling system as a target for pulmonary arterial hypertension therapy. European Respiratory Journal, European Respiratory Society, 2015, 45 (4), pp.1066-1080. ⟨10.1183/09031936.00193014⟩. ⟨inserm-02579431⟩
  • Nicolas Ricard, Ly Tu, Morane Le Hiress, Alice Huertas, Carole Phan, et al.. Increased Pericyte Coverage Mediated by Endothelial-Derived Fibroblast Growth Factor-2 and Interleukin-6 Is a Source of Smooth Muscle–Like Cells in Pulmonary Hypertension. Circulation, American Heart Association, 2014, 129 (15), pp.1586-1597. ⟨10.1161/CIRCULATIONAHA.113.007469⟩. ⟨inserm-02578269⟩
  • Marine Germain, Mélanie Eyries, David Montani, Odette Poirier, Barbara Girerd, et al.. Genome-wide association analysis identifies a susceptibility locus for pulmonary arterial hypertension. Nature Genetics, Nature Publishing Group, 2013, 45 (5), pp.518-521. ⟨10.1038/ng.2581⟩. ⟨hal-02565627⟩
  • Ly Tu, Frances de Man, Barbara Girerd, Alice Huertas, Marie-Camille Chaumais, et al.. A critical role for p130Cas in the progression of pulmonary hypertension in humans and rodents.: p130Cas Over-Expression in Pulmonary Hypertension. American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 2012, 186 (7), pp.666-76. ⟨10.1164/rccm.201202-0309OC⟩. ⟨inserm-00905191⟩
  • Frances de Man, Ly Tu, Louis Handoko, Silvia Rain, Gerrina Ruiter, et al.. Dysregulated renin-angiotensin-aldosterone system contributes to pulmonary arterial hypertension.: RAAS-activity in iPAH-patients. American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 2012, 186 (8), pp.780-9. ⟨10.1164/rccm.201203-0411OC⟩. ⟨inserm-00905193⟩
  • Alice Huertas, Ly Tu, Natalia Gambaryan, Barbara Girerd, Frédéric Perros, et al.. Leptin and regulatory T-lymphocytes in idiopathic pulmonary arterial hypertension.. European Respiratory Journal, European Respiratory Society, 2012, 40 (4), pp.895-904. ⟨10.1183/09031936.00159911⟩. ⟨inserm-00913076⟩
  • David Montani, Emmanuel Bergot, Sven Günther, Laurent Savale, Anne Bergeron, et al.. Pulmonary arterial hypertension in patients treated by dasatinib.. Circulation, American Heart Association, 2012, 125 (17), pp.2128-37. ⟨10.1161/CIRCULATIONAHA.111.079921⟩. ⟨inserm-00697146⟩
  • Ly Tu, Laurence Dewachter, Benoit Gore, Elie Fadel, Philippe Dartevelle, et al.. Autocrine fibroblast growth factor-2 signaling contributes to altered endothelial phenotype in pulmonary hypertension.: Autocrine Loop of EC-Derived FGF2 in IPAH. American Journal of Respiratory Cell and Molecular Biology, American Thoracic Society, 2011, 45 (2), pp.311-22. ⟨10.1165/rcmb.2010-0317OC⟩. ⟨inserm-00579959⟩
  • Laurence Dewachter, Serge Adnot, Christophe Guignabert, Ly Tu, Elisabeth Marcos, et al.. Bone morphogenetic protein signalling in heritable versus idiopathic pulmonary hypertension.. European Respiratory Journal, European Respiratory Society, 2009, 34 (5), pp.1100-10. ⟨10.1183/09031936.00183008⟩. ⟨inserm-00433927⟩
  • Christophe Guignabert, Ly Tu, Mohamed Izikki, Laurence Dewachter, Patricia Zadigue, et al.. Dichloroacetate treatment partially regresses established pulmonary hypertension in mice with SM22alpha-targeted overexpression of the serotonin transporter.: Efficacy Of DCA Treatment In SM22-5-HTT+ Mice. FASEB Journal, Federation of American Society of Experimental Biology, 2009, 23 (12), pp.4135-47. ⟨10.1096/fj.09-131664⟩. ⟨inserm-00499630⟩
  • Mohamed Izikki, Christophe Guignabert, Elie Fadel, Marc Humbert, Ly Tu, et al.. Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents.: FGF2 Inhibition in Pulmonary Hypertension. Journal of Clinical Investigation, American Society for Clinical Investigation, 2009, 119 (3), pp.512-23. ⟨10.1172/JCI35070⟩. ⟨inserm-00499635⟩
  • Christophe Guignabert, Cristina Alvira, Tero-Pekka Alastalo, Hirofumi Sawada, Georg Hansmann, et al.. Tie2-mediated loss of peroxisome proliferator-activated receptor-gamma in mice causes PDGF receptor-beta-dependent pulmonary arterial muscularization.: Pulmonary Hypertension In Tie2 PPAR-/- Mice. American Journal of Physiology - Lung Cellular and Molecular Physiology, American Physiological Society, 2009, 297 (6), pp.L1082-90. ⟨10.1152/ajplung.00199.2009⟩. ⟨inserm-00499633⟩
  • François Maquerlot, Stéphane Galiacy, Michel Malo, Christophe Guignabert, Daniel Lawrence, et al.. Dual role for plasminogen activator inhibitor type 1 as soluble and as matricellular regulator of epithelial alveolar cell wound healing.. American Journal of Pathology, American Society for Investigative Pathology, 2006, 169 (5), pp.1624-32. ⟨inserm-00186832⟩
  • Christophe Guignabert, Mohamed Izikki, Ly Ieng Tu, Zhenlin Li, Patricia Zadigue, et al.. Transgenic mice overexpressing the 5-hydroxytryptamine transporter gene in smooth muscle develop pulmonary hypertension.: Pulmonary Hypertension in Transgenic 5-HTT+ Mice. Circulation Research, American Heart Association, 2006, 98 (10), pp.1323-30. ⟨10.1161/01.RES.0000222546.45372.a0⟩. ⟨inserm-00499636⟩
  • Christophe Guignabert, Laurent Taysse, Jean-Henri Calvet, Emmanuelle Planus, Séraphin Delamanche, et al.. Effect of doxycycline on sulfur mustard-induced respiratory lesions in guinea pigs.: Doxycycline Prevents SM-Induced Respiratory Lesions. American Journal of Physiology - Lung Cellular and Molecular Physiology, American Physiological Society, 2005, 289 (1), pp.L67-74. ⟨10.1152/ajplung.00475.2004⟩. ⟨inserm-00499644⟩
  • Christophe Guignabert, Bernadette Raffestin, Rima Benferhat, William Raoul, Patricia Zadigue, et al.. Serotonin transporter inhibition prevents and reverses monocrotaline-induced pulmonary hypertension in rats.: 5-HT Transporter Inhibition Prevents PH. Circulation, American Heart Association, 2005, 111 (21), pp.2812-9. ⟨10.1161/CIRCULATIONAHA.104.524926⟩. ⟨inserm-00499643⟩