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Researcher identifiers

Number of documents

39

Director of Research DR2 INRAE in Virology, Laboratory of Molecular Virology and Immunology


PERSONAL INFORMATION

 CHEVALIER Christophe

Male, Born December 5th 1976, in Thiais, France, French nationality

E-mail: christophe.chevalier@inrae.fr  Web page: https://orcid.org/0000-0003-3231-9027

Author ID: ORCID: 0000-0003-3231-9027, ResearcherID: C-2575-2009, Loop profile: 380767

 EDUCATION

 2019   Habilitation à Diriger des Recherches, highest French academic degree allowing independent supervision of PhDs, U. Paris Saclay France

2003   PhD in Microbiology, General Virology: Study of the morphogenesis of Infectious Bursal Disease Virus, U. Paris 7 France.

2000   Master in General Virology, U. Lille France.

2000   Graduated of the Virology Course, Pasteur Institute, Paris, France

 CURRENT POSITION

 2020 – present   Director of Research, Laboratory of Molecular Virology and Immunology, Influenza Virus Research Group, INRAE, Université Paris-Saclay, Jouy-en-Josas, France.

 PREVIOUS POSITIONS

 2010 – 2020      Research Fellow (Chargé de Recherche 1, CRCN), Laboratory of Molecular Virology and Immunology, Influenza Virus Research Group, INRAE, Jouy-en-Josas, France

2005 – 2010      Research Fellow (Chargé de Recherche 2), Laboratory of Molecular Virology and Immunology, Influenza Virus Research Group, INRAE, Jouy-en-Josas, France

 RESEARCH INTEREST

1999 – present  Molecular Biology, Virology, Structural and functional study of viral proteins, Fluorescence and electron microscopies, Development of vaccines and therapeutics

2012 – present  Synchrotron Radiation Experiments (infrared spectroscopy, DUV microscopy, cryo-SXT), Multivariate data analysis

 

2013 – present   Accreditation to animal experimentation, Animal model of infection (mice, chicken), In vivo Imaging System

• FELLOWSHIPS AND AWARDS

 2003-2005        Post-doctoral fellowship, Grant NIH – University of Texas Medical Branch (section 62553), Unit of molecular genetics in respiratory viruses – Hepatitis group, CNRS URA 1966, Pasteur Institute, Paris, France

 SUPERVISION OF GRADUATE STUDENTS AND POSTDOCTORAL FELLOWS

2003-present     supervision of 7 post-doctoral fellows, 3 PhD students (1 University Orsay, 1 University   Paris 7 Denis Diderot, 1 University Paris-Saclay), 11 master students, 2 engineers. Current PhD is:

2021-2024        PhD Elise Bruder, Study of the impact of PB1-F2 in the pathogenicity, emergence and transmissibility of influenza A viruses (Doctoral School SDSV, University Paris-Saclay)

 TEACHING ACTIVITIES

 2011-2020        Training and accreditation of staff and students to work in biosafety level 3+ facilities

2019                  Lecturer/Trainer Host-Pathogen Interactions, Factor of Virulence of Influenza Viruses, University Paris-Saclay, France (3 weeks)

2010-2012        Lecturer, “Influenza Viruses: Structure and Function of the viral proteins”, Veterinary school of Maisons-Alfort, France

2009                  Lecturer, “Viral Pseudo and Nanoparticles, new application”, Faculty of Pharmacy, Châtenay-Malabry, France

 INSTITUTIONAL RESPONSIBILITIES

 2011 – present Responsible of the Biosafety Level 3+ biocontainment facility of the laboratory of Molecular Virology and Immunology (Influenza Virus, Hepatitis C Virus, Sars-Cov2…), INRAE, Jouy-en-Josas, France

2017 – present  Member of the users’ scientific committee at the synchrotron SOLEIL, Saint-Aubin, France

 REVIEWING AND EDITORIAL ACTIVITIES

 2003 – present Peer Reviewer for 20+ international journals in virology and microbiology

2017 – 2020      Guest Associate Editor, Frontiers in Immunology

2018 – present  Review Editor, Frontiers in Microbiology, Infectious Agents and Disease

2017 – present Member of the Editorial Board, of Vaccines and Pathogens, MDPI

 MEMBERSHIPS OF SCIENTIFIC SOCIETIES

 2018 – present  Founder and Board Member of the French Influenza Virus research Network (resaFLU) and chairman of the “physiopathology of infection” research axis. Organization of meeting (2019, Lyon, France, ~100 attendees) and webinars (3/years). Webmaster (website in construction https://gdr.resaflu.prod.lamp.cnrs.fr/)

 MAJOR COLLABORATIONS

 2010 – 2014      Dr. Hafsa Korri-Youssoufi, Institut de Chimie Moléculaire et des matériaux, Université d’Orsay, France

2011 – present  Dr. Frederic Jamme, DISCO beamline, Synchrotron SOLEIL, Saint-Aubin, France

2014 – present Pr. Denis Archambault et Pr. Steve Bourgault, Université du Québec à Montréal, Canada

2018 – present  Dr. Eva Pereiro, MISTRAL Beamline, Synchrotron ALBA, Cerdanyola del Vallès, Barcelona, Spain


Journal articles39 documents

  • Ximena Zottig, Soultan Al-Halifa, Mélanie Côté-Cyr, Cynthia Calzas, Ronan Le Goffic, et al.. Self-assembled peptide nanorod vaccine confers protection against influenza A virus. Biomaterials, Elsevier, 2021, 269, ⟨10.1016/j.biomaterials.2021.120672⟩. ⟨hal-03319841⟩
  • Joëlle Mettier, Daniel Marc, Laura Sedano, Bruno da Costa, Christophe Chevalier, et al.. Study of the host specificity of PB1-F2-associated virulence. Virulence, Taylor & Francis, 2021, 12 (1), pp.1647 - 1660. ⟨10.1080/21505594.2021.1933848⟩. ⟨hal-03264952⟩
  • Cynthia Calzas, Molida Mao, Mathilde Turpaud, Quentin Viboud, Joelle Mettier, et al.. Immunogenicity and Protective Potential of Mucosal Vaccine Formulations Based on Conserved Epitopes of Influenza A Viruses Fused to an Innovative Ring Nanoplatform in Mice and Chickens. Frontiers in Immunology, Frontiers, 2021, 12, ⟨10.3389/fimmu.2021.772550⟩. ⟨hal-03575999⟩
  • Christophe Chevalier, Olivier Leymarie, Laura Sedano, Bruno da Costa, Charles-Adrien Richard, et al.. PB1-F2 amyloid-like fibers correlate with proinflammatory signaling and respiratory distress in influenza-infected mice. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2021, 297 (1), ⟨10.1016/j.jbc.2021.100885⟩. ⟨hal-03299147⟩
  • Olivier Leymarie, Ronan Le Goffic, Frederic Jamme, Christophe Chevalier. Impact of the influenza protein PB1-F2 on the biochemical composition of human epithelial cells revealed by synchrotron Fourier transform infrared spectromicroscopy. Journal of Spectral Imaging, IM Publications, 2020, 8 (18), ⟨10.1255/jsi.2019.a18⟩. ⟨hal-02873862⟩
  • Cynthia Calzas, Delphyne Descamps, Michel Chignard, Christophe Chevalier. Editorial: Innovative Therapeutic and Vaccine Approaches Against Respiratory Pathogens. Frontiers in Immunology, Frontiers, 2019, 10, ⟨10.3389/fimmu.2019.02960⟩. ⟨hal-02943195⟩
  • Christophe Chevalier, Cynthia Calzas. Innovative mucosal vaccine formulations against Influenza a virus Infections. Frontiers in Immunology, Frontiers, 2019, pp.1-21. ⟨10.3389/fimmu.2019.01605⟩. ⟨hal-02619967⟩
  • Olivier Leymarie, Léa Meyer, Pierre Louis Herve, Bruno da Costa, Bernard Delmas, et al.. Host response comparison of H1N1-and H5N1-infected mice identifies two potential death mechanisms. International Journal of Molecular Sciences, MDPI, 2017, 18 (8), ⟨10.3390/ijms18081631⟩. ⟨hal-02617657⟩
  • Charlotte Deloizy, Even Fossum, Christophe Barnier-Quer, Celine Urien, Tiphany Chrun, et al.. The anti-influenza M2e antibody response is promoted by XCR1 targeting in pig skin. Scientific Reports, Nature Publishing Group, 2017, 7, ⟨10.1038/s41598-017-07372-9⟩. ⟨hal-02626640⟩
  • Cindy Bernelin-Cottet, Charlotte Deloizy, Ondrej Stanek, Céline Barc, Edwige Bouguyon, et al.. Corrigendum: A Universal Influenza Vaccine Can Lead to Disease Exacerbation or Viral Control Depending on Delivery Strategies. Frontiers in Immunology, Frontiers, 2017, 8, pp.831. ⟨10.3389/fimmu.2017.00831⟩. ⟨hal-02618722⟩
  • Léa Meyer, Olivier Leymarie, Christophe Chevalier, Evelyne Esnault, Marco Moroldo, et al.. Transcriptomic profiling of a chicken lung epithelial cell line (CLEC213) reveals a mitochondrial respiratory chain activity boost during influenza virus infection. PLoS ONE, Public Library of Science, 2017, 12 (4), 18 p. ⟨10.1371/journal.pone.0176355⟩. ⟨hal-01605882⟩
  • Jasmina Vidic, Charles-Adrien Richard, Christine Péchoux, Bruno da Costa, Nicolas Bertho, et al.. Amyloid assemblies of influenza a virus PB1-F2 protein Damage membrane and induce cytotoxicity. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2016, 291 (2), pp.739-751. ⟨10.1074/jbc.M115.652917⟩. ⟨hal-02637618⟩
  • Dalila Ajjaji, Charles-Adrien Richard, Sandra Mazerat, Christophe Chevalier, Jasmina Vidic. N-terminal domain of PB1-F2 protein of influenza A virus can fold into amyloid-like oligomers and damage cholesterol and cardiolipid containing membranes. Biochemical and Biophysical Research Communications, Elsevier, 2016, 477 (1), pp.27-32. ⟨10.1016/j.bbrc.2016.06.016⟩. ⟨hal-02636639⟩
  • Aurore Vidy-Roche, Pauline Maisonnasse, Bruno da Costa, Bernard Delmas, Christophe Chevalier, et al.. The Influenza Virus Protein PB1-F2 Increases Viral Pathogenesis through Neutrophil Recruitment and NK Cells Inhibition. PLoS ONE, Public Library of Science, 2016, 11 (10), pp.1-19. ⟨10.1371/journal.pone.0165361⟩. ⟨hal-01608535⟩
  • Cindy Bernelin-Cottet, Charlotte Deloizy, Ondrej Stanek, Céline Barc, Edwige Bouguyon, et al.. A Universal Influenza Vaccine Can Lead to Disease Exacerbation or Viral Control Depending on Delivery Strategies. Frontiers in Immunology, Frontiers, 2016, 8, pp.1-1. ⟨10.3389/fimmu.2016.00641⟩. ⟨hal-01569908⟩
  • Christophe Chevalier, Ronan Le Goffic, Frédéric Jamme, Olivier Leymarie, Matthieu Réfrégiers, et al.. Synchrotron Infrared and Deep UV Fluorescent Microspectroscopy Study of PB1-F2 β-Aggregated Structures in Influenza A Virus-infected Cells. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2016, 291 (17), pp.9060 - 9072. ⟨10.1074/jbc.M115.710533⟩. ⟨hal-01724147⟩
  • Olivier Leymarie, Carissa Embury-Hyatt, Christophe Chevalier, Luc Jouneau, Marco Moroldo, et al.. PB1-F2 attenuates virulence of highly pathogenic avian H5N1 influenza virus in chickens. PLoS ONE, Public Library of Science, 2014, 9 (6), ⟨10.1371/journal.pone.0100679⟩. ⟨hal-01194021⟩
  • Anna Miodek, Jasmina Vidic, Helene Sauriat-Dorizon, Charles-Adrien Richard, Ronan Le Goffic, et al.. Electrochemical Detection of the Oligomerization of PB1-F2 Influenza A Virus Protein in Infected Cells. Analytical Chemistry, American Chemical Society, 2014, 86 (18), pp.9098 - 9105. ⟨10.1021/ac5018056⟩. ⟨hal-02635306⟩
  • Pierre-Louis Hervé, Mariam Raliou, Christiane Bourdieu, Catherine Dubuquoy, Agnes Petit-Camurdan, et al.. A Novel Subnucleocapsid Nanoplatform for Mucosal Vaccination against Influenza Virus That Targets the Ectodomain of Matrix Protein 2. Journal of Virology, American Society for Microbiology, 2014, 88 (1), pp.325-338. ⟨10.1128/JVI.01141-13⟩. ⟨hal-02637841⟩
  • Anna Miodek, Helene Sauriat-Dorizon, Christophe Chevalier, Bernard Delmas, Jasmina Vidic, et al.. Direct electrochemical detection of PB1-F2 protein of influenza A virus in infected cells. Biosensors and Bioelectronics, Elsevier, 2014, 59, pp.6-13. ⟨10.1016/j.bios.2014.02.037⟩. ⟨hal-02635315⟩
  • Qiaojing Li, Christophe Chevalier, Celine Henry, Charles-Adrien Richard, Mohammed Moudjou, et al.. Shadoo binds lipid membranes and undergoes aggregation and fibrillization. Biochemical and Biophysical Research Communications, Elsevier, 2013, 438 (3), pp.519 - 525. ⟨10.1016/j.bbrc.2013.07.104⟩. ⟨hal-02643069⟩
  • Olivier Leymarie, Gregory Jouvion, Pierre-Louis Hervé, Christophe Chevalier, Valérie Lorin, et al.. Kinetic characterization of PB1-F2-mediated immunopathology during highly pathogenic avian H5N1 influenza virus infection.. PLoS ONE, Public Library of Science, 2013, 8 (3), pp.e57894. ⟨10.1371/journal.pone.0057894⟩. ⟨hal-01004085⟩
  • Noura Kechaou, Florian Chain, Jean-Jacques Gratadoux, Sebastien Blugeon, Nicolas Bertho, et al.. Identification of One Novel Candidate Probiotic Lactobacillus plantarum Strain Active against Influenza Virus Infection in Mice by a Large-Scale Screening. Applied and Environmental Microbiology, American Society for Microbiology, 2013, 79 (5), pp.1491 - 1499. ⟨10.1128/AEM.03075-12⟩. ⟨hal-01001569⟩
  • Jasmina Vidic, Ronan Le Goffic, Anna Miodek, Christiane Bourdieu, Charles-Adrien Richard, et al.. Detection of soluble oligomers formed by PB1-F2 influenza A virus protein in vitro. Journal of Analytical & Bioanalytical Techniques, Omics Publishing Group, 2013, 4 (3), pp.1-2. ⟨10.4172/2155-9872.1000169⟩. ⟨hal-02642907⟩
  • Jasmina Vidic, Christophe Chevalier, Ronan Le Goffic, Anna Miodek, Christiane Bourdieu, et al.. Surface plasmon resonance immunosensor for detection of pb1-f2 influenza a virus protein in infected biological samples. Journal of Analytical & Bioanalytical Techniques, Omics Publishing Group, 2013, S7, ⟨10.4172/2155-9872.S7-006⟩. ⟨hal-02642777⟩
  • Bogdan Tarus, Christophe Chevalier, Charles-Adrien Richard, Bernard Delmas, Carmelo Di Primo, et al.. Molecular dynamics studies of the nucleoprotein of influenza A virus: role of the protein flexibility in RNA binding. PLoS ONE, Public Library of Science, 2012, 7 (1), pp.e30038. ⟨10.1371/journal.pone.0030038⟩. ⟨hal-02647086⟩
  • Bogdan Tarus, Olivier Bakowiez, Sophie Chenavas, Lucie Duchemin, L.F. Estrozi, et al.. Oligomerization paths of the nucleoprotein of influenza A virus. Biochimie, Elsevier, 2012, 94 (3), pp.776-785. ⟨hal-02650463⟩
  • Christophe Chevalier, Ali Al Bazzal, Jasmina Vidic, Vincent Fevrier, Christiane Bourdieu, et al.. PB1-F2 Influenza A Virus Protein Adopts a beta-Sheet Conformation and Forms Amyloid Fibers in Membrane Environments. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2010, 285 (17), pp.13233-13243. ⟨10.1074/jbc.M109.067710⟩. ⟨hal-02664783⟩
  • Ronan Le Goffic, Edwige Bouguyon, Christophe Chevalier, Jasmina Vidic, Bruno da Costa, et al.. Influenza A Virus Protein PB1-F2 Exacerbates IFN-b Expression of Human Respiratory Epithelial Cells. Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2010, 185 (8), pp.4812-4823. ⟨10.4049/jimmunol.0903952⟩. ⟨hal-01193647⟩
  • Fasseli Coulibaly, Christophe Chevalier, Marie Galloux, Bruno da Costa, Jean Lepault, et al.. Les relations structurales entre birnavirus et autres virus icosaédriques à ARN. Virologie, John Libbey Eurotext 2006, 10 (3), pp.233-235. ⟨hal-02655894⟩
  • Joan Pous, Christophe Chevalier, Malika Ouldali, Jorge Navaza, Bernard Delmas, et al.. Structure of birnavirus-like particles determined by combined electron cryomicroscopy and X-ray crystallography. Journal of General Virology, Microbiology Society, 2005, 86 (8), pp.2339-20346. ⟨10.1099/vir.0.80942-0⟩. ⟨hal-02681514⟩
  • Christophe Chevalier, Marie Galloux, Joan Pons, Celine Henry, Bruno da Costa, et al.. Structural Peptides of a Nonenveloped Virus Are Involved in Assembly and Membrane Translocation. Journal of Virology, American Society for Microbiology, 2005, 79 (19), pp.12253-12263. ⟨10.1128/JVI.79.19.12253-12263.2005⟩. ⟨hal-02683022⟩
  • Fasseli Coulibaly, Christophe Chevalier, Irina Gutsche, Joan Pous, Jorge Navaza, et al.. The birnavirus crystal structure reveals structural relationships among icosahedral viruses. Cell, Elsevier, 2005, 120 (6), pp.761-772. ⟨10.1016/j.cell.2005.01.009⟩. ⟨hal-02683425⟩
  • Christophe Chevalier, Jean Lepault, Bruno da Costa, Bernard Delmas. The last C-terminal residue of VP3, glutamic acid 257, controls capsid assembly of infectious bursal disease virus. Journal of Virology, American Society for Microbiology, 2004, 78 (7), pp.3296-3303. ⟨10.1128/JVI.78.7.3296-3303.2004⟩. ⟨hal-02682913⟩
  • Marie Galloux, Christophe Chevalier, Celine Henry, Jean-Claude Huet, Bruno da Costa, et al.. Peptides resulting from the pVP2 C-terminal processing are present in infectious pancreatic necrosis virus particles. Journal of General Virology, Microbiology Society, 2004, 85 (8), pp.2231-2236. ⟨10.1099/vir.0.80012-0⟩. ⟨hal-02683321⟩
  • Achille François, Christophe Chevalier, Bernard Delmas, Nicolas Eterradossi, Didier Toquin, et al.. Avian adenovirus CELO recombinants expressing VP2 of infectious bursal disease virus induce protection against bursal disease in chickens. Vaccine, Elsevier, 2004, 22 (17-18), pp.2351-2360. ⟨10.1016/j.vaccine.2003.10.039⟩. ⟨hal-02680360⟩
  • Bruno da Costa, S. Soignier, Christophe Chevalier, C. Henry, C. Thory, et al.. Blotched snakehead virus is a new aquatic birnavirus that is slightly more related to avibirnavirus than to aquabirnavirus. Journal of Virology, American Society for Microbiology, 2003, 77 (1), pp.719-725. ⟨10.1128/JVI.77.1.719-725.2003⟩. ⟨hal-02675513⟩
  • Christophe Chevalier, Inge Erk, Bruno da Costa, Jean Lepault, Bernard Delmas. Contraindre les protéines de capside de birnavirus à s'autoassembler en pseudo-particules. Virologie, John Libbey Eurotext 2002, 6 (2), pp.132-134. ⟨hal-02676375⟩
  • Bruno da Costa, Christophe Chevalier, C. Henry, J.C. Huet, S. Petit, et al.. The capsid of infectious bursal disease virus contains several small peptides arising from the maturation process of pVP2. Journal of Virology, American Society for Microbiology, 2002, 76 (5), pp.2393-2402. ⟨10.1128/JVI.76.5.2393-2402.2002⟩. ⟨hal-02678629⟩