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Christoph Grunau

The goal of our group is to elucidate the multiple relations between environment, organisms and their fitness in the lab and in the field, in order to understand and control host-symbiont/parasite interactions. We see inheritance in a broad sense including genetic, epigenetic, cytoplasmic, and holobiont elements.
My specialty is evolutionary epigenetics.

Sep 2011 – Sep 2011

Université de Perpignan

HDR, Epigenetics

Perpignan, France

Jan 1995 – Dec 1999

IMB Jena

PhD, Epigenetics

Jena, Thuringia, Germany

Sep 1994 – Dec 1995


PreDoc, Microbiology

Wako, Japan

Sep 1988 – Aug 1994

Friedrich-Schiller-University Jena

Diploma, Biology

Jena, Germany

Research Experience

Jan 2021– present 


Sep 2013 – present

Director of IHPE (UMR5244)


Professor (Full)

Université de Perpignan, Laboratory of Host-Pathogen-Environnement Interactions (IHPE)

Perpignan, France

Sep 2007 – Aug 2013

Professor (Assistant)

Université de Perpignan, Laboratory of Ecology and Evolution of Interactions 2EI

Perpignan, France

Sep 2006 – Aug 2007

PostDoc Position

Université de Perpignan, 

Perpignan, France

Jan 2000 – Mar 2005

PostDoc Position

French National Centre for Scientific Research, Institut de Génétique Humaine

Montpellier, Languedoc-Roussillon, France

Jan 1996 – Dec 1999

PhD Student

Institute of Molecular Biotechnology, Jena, 

Jena, Thuringia, Germany

Oct 1994 – Dec 1995


RIKEN, Intestinal Microbe Symbiosis Research Laboratory

Wako, Saitama, Japan

Sep 1993 – Aug 1994


Max-Delbrück-Centrum für Molekulare Medizin, 

Berlin, Germany

Journal articles65 documents

  • Pierre-Louis Stenger, Chin-Long Ky, Céline Reisser, Céline Cosseau, Christoph Grunau, et al.. Environmentally Driven Color Variation in the Pearl Oyster Pinctada margaritifera var. cumingii (Linnaeus, 1758) Is Associated With Differential Methylation of CpGs in Pigment- and Biomineralization-Related Genes. Frontiers in Genetics, Frontiers, 2021, 12, pp.630290. ⟨10.3389/fgene.2021.630290⟩. ⟨hal-03178846⟩
  • Mélanie Blanc, Philipp Antczak, Xavier Cousin, Christoph Grunau, Nikolai Scherbak, et al.. The insecticide permethrin induces transgenerational behavioral changes linked to transcriptomic and epigenetic alterations in zebrafish (Danio rerio). Science of the Total Environment, Elsevier, 2021, 779, pp.146404. ⟨10.1016/j.scitotenv.2021.146404⟩. ⟨hal-03175988⟩
  • Ronaldo de Carvalho Augusto, Olivier Rey, Céline Cosseau, Cristian Chaparro, Jeremie Vidal-Dupiol, et al.. A simple ATAC-seq protocol for population epigenetics. Wellcome Open Research, F1000Research, 2021, 5, pp.121. ⟨10.12688/wellcomeopenres.15552.2⟩. ⟨hal-03145575⟩
  • Pierick Mouginot, Nelia Luviano Aparicio, Delphine Gourcilleau, Mathieu Latutrie, Sara Marin, et al.. Phenotypic response to light versus shade associated with DNA methylation changes in Snapdragon plants (Antirrhinum majus). Genes, MDPI, 2021, 12 (2), pp.227. ⟨10.3390/genes12020227⟩. ⟨hal-03132536⟩
  • Ronaldo de Carvalho Augusto, Ronaldo Augusto, Aki Minoda, Christoph Grunau. A simple ATAC-seq protocol for population epigenetics [version 1; peer review: 1 approved with reservations]. Wellcome Open Research, F1000Research, 2020, 5, pp.121. ⟨10.12688/wellcomeopenres.15552.1⟩. ⟨hal-02428832⟩
  • Marion Picard, Beatriz Vicoso, David Roquis, Ingo Bulla, Ronaldo de Carvalho Augusto, et al.. Dosage compensation throughout the Schistosoma mansoni lifecycle: specific chromatin landscape of the Z chromosome. Genome Biology and Evolution, Society for Molecular Biology and Evolution, 2019, 11 (7), pp.1909-1922. ⟨10.1093/gbe/evz133/5527757⟩. ⟨hal-02177468⟩
  • Ronaldo de Carvalho Augusto, David Duval, Christoph Grunau. Effects of the environment on developmental plasticity and infection success of Schistosoma parasites – an epigenetic perspective. Frontiers in Microbiology, Frontiers Media, 2019, 10, pp.1475. ⟨10.3389/fmicb.2019.01475⟩. ⟨hal-02178309⟩
  • Christoph Grunau, Jérémy Le Luyer, Martin Laporte, Dominique Joly. The Epigenetics Dilemma. Genes, MDPI, 2019, 11 (1), pp.23. ⟨10.3390/genes11010023⟩. ⟨hal-02428660⟩
  • Benoît Aliaga, Ingo Bulla, Gabriel Mouahid, David Duval, Christoph Grunau. Universality of the DNA methylation codes in Eucaryotes. Scientific Reports, Nature Publishing Group, 2019, 9, pp.173. ⟨10.1038/s41598-018-37407-8⟩. ⟨hal-01905101⟩
  • Julien Kincaid-Smith, Marion A.-L. Picard, Celine Cosseau, Jerome Boissier, Dany Severac, et al.. Parent-of-Origin Dependent Gene Expression in Male and Female Schistosome Parasites. Genome Biology and Evolution, Society for Molecular Biology and Evolution, In press, 10 (3), pp.840-856. ⟨10.1093/gbe/evy037⟩. ⟨hal-01729365⟩
  • Christoph Grunau, Susanne Voigt, Ralph Dobler, Damian Dowling, Klaus Reinhardt. The Cytoplasm Affects the Epigenome in Drosophila melanogaster. Epigenomes, MDPI, 2018, 2 (3), pp.17. ⟨10.3390/epigenomes2030017⟩. ⟨hal-01887456⟩
  • David Roquis, Aaron Taudt, Kathrin Geyer, Gilda Padalino, Karl Hoffmann, et al.. Histone methylation changes are required for life cycle progression in the human parasite Schistosoma mansoni. PLoS Pathogens, Public Library of Science, 2018, 14 (5), pp.e1007066. ⟨10.1371/journal.ppat.1007066⟩. ⟨hal-01808531⟩
  • Gabriel Mouahid, Anne Rognon, Ronaldo de Carvalho Augusto, Patrick Driguez, Kathy Geyer, et al.. Transplantation of schistosome sporocysts between host snails: A video guide. Wellcome Open Research, F1000Research, 2018, 3, pp.3. ⟨10.12688/wellcomeopenres.13488.1⟩. ⟨hal-01729358⟩
  • Ingo Bulla, Benoît Aliaga, Virginia Lacal, Jan Bulla, Christoph Grunau, et al.. Notos -a galaxy tool to analyze CpN observed expected ratios for inferring DNA methylation types. BMC Bioinformatics, BioMed Central, 2018, 19, pp.105. ⟨10.1186/s12859-018-2115-4⟩. ⟨hal-01746203⟩
  • Arnaud Sentis, Raphaël Bertram, Nathalie Dardenne, Felipe Ramon-Portugal, Gilles Espinasse, et al.. Evolution without standing genetic variation: change in transgenerational plastic response under persistent predation pressure. Heredity, Nature Publishing Group, 2018, 121 (3), pp.266-281. ⟨10.1038/s41437-018-0108-8⟩. ⟨hal-01887396⟩
  • Richard Galinier, Emmanuel Roger, Yves Moné, David Duval, Anaïs Portet, et al.. A multistrain approach to studying the mechanisms underlying compatibility in the interaction between Biomphalaria glabrata and Schistosoma mansoni. PLoS Neglected Tropical Diseases, Public Library of Science, 2017, 11 (3), pp.e0005398. ⟨10.1371/journal.pntd.0005398.s005⟩. ⟨hal-01511153⟩
  • C. Adema, L. Hillier, C. Jones, E.S. Loker, M. Knight, et al.. Whole genome analysis of a schistosomiasis-transmitting freshwater snail. Nature Communications, Nature Publishing Group, 2017, 8, pp.15451. ⟨10.1038/ncomms15451⟩. ⟨hal-01523953⟩
  • Anaïs Portet, Silvain Pinaud, Guillaume Tetreau, Richard Galinier, Céline Cosseau, et al.. Integrated multi-omic analyses in Biomphalaria-Schistosoma dialogue reveal the immunobiological significance of FREP- Sm PoMuc interaction. Developmental and Comparative Immunology, Elsevier, 2017, 75, pp.16 - 27. ⟨10.1016/j.dci.2017.02.025⟩. ⟨hal-01598455⟩
  • Kathrin Geyer, Umar Niazi, David Duval, Céline Cosseau, Chad Tomlinson, et al.. The Biomphalaria glabrata DNA methylation machinery displays spatial tissue expression, is differentially active in distinct snail populations and is modulated by interactions with Schistosoma mansoni. PLoS Neglected Tropical Diseases, Public Library of Science, 2017, 11 (5), pp.e0005246. ⟨10.1371/journal.pntd.0005246⟩. ⟨hal-01523805⟩
  • Rodolfo Rondon, Christoph Grunau, Manon Fallet, Nicolas Charlemagne, Rossana Sussarellu, et al.. Effects of a parental exposure to diuron on Pacific oyster spat methylome. Environmental Epigenetics, Oxford University Press, 2017, 3 (1), pp.dvx004. ⟨10.1093/eep/dvx004⟩. ⟨hal-01511486⟩
  • Guillaume Mitta, Benjamin Gourbal, Christoph Grunau, M. Knight, J.M. Bridger, et al.. The compatibility between Biomphalaria glabrata snails and Schistosoma mansoni: an increasingly complex puzzle. Advances in Parasitology, Elsevier, 2017, 97, pp.111-145. ⟨10.1016/bs.apar.2016.08.006⟩. ⟨hal-01511043⟩
  • Ronaldo de Carvalho Augusto, Guillaume Tetreau, Philippe Chan, Marie-Laure Walet-Balieu, Clélia Christina Mello-Silva, et al.. Double impact: natural molluscicide for schistosomiasis vector control also impedes development of Schistosoma mansoni cercariae into adult parasites. PLoS Neglected Tropical Diseases, Public Library of Science, 2017, 11 (7), pp.e0005789. ⟨10.1371/journal.pntd.0005789⟩. ⟨hal-01598383⟩
  • Céline Cosseau, Olaf Wolkenhauer, Gilda Padalino, Kathrin K. Geyer, Karl F. Hoffmann, et al.. (Epi)genetic inheritance in Schistosoma mansoni: a system approach. Trends in Parasitology, Elsevier, 2017, 1590, pp.285-294. ⟨10.1016/⟩. ⟨hal-01511049⟩
  • Marion Picard, Jérôme Boissier, David Roquis, Christoph Grunau, Jean-François Allienne, et al.. Sex-biased transcriptome of Schistosoma mansoni: host-parasite interaction, genetic determinants and epigenetic regulators are associated with sexual differentiation. PLoS Neglected Tropical Diseases, Public Library of Science, 2016, 10 (9), pp.e0004930. ⟨10.1371/journal.pntd.0004930.s010⟩. ⟨hal-01387886⟩
  • David Roquis, Anne Rognon, Cristian Chapparo, Jérôme Boissier, Nathalie Arancibia, et al.. Frequency and mitotic heritability of epimutations in Schistosoma mansoni. Molecular Ecology, Wiley, 2016, EPIGENETIC STUDIES IN ECOLOGY AND EVOLUTION, 25 (8), pp.1741-1758. ⟨10.1111/mec.13555⟩. ⟨hal-01311089⟩
  • Rodolfo Rondon, F. Akcha, P. Alonso, D. Menard, J. Rouxel, et al.. Transcriptional changes in Crassostrea gigas oyster spat following a parental exposure to the herbicide diuron. Aquatic Toxicology, Elsevier, 2016, 175, pp.47-55. ⟨10.1016/j.aquatox.2016.03.007⟩. ⟨hal-01311107⟩
  • Sara Fneich, André Théron, Céline Cosseau, Anne Rognon, Benoit Aliaga, et al.. Epigenetic origin of adaptive phenotypic variants in the human blood-fluke Schistosoma mansoni. Epigenetics and Chromatin, BioMed Central, 2016, 9, pp.227. ⟨10.1186/s13072-016-0076-2⟩. ⟨hal-01364014⟩
  • David Roquis, Julie Mireille Lepesant, Marion A.L. Picard, M. Freitag, Hugues Parrinello, et al.. The Epigenome of Schistosoma mansoni Provides Insight about How Cercariae Poise Transcription until Infection. PLoS Neglected Tropical Diseases, Public Library of Science, 2015, 9 (8), pp.e0003853. ⟨10.1371/journal.pntd.0003853⟩. ⟨hal-01259820⟩
  • Nolwenn M Dheilly, David Duval, Gabriel Mouahid, Rémi Emans, Jean-François Allienne, et al.. A family of variable immunoglobulin and lectin domain containing molecules in the snail Biomphalaria glabrata. Developmental and Comparative Immunology, Elsevier, 2015, 48 (1), pp.234-243. ⟨10.1016/j.dci.2014.10.009⟩. ⟨hal-01082870⟩
  • Marion A.L. Picard, Céline Cosseau, Gabriel Mouahid, David Duval, Christoph Grunau, et al.. The roles of DMRT (Double sex/Male-abnormal-3 Related Transcription factor) genes in sex determination and differentiation mechanisms: ubiquity and diversity across the animal kingdom. Comptes Rendus Biologies, Elsevier Masson, 2015, 338 (7), pp.451-462. ⟨10.1016/j.crvi.2015.04.010⟩. ⟨hal-01163079⟩
  • Jeremie Vidal-Dupiol, Nolwenn M Dheilly, Rodolfo Rondon, Christoph Grunau, Cé Line Cosseau, et al.. Thermal Stress Triggers Broad Pocillopora damicornis Transcriptomic Remodeling, while Vibrio coralliilyticus Infection Induces a More Targeted Immuno-Suppression Response. PLoS ONE, Public Library of Science, 2014, 9 (9), pp.e107672. ⟨10.1371/journal.pone⟩. ⟨hal-01112610⟩
  • N.D. Tossavi, A Gbankoto, A Adité, Moudachirou Ibikounlé, Christoph Grunau, et al.. Metazoan parasite communities of catfishes (Teleostei: Siluridae) in Benin (West Africa).. Parasitology Research, Springer Verlag (Germany), 2014, 113 (11), pp.3973-3983. ⟨10.1007/s00436-014-4063-x⟩. ⟨hal-01112591⟩
  • Nolwenn M Dheilly, Coen Adema, David A Raftos, Benjamin Gourbal, Christoph Grunau, et al.. No more non-model species: The promise of next generation sequencing for comparative immunology.. Developmental and Comparative Immunology, Elsevier, 2014, 45 (1), pp.56-66. ⟨10.1016/j.dci.2014.01.022⟩. ⟨halsde-00965375⟩
  • Laetitia Perfus-Barbeoch, Philippe Castagnone-Sereno, Michael Reichelt, Sara Fneich, David Roquis, et al.. Elucidating the molecular bases of epigenetic inheritance in non-model invertebrates: the case of the root-knot nematode Meloidogyne incognita. Frontiers in Physiology, Frontiers, 2014, 5, pp.211. ⟨10.3389/fphys.2014.00211⟩. ⟨hal-01112344⟩
  • David Roquis, Julie M. J. Lepesant, Emanuel Villafan, Jérôme Boissier, Cristina Vieira, et al.. Exposure to hycanthone alters chromatin structure around specific gene functions and specific repeats in Schistosoma mansoni.. Frontiers in Genetics, Frontiers, 2014, 5, pp.207. ⟨10.3389/fgene.2014.00207⟩. ⟨hal-01112701⟩
  • Julie a J Clément, Eve Toulza, Mathieu Gautier, Hugues Parrinello, David Roquis, et al.. Private Selective Sweeps Identified from Next-Generation Pool-Sequencing Reveal Convergent Pathways under Selection in Two Inbred Schistosoma mansoni Strains.. PLoS Neglected Tropical Diseases, Public Library of Science, 2013, 7 (12), pp.e2591. ⟨10.1371/journal.pntd.0002591⟩. ⟨hal-00938922⟩
  • Jeremie Vidal-Dupiol, Didier Zoccola, Eric Tambutté, Christoph Grunau, Céline Cosseau, et al.. Genes related to ion-transport and energy production are upregulated in response to CO2-Driven pH decrease in corals: new insights from transcriptome analysis. PLoS ONE, Public Library of Science, 2013, 8 (3), pp.e58652. ⟨halsde-00805879⟩
  • Sara Fneich, Nolwenn Dheilly, Coen Adema, Anne Rognon, Michael Reichelt, et al.. 5-methyl-cytosine and 5-hydroxy-methyl-cytosine in the genome of Biomphalaria glabrata, a snail intermediate host of Schistosoma mansoni.. Parasites and Vectors, BioMed Central, 2013, 6, pp.167. ⟨10.1186/1756-3305-6-167⟩. ⟨halsde-00839033⟩
  • Julie M J Lepesant, Jérôme Boissier, Déborah Climent, Céline Cosseau, Christoph Grunau. Female biased sex-ratio in Schistosoma mansoni after exposure to an allopatric intermediate host strain of Biomphalaria glabrata.. Experimental Parasitology, Elsevier, 2013, 135, pp.350-356. ⟨10.1016/j.exppara.2013.07.023⟩. ⟨halsde-00856611⟩
  • Cecile Perrin, Julie Mireille Lepesant, Emmanuel Roger, David Duval, Sara Fneich, et al.. Schistosoma mansoni mucin genes expression (SmPoMuc): an epigenetic control to shape the adaptation to new host. PLoS Pathogens, Public Library of Science, 2013, 9 (8), pp.e1003571. ⟨10.1371/journal.ppat.1003571⟩. ⟨halsde-00856613⟩
  • Frédéric Thomas, Daniel Fisher, Philippe Fort, Jean-Pierre Marie, Simon Daoust, et al.. Applying ecological and evolutionary theory to cancer: a long and winding road. Evolutionary Applications, Blackwell, 2013, 6 (1), pp.1-10. ⟨10.1111/eva.12021⟩. ⟨halsde-00790602⟩
  • Julie Mireille Lepesant, David Roquis, Rémi Emans, Céline Cosseau, Nathalie Arancibia, et al.. Combination of de-novo assembly of massive sequencing reads with classical repeat prediction improves identification of repetitive sequences in Schistosoma mansoni. Experimental Parasitology, Elsevier, 2012, 130 (4), pp.470-474. ⟨10.1016/j.exppara.2012.02.010⟩. ⟨halsde-00674586⟩
  • Julie Mj Lepesant, Celine Cosseau, Jerome Boissier, Michael Freitag, Julien Portela, et al.. Chromatin structure changes around satellite repeats on the Schistosoma mansoni female sex chromosome suggest a possible mechanism for sex chromosome emergence.. Genome Biology, BioMed Central, 2012, 13 (2), pp.R14. ⟨10.1186/gb-2012-13-2-r14⟩. ⟨halsde-00677346⟩
  • J. M. J. Lepesant, Christoph Grunau, C. Cosseau. Towards an understanding of the epigenetics of schistosomes: a comparative epigenomic study. Memórias do Instituto Oswaldo Cruz, Instituto Oswaldo Cruz, Ministério da Saúde, 2011, 106 (7), pp.823-830. ⟨halsde-00643863⟩
  • S. Beltran, B. Gourbal, J. Boissier, D. Duval, S. Kieffer-Jaquinod, et al.. Vertebrate host protective immunity drives genetic diversity and antigenic polymorphism in Schistosoma mansoni.. Journal of Evolutionary Biology, Wiley, 2011, 24 (3), pp.554-72. ⟨10.1111/j.1420-9101.2010.02190.x⟩. ⟨halsde-00580773⟩
  • Céline Cosseau, Christoph Grunau. Native chromatin immunoprecipitation.. Methods in Molecular Biology, Humana Press/Springer Imprint, 2011, 791, pp.195-212. ⟨10.1007/978-1-61779-316-5_15⟩. ⟨halsde-00629480⟩
  • M. M. Mourão, Christoph Grunau, P. T. Loverde, M. K. Jones, G. Oliveira. Recent advances in Schistosoma genomics.. Parasite Immunology, Wiley, 2011, 34 (2-3), pp.151-162. ⟨10.1111/j.1365-3024.2011.01349.x⟩. ⟨halsde-00665474⟩
  • Julien Portela, Christoph Grunau, Celine Cosseau, Sophie Beltran, Christelle Dantec, et al.. Whole-genome in-silico subtractive hybridization (WISH) - using massive sequencing for the identification of unique and repetitive sex-specific sequences: the example of Schistosoma mansoni.. BMC Genomics, BioMed Central, 2010, 11 (1), pp.387. ⟨10.1186/1471-2164-11-387⟩. ⟨halsde-00495369⟩
  • Sylvain Chantepie, Dominique Vaur, Christoph Grunau, Véronique Salaün, Mélanie Briand, et al.. ZAP-70 intron1 DNA methylation status: Determination by pyrosequencing in B chronic lymphocytic leukemia. Leukemia Research, Elsevier, 2010, 34 (6), pp.800-808. ⟨10.1016/j.leukres.2009.10.018⟩. ⟨hal-02358614⟩
  • S.P. Chantepie, S. Vaur, Christoph Grunau, V. Salaün, M. Briand, et al.. ZAP-70 intron 1 DNA methylation status: Determination by pyrosequencing in B chronic lymphocytic leukemia. Leukemia Research, Elsevier, 2010, 34 (6), pp.800-808. ⟨10.1016/j.leukres.2009.10.018⟩. ⟨halsde-00495188⟩
  • Christoph Grunau, Jérôme Boissier. No evidence for lateral gene transfer between salmonids and schistosomes.. Nature Genetics, Nature Publishing Group, 2010, 42 (11), pp.918-9. ⟨10.1038/ng1110-918⟩. ⟨halsde-00608638⟩
  • Céline Cosseau, A. Azzi, A. Rognon, J. Boissier, S. Gourbière, et al.. Epigenetic and phenotypic variability in populaitons of Schistosoma mansoni - a possible kick-off for adaptative host/parasite evolution. Oikos, Nordic Ecological Society, 2010, 119 (4), pp.669-678. ⟨10.1111/j.1600-0706.2009.18040.x⟩. ⟨halsde-00495189⟩
  • M.S. Blouin, V. Thuillier, B. Cooper, V. Amarasinghe, L. Cluzel, et al.. No evidence for large difference in genomic methylation between wild and hatchery steelhead (Oncorhynchus mykiss). Canadian Journal of Fisheries and Aquatic Sciences, NRC Research Press, 2010, 67 (2), pp.217-224. ⟨10.1139/F09-174⟩. ⟨halsde-00495179⟩
  • A. Azzi, C. Cosseau, Christoph Grunau. Schistosoma mansoni: Developmental arrest of miracidia treated with histone deacetylase inhibitors. Experimental Parasitology, Elsevier, 2009, 121, pp.288-291. ⟨10.1016/j.exppara.2008.11.010⟩. ⟨halsde-00371695⟩
  • Florence Dubois, Stéphanie Caby, Frédérik Oger, Céline Cosseau, Monique Capron, et al.. Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni.. Molecular and Biochemical Parasitology, Elsevier, 2009, 168 (1), pp.7-15. ⟨10.1016/j.molbiopara.2009.06.001⟩. ⟨halsde-00459184⟩
  • Céline Cosseau, Abdelhalim Azzi, Kristina Smith, Michael Freitag, Guillaume Mitta, et al.. Native chromatin immunoprecipitation (N-ChIP) and ChIP-Seq of Schistosoma mansoni: Critical experimental parameters.. Molecular and Biochemical Parasitology, Elsevier, 2009, 166 (1), pp.70-6. ⟨10.1016/j.molbiopara.2009.02.015⟩. ⟨halsde-00459175⟩
  • A. Bouchut, Elise Roger, B. Gourbal, Christoph Grunau, Christine Cousteau, et al.. The compatibility polymorphism in invertebrate host/trematode interactions : research of molecular determinants. Parasite, EDP Sciences, 2008, 15, pp.304-309. ⟨10.1051/parasite/2008153304⟩. ⟨hal-02668649⟩
  • E. Roger, B. Gourbal, Christoph Grunau, R.J. Pierce, R. Galinier, et al.. Expression analysis of highly polymorphic mucin proteins (Sm PoMuc) from the parasite Schistosoma mansoni. Molecular and Biochemical Parasitology, Elsevier, 2008, 157, pp.217-227. ⟨10.1016/j.molbiopara.2007.11.015⟩. ⟨halsde-00286479⟩
  • E. Roger, G. Mitta, Y. Moné, A. Bouchut, A. Rognon, et al.. Molecular determinants of compatibility polymorphism in the Biomphalaria glabrata / Schistosoma mansoni model: New candidates identified by a global comparative proteomics approach. Molecular and Biochemical Parasitology, Elsevier, 2008, 157, pp.205-216. ⟨10.1016/j.molbiopara.2007.11.003⟩. ⟨halsde-00286494⟩
  • A. Bouchut, E. Roger, B. Gourbal, Christoph Grunau, C. Coustau, et al.. The compatibility polymorphism in invertebrate host/trematodes interactions: research of molecular determinants. Parasite, EDP Sciences, 2008, 15 (3), pp.304-309. ⟨halsde-00344425⟩
  • Emmanuel Roger, Christoph Grunau, Raymond Pierce, Hirohisa Hirai, Benjamin Gourbal, et al.. Controlled chaos of polymorphic mucins in a metazoan parasite (Schistosoma mansoni) interacting with its invertebrate host (Biomphalaria glabrata).. PLoS Neglected Tropical Diseases, Public Library of Science, 2008, 2 (11), pp.e330. ⟨10.1371/journal.pntd.0000330⟩. ⟨halsde-00344615⟩
  • Christoph Grunau, Me Brun, I. Rivals, Janick Selves, W. Hindermann, et al.. BAGE hypomethylation, a new epigenetic biomarker for colon cancer detection. Cancer Epidemiology, Biomarkers and Prevention, American Association for Cancer Research, 2008, 17 (6), pp.1374-1379. ⟨10.1158/1055-9965.EPI-07-2656⟩. ⟨hal-00289933⟩
  • François Guillou, Emmanuel Roger, Yves Moné, Anne Rognon, Christoph Grunau, et al.. Excretory-secretory proteome of larval Schistosoma mansoni and Echinostoma caproni, two parasites of Biomphalaria glabrata.. Molecular and Biochemical Parasitology, Elsevier, 2007, 155 (1), pp.45-56. ⟨10.1016/j.molbiopara.2007.05.009⟩. ⟨hal-00170690⟩
  • Christoph Grunau, J. Buard, Me Brun, A. de Sario. Mapping of the juxtacentromeric heterochromatin-euchromatin frontier of human chromosome 21.. Genome Research, Cold Spring Harbor Laboratory Press, 2006, 16, pp.1198-1207. ⟨10.1101/gr.5440306⟩. ⟨hal-00113088⟩
  • Krieger S, Christoph Grunau, Sabbah M, Brigitte Sola. Cyclin D1 Gene Activation in Human Myeloma Cells Is Independent of DNA Hypomethylation or Histone Hyperacetylation.. Experimental Hematology, Elsevier, 2005, ⟨10.1016/j.exphem.2005.03.011⟩. ⟨hal-01762030⟩

Conference papers8 documents

  • Céline Cosseau, Eve Toulza, Richard Galinier, Benjamin Gourbal, Christoph Grunau. A systems biology approach linking genetic, epigenetic, cytoplasmic and holobiont inheritance to understand rapid adaptation of parasitic flatworms (Schistosoma sp.). 66th Annual Meeting of the American Society of Tropical Medicine and Hygiene, Nov 2017, Baltimore, United States. pp.183. ⟨hal-03132820⟩
  • Sara Fneich, Céline Cosseau, André Théron, Anne Rognon, Guillaume Mitta, et al.. L’héritabilité des mécanismes épigénétiques contrôlant le succès d’infestation du parasite Schistosoma mansoni. 9e Réunion du REID Réseau Ecologie des Interactions Durables, Feb 2014, Montpellier, France. ⟨hal-01134509⟩
  • David Roquis, Céline Cosseau, Christoph Grunau. Evolution adaptative : et si Lamarck avait raison ?. 3e congrès pluridisciplinaire des Doctorants UPVD, Université de Perpignan Via Domitia, May 2014, Perpignan, France. ⟨hal-01164367⟩
  • J. Lepesant, C. Cosseau, C. Perrin, G. Mitta, Christoph Grunau. A role for epigenetics in adaptative evolution. Young Researchers in Life Sciences, Jun 2010, Paris, France. ⟨halsde-00495195⟩
  • Y. Moné, E. Roger, Christoph Grunau, B. Gourbal, G. Mitta. Déterminants moléculaires de la compatibilité dans l'interaction Biomphalaria glabrata / Schistosoma mansoni : approche protéomique comparative et caractérisation des mucines polymorphes de S. mansoni (SmPoMuc). Immuninv 2008, Apr 2008, Montpellier, France. ⟨halsde-00330460⟩
  • E. Roger, B.E.F. Gourbal, Christoph Grunau, R. Pierce, G. Mitta. Des mucines polymorphes (SmPoMucs) au coeur de l'interaction entre B. glabrata et S. mansoni. Réunion annuelle du Réseau Ecologie des Interactions Durables, Jan 2008, Tours, France. ⟨halsde-00329976⟩
  • E. Roger, Christoph Grunau, B.E.F. Gourbal, C. Cosseau, G. Mitta. The compatibility polymorphism in trematodes/invertebrate host interactions: research of molecular determinants. Xth EMOP European Multicolloquium Of Parasitology, Aug 2008, Paris, France. ⟨halsde-00329971⟩
  • E. Roger, Christoph Grunau, H. Hirai, R. Pierce, B. Gourbal, et al.. Le polymorphisme de mucines (SmPoMucs) au coeur de l'interaction entre B. glabrata et S. mansoni : un "chaos contrôlé". Immuninv. 2008, Apr 2008, Montpellier, France. ⟨halsde-00329916⟩

Poster communications2 documents

  • Manon Fallet, Bruno Petton, Julien de Lorgeril, Sébastien Comarmond, Cristian Chaparro, et al.. Transgenerational response to early microbial exposure in the oyster Crassostrea gigas and positive impact on survival capacities to juvenile mortality syndrome. 5. Journée d'Animation Scientifique du réseau épiPhase, Jun 2019, Toulouse, France. 35 p., 2019, épiPHASE. ⟨hal-02736036⟩
  • Céline Cosseau, Julie M J Lepesant, David Roquis, Nathalie Arancibia, Christoph Grunau. Environmentally induced epigenetic plasticity in the human parasite Schistosoma mansoni. Conférences Jacques Monod « Les maladies infectieuses comme moteur de l’évolution : les défis à venir », Sep 2014, Roscoff, France. ⟨hal-01134476⟩

Books1 document

  • Dominique Joly, Christoph Grunau. Prospective Épigénétique en Ecologie et Environnement de l’Institut Ecologie et Environnement du CNRS. Les Cahiers Prospectives (CNRS-INEE) n°8 Novembre 80 pages.. pp.80 Pages, 2018. ⟨hal-02366517⟩

Book sections4 documents

  • Ronaldo de Carvalho Augusto, Céline Cosseau, Christoph Grunau. Histone Methylome of the Human Parasite Schistosoma Mansoni. The DNA, RNA, and Histone Methylomes. RNA Technologies, Springer, pp.607-624, 2019, 978-3-030-14791-4. ⟨10.1007/978-3-030-14792-1_24⟩. ⟨hal-03187605⟩
  • Francesca Merlin, Antonine Nicoglou, Christoph Grunau, Danchin Etienne. Qu'est-ce que l'épigénétique ?. D Joly & C Grunau (dir.) Prospective épigénétique écologie & évolution, Une prospective de l'Institut écologie et environnement, N. 8 - Novembre 2018., 2018. ⟨hal-02926493⟩
  • Benjamin Gourbal, André Théron, Christoph Grunau, David Duval, Guillaume Mitta. Polymorphic mucin-like proteins in Schistosoma mansoni, a variable antigen and a key component of the compatibility between the schistosome and its snail host. Hsu, E.; Du Pasquier, L. Pathogen-host interactions: antigenic variation v. somatic adaptations, 57, Springer, pp.91-108, 2015, Results and problems in cell differentiation, 978-3319208183. ⟨10.1007/978-3-319-20819-0_4⟩. ⟨hal-03110515⟩
  • Christoph Grunau. Methylation mapping in humans. Epigenetics: linking genotype and phenotype in development and evolution, University of California Press, pp.70-86, 2011, 978-0-520-94882-2. ⟨hal-00941929⟩

Preprints, Working Papers, ...10 documents

  • David Roquis, Ariadna Picart Picolo, Kelly Raffalli, Pascal Romans, Patrick Masanet, et al.. The tropical coral Pocillopora acuta has a mosaic DNA methylome, an unusual chromatin structure and shows histone H3 clipping. 2021. ⟨hal-03239798⟩
  • Nelia Luviano, Marie Lopez, Fleur Gawehns, Cristian Chaparro, Paola Arimondo, et al.. The methylome of Biomphalaria glabrata and other mollusks: enduring modification of epigenetic landscape and phenotypic traits by a new DNA methylation inhibitor. 2021. ⟨hal-03239598⟩
  • M.D. Sow, A-L Le Gac, R. Fichot, S. Lanciano, A. Delaunay, et al.. Hypomethylated poplars show higher tolerance to water deficit and highlight a dual role for DNA methylation in shoot meristem: regulation of stress response and genome integrity. 2021. ⟨hal-03239719⟩
  • Chrystelle Lasica, Ronaldo de Carvalho Augusto, Helene Mone, Gabriel Mouahid, Cristian Chaparro, et al.. Automated ChIPmentation procedure on limited biological material of the human blood fluke Schistosoma mansoni. 2021. ⟨hal-03255320⟩
  • Rahim Hassanaly-Goulamhoussen, Ronaldo de Carvalho Augusto, Nathalie Marteu-Garello, Arthur Péré, Bruno Favery, et al.. Chromatin landscape dynamics in development of the plant parasitic nematode Meloidogyne incognita. 2021. ⟨hal-03227610⟩
  • Jeremie Vidal-Dupiol, Cristian Chaparro, Marine Pratlong, Pierre Pontarotti, Christoph Grunau, et al.. Sequencing, de novo assembly and annotation of the genome of the scleractinian coral, Pocillopora acuta. 2021. ⟨hal-03239739⟩
  • Anabelle Planques, Pierre Kerner, Laure Ferry, Christoph Grunau, Eve Gazave, et al.. DNA methylation during development and regeneration of the annelid Platynereis dumerilii. 2020. ⟨hal-03083515⟩
  • Ronaldo de Carvalho Augusto, Aki Minoda, Oliver Rey, Céline Cosseau, Cristian Chaparro, et al.. Chromatin structure changes in Daphnia populations upon exposure to environmental cues – or – The discovery of Wolterecks “Matrix”. 2020. ⟨hal-02991174⟩
  • Ronaldo de Carvalho Augusto, Aki Minoda, Oliver Rey, Céline Cosseau, Cristian Chaparro, et al.. Chromatin structure changes in Daphnia populations upon exposure to environmental cues – or – The discovery of Wolterecks “Matrix”.. 2019. ⟨hal-02366511⟩
  • Julien Kincaid Smith, Alan Tracey, Ronaldo de Carvalho Augusto, Ingo Bulla, Nancy Holroyd, et al.. Whole genome sequencing and morphological analysis of the human-infecting schistosome emerging in Europe reveals a complex admixture between Schistosoma haematobium and Schistosoma bovis parasites.. 2018. ⟨hal-03134801⟩