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Christine Leroux

15
Documents
Identifiants chercheurs

Présentation

Christine Leroux (women, PhD, HDR) is a research director from INRAE, the French national institute for research in agriculture, nutrition and environment. After obtaining her PhD in Molecular Genetics (University of Orsay-Paris XI, France) in 1992, Christine started to work at INRA on milk components biosynthesis and secretion in dairy ruminants. She studies the effects of different factors (mainly genetics and nutritional) influencing mammary gland functioning during lactation. Christine’s research aims to improve nutritional quality of milk for consumers and to identify indicators of animal metabolism and health using strategies of nutrigenomics. She firstly studied the effects of genetics polymorphism on protein synthesis, and then she worked on effects of ruminant nutrition on mammary and in a lesser extent on adipose tissues gene expression associated with milk fat composition. More recently, she initiated studies on microRNA and their nutritional regulation in mammary gland. She was visiting researcher scientist at University of California Davis (2017-2019) where she investigated the potential role of milk microRNA as a food source bioactive and contributor to human health. End of 2020, she had 5383 citations and an h-index of 41 referenced by Google Scholar. She participated to 15 national and international research projects. She has 8 years of experience of management of research groups (more than 15 persons) and of a transcriptomic platform, and she has supervised over 26 students (both undergraduates and graduates).

Publications

sandrine-le-guillou

MiRNome variations in milk fractions during feed restrictions of different intensities in dairy cows

Antoine Leduc , Sandrine Le Guillou , Denis Laloë , Lucile Herve , Johann Laubier
BMC Genomics, 2023, 24 (1), pp.680. ⟨10.1186/s12864-023-09769-5⟩
Article dans une revue hal-04284310v1
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L’épigénétique et la construction du phénotype chez le bovin

Nathalie Beaujean , Marion Boutinaud , Eve Devinoy , Hélène Jammes , Sandrine Le Guillou
INRAE Productions Animales, 2020, 33 (2), pp.109-124. ⟨10.20870/productions-animales.2020.33.2.4477⟩
Article dans une revue hal-02947903v1
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Defects of the endoplasmic reticulum and changes to lipid droplet size in mammary epithelial cells due to miR-30b-5p overexpression are correlated to a reduction in Atlastin 2 expression

Sandrine Le Guillou , Johann Laubier , Christine Longin , Etienne Aujean , Johan Castille
Biochemical and Biophysical Research Communications, 2019, 512 (2), pp.283-288. ⟨10.1016/j.bbrc.2019.03.022⟩
Article dans une revue hal-02627428v1
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Sunflower oil supplementation affects the expression of miR-20a-5p and miR-142-5p in the lactating bovine mammary gland

Lenha Mobuchon , Sandrine Le Guillou , Sylvain Marthey , Johann Laubier , Denis Laloë
PLoS ONE, 2017, 12 (12), pp.e0185511. ⟨10.1371/journal.pone.0185511⟩
Article dans une revue hal-02617650v1
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Food deprivation affects the miRNome in the lactating goat mammary gland

Lenha Mobuchon , Sylvain S. Marthey , Sandrine Le Guillou , Denis Laloë , Fabienne Le Provost
PLoS ONE, 2015, 10 (10), 20 p. ⟨10.1371/journal.pone.0140111⟩
Article dans une revue hal-02630964v1
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Annotation of the goat genome using next generation sequencing of microRNA expressed by the lactating mammary gland: comparison of three approaches

Lenha Mobuchon , Sylvain Marthey , Mekki Boussaha , Sandrine Le Guillou , Christine Leroux
BMC Genomics, 2015, 16, pp.285. ⟨10.1186/s12864-015-1471-y⟩
Article dans une revue hal-01194123v1
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Characterisation and comparison of lactating mouse and bovine mammary gland miRNomes

Sandrine Le Guillou , Sylvain Marthey , Denis Laloë , Johann Laubier , Lenha Mobuchon
PLoS ONE, 2014, 9 (3), pp.e91938. ⟨10.1371/journal.pone.0091938⟩
Article dans une revue hal-01193833v1

La composition en microARN du lait sous influence des races bovines

Sandrine Le Guillou , Ouleye Sidibe , Antoine Leduc , Johann Laubier , Yannick Faulconnier
Journées Scientifiques du Département Génétique Animale (JSGA), Département Génétique Animale, INRAE, Sep 2022, Bordeaux, France
Communication dans un congrès hal-04227375v1

Impact d’une restriction alimentaire sur les miRNome et protéome du lait chez la vache laitière

Antoine Leduc , Sandrine Le Guillou , L. Bianchi , Lydie Oliveira Correia , Andrea Rau
Glande mammaire lait / Galactinnov, Nov 2021, En ligne, France
Communication dans un congrès hal-03747713v1

Feed restriction affects protein and microRNA levels in dairy cows' milk

Antoine Leduc , Sandrine Le Guillou , L Bianchi , M. Gelé , Lucile Herve
72. Annual meeting of the european federation of animal science (EAAP), Aug 2021, Davos, Switzerland. pp.620
Communication dans un congrès hal-03318595v1

Impact des microARNs sur la lactation et la régulation nutritionnelle de leur expression dans la glande mammaire

Lenha Mobuchon , Sandrine Le Guillou , Sylvain S. Marthey , Johann J. Laubier , Mekki Boussaha
2. Réunion d'Animation épiPHASE, Institut National de Recherche Agronomique (INRA). UAR Département Physiologie Animale et Systèmes d'Elevage (0558)., Mar 2016, Saint-Pée-sur-Nivelle, France
Communication dans un congrès hal-02795094v1

Characterisation and comparison of lactating mouse and bovine mammary gland miRNomes

Sandrine Le Guillou , Sylvain Marthey , Denis Laloë , Johann Laubier , Lenha Mobuchon
Gordon Research Conference on Mammary Gland Biology, Jun 2014, Lucca, Italy. 1 p
Communication dans un congrès hal-01193894v1

Nutritional regulation of microRNAs in the lactating goat mammary gland

Lenha Mobuchon , Sylvain Marthey , Sandrine Le Guillou , Denis Laloë , Christine Leroux
Gordon Research Conference on Mammary Gland Biology, Jun 2014, Lucca, Italy
Communication dans un congrès hal-01193908v1
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Species comparison of lactating mammary gland miRNomes: to the identification of conserved lactation-related microRNA

Sandrine Le Guillou , Sylvain S. Marthey , Denis Laloë , Johann J. Laubier , Jordann J. Domagalski
12th International Meeting - Cellular aspects of mRNA fate, Université Pierre et Marie Curie - Paris 6 (UPMC). FRA., Jun 2013, Paris, France. pp.1
Communication dans un congrès hal-01001041v1