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Christine Leroux

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Documents
Identifiants chercheurs

Présentation

Christine Leroux (women, PhD, HDR) is a research director from INRAE, the French national institute for research in agriculture, nutrition and environment. After obtaining her PhD in Molecular Genetics (University of Orsay-Paris XI, France) in 1992, Christine started to work at INRA on milk components biosynthesis and secretion in dairy ruminants. She studies the effects of different factors (mainly genetics and nutritional) influencing mammary gland functioning during lactation. Christine’s research aims to improve nutritional quality of milk for consumers and to identify indicators of animal metabolism and health using strategies of nutrigenomics. She firstly studied the effects of genetics polymorphism on protein synthesis, and then she worked on effects of ruminant nutrition on mammary and in a lesser extent on adipose tissues gene expression associated with milk fat composition. More recently, she initiated studies on microRNA and their nutritional regulation in mammary gland. She was visiting researcher scientist at University of California Davis (2017-2019) where she investigated the potential role of milk microRNA as a food source bioactive and contributor to human health. End of 2020, she had 5383 citations and an h-index of 41 referenced by Google Scholar. She participated to 15 national and international research projects. She has 8 years of experience of management of research groups (more than 15 persons) and of a transcriptomic platform, and she has supervised over 26 students (both undergraduates and graduates).

Publications

laurence-bernard

Extruded linseed alone or in combination with fish oil modifies mammary gene expression profiles in lactating goats

Yannick Faulconnier , Laurence Bernard , Céline Boby , Jordann Domagalski , Yves Chilliard
Animal, 2018, 12 (8), pp.1564-1575. ⟨10.1017/S1751731117002816⟩
Article dans une revue hal-02622050v1

Bovine mammary nutrigenomics and changes in the milk composition due to rapeseed or sunflower oil supplementation of high-forage or high-concentrate diets

Christine Leroux , Laurence Bernard , Yannick Faulconnier , Jacques J. Rouel , Anne de La Foye
Journal of Nutrigenetics and Nutrigenomics, 2016, 9 (2-4), pp.65-82. ⟨10.1159/000445996⟩
Article dans une revue hal-02640940v1

Milk fatty acid composition and mammary lipogenic genes expression in bovine cloned and control cattle

Laurence Bernard , Christophe Richard , Valerie Gelin , Christine Leroux , Yvan Heyman
Livestock Science, 2015, 176, pp.188-195. ⟨10.1016/j.livsci.2015.03.016⟩
Article dans une revue hal-02640576v1

Dietary sunflower oil modulates milk fatty acid composition without major changes in adipose and mammary tissue fatty acid profile or related gene mRNA abundance in sheep

T. Castro-Carrera , P. Frutos , Christine Leroux , Yves Y. Chilliard , G. Hervás
Animal, 2015, 9 (4), pp.582-591. ⟨10.1017/S1751731114002882⟩
Article dans une revue hal-02636182v1

Effect of extruded linseeds alone or in combination with fish oil on intake, milk production, plasma metabolite concentrations and milk fatty acid composition in lactating goats

Laurence Bernard , Christine Leroux , Jacques J. Rouel , Carole Delavaud , Kevin John Shingfield
Animal, 2015, 9 (5), pp.810-821. ⟨10.1017/S1751731114003048⟩
Article dans une revue hal-02631935v1

Effects of diet and physiological factors on milk fat synthesis, milk fat composition and lipolysis in the goat: A short review

Yves Y. Chilliard , Pablo Gutierrez Toral , Kevin John Shingfield , Jacques J. Rouel , Christine Leroux
Small Ruminant Research, 2014, 122 (1-3), pp.31-37. ⟨10.1016/j.smallrumres.2014.07.014⟩
Article dans une revue hal-02639525v1
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La fonction de lactation : régulation de la biosynthèse des constituants du lait

Christine Leroux , Laurence Bernard , Frederic Dessauge , Fabienne Le Provost , Patrice Martin
INRA Productions Animales, 2013, 26 (2), pp.117-128
Article dans une revue hal-01019559v1

Effects of fish oil and additional starch on tissue fatty acid profile and lipogenic gene mRNA abundance in lactating goats fed a diet containing sunflower-seed oil

Pablo Gutierrez Toral , Laurence Bernard , Carole Delavaud , Dominique Gruffat , Christine Leroux
Animal, 2013, 7 (6), pp.948-956. ⟨10.1017/S1751731113000049⟩
Article dans une revue hal-02643437v1

Long-chain fatty acids differentially alter lipogenesis in bovine and caprine mammary slices

Laurence Bernard , Mohammed Bagher M. B. Montazer Torbati , Benoit Graulet , Christine Leroux , Yves Y. Chilliard
Journal of Dairy Research, 2013, 80 (1), pp.89-95. ⟨10.1017/S0022029912000726⟩
Article dans une revue hal-02643537v1
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Nutritional regulation of mammary lipogenesis and milk fat in ruminant: contribution to sustainable milk production

Laurence Bernard , Christine Leroux , Yves Y. Chilliard
Revista Colombiana de Ciencias Pecuarias, 2013, 26, pp.292-302
Article dans une revue hal-02642036v1

Selection of reference genes for quantitative real-time PCR normalisation in adipose tissue, muscle, liver and mammary gland from ruminants

Muriel Bonnet , Laurence Bernard , Sébastien Bes , Christine Leroux
Animal, 2013, 7 (8), pp.1344-1353. ⟨10.1017/S1751731113000475⟩
Article dans une revue hal-02645011v1
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Effect of the level and type of starchy concentrate on tissue lipid metabolism, gene expression and milk fatty acid secretion in Alpine goats receiving a diet rich in sunflower-seed oil

Laurence Bernard , Christine Leroux , Jacques J. Rouel , Muriel Bonnet , Yves Y. Chilliard
British Journal of Nutrition, 2012, 107 (8), pp.1147-1159. ⟨10.1017/S0007114511004181⟩
Article dans une revue hal-02648706v1

Effects of polyunsaturated fatty acids from plant oils and algae on milk fat yield and composition are associated with mammary lipogenic and SREBF1 gene expression

Joaquin Angulo , Liliana Mahecha , Karin Nuernberg , Gerd Nuernberg , Dirk Dannenberger
Animal, 2012, 6 (12), pp.1961-1972. ⟨10.1017/S1751731112000845⟩
Article dans une revue hal-02652522v1

Effect of sunflower-seed oil and linseed oil on tissue lipid metabolism, gene expression, and milk fatty acid secretion in Alpine goats fed maize silage–based diets

Laurence Bernard , Muriel Bonnet , Christine Leroux , Kevin John Shingfield , Yves Y. Chilliard
Journal of Dairy Science, 2009, 92 (12), pp.6083-6094. ⟨10.3168/jds.2009-2048⟩
Article dans une revue hal-02657889v1
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Perspectives offertes par les approches en «omique» pour l’amélioration de la durabilité de l’élevage des herbivores

Jean-François J.-F. Hocquette , Hamid Boudra , Isabelle Cassar-Malek , Christine Leroux , Brigitte B. Picard
INRA Productions Animales, 2009, 22 (5), pp.385-396
Article dans une revue hal-02662984v1

Whole intact rapeseeds or sunflower oil in high-forage or high-concentrate diets affects milk yield, milk composition, and mammary gene expression profile in goats

Severine Ollier , Christine Leroux , Anne de La Foye , Laurence Bernard , Jacques J. Rouel
Journal of Dairy Science, 2009, 92 (11), pp.5544-5560. ⟨10.3168/jds.2009-2022⟩
Article dans une revue hal-02665026v1

Mammary transcriptome analysis of food-deprived lactating goats highlights genes involved in milk secretion and programmed cell death 1,2

Severine Ollier , Christèle Robert-Granié , Laurence Bernard , Yves Y. Chilliard , Christine Leroux
Journal of Nutrition, 2007, 137, pp.560-567
Article dans une revue hal-02657141v1

Food-deprived lactating goats highlights genes involved in milk secretion and programmed cell death.

S. Ollier , Christèle Robert-Granié , Laurence Bernard , Yves Chilliard , Christine Leroux
Journal of Nutrition, 2007, 137, pp.1-8
Article dans une revue hal-02656471v1

Mammary lipid metabolism and milk fatty acid secretion in alpine goasts fed vegetable lipids

Laurence Bernard , Jacques Rouel , Christine Leroux , Anne Ferlay , Yannick Faulconnier
Journal of Dairy Science, 2005, 88 (4), pp.1478-1482. ⟨10.3168/jds.S0022-0302(05)72816-2⟩
Article dans une revue hal-02680222v1

Expression and nutritional regulation of lipogenic genes in mammary gland and adipose tissues of lactating goats

Laurence Bernard , Christine Leroux , Muriel Bonnet , Jacques Rouel , Patrice Martin
Journal of Dairy Research, 2005, 72, pp.250-255. ⟨10.1017/S0022029905000786⟩
Article dans une revue hal-02682974v1
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Real-time RT-PCR and cDNA macroarray to study the impact of the genetic polymorphism at the $\alpha_{s1}$-casein locus on the expression of genes in the goat mammary gland during lactation

Christine Leroux , Fabienne Le Provost , Elisabeth Petit , Laurence Bernard , Yves Chilliard
Reproduction Nutrition Development, 2003, 43 (5), pp.459-469. ⟨10.1051/rnd:2003032⟩
Article dans une revue hal-00900521v1

Characterization of the caprine stearoyl-CoA desaturase gene and its mRNA showing an unusually long 3'-UTR sequence arising from a single exon

Laurence Bernard , Christine Leroux , Hélène Hayes , Mathieu Gautier , Yves Chilliard
Gene, 2001, 281 (1-2), pp.53-61. ⟨10.1016/S0378-1119(01)00822-8⟩
Article dans une revue hal-02683444v1

Characterization of the caprine stearoyl-CoA desaturase gene and its mRNA showing an unusually long 3' -UTR sequence arising from a single exon

Laurence Bernard , Christine Leroux , Hélène Hayes , M. Gautier , Yves Chilliard
Gene, 2001, 281, pp.53-61
Article dans une revue hal-02672941v1
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Characterization of milk small extracellular vesicles to study adaptation to lactation in ruminants

C Boby , A Delavaud , J Pires , L E Monfoulet , S Bes
74th Annual Meeting of the European Federation of Animal Science, Aug 2023, Lyon, France. ⟨10.3920/978-90-8686-936-7⟩
Communication dans un congrès hal-04195798v1
Image document

Les exosomes : des véhicules de signatures moléculaires pour comprendre le dialogue entre les organes des ruminants

Céline Boby , José Pires , Arnaud Delavaud , Laurent-Emmanuel Monfoulet , Laurence Bernard
1. Rencontres Clermontoises sur les Vésicules Extracellulaires, Laurent-Emmanuel MONFOULET-INRAE-UNH (Organisateur), Feb 2022, Clermont-Ferrand, France. ⟨10.17180/ev22-co02⟩
Communication dans un congrès hal-03561304v1

Des biomarqueurs aux outils de prédiction des performances des ruminants et de la qualité de leurs produits

Brigitte Picard , Laurence Bernard , Isabelle Cassar-Malek , Carole Delavaud , Mylène Delosière
Journées d’Animation Scientifique (JAS) du Département Physiologie Animale et Systèmes d'Elevage, Apr 2018, Rennes, France
Communication dans un congrès hal-02940696v1

Une approche intégrée pour comprendre le dialogue entre tissus/organes chez les ruminants producteurs

Isabelle Cassar-Malek , Mylène Delosière , Laurence Bernard , Céline Boby , Carole Delavaud
Journées d’Animation Scientifique (JAS) du Département Physiologie Animale et Systèmes d'Elevage, Apr 2018, Rennes, France
Communication dans un congrès hal-02940675v1

Regulacion nutricional de la expresion de los genes implicados en la lipogenesis en ovejas alimentadas con aceite de girasol. 2. Tejidos adiposos subcutaneo y perirrenal

Pablo Gutierrez Toral , T. Castro-Carrera , Christine Leroux , G. Hervás , Laurence Bernard
15. Jornadas sobre Produccion Animal, Zaragoza 14 y 15 de mayo de 2013., May 2013, Saragosse, España. pp.213-215
Communication dans un congrès hal-02747675v1
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Nutritional regulation of mammary lipogenesis and milk fat in ruminant: contribution to sustainable milk production

Laurence Bernard , Christine Leroux , Yves Y. Chilliard
12. Encuentro Nacional y 5. Internacional de los Investigadores de las Ciencias Pecuarias: ENICIP, 2013, Medellin, Colombia
Communication dans un congrès hal-02805781v1
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Feeding different lipid supplements through lactation in dairy goats: 1) effects on energy balance and milk production

M. Eknaes , H. Volden , K. Hove , Ra. Inglingstad , Laurence Bernard
European Regional Conference On Goats, Jun 2013, Tromso, Norway. 2 p
Communication dans un congrès hal-02744993v1
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Effects of feeding and physiological factors on goat milk fatty acid secretion and milk fat lipolysis

Yves Y. Chilliard , Pablo Gutierrez Toral , J Shingfield , Jacques J. Rouel , Christine Leroux
European Regional Conference On Goats, Jun 2013, Tromso, Norway. 3 p
Communication dans un congrès hal-02746500v1
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MilkChEST, an integrative approach of the secretion pathways in the mammary epithelial cell: molecular dissection of milk fat adaptability

Christine Leroux , Christian Beauvallet , Laurence Bernard , Claudia Bevilacqua , Frédéric Bouvier
European Regional Conference On Goats, Jun 2013, Tromsø, Norway
Communication dans un congrès hal-01194090v1

Regulacion nutricional de la expresion de los genes implicados en la lipogenesis en ovejas alimentadas con aceite de girasol. 1. Tejido secretor mamario

Pablo Gutierrez Toral , T. Castro-Carrera , Laurence Bernard , G. Hervás , Christine Leroux
15. Jornadas sobre Produccion Animal, May 2013, Zaragoza, España. pp.210-212
Communication dans un congrès hal-02747345v1

La nature du fourrage modifie la matière grasse laitière et le transcriptome mammaire de chèvres en lactation

Christine Leroux , Jacques J. Rouel , Yannick Faulconnier , Jordann J. Domagalski , Yoan Gaudron
3. Journées d’Animation Scientifique du Département de Physiologie Animale et Systèmes d’Elevage, Oct 2009, Tours, France
Communication dans un congrès hal-02757811v1

Trans fatty acids and mammary lipogenesis in ruminants

Kevin J. Shingfield , Laurence Bernard , Christine Leroux , Yves Y. Chilliard
11. International Symposium on Ruminant Physiology, Sep 2009, Clermont-Ferrand, France
Communication dans un congrès hal-02755716v1

Identification de gènes et réseaux de gènes impliqués dans la variation de composition du lait observée avec la mutation K232A au locus DGAT1 bovin.

Felicie Faucon , Emmanuelle Rebours , Christèle Robert-Granié , Laurence Bernard , Olivia Ménard
VII Colloque AGENAE-Genanimal, Oct 2009, Tours, France. pp.Inconnu
Communication dans un congrès hal-02824239v1

DGAT1 K232A polymorphism greatly affects mammary tissue activity of milk component synthesis

Felicie Faucon , Emmanuelle Rebours , Christèle Robert-Granié , Laurence Bernard , Olivia Ménard
60. Annual Meeting of the European Association for Animal Production, Aug 2009, Barcelone, Spain
Communication dans un congrès hal-01193503v1

Role of trans fatty acids in the nutritional regulation of mammary lipogenesis in ruminants

K.J. Shingfield , Laurence Bernard , Christine Leroux , Yves Y. Chilliard
11. International Symposium on Ruminant Physiology (ISRP), Sep 2009, Clermont-Ferrand, France. ⟨10.1017/S1751731110000510⟩
Communication dans un congrès hal-02758507v1

Effet du polymorphisme (AA/GC) au locus DGAT1 sur l'activité transcriptionnelle du tissu mammaire bovin, sur la composition du lait et sur les caractéristiques des globules gras et des micelles de caséines

Felicie Faucon , Emmanuelle Rebours , Laurence Bernard , Catherine Hurtaud , Guy Miranda
15. Rencontres autour des Recherches sur les Ruminants, Dec 2008, Paris, France
Communication dans un congrès hal-01193493v1

Contribution des approches en « omique » à l’élevage durable des herbivores

Jean-François J.-F. Hocquette , Hamid Boudra , Isabelle Cassar-Malek , Christine Leroux , Brigitte B. Picard
15. Rencontres Recherches Ruminants (3R), Dec 2008, Paris, France
Communication dans un congrès hal-02752116v1

Diet and physiological state influence gene expression in herbivores

Isabelle Cassar-Malek , Christine Leroux , Dominique Gruffat , Muriel Bonnet , Laurence Bernard
7. International Symposium on the Nutrition of Herbivores, Sep 2007, Beijing, China
Communication dans un congrès hal-02750923v1

Transcriptomic profile in mammary gland is modified by nutrition in lactating goats

Christine Leroux , Severine Ollier , Sébastien Bes , Marion Goutte , Laurence Bernard
2. International Symposium on Energy and Protein Metabolism and Nutrition (ISEP 2007), Sep 2007, Vichy, France
Communication dans un congrès hal-02752602v1

Rumen biohydrogenation and nutritional quality of cow and goat milk fat

Yves Y. Chilliard , Frederic F. Glasser , Anne Ferlay , Alexandre Roy , Jacques J. Rouel
4. Euro Fed Lipid Congress, Oct 2006, Madrid, Spain
Communication dans un congrès hal-02750620v1

Milk fatty acid profile in goats receiving high forage or high concentrate diets supplemented, or not, with either whole rapeseeds or sunflower oil

Yves Y. Chilliard , Severine Ollier , Jacques J. Rouel , Laurence Bernard , Christine Leroux
57. Annual Meeting of the European Association for Animal Production (EAAP), Sep 2006, Antalya, Turkey
Communication dans un congrès hal-02753643v1

Comparaison des transcriptomes mammaires de chèvres placées dans des conditions nutritionnelles extrêmes, pour étudier la synthèse et la sécrétion des lipides du lait

Severine Ollier , Sophie Pollet , Caroline Bauchart , Marion Goutte , Sébastien Bes
12. Rencontres autour des Recherches sur les Ruminants, Dec 2005, Paris, France
Communication dans un congrès hal-02764381v1

Effects of concentrate level and starch degradability on expression of mammary lipogenic genes in goats receiving a diet supplemented with sunflower oil

Laurence Bernard , Christine Leroux , Yannick Faulconnier , Denys Durand , Yves Y. Chilliard
3. International Workshop on Mammary Gland and Biotechnology : Nutrition, Genomics and Breast Cancer, Sep 2005, Barcelone, Spain
Communication dans un congrès hal-02759093v1

Effects of concentrate level and starch degradability on expression of mammary lipogenic genes in goats receiving a diet supplemented in sunflower oil

Laurence Bernard , Christine Leroux , Yannick Faulconnier , Denys Durand , Yves Y. Chilliard
56. Annual Meeting of the European Association for Animal Production (EAAP), Jun 2005, Uppsala, Sweden
Communication dans un congrès hal-02759524v1

La nutri-génomique de la glande mammaire de chèvres dans des conditions nutritionnelles extrêmes, en relation avec la synthèse et la sécrétion des lipides du lait

Severine Ollier , Sophie Pollet , Caroline Bauchart , Marion Goutte , Sébastien Bes
1. Journées d'Animation Scientifique du Département de Physiologie Animale et Systèmes d'Élevage, Mar 2005, Tours, France
Communication dans un congrès hal-02764246v1

Real-time RT-PCR and cDNA macroarray to study the impact of the genetic polymorphism at the alphaS1-casein locus on the expression of genes in the goat mammary gland during lactation

Christine Leroux , Fabienne Le Provost , F. Petit , Laurence Bernard , Yves Chilliard
INRA Meeting on Genomic, Proteomic and Lactation, Nov 2002, Jouy en Josas, France. ⟨10.1051/rnd:2003032⟩
Communication dans un congrès hal-02764107v1

Characterisation of the caprine stearoyl-CoA desaturase gene: application to the quantification of its mRNA in the mammary gland by real time RT-PCR.

Laurence Bernard , Christine Leroux , Yves Chilliard , Patrice Martin
4th French-Polish Symposium, 2001, Paris, pp.Inconnu
Communication dans un congrès hal-02828602v1
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Expression and nutritional regulation of Stearoyl-CoA desaturase genes in the ruminant mammary gland: relationship with milk fatty acid composition

Laurence Bernard , Christine Leroux , Yves Y. Chilliard
Stearoyl-CoA desaturase genes in lipid metabolism, Springer Science+Business Media, 239 p., 2013, 978-1-4614-7968-0. ⟨10.1007/978-1-4614-7969-7_13⟩
Chapitre d'ouvrage hal-02810768v1

Contribution of 'Omics' Approaches to Sustainable Herbivore Production

Jean-François J.-F. Hocquette , Hamid Boudra , Isabelle Cassar-Malek , Christine Leroux , Brigitte B. Picard
Sustainable Agriculture and New Biotechnologies (Advances in Agroecology), CRC Press, 2011, 978-1439825044. ⟨10.1201/b10977-6⟩
Chapitre d'ouvrage hal-02811152v1

Expression and nutritional regulation of lipogenic genes in the ruminant lactating mammary gland

Laurence Bernard , Christine Leroux , Yves Y. Chilliard
Bioactive Components of Milk, 606, Springer, 2008, Advances in Experimental Medicine and Biology, 978-0-387-74086-7 (Print) 978-0-387-74087-4 (Online)
Chapitre d'ouvrage hal-02822333v1

Optimising goat's milk and cheese fatty acid composition

Yves Y. Chilliard , Jacques J. Rouel , Anne Ferlay , Laurence Bernard , Patrice Gaborit
Improving the fat content of foods, Woodhead Publishing Ltd, 2006, 978-1-85573-965-9
Chapitre d'ouvrage hal-02814060v1

Characterisation and nutritional regulation of the main lipogenic genes in the ruminant lactating mammary gland

Laurence Bernard , Christine Leroux , Yves Y. Chilliard
Ruminant Physiology: Digestion, metabolism and impact of nutrition on gene expression, immunology and stress, Wageningen Academic Publishers, 2006, 978-90-76998-640
Chapitre d'ouvrage hal-02813288v1