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Christine Leroux

24
Documents
Identifiants chercheurs

Présentation

Christine Leroux (women, PhD, HDR) is a research director from INRAE, the French national institute for research in agriculture, nutrition and environment. After obtaining her PhD in Molecular Genetics (University of Orsay-Paris XI, France) in 1992, Christine started to work at INRA on milk components biosynthesis and secretion in dairy ruminants. She studies the effects of different factors (mainly genetics and nutritional) influencing mammary gland functioning during lactation. Christine’s research aims to improve nutritional quality of milk for consumers and to identify indicators of animal metabolism and health using strategies of nutrigenomics. She firstly studied the effects of genetics polymorphism on protein synthesis, and then she worked on effects of ruminant nutrition on mammary and in a lesser extent on adipose tissues gene expression associated with milk fat composition. More recently, she initiated studies on microRNA and their nutritional regulation in mammary gland. She was visiting researcher scientist at University of California Davis (2017-2019) where she investigated the potential role of milk microRNA as a food source bioactive and contributor to human health. End of 2020, she had 5383 citations and an h-index of 41 referenced by Google Scholar. She participated to 15 national and international research projects. She has 8 years of experience of management of research groups (more than 15 persons) and of a transcriptomic platform, and she has supervised over 26 students (both undergraduates and graduates).

Publications

jose-pires

MiRNome variations in milk fractions during feed restrictions of different intensities in dairy cows

Antoine Leduc , Sandrine Le Guillou , Denis Laloë , Lucile Herve , Johann Laubier
BMC Genomics, 2023, 24 (1), pp.680. ⟨10.1186/s12864-023-09769-5⟩
Article dans une revue hal-04284310v1
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Milk fat miRNome changes in response to LPS challenge in Holstein cows

Christine Leroux , Matteo Cuccato , Karol Pawłowski , Francesca Tiziana Cannizzo , Paola Sacchi
Veterinary Research, 2023, 54 (1), pp.111. ⟨10.1186/s13567-023-01231-4⟩
Article dans une revue hal-04328606v1
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Milk metabolites and fatty acids as noninvasive biomarkers of metabolic status and energy balance in early-lactation cows

José Pires , T. Larsen , Christine Leroux
Journal of Dairy Science, 2022, 105 (1), pp.201-220. ⟨10.3168/jds.2021-20465⟩
Article dans une revue hal-03424547v1

Milk fat globules as a source of microRNAs for mastitis detection

Christine Leroux , Karol Pawlowski , Pierre-Alexis Billa , José A.A. Pires , Yannick Faulconnier
Livestock Science, 2022, 263, pp.104997. ⟨10.1016/j.livsci.2022.104997⟩
Article dans une revue hal-03781656v1
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Milk proteins as a feed restriction signature indicating the metabolic adaptation of dairy cows

Antoine Leduc , S. Le Guillou , L. Bianchi , L. Oliveira Correia , M. Gelé
Scientific Reports, 2022, 12 (1), pp.18886. ⟨10.1038/s41598-022-21804-1⟩
Article dans une revue hal-03860146v1
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Nutrigenomic analyses reveal miRNAs and mRNAs affected by feed restriction in the mammary gland of midlactation dairy cows

Pierre-Alexis Billa , Yannick Faulconnier , Tao Ye , Céline Bourdon , José Pires
PLoS ONE, 2021, 16 (4), ⟨10.1371/journal.pone.0248680⟩
Article dans une revue hal-03200342v1
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Milk metabolites as noninvasive indicators of nutritional status of mid-lactation Holstein and Montbéliarde cows

Pierre-Alexis Billa , Yannick Faulconnier , Torben Larsen , Christine Leroux , José Pires
Journal of Dairy Science, 2020, 103 (4), pp.3133-3146. ⟨10.3168/jds.2019-17466⟩
Article dans une revue hal-02624734v1
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Undernutrition modified metabolic responses to intramammary lipopolysaccharide but had limited effects on selected inflammation indicators in early-lactation cows

José Pires , Karol Pawlowski , Jacques Rouel , Carole Delavaud , Gilles Foucras
Journal of Dairy Science, 2019, 102 (6), pp.5347-5360. ⟨10.3168/jds.2018-15446⟩
Article dans une revue hal-02620566v1
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Mammary gland transcriptome and proteome modifications by nutrient restriction in early lactation Holstein cows challenged with intramammary lipopolysaccharide

Karol Pawlowski , José Pires , Yannick Faulconnier , Christophe Chambon , Pierre Germon
International Journal of Molecular Sciences, 2019, 20 (5), 19 p. ⟨10.3390/ijms20051156⟩
Article dans une revue hal-02625031v1
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Deep RNA-Seq reveals miRNome differences in mammary tissue of lactating Holstein and Montbéliarde cows

Pierre-Alexis Billa , Yannick Faulconnier , T. Ye , M. Chervet , Fabienne Le Provost
BMC Genomics, 2019, 20, pp.621
Article dans une revue hal-02620652v1
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Effects of Azgp1-/- on mammary gland, adipose tissue and liver gene expression and milk lipid composition in lactating mice

Yannick Faulconnier , Céline Boby , José Pires , Cyril Labonne , Christine Leroux
Gene, 2019, 692, pp.201-207. ⟨10.1016/j.gene.2019.01.010⟩
Article dans une revue hal-02627788v1
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Characterization of milk small extracellular vesicles to study adaptation to lactation in ruminants

C Boby , A Delavaud , J Pires , L E Monfoulet , S Bes
74th Annual Meeting of the European Federation of Animal Science, Aug 2023, Lyon, France. ⟨10.3920/978-90-8686-936-7⟩
Communication dans un congrès hal-04195798v1
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Validation of HappyMoo MIR energy balance models on external datasets with feeding restriction

M Calmels , J Pires , M Boutinaud , Antoine Leduc , C Leroux
74. Annual meeting of the european federation of animal science (EAAP), EAAP, Aug 2023, Lyon, France. pp.1029
Communication dans un congrès hal-04195776v1
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Les exosomes : des véhicules de signatures moléculaires pour comprendre le dialogue entre les organes des ruminants

Céline Boby , José Pires , Arnaud Delavaud , Laurent-Emmanuel Monfoulet , Laurence Bernard
1. Rencontres Clermontoises sur les Vésicules Extracellulaires, Laurent-Emmanuel MONFOULET-INRAE-UNH (Organisateur), Feb 2022, Clermont-Ferrand, France. ⟨10.17180/ev22-co02⟩
Communication dans un congrès hal-03561304v1

Feed restriction affects protein and microRNA levels in dairy cows' milk

Antoine Leduc , Sandrine Le Guillou , L Bianchi , M. Gelé , Lucile Herve
72. Annual meeting of the european federation of animal science (EAAP), Aug 2021, Davos, Switzerland. pp.620
Communication dans un congrès hal-03318595v1
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Les métabolites et les acides gras du lait : des indicateurs non invasifs du statut métabolique et du bilan énergétique chez les vaches laitières

José Pires , Pierre-Alexis Billa , Torben Larsen , Yannick Faulconnier , Christine Leroux
Résumés - Réunion virtuelle Glande mammaire lait / Galactinnov, INRAE, Animation transversale Phase Galactinov, Nov 2021, en ligne, France
Communication dans un congrès hal-03958170v1

Impact d’une restriction alimentaire sur les miRNome et protéome du lait chez la vache laitière

Antoine Leduc , Sandrine Le Guillou , L. Bianchi , Lydie Oliveira Correia , Andrea Rau
Glande mammaire lait / Galactinnov, Nov 2021, En ligne, France
Communication dans un congrès hal-03747713v1
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Examples of current research on indicators of adaptative response in periparturient dairy ruminants

Carole Delavaud , José Pires , Mylène Delosière , Christine Leroux , Muriel Bonnet
Cycle de conférences 'Global Health', Jan 2020, Clermont-Ferrand, France
Communication dans un congrès hal-02503309v1
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Les métabolites du lait comme indicateurs non invasifs du statut nutritionnel chez les vaches Holstein et Montbéliarde en milieu de lactation

Pierre-Alexis Billa , Yannick Faulconnier , Torben Larsen , Christine Leroux , José Pires
24. Rencontres autour des Recherches sur les Ruminants (3R), Dec 2018, Paris, France
Communication dans un congrès hal-02734722v1

Milk metabolites as noninvasive indicators of physiological state and energy balance of early lactation cows

José Pires , Christine Leroux , Torben Larsen
10. International Symposium on the Nutrition of Herbivores (ISNH10), Sep 2018, Clermont-Ferrand, France
Communication dans un congrès hal-02738279v1

Des biomarqueurs aux outils de prédiction des performances des ruminants et de la qualité de leurs produits

Brigitte Picard , Laurence Bernard , Isabelle Cassar-Malek , Carole Delavaud , Mylène Delosière
Journées d’Animation Scientifique (JAS) du Département Physiologie Animale et Systèmes d'Elevage, Apr 2018, Rennes, France
Communication dans un congrès hal-02940696v1

Une approche intégrée pour comprendre le dialogue entre tissus/organes chez les ruminants producteurs

Isabelle Cassar-Malek , Mylène Delosière , Laurence Bernard , Céline Boby , Carole Delavaud
Journées d’Animation Scientifique (JAS) du Département Physiologie Animale et Systèmes d'Elevage, Apr 2018, Rennes, France
Communication dans un congrès hal-02940675v1

Signatures épigénétiques associées à l’état physiologique, nutritionnel et pathologique chez la vache laitière en postpartum

Maxime Gasselin , Marion Boutinaud , Laura Notebaert , Jean-Philippe Perrier , François Piumi
3. Journée de Séminaires du Département Phase sur l'Epigénétique EpiPhase, May 2017, Jouy-en-Josas, France. 1 p
Communication dans un congrès hal-01605492v1

Milk fat globules as a source of mammary microRNA

Karol Pawlowski , Daiane Lago Novais , José Pires , Lenha Mobuchon , Yannick Faulconnier
International Symposium on Microgenomics 2016, Jun 2016, Paris, France
Communication dans un congrès hal-02743285v1