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Christine Leroux

9
Documents
Identifiants chercheurs

Présentation

Christine Leroux (women, PhD, HDR) is a research director from INRAE, the French national institute for research in agriculture, nutrition and environment. After obtaining her PhD in Molecular Genetics (University of Orsay-Paris XI, France) in 1992, Christine started to work at INRA on milk components biosynthesis and secretion in dairy ruminants. She studies the effects of different factors (mainly genetics and nutritional) influencing mammary gland functioning during lactation. Christine’s research aims to improve nutritional quality of milk for consumers and to identify indicators of animal metabolism and health using strategies of nutrigenomics. She firstly studied the effects of genetics polymorphism on protein synthesis, and then she worked on effects of ruminant nutrition on mammary and in a lesser extent on adipose tissues gene expression associated with milk fat composition. More recently, she initiated studies on microRNA and their nutritional regulation in mammary gland. She was visiting researcher scientist at University of California Davis (2017-2019) where she investigated the potential role of milk microRNA as a food source bioactive and contributor to human health. End of 2020, she had 5383 citations and an h-index of 41 referenced by Google Scholar. She participated to 15 national and international research projects. She has 8 years of experience of management of research groups (more than 15 persons) and of a transcriptomic platform, and she has supervised over 26 students (both undergraduates and graduates).

Publications

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Comparative transcriptome analysis of goat (Capra hircus) adipose tissue reveals physiological regulation of body reserve recovery after the peak of lactation

Yannick Faulconnier , Céline Boby , Fanny Coulpier , Sophie Lemoine , Patrice Martin
Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics, 2022, 41, pp.100956. ⟨10.1016/j.cbd.2021.100956⟩
Article dans une revue hal-03524137v1

Different miRNA contents between mammary epithelial cells and milk fat globules: a random or a targeted process?

Karol Pawlowski , Daiane Lago-Novais , Claudia Bevilacqua , Lenha Mobuchon , Nicolas Crapart
Molecular Biology Reports, 2020, 47 (10), pp.8259-8264. ⟨10.1007/s11033-020-05787-8⟩
Article dans une revue hal-03151812v1
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Effects of Azgp1-/- on mammary gland, adipose tissue and liver gene expression and milk lipid composition in lactating mice

Yannick Faulconnier , Céline Boby , José Pires , Cyril Labonne , Christine Leroux
Gene, 2019, 692, pp.201-207. ⟨10.1016/j.gene.2019.01.010⟩
Article dans une revue hal-02627788v1
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Mammary gland transcriptome and proteome modifications by nutrient restriction in early lactation Holstein cows challenged with intramammary lipopolysaccharide

Karol Pawlowski , José Pires , Yannick Faulconnier , Christophe Chambon , Pierre Germon
International Journal of Molecular Sciences, 2019, 20 (5), 19 p. ⟨10.3390/ijms20051156⟩
Article dans une revue hal-02625031v1

Extruded linseed alone or in combination with fish oil modifies mammary gene expression profiles in lactating goats

Yannick Faulconnier , Laurence Bernard , Céline Boby , Jordann Domagalski , Yves Chilliard
Animal, 2018, 12 (8), pp.1564-1575. ⟨10.1017/S1751731117002816⟩
Article dans une revue hal-02622050v1
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Dietary flavanols modulate the transcription of genes associated with cardiovascular pathology without changes in their DNA methylation state

Dragan Milenkovic , Wim Vanden Berghe , Céline Boby , Christine Leroux , K. Declerc
PLoS ONE, 2014, 9 (4), pp.e95527. ⟨10.1371/journal.pone.0095527⟩
Article dans une revue hal-02634108v1
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Characterization of milk small extracellular vesicles to study adaptation to lactation in ruminants

C Boby , A Delavaud , J Pires , L E Monfoulet , S Bes
74th Annual Meeting of the European Federation of Animal Science, Aug 2023, Lyon, France. ⟨10.3920/978-90-8686-936-7⟩
Communication dans un congrès hal-04195798v1
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Les exosomes : des véhicules de signatures moléculaires pour comprendre le dialogue entre les organes des ruminants

Céline Boby , José Pires , Arnaud Delavaud , Laurent-Emmanuel Monfoulet , Laurence Bernard
1. Rencontres Clermontoises sur les Vésicules Extracellulaires, Laurent-Emmanuel MONFOULET-INRAE-UNH (Organisateur), Feb 2022, Clermont-Ferrand, France. ⟨10.17180/ev22-co02⟩
Communication dans un congrès hal-03561304v1

Une approche intégrée pour comprendre le dialogue entre tissus/organes chez les ruminants producteurs

Isabelle Cassar-Malek , Mylène Delosière , Laurence Bernard , Céline Boby , Carole Delavaud
Journées d’Animation Scientifique (JAS) du Département Physiologie Animale et Systèmes d'Elevage, Apr 2018, Rennes, France
Communication dans un congrès hal-02940675v1