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AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease

Rafael P. Vazquez-Manrique , Francesca Farina , Karine Cambon , Maria Dolores Sequedo , Alex J. Parker , et al.
Human Molecular Genetics, 2016, 25 (6), pp.1043-1058. ⟨10.1093/hmg/ddv513⟩
Article dans une revue hal-01545502v1

The stress response factor daf-16 /FOXO is required for multiple compound families to prolong the function of neurons with Huntington’s disease

Francesca Farina , Emmanuel Lambert , Lucie Commeau , François-Xavier Lejeune , Nathalie Roudier , et al.
Scientific Reports, 2017, 7 (1), pp.4014. ⟨10.1097/MCO.0000000000000382⟩
Article dans une revue hal-01545500v1
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Cell-Type-Specific Gene Expression Profiling in Adult Mouse Brain Reveals Normal and Disease-State Signatures

Nicolas Merienne , Cécile Meunier , Anne Schneider , Jonathan Seguin , Satish Nair , et al.
Cell Reports, 2019, 26 (9), pp.2477-2493.e9. ⟨10.1016/j.celrep.2019.02.003⟩
Article dans une revue hal-02087719v1

Precision machine learning to understand micro-RNA regulation in neurodegenerative diseases

Lucile Mégret , Cloé Mendoza , Maialen Arrieta Lobo , Emmanuel Brouillet , Thi-Thanh-Yen Nguyen , et al.
Frontiers in Molecular Neuroscience, 2022, 15, ⟨10.3389/fnmol.2022.914830⟩
Article dans une revue hal-03869363v1
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Identification of Modulators of the C. elegans Aryl Hydrocarbon Receptor and Characterization of Transcriptomic and Metabolic AhR-1 Profiles

Lucie Larigot , Linh-Chi Bui , Marine de Bouvier , Ophélie Pierre , Grégory Pinon , et al.
Antioxidants , 2022, 11 (5), pp.1030. ⟨10.3390/antiox11051030⟩
Article dans une revue hal-03745310v1

Cdc42-interacting protein 4 binds to huntingtin: Neuropathologic and biological evidence for a role in Huntington's disease

Sébastien Holbert , Alpaslan Dedeoglu , Sandrine Humbert , Frédéric Saudlou , Robert J. Ferrante , et al.
Proceedings of the National Academy of Sciences of the United States of America, 2003, 100 (5), pp.2712 - 2717. ⟨10.1073/pnas.0437967100⟩
Article dans une revue hal-02682845v1

Pathways to decoding the clinical potential of stress response FOXO-interaction networks for Huntington's disease: of gene prioritization and context dependence

Frederic Parmentier , Francois-Xavier Lejeune , Christian Neri
Frontiers in Aging Neuroscience, 2013, 5, pp.UNSP 22. ⟨10.3389/fnagi.2013.00022⟩
Article dans une revue hal-01545516v1

CA150 expression delays striatal cell death in overexpression and knock-in conditions for mutant huntingtin neurotoxicity

Margarita Arango , Sébastien Holbert , Dania Zala , Emmanuel Brouillet , James Pearson , et al.
Journal of Neuroscience, 2006, 26 (17), pp.4649 - 4659. ⟨10.1523/JNEUROSCI.5409-05.2006⟩
Article dans une revue hal-02666883v1
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The Oxygen Paradox, the French Paradox, and age-related diseases

Joanna M. S. Davies , Josiane Cillard , Bertrand Friguet , Enrique Cadenas , Jean Cadet , et al.
GeroScience, 2017, 39 (5-6), pp.499-550. ⟨10.1007/s11357-017-0002-y⟩
Article dans une revue hal-01718093v1
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Optimal transport-based machine learning to match specific patterns: application to the detection of molecular regulation patterns in omics data

Thi Thanh Yen Nguyen , Warith Harchaoui , Lucile Mégret , Cloe Mendoza , Olivier Bouaziz , et al.
2023
Pré-publication, Document de travail hal-03293786v3
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Differential default mode network trajectories in asymptomatic individuals at risk for Alzheimer's disease

Patrizia A Chiesa , Enrica Cavedo , Andrea Vergallo , Simone Lista , Marie-Claude Potier , et al.
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019, 15 (7), pp.940-950. ⟨10.1016/j.jalz.2019.03.006⟩
Article dans une revue hal-02368904v1

CAG/CTG and CGG/GCC repeats in human brain reference cDNAs: Outcome in searching for new dynamic mutations

Véronique Albanèse , Sébastien Holbert , Claudine Saada , Sebastian Meier-Ewert , Anne Sophie Lebre , et al.
Genomics, 1998, 47 (3), pp.414 - 418. ⟨10.1006/geno.1997.5130⟩
Article dans une revue istex hal-02696172v1

Integration of beta-Catenin, Sirtuin, and FOXO Signaling Protects from Mutant Huntingtin Toxicity

J. Alex Parker , Rafael P. Vazquez-Manrique , Cendrine Tourette , Francesca Farina , Nicolas Offner , et al.
Journal of Neuroscience, 2012, 32 (36), pp.12630-12640. ⟨10.1523/JNEUROSCI.0277-12.2012⟩
Article dans une revue hal-01545520v1

Neuronal identity genes regulated by super-enhancers are preferentially down-regulated in the striatum of Huntington's disease mice

M. Achour , S. Le Gras , C. Keime , F. Parmentier , F. Lejeune , et al.
Human Molecular Genetics, 2015, 24 (12), pp.3481-3496. ⟨10.1093/hmg/ddv099⟩
Article dans une revue hal-02106606v1

Biosensing Extracellular Vesicle Subpopulations in Neurodegenerative Disease Conditions

Yacine Mazouzi , Fadoua Sallem , Francesca Farina , Alexis Loiseau , Natayme Rocha Tartaglia , et al.
ACS Sensors, 2022, 7 (6), pp.1657-1665. ⟨10.1021/acssensors.1c02658⟩
Article dans une revue hal-03791750v1
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Combining feature selection and shape analysis uncovers precise rules for miRNA regulation in Huntington’s disease mice

Lucile Mégret , Satish Sasidharan Nair , Julia Dancourt , Jeff Aaronson , Jim Rosinski , et al.
BMC Bioinformatics, 2020, 21 (1), pp.75. ⟨10.1186/s12859-020-3418-9⟩
Article dans une revue inserm-02512089v1

Association between Cognitive Status before Surgery and Outcomes in Elderly Patients with Hip Fracture in a Dedicated Orthogeriatric Care Pathway

Lorene Zerah , Judith Cohen-Bittan , Mathieu Raux , Anthony Meziere , Cendrine Tourette , et al.
Journal of Alzheimer's Disease, 2017, pp.1-12. ⟨10.3233/JAD-160655⟩
Article dans une revue hal-03970430v1

Plasma tau correlates with basal forebrain atrophy rates in people at risk for Alzheimer disease

Enrica Cavedo , Simone Lista , Marion Houot , Andrea Vergallo , Michel Grothe , et al.
Neurology, 2019, 94 (1), pp.e30-e41. ⟨10.1212/WNL.0000000000008696⟩
Article dans une revue hal-03769491v1
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Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Clotilde Thery , Kenneth Witwer , Elena Aikawa , Maria Jose Alcaraz , Johnathon Anderson , et al.
Journal of Extracellular Vesicles, 2018, 7 (1), pp.1535750. ⟨10.1080/20013078.2018.1535750⟩
Article dans une revue hal-02323217v1

[C. elegans as a model for human inherited degenerative diseases]

Laurent Ségalat , Christian Néri
Médecine/Sciences, 2003, 19 (12), pp.1218-25
Article dans une revue hal-00194459v1

Genetic and pharmacological suppression of polyglutamine-dependent neuronal dysfunction in Caenorhabditis elegans

J. Alex Parker , Sébastien Holbert , Emmanuel Lambert , Salima Abderrahmane , Christian Néri
Journal of Molecular Neuroscience, 2004, 23 (1-2), pp.61 - 67. ⟨10.1385/JMN:23:1-2:061⟩
Article dans une revue istex hal-02675749v1
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Biomarkers of vascular dysfunction and cognitive decline in patients with Alzheimer’s disease: no evidence for association in elderly subjects

Alice Breining , Jean-Sébastien Silvestre , Bénédicte Dieudonné , José Vilar , Véronique Faucounau , et al.
Aging Clinical and Experimental Research, 2016, pp.1-9. ⟨10.1007/s40520-016-0535-4⟩
Article dans une revue hal-01383389v1
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Shape deformation analysis reveals the temporal dynamics of cell-type-specific homeostatic and pathogenic responses to mutant huntingtin

Lucile Mégret , Barbara Gris , Satish Sasidharan Nair , Jasmin Cevost , Mary Wertz , et al.
eLife, 2021, 10, pp.e64984. ⟨10.7554/eLife.64984⟩
Article dans une revue hal-03151218v1

C-elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress

Ilija Melentijevic , Marton L. Toth , Meghan L. Arnold , Ryan J. Guasp , Girish Harinath , et al.
Nature, 2017, 542 (7641), pp.367+. ⟨10.1038/nature21362⟩
Article dans une revue hal-01545495v1

NP03, a novel low-dose lithium formulation, is neuroprotective in the YAC128 mouse model of Huntington disease

Mahmoud A. Pouladi , Elsa Brillaud , Yuanyun Xie , Paola Conforti , Rona K. Graham , et al.
Neurobiology of Disease, 2012, 48 (3), pp.282-289. ⟨10.1016/j.nbd.2012.06.026⟩
Article dans une revue istex hal-01545519v1
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Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology

Harald Hampel , Nicola Toschi , Claudio Babiloni , Filippo Baldacci , Keith L Black , et al.
Journal of Alzheimer's Disease, 2018, 64 (s1), pp.S47 - S105. ⟨10.3233/jad-179932⟩
Article dans une revue hal-01910402v1

Sirtuin inhibition protects from the polyalanine muscular dystrophy protein PABPN1

Helene Catoire , Matthieu Y. Pasco , Aida Abu-Baker , Sébastien Holbert , Cendrine Tourette , et al.
Human Molecular Genetics, 2008, 17 (14), pp.2108 - 2117. ⟨10.1093/hmg/ddn109⟩
Article dans une revue hal-02655510v1
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Association of plasma YKL-40 with brain amyloid-β levels, memory performance, and sex in subjective memory complainers

Andrea Vergallo , Simone Lista , Pablo Lemercier , Patrizia A. Chiesa , Henrik Zetterberg , et al.
Neurobiology of Aging, 2020, 96, pp.22-32. ⟨10.1016/j.neurobiolaging.2020.07.009⟩
Article dans une revue hal-03491473v1

Role and therapeutic potential of the pro-longevity factor FOXO and its regulators in neurodegenerative disease

Christian Neri
Frontiers in Pharmacology, 2012, 3, pp.UNSP 15. ⟨10.3389/fphar.2012.00015⟩
Article dans une revue hal-01545518v1
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Morphological remodeling of C. elegans neurons during aging is modified by compromised protein homeostasis

Elena M. Vayndorf , Courtney Scerbak , Skyler Hunter , Jason R. Neuswanger , Marton Toth , et al.
npj Aging and Mechanisms of Disease, 2016, 2, pp.16001. ⟨10.1038/npjamd.2016.1⟩
Article dans une revue hal-01545501v1