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Christian D. MULLER

60
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Présentation

1. Christian D. MULLER, Dr. ès Sciences and PhD in cellular and molecular pharmacology, CNRS senior scientist, managed for 4 years as director, eBioCyt UPS1401-unistra, a platform he created in 2012 at the faculty of Pharmacy of the University of Strasbourg (France). He graduated his PhD in pharmacology in 1983 and was appointed by the CNRS on his first candidature the same year. After his second PhD (Docteur ès Sciences) in 1989, he held a 2-year post-doc in the Stanford University issued company Syntex Research as a research associate (Palo Alto, CA, USA). Coming back to France he joined the faculty of Pharmacy, where he started the cytometry core facilities of the federative institute IFR85 "Gilbert Laustriat". In 1996 CD Muller was co-founder of the startup Antibody Solutions, a biotech company still active in California. His cytomic plate-form (with 3 capillary cytometers and 1 adherent cell cytometer) was nominated in 2007 as 1st European excellence center by Guava/Millipore/Merck USA. For 10 years (1997-2007) he has been an elected member of the board of the French Association of Cytometry (AFC). He has authored 104 peer- reviewed scientific articles plus 7 articles in books. Since April 2016 he joined with his plate-form the Institut Pluridisciplinaire Hubert Curien, CNRS unit UMR 7178, in the faculty of Pharmacy in Strasbourg where he continues is work in cytomic applied to cancer.

Publications

Celastrol and Resveratrol Modulate SIRT Genes Expression and Exert Anticancer Activity in Colon Cancer Cells and Cancer Stem-like Cells

Helena Moreira , Anna Szyjka , Justyna Grzesik , Katarzyna Pelc , Magdalena Żuk
Cancers, 2022, 14 (6), pp.1372. ⟨10.3390/cancers14061372⟩
Article dans une revue hal-03663462v1

CRIP1 expression in monocytes related to hypertension

Olga Schweigert , Julia Adler , Nathalie Langst , Dylan Aissi , Jorge Duque Escobar
Clinical Science, 2021, ⟨10.1042/CS20201372⟩
Article dans une revue hal-03225628v1
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Three dimensional in vitro culture systems in anticancer drug discovery targeted on cancer stem cells

Anna Radajewska , Oskar Przybyszewski , Fathi Emhemmed , Christian D. Muller , Ewa Barg
American Journal of Cancer Research, 2021, 11 (10), pp.4931-4946
Article dans une revue hal-03431653v1
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Central amygdala micro-circuits mediate fear extinction

Nigel Whittle , Jonathan Fadok , Kathryn P. Macpherson , Robin Nguyen , Paolo Botta
Nature Communications, 2021, 12 (1), ⟨10.1038/s41467-021-24068-x⟩
Article dans une revue hal-03424191v1
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TIP60 governs the auto-ubiquitination of UHRF1 through USP7 dissociation from the UHRF1/USP7 complex

Tanveer Ahmad , Waseem Ashraf , Abdulkhaleg Ibrahim , Liliyana Zaayter , Christian D. Muller
International Journal of Oncology, 2021, 59 (5), ⟨10.21203/rs.3.rs-66228/v1⟩
Article dans une revue hal-03035702v1
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Selenotriapine – An isostere of the most studied thiosemicarbazone with pronounced pro-apoptotic activity, low toxicity and ability to challenge phenotype reprogramming of 3-D mammary adenocarcinoma tumors

Nenad R. Filipović , Snežana Bjelogrlić , Sveva Pelliccia , Vesna Jovanović , Milan Kojić
Arabian Journal of Chemistry, 2020, 13 (1), pp.1466 - 1489. ⟨10.1016/j.arabjc.2017.11.017⟩
Article dans une revue hal-02106906v1
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Anti-Proliferative and Apoptosis-Inducing Activity of Acacia Modesta and Opuntia Monocantha Extracts on HeLa Cells

Farah Abid , Muhammad Saleem , Christian D. Muller , Mulazim Hussain Asim , Shumaila Arshad
Asian Pacific Journal of Cancer Prevention, 2020, 21 (10), pp.3125-3131. ⟨10.31557/APJCP.2020.21.10.3125⟩
Article dans une revue hal-02994493v1
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Biological Activities of Aqueous Extracts from Carob Plant (Ceratonia siliqua L.) by Antioxidant, Analgesic and Proapoptotic Properties Evaluation

Siwar Ben Ayache , Emna Behija Saafi , Fathi Emhemmed , Guido Flamini , Lotfi Achour
Molecules, 2020, 25 (14), pp.3120. ⟨10.3390/molecules25143120⟩
Article dans une revue hal-02955858v1

Optimized Extraction, Preliminary Characterization and Evaluation of the in Vitro Anticancer Activity of Phlorotannin-Rich Fraction from the Brown Seaweed, Cystoseira sedoides

Amal Abdelhamid , Sirine Lajili , Mohamed Amine Elkaibi , Yosra Ben Salem , Ameni Abdelhamid
Journal of Aquatic Food Product Technology, 2019, 28 (9), pp.892-909. ⟨10.1080/10498850.2019.1662865⟩
Article dans une revue hal-02474625v1

Phosphinine‐Based Ligands in Gold‐Catalyzed Reactions

Massimo Rigo , Evi Habraken , Koyel Bhattacharyya , Manuela Weber , Andreas W Ehlers
Chemistry - A European Journal, 2019, ⟨10.1002/chem.201900938⟩
Article dans une revue hal-02401724v1

Pd(II) complexes with N-heteroaromatic hydrazone ligands: Anticancer activity, in silico and experimental target identification

Snežana Bjelogrlić , Tamara Todorović , Milan Kojić , Milan Senćanski , Milan Nikolić
Journal of Inorganic Biochemistry, 2019, 199, pp.110758. ⟨10.1016/j.jinorgbio.2019.110758⟩
Article dans une revue hal-02990983v1

Characterization of sulfated polysaccharide from Laurencia obtusa and its apoptotic, gastroprotective and antioxidant activities

Sirine Lajili , Hiba Hadj Ammar , Zeineb Mzoughi , Haifa Bel Haj Amor , Christian D. Muller
International Journal of Biological Macromolecules, 2019, 126, pp.326-336. ⟨10.1016/j.ijbiomac.2018.12.089⟩
Article dans une revue hal-02106790v1

Pyridyl‐Functionalized 1‐Phosphabarrelene: Synthesis, Coordination Chemistry and Photochemical di‐π‐Methane Rearrangement

Marlene Bruce , Martin Papke , Andreas W Ehlers , Manuela Weber , Dieter Lentz
Chemistry - A European Journal, 2019, 25 (63), pp.14332-14340. ⟨10.1002/chem.201903344⟩
Article dans une revue hal-02401679v1

Marine Microalgae: Promising Source for New Bioactive Compounds

Christian D. Muller , Caterina de Vera , Guillermo Díaz Crespín , Antonio Hernández Daranas , Sofia Montalvão Looga
Marine drugs, 2018, 16 (9), pp.317. ⟨10.3390/md16090317⟩
Article dans une revue hal-02106793v1

Arginine-selective bioconjugation with 4-azidophenyl glyoxal: application to the single and dual functionalisation of native antibodies

Igor Dovgan , Stéphane Erb , Steve Hessmann , Sylvain Ursuegui , Chloé Michel
Organic & Biomolecular Chemistry, 2018, 16 (8), pp.1305-1311. ⟨10.1039/c7ob02844j⟩
Article dans une revue hal-02327924v1
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Structural determination of two new acacic acid-type saponins from the stem barks of Albizia zygia (DC.) J. F. Macbr

Olivier Placide Noté , Line Made Simo , Joséphine Ngo Mbing , Dominique Guillaume , Christian D. Muller
Natural Product Research, 2018, 33 (2), pp.180-188. ⟨10.1080/14786419.2018.1440228⟩
Article dans une revue hal-02992576v1

Pro-apoptotic activity of new triterpenoid saponins from the roots of Albizia adianthifolia (Schumach.) W.Wight

Olivier Placide Noté , Eutrophe Le Doux Kamto , Daniel Djou Toukea , Sarah Ali Aouazou , Joséphine Ngo Mbing
Fitoterapia, 2018, 129, pp.34-41. ⟨10.1016/j.fitote.2018.06.008⟩
Article dans une revue hal-02106792v1

In situ targeted activation of an anticancer agent using ultrasound-triggered release of composite droplets

Sergii Kolodych , Chloé Michel , Sébastien Delacroix , Oleksandr Koniev , Anthony Ehkirch
European Journal of Medicinal Chemistry, 2017, 142, pp.2-7. ⟨10.1016/j.ejmech.2017.03.057⟩
Article dans une revue hal-02174984v1

New Cytotoxic Triterpenoid Saponins from the Roots of Albizia gummifera (J.F.G mel .) C.A. Sm .

Line Made Simo , Olivier Placide Noté , Joséphine Ngo Mbing , Sarah Ali Aouazou , Dominique Guillaume
Chemistry and Biodiversity, 2017, 14 (10), pp.e1700260. ⟨10.1002/cbdv.201700260⟩
Article dans une revue hal-02106897v1

Pro-apoptotic activity of acylated triterpenoid saponins from the stem bark of Albizia chevalieri harms

Olivier Placide Noté , Lin Marcellin Messi , Joséphine Ngo Mbing , Sarah Ali Azouaou , Mamadou Sarr
Phytochemistry Letters, 2017, 22, pp.95-101. ⟨10.1016/j.phytol.2017.09.008⟩
Article dans une revue hal-02106899v1

Development and evaluation of β-galactosidase-sensitive antibody-drug conjugates

Sergii Kolodych , Chloé Michel , Sébastien Delacroix , Oleksandr Koniev , Anthony Ehkirch
European Journal of Medicinal Chemistry, 2017, 142, pp.376 - 382. ⟨10.1016/j.ejmech.2017.08.008⟩
Article dans une revue hal-01649358v1

Anticancer activity of diterpenes and steroids from Eunicella singularis against two- and threedimensional breast cancer cell models

Christian D. Muller , Sirine Lajili , Monia Deghrigue , Amal Abdelhamid , Snežana Bjelogrlić
Journal of Coastal Life Medicine, 2017, 5 (12), pp.531-539. ⟨10.12980/jclm.5.2017J7-155⟩
Article dans une revue hal-02106900v1

Pro-differentiating effects of a synthetic flavagline on human teratocarcinomal cancer stem-like cells

Fathi Emhemmed , Sarah Ali Azouaou , Qian Zhao , Aline Appert-Collin , Amar Bennasroune
Cell Biology and Toxicology, 2017, 33 (3), pp.295-306. ⟨10.1007/s10565-016-9375-4⟩
Article dans une revue hal-02106909v1

Isolation of novel stilbenoids from the roots of Cyrtopodium paniculatum (Orchidaceae)

Florence Auberon , Opeyemi Joshua Olatunji , Diamondra Raminoson , Christian D. Muller , Beatriz Soengas
Fitoterapia, 2017, 116, pp.99-105. ⟨10.1016/j.fitote.2016.11.015⟩
Article dans une revue hal-02106911v1

Two new triterpenoid saponins from the roots of Albizia zygia (DC.) J.F. Macbr.

Olivier Placide Noté , Line Simo , Joséphine Ngo Mbing , Dominique Guillaume , Sarah Ali Aouazou
Phytochemistry Letters, 2016, 18, pp.128-135. ⟨10.1016/j.phytol.2016.09.010⟩
Article dans une revue hal-02106916v1

Ni( ii ) complex with bishydrazone ligand: synthesis, characterization, DNA binding studies and pro-apoptotic and pro-differentiation induction in human cancerous cell lines

Christian D. Muller , Nenad Filipović , Snežana Bjelogrlić , Tamara Todorović , Vladimir Blagojević
RSC Advances, 2016, 6 (110), pp.108726-108740. ⟨10.1039/c6ra24604d⟩
Article dans une revue hal-02106934v1

Pregnane Glycosides from Cynanchum marnierianum Stimulate GLP-1 Secretion in STC-1 Cells

Christian D. Muller , Michail Tsoukalas , Christian Muller , Annelise Lobstein , Aurelie A. Urbain
Planta Medica, 2016, 82 (11/12), pp.992-999. ⟨10.1055/s-0042-107675⟩
Article dans une revue hal-02106915v1

Phenotype-specific apoptosis induced by three new triterpenoid saponins from Albizia glaberrima (Schumach. & Thonn.) Benth

Olivier Placide Noté , Sarah Ali Azouaou , Line Simo , Cyril Antheaume , Dominique Guillaume
Fitoterapia, 2016, 109, pp.80-86. ⟨10.1016/j.fitote.2015.12.012⟩
Article dans une revue hal-02106918v1

Additional Insights into the Obtusallene Family: Components of Laurencia marilzae

Christian D. Muller , Adrián Gutiérrez-Cepeda , Jose Fernandez , Manuel Norte , Matías López-Rodríguez
Journal of Natural Products, 2016, 79 (4), pp.1184-1188. ⟨10.1021/acs.jnatprod.5b01080⟩
Article dans une revue hal-02106930v1

Pro-apoptotic and pro-differentiation induction by 8-quinolinecarboxaldehyde selenosemicarbazone and its Co( iii ) complex in human cancer cell lines

Nenad Filipović , Snežana Bjelogrlić , Gustavo Portalone , Sveva Pelliccia , Romano Silvestri
MedChemComm, 2016, 7 (8), pp.1604-1616. ⟨10.1039/c6md00199h⟩
Article dans une revue hal-02106935v1

In vitro immunomodulatory activity and in vivo anti-inflammatory and analgesic potential with gastroprotective effect of the Mediterranean red alga Laurencia obtusa

Christian D. Muller , Sirine Lajili , Monia Deghrigue , Haifa Bel Haj Amor , Christian Muller
Pharmaceutical biology, 2016, 54 (11), pp.2486-2495. ⟨10.3109/13880209.2016.1160937⟩
Article dans une revue hal-02106920v1

Anti-inflammatory, analgesic activities and gastro-protective effects of the phenolic contents of the red alga, Laurencia obtusa

Christian D. Muller , Sirine Lajili , Sarah Ali Azouaou , Manel Turki , Christian Muller
European Journal of Integrative Medicine, 2016, 8 (3), pp.298-306. ⟨10.1016/j.eujim.2015.12.006⟩
Article dans une revue hal-02106925v1

Tannin extract from maritime pine bark exhibits anticancer properties by targeting the epigenetic UHRF1/DNMT1 tandem leading to the re-expression of TP73

Waseem Ashraf , Tanveer Ahmad , Naif Almalki , Mounira Krifa , Liliyana Zaayter
Food and Function, 2016, 35 (1), ⟨10.1039/d1fo01484f⟩
Article dans une revue hal-03484328v1

AstRoMap European Astrobiology Roadmap

Gerda Horneck , Nicolas Walter , Frances Westall , John Lee Grenfell , William Martin
Astrobiology, 2016, 16 (3), pp.201-243. ⟨10.1089/ast.2015.1441⟩
Article dans une revue hal-02069085v1

Co(III) complex with ( E )-2-(2-(pyridine-2-ylmethylene)hydrazinyl)-4-(4-tolyl)-1,3-thiazole: structure and activity against 2-D and 3-D cancer cell models

Christian D. Muller , Hana Elshaflu , Snežana Bjelogrlić , Christian Muller , Tamara Todorović
Journal of Coordination Chemistry, 2016, 69 (22), pp.3354-3366. ⟨10.1080/00958972.2016.1232404⟩
Article dans une revue hal-02106938v1

Quinoline based mono- and bis-(thio)carbohydrazones: synthesis, anticancer activity in 2D and 3D cancer and cancer stem cell models

Aleksandra Božić , Aleksandar Marinković , Snežana Bjelogrlić , Tamara R. Todorović , Ilija N. Cvijetić
RSC Advances, 2016, 6 (106), pp.104763 - 104781. ⟨10.1039/c6ra23940d⟩
Article dans une revue hal-01425958v1

Synthetic analogues of marine alkaloid clathrodin differently induce phosphatidylserine exposure in monocytic cancer cells then in cancer stem cell lines

Christian D. Muller , Dominik Nabergoj , Sanja Vrbek , Nace Zidar , Tihomir Tomašić
MedChemComm, 2016, 7 (8), pp.1546-1554. ⟨10.1039/c6md00163g⟩
Article dans une revue hal-02106919v1

Zn( ii ) complex with 2-quinolinecarboxaldehyde selenosemicarbazone: synthesis, structure, interaction studies with DNA/HSA, molecular docking and caspase-8 and -9 independent apoptose induction

Christian D. Muller , Nenad Filipović , Snežana Bjelogrlić , Aleksandar Marinković , Tatjana Ž. Verbić
RSC Advances, 2015, 5 (115), pp.95191-95211. ⟨10.1039/c5ra19849f⟩
Article dans une revue hal-02106948v1

Setting P-Donor Ligands into Context: An Application of the Ligand Knowledge Base (LKB) Approach

Natalie Fey , Sofia Papadouli , Paul G Pringle , Arne Ficks , James T Fleming
Phosphorus, Sulfur, and Silicon and the Related Elements, 2015, 190 (5-6), pp.706-714. ⟨10.1080/10426507.2014.983599⟩
Article dans une revue hal-02001083v1

Spiro Diorthoester (SpiDo), a Human Plasma Stable Acid-Sensitive Cleavable Linker for Lysosomal Release

Christian D. Muller , Geoffray Leriche , Marc Nothisen , Nadège Baumlin , Christian Muller
Bioconjugate Chemistry, 2015, 26 (8), pp.1461-1465. ⟨10.1021/acs.bioconjchem.5b00280⟩
Article dans une revue hal-02106946v1

Impact of Procyanidins from Different Berries on Caspase 8 Activation in Colon Cancer

Christian D. Muller , Carole Minker , Livine Duban , Daniel Karas , Päivi Järvinen
Oxidative Medicine and Cellular Longevity, 2015, 2015, pp.1-13. ⟨10.1155/2015/154164⟩
Article dans une revue hal-02106943v1

Analogues of the marine alkaloids oroidin, clathrodin, and hymenidin induce apoptosis in human HepG2 and THP-1 cancer cells

Christian D. Muller , Tihomir Tomašič , Dominik Nabergoj , Sanja Vrbek , Nace Zidar
MedChemComm, 2015, 6 (1), pp.105-110. ⟨10.1039/c4md00286e⟩
Article dans une revue hal-02106940v1

Oxidative Stress Type Influences the Properties of Antioxidants Containing Polyphenols in RINm5F Beta Cells

Nathalie Auberval , Stéphanie Dal , William Bietiger , Elodie Seyfritz , Jean Peluso
Evidence-Based Complementary and Alternative Medicine, 2015, 2015, pp.1-11. ⟨10.1155/2015/859048⟩
Article dans une revue hal-02106949v1

Reactivity of Aromatic Phosphorus Heterocycles - Differences Between Nonfunctionalized and Pyridyl-Substituted 2,4,6-Triarylphosphinines

Gregor Pfeifer , Philippe Ribagnac , X. F Le Goff , Jelena Wiecko , Nicolas Mézailles
European Journal of Inorganic Chemistry, 2015, 2015 (2), pp.240-249
Article dans une revue hal-01998962v1

Lack of the presynaptic RhoGAP protein oligophrenin1 leads to cognitive disabilities through dysregulation of the cAMP/PKA signalling pathway

Malik Khelfaoui , Frédéric Gambino , Xander Houbaert , Bruno Ragazzon , Christian Muller
Philosophical Transactions of the Royal Society B: Biological Sciences, 2014, 369 (1633), pp.20130160. ⟨10.1098/rstb.2013.0160⟩
Article dans une revue hal-02392406v1

Selective anticancer effects of a synthetic flavagline on human Oct4-expressing cancer stem-like cells via a p38 MAPK-dependent caspase-3-dependent pathway

Christian D. Muller , Fathi Emhemmed , Sarah Ali Azouaou , Frédéric Thuaud , Valerie Schini-Kerth
Biochemical Pharmacology, 2014, 89 (2), pp.185-196. ⟨10.1016/j.bcp.2014.02.020⟩
Article dans une revue hal-02106955v1

Coronin 1 Regulates Cognition and Behavior through Modulation of cAMP/Protein Kinase A Signaling

Rajesh Jayachandran , Xiaolong Liu , Somdeb Bosedasgupta , Philipp Müller , Chun-Lei Zhang
PLoS Biology, 2014, 12 (3), pp.e1001820. ⟨10.1371/journal.pbio.1001820⟩
Article dans une revue hal-02392404v1

Exploring Marine Resources for Bioactive Compounds

Christian D. Muller , Paula Kiuru , M. Dʼauria , Christian Muller , Päivi Tammela
Planta Medica, 2014, 80 (14), pp.1234-1246. ⟨10.1055/s-0034-1383001⟩
Article dans une revue hal-02106953v1

Application of Magnetocaloric Heat Pumps in Mobile Air-Conditioning

B. Torregrosa-Jaime , C. Vasile , Michel Risser , Christian Muller , Jose Corberan
SAE Int. J. Passeng. Cars - Mech. Syst, 2013, pp.520-528. ⟨10.4271/2013-01-0239⟩
Article dans une revue hal-00872281v1

On the use of capillary cytometry for assessing the bactericidal effect of TiO 2 . Identification and involvement of reactive oxygen species

Christian D. Muller , Gaëlle Carré , Dounia Benhamida , Jean Peluso , Christian Muller
Photochemical & Photobiological Sciences , 2013, 12 (4), pp.610-620. ⟨10.1039/c2pp25189b⟩
Article dans une revue hal-02106787v1

A nice refreshing technological breeze was blowing this June at the CYTO 2012 ISAC meeting in Leipzig (Germany)

Christian D. Muller , Christian Muller
Cytometry Part A, 2012, 81A (10), pp.929-929. ⟨10.1002/cyto.a.22114⟩
Article dans une revue hal-02106962v1

1α,25(OH)2-3-Epi-Vitamin D3, a Natural Physiological Metabolite of Vitamin D3: Its Synthesis, Biological Activity and Crystal Structure with Its Receptor

Ferdinand Molnar , Rita Sigueiro , Yoshiteru Sato , Clarisse Araujo , Inge Schuster
PLoS ONE, 2011, 6 (3), pp.e18124. ⟨10.1371/journal.pone.0018124⟩
Article dans une revue hal-04500358v1

Numerical analysis of an active magnetic regenerator

Julien Roudaut , Afef Kedous-Lebouc , Jean-Paul Yonnet , Christian Muller
International Journal of Refrigeration IJR, 2011, 34 (8), pp.1797-1804
Article dans une revue hal-00789691v1
Image document

Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1

Mahmoud Alhosin , Abdurazzag Abusnina , Mayada Achour , Tanveer Sharif , Christian Muller
Biochemical Pharmacology, 2010, 79 (9), pp.1251. ⟨10.1016/j.bcp.2009.12.015⟩
Article dans une revue hal-00573917v1

Synthesis of 3-O-methylviridicatin analogues with improved anti-TNF-α properties

Nigel Ribeiro , Helena Tabaka , Jean Peluso , Ludivine Fetzer , Canan G Nebigil
Bioorganic and Medicinal Chemistry Letters, 2007, 17 (20), pp.5523-5524. ⟨10.1016/j.bmcl.2007.08.036⟩
Article dans une revue hal-02391115v1

Modified mean-field theory with phenomenological model of volume effects for 1st order transition magnetocaloric materials

Michel Risser , Sergiu Lionte , Vincent Hardy , Christian Muller
7TH INTERNATIONAL CONFERENCE ON MAGNETIC REFRIGERATION AT ROOM TEMPERATURE, Sep 2016, Torino, Italy. 131 (4p.), ⟨10.18462/iir.thermag.2016.0131⟩
Communication dans un congrès hal-02161214v1

Numerical analysis of an active magnetic regenerator - A parametric study

Julien Roudaut , Afef Kedous-Lebouc , Jean-Paul Yonnet , Christian Muller
The 4th International Conference of IIR on Magnetic Refrigeration at Room Temperature, Aug 2010, Baotou, China. pp 507-516
Communication dans un congrès hal-00520904v1

Comparison of magnetic field sources for magnetic refrigeration at room temperature

Julien Roudaut , Jean-Paul Yonnet , Afef Kedous-Lebouc , Christian Muller
The 4th International Conference of IIR on Magnetic Refrigeration at Room Temperature, Aug 2010, Baotou, China. pp.497-506
Communication dans un congrès hal-00520913v1
Image document

Le criblage cytomique à haut contenu

Christian D. Muller
Jean-François Mayol, Corinne Laplace-Builhé et Christian D. Muller. La cytométrie en flux, Lavoisier, Chapitre 16, 2020
Chapitre d'ouvrage hal-02991086v1