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A p53 score derived from TP53 CRISPR/Cas9 HMCLs predicts survival and reveals major role of BAX in BH3 mimetics response

Romane Durand , Géraldine Descamps , Christelle Dousset , Céline Bellanger , Sophie Maïga , et al.
Article dans une revue hal-04359884v1
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Decitabine and Melphalan Fail to Reactivate p73 in p53 Deficient Myeloma Cells

Pierre-Samuel Gillardin , Géraldine Descamps , Sophie Maiga , Benoit Tessoulin , Hanane Djamai , et al.
International Journal of Molecular Sciences, 2017, 19 (1), ⟨10.3390/ijms19010040⟩
Article dans une revue inserm-01691503v1
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Unraveling MCL biology to understand resistance and identify vulnerabilities

Clémentine Sarkozy , Benoit Tessoulin , David Chiron
Article dans une revue hal-04547407v1
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p53 dysregulation in B-cell malignancies: More than a single gene in the pathway to hell

Benoit Tessoulin , Marion Eveillard , Anne Lok , David Chiron , Philippe Moreau , et al.
Blood Reviews, 2017, [Epub ahead of print]. ⟨10.1016/j.blre.2017.03.001⟩
Article dans une revue inserm-01493742v1
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Ibrutinib, Obinutuzumab And Venetoclax In Relapsed and Untreated Patients with Mantle-Cell Lymphoma, a phase I/II trial

Steven Le Gouill , Franck Morschhauser , David Chiron , Krimo Bouabdallah , Guillaume Cartron , et al.
Blood, 2020, Online ahead of print. ⟨10.1182/blood.2020008727⟩
Article dans une revue inserm-03063717v1
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Oxaliplatin before autologous transplantation in combination with high-dose cytarabine and rituximab provides longer disease control than cisplatin or carboplatin in patients with mantle-cell lymphoma: results from the LyMA prospective trial

Benoit Tessoulin , David Chiron , Catherine Thieblemont , Lucie Oberic , Kamal Bouadballah , et al.
Bone Marrow Transplantation, 2021, 56 (7), pp.1700-1709. ⟨10.1038/s41409-020-01198-2⟩
Article dans une revue hal-03203334v1
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Myeloma Cell Self-Renewal Depends on JAG2 Expression and Is Mediated by IGF1 or SCF Loop

David Chiron , Sophie Maiga , Géraldine Descamps , Severine Marionneau-Lambot , Catherine Pellat-Deceunynck
ASH meeting 2010, Dec 2010, Orlando, United States. pp.127, ⟨10.1182/blood.V116.21.127.127⟩
Communication dans un congrès inserm-02459063v1
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The REFRACT-LYMA cohort study: a French observational prospective cohort study of patients with mantle cell lymphoma

Matthieu Hanf , David Chiron , Sophie de Visme , Cyrille Touzeau , Hervé Maisonneuve , et al.
BMC Cancer, 2016, 16 (1), pp.802. ⟨10.1186/s12885-016-2844-6⟩
Article dans une revue inserm-01381110v1
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Commentary on Rodrigues et al : Towards ecosystem integration for a better understanding of B-cell lymphomas aggressiveness

David Chiron
British Journal of Haematology, 2021
Article dans une revue inserm-03128392v1
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p53 regulates CD46 expression and measles virus infection in myeloma cells

Anne Lok , Géraldine Descamps , Benoit Tessoulin , David Chiron , Marion Eveillard , et al.
Blood Advances, 2018, 2 (23), pp.3492-3505. ⟨10.1182/bloodadvances.2018025106⟩
Article dans une revue inserm-01957487v1
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CARD11 gain of function upregulates BCL2A1 and promotes resistance to targeted therapies combination in B-cell lymphoma

Salomé Decombis , Céline Bellanger , Yannick Le Bris , Candice Madiot , Jane Jardine , et al.
Article dans une revue hal-04195394v1
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CSF1R and BTK inhibitions as novel strategies to disrupt the dialogue between mantle cell lymphoma and macrophages

Antonin Papin , Benoit Tessoulin , Céline Bellanger , Anne Moreau , Yannick Le Bris , et al.
Leukemia, In press, Epub ahead of print
Article dans une revue inserm-02081007v1
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The REFRACT-LYMA cohort study: a French observational prospective cohort study of patients with mantle cell lymphoma.

Matthieu Hanf , David Chiron , Sophie de Visme , Cyrille Touzeau , Hervé Maisonneuve , et al.
BMC Cancer, 2016, 16 (1), pp.802. ⟨10.1186/s12885-016-2844-6⟩
Article dans une revue hal-01524145v1
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Cell-Cycle Reprogramming for PI3K Inhibition Overrides a Relapse-Specific C481S BTK Mutation Revealed by Longitudinal Functional Genomics in Mantle Cell Lymphoma

David Chiron , Maurizio Di Liberto , Peter Martin , Xiangao Huang , Jeff Sharman , et al.
Cancer Discovery, 2014, 4 (9), pp.1022-35. ⟨10.1158/2159-8290.CD-14-0098⟩
Article dans une revue inserm-02490276v1
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Whole-exon sequencing of human myeloma cell lines shows mutations related to myeloma patients at relapse with major hits in the DNA regulation and repair pathways

Benoit Tessoulin , Agnès Moreau-Aubry , Géraldine Descamps , Patricia Gomez-Bougie , Sophie Maiga , et al.
Journal of Hematology and Oncology, 2018, 11 (1), pp.137. ⟨10.1186/s13045-018-0679-0⟩
Article dans une revue inserm-01958772v1
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Tumor Microenvironment and Immunotherapy-Based Approaches in Mantle Cell Lymphoma

Khalil Saleh , Morgane Cheminant , David Chiron , Barbara Burroni , Vincent Ribrag , et al.
Cancers, 2022, 14 (13), pp.3229. ⟨10.3390/cancers14133229⟩
Article dans une revue hal-03745694v1
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Three targets in 1 shot against ibrutinib resistance

David Chiron
Blood, 2019
Article dans une revue inserm-02080892v1

Toll-like receptors: lessons to learn from normal and malignant human B cells

David Chiron , Isabelle Bekeredjian-Ding , Catherine Pellat-Deceunynck , Régis Bataille , Gaetan Jego
Article dans une revue inserm-02459027v1
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The IL32/BAFF axis supports prosurvival dialogs in the lymphoma ecosystem and is disrupted by NIK inhibition

Salomé Decombis , Antonin Papin , Céline Bellanger , Clara Sortais , Christelle Dousset , et al.
Haematologica, 2022, Online ahead of print. ⟨10.3324/haematol.2021.279800⟩
Article dans une revue inserm-03625695v1
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Rational targeted therapies to overcome microenvironment-dependent expansion of mantle cell lymphoma

David Chiron , Céline Bellanger , Antonin Papin , Benoit Tessoulin , Christelle Dousset , et al.
Article dans une revue inserm-01405674v2
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Restoring Apoptosis with BH3 Mimetics in Mature B-Cell Malignancies

Maxime Jullien , Patricia Gomez-Bougie , David Chiron , Cyrille Touzeau
Cells, 2020, 9 (3), pp.E717. ⟨10.3390/cells9030717⟩
Article dans une revue inserm-02512852v1