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Publications de Céline Brochot


Journal articles69 documents

  • Cleo Tebby, Julien Caudeville, yasmil Fernandez, Céline Brochot. Mapping blood lead levels in French children due to environmental contamination using a modeling approach. Science of the Total Environment, Elsevier, 2022, 808, pp.152149. ⟨10.1016/j.scitotenv.2021.152149⟩. ⟨ineris-03563032⟩
  • Corentin Regrain, Florence Anna Zeman, Mohammed Guedda, Karen Chardon, Véronique Bach, et al.. Spatio-temporal assessment of pregnant women exposure to chlorpyrifos at a regional scale. Journal of Exposure Science and Environmental Epidemiology, Nature Publishing Group, In press, ⟨10.1038/s41370-021-00315-7⟩. ⟨ineris-03218244⟩
  • Julien Caudeville, Corentin Regrain, Frederic Tognet, Roseline Bonnard, Mohammed Guedda, et al.. Characterizing environmental geographic inequalities using an integrated exposure assessment. Environmental Health, BioMed Central, 2021, 20, pp.58. ⟨10.1186/s12940-021-00736-9⟩. ⟨ineris-03266904⟩
  • Stéphane Personne, Céline Brochot, Paulo Marcelo, Aurélie Corona, Sophie Desmots, et al.. Evaluation of Placental Transfer and Tissue Distribution of cis- and Trans-Permethrin in Pregnant Rats and Fetuses Using a Physiological-Based Pharmacokinetic Model. Frontiers in Pediatrics, Frontiers, 2021, 9, ⟨10.3389/fped.2021.730383⟩. ⟨ineris-03498668⟩
  • Paul Quindroit, Amélie Crepet, Céline Brochot. Estimating human exposure to pyrethroids’ mixtures from biomonitoring data using physiologically based pharmacokinetic modeling. Environmental Research, Elsevier, 2021, 192, pp.110281. ⟨10.1016/j.envres.2020.110281⟩. ⟨ineris-03318013⟩
  • Marc Codaccioni, Céline Brochot. Assessing the impacts on fetal dosimetry of the modelling of the placental transfers of xenobiotics in a pregnancy physiologically based pharmacokinetic model. Toxicology and Applied Pharmacology, Elsevier, 2020, 409, pp.115318. ⟨10.1016/j.taap.2020.115318⟩. ⟨ineris-03318332⟩
  • Hilko van Der Voet, Johannes W. Kruisselbrink, Waldo J. de Boer, Marco S. van Lenthe, J.J.B. van den Heuvel, et al.. The MCRA toolbox of models and data to support chemical mixture risk assessment. Food and Chemical Toxicology, Elsevier, 2020, 138, pp.111185. ⟨10.1016/j.fct.2020.111185⟩. ⟨ineris-03318304⟩
  • Marie Vanacker, Paul Quindroit, Karine Angeli, Corinne Mandin, Philippe Glorennec, et al.. Aggregate and cumulative chronic risk assessment for pyrethroids in the French adult population. Food and Chemical Toxicology, Elsevier, 2020, 143, pp.111519. ⟨10.1016/j.fct.2020.111519⟩. ⟨hal-02890342⟩
  • Karine Audouze, Denis Sarigiannis, Paloma Alonso-Magdalena, Céline Brochot, Maribel Casas, et al.. Integrative Strategy of Testing Systems for Identification of Endocrine Disruptors Inducing Metabolic Disorders - An Introduction to the OBERON Project. International Journal of Molecular Sciences, MDPI, 2020, 21 (8), pp.2988. ⟨10.3390/ijms21082988⟩. ⟨ineris-03318314⟩
  • Cléo Tebby, Hilko van Der Voet, Georges de Sousa, Emiel Rorije, Vikas Kumar, et al.. A generic PBTK model implemented in the MCRA platform: Predictive performance and uses in risk assessment of chemicals. Food and Chemical Toxicology, Elsevier, 2020, 142, ⟨10.1016/j.fct.2020.111440⟩. ⟨hal-02735573⟩
  • Paul Quindroit, Rémy Beaudouin, Céline Brochot. Estimating the cumulative human exposures to pyrethroids by combined multi-route PBPK models : Application to the French population. Toxicology Letters, Elsevier, 2019, 312, pp.125-138. ⟨10.1016/j.toxlet.2019.05.007⟩. ⟨ineris-03319061⟩
  • Audrey Grech, Cléo Tebby, Céline Brochot, Frédéric y. Bois, Anne Bado-Nilles, et al.. Generic physiologically-based toxicokinetic modelling for fish : Integration of environmental factors and species variability. Science of the Total Environment, Elsevier, 2019, 651, pp.516-531. ⟨10.1016/j.scitotenv.2018.09.163⟩. ⟨ineris-03318091⟩
  • Cléo Tebby, Céline Brochot, Jean-Lou Dorne, Rémy Beaudouin. Investigating the interaction between melamine and cyanuric acid using a Physiologically-Based Toxicokinetic model in rainbow trout. Toxicology and Applied Pharmacology, Elsevier, 2019, 370, pp.184-195. ⟨10.1016/j.taap.2019.03.021⟩. ⟨ineris-03319058⟩
  • Marc Codaccioni, Frédéric Bois, Céline Brochot. Placental transfer of xenobiotics in pregnancy physiologically-based pharmacokinetic models: Structure and data. Computational Toxicology, 2019, 12, pp.100111. ⟨10.1016/j.comtox.2019.100111⟩. ⟨ineris-02350756⟩
  • Céline Brochot, Maribel Casas, Cyntia Manzano-Salgado, Florence Anna Zeman, Thomas Schettgen, et al.. Prediction of maternal and foetal exposures to perfluoroalkyl compounds in a Spanish birth cohort using toxicokinetic modelling. Toxicology and Applied Pharmacology, Elsevier, 2019, 379, pp.art. 114640. ⟨10.1016/j.taap.2019.114640⟩. ⟨ineris-03319063⟩
  • D.A. Sarigiannis, Spryros Karakitsios, Elena Dominguez-Romero, Krystalia Papadaki, Céline Brochot, et al.. Physiology-based toxicokinetic modelling in the frame of the European Human Biomonitoring Initiative. Environmental Research, Elsevier, 2019, 172, pp.216-230. ⟨10.1016/j.envres.2019.01.045⟩. ⟨ineris-03319121⟩
  • Stéphane Personne, Paulo Marcelo, Serge Pilard, Sylvie Baltora-Rosset, Aurélie Corona, et al.. Determination of maternal and foetal distribution of cis- and trans-permethrin isomers and their metabolites in pregnant rats by liquid chromatography tandem mass spectrometry (LC-MS/MS). Analytical and Bioanalytical Chemistry, Springer Verlag, 2019, 411 (30), pp.8043-8052. ⟨10.1007/s00216-019-02157-7⟩. ⟨ineris-03229714⟩
  • Julien Caudeville, Corentin Regrain, Roseline Bonnard, Laurent Letinois, Frédéric Tognet, et al.. Caractérisation de l’exposition environnementale spatialisée à un pyréthrinoïde en Picardie. Environnement, Risques and Santé, John Libbey Eurotext, 2019, 18 (5), pp.392-400. ⟨10.1684/ers.2019.1340⟩. ⟨ineris-03229712⟩
  • Léa Maitre, Jeroen de Bont, Maribel Casas, Olivier Robinson, Gunn Marit Aasvang, et al.. Human Early Life Exposome (HELIX) study : a European population-based exposome cohort. BMJ Open, BMJ Publishing Group, 2018, 8, pp.e021311. ⟨10.1136/bmjopen-2017-021311⟩. ⟨ineris-03319120⟩
  • Maribel Casas, Xavier Basagana, Amrit K. Sakhi, Line S. Haug, Claire Philippat, et al.. Variability of urinary concentrations of non-persistent chemicals in pregnant women and school-aged children. Environment International, Elsevier, 2018, 121, pp.561-573. ⟨10.1016/j.envint.2018.09.046⟩. ⟨ineris-01960310⟩
  • Céline Brochot. Modéliser l’exposition environnementale et les imprégnations des populations à des substances chimiques : l’outil merlin-expo. Rapport Scientifique INERIS, 2017, 2016-2017, pp.56-57. ⟨ineris-01869670⟩
  • Audrey Grech, Céline Brochot, Jean-Lou Dorne, Nadia Quignot, Frédéric y. Bois, et al.. Toxicokinetic models and related tools in environmental risk assessment of chemicals. Science of the Total Environment, Elsevier, 2017, 578, pp.1-15. ⟨10.1016/j.scitotenv.2016.10.146⟩. ⟨ineris-01853417⟩
  • Mirja van Holderbeke, Tine Fierens, Arnout Standaert, Christa Cornelis, Céline Brochot, et al.. Assessing multimedia/multipathway exposures to inorganic arsenic at population and individual level using MERLIN-Expo. Science of the Total Environment, Elsevier, 2016, 568, pp.794-802. ⟨10.1016/j.scitotenv.2016.04.038⟩. ⟨ineris-01854121⟩
  • Tine Fierens, Mirja van Holderbeke, Arnout Standaert, Christa Cornelis, Céline Brochot, et al.. Multimedia & PBPK modelling with MERLIN-Expo versus biomonitoring for assessing Pb exposure of pre-school children in a residential setting. Science of the Total Environment, Elsevier, 2016, 568, pp.785-793. ⟨10.1016/j.scitotenv.2016.03.194⟩. ⟨ineris-01854122⟩
  • Sophie Teng, Cleo Tebby, Sylvie Barcellini-Couget, Georges de Sousa, Céline Brochot, et al.. Analysis of real-time mixture cytotoxicity data following repeated exposure using BK/TD models. Toxicology and Applied Pharmacology, Elsevier, 2016, 305, pp.118-126. ⟨10.1016/j.taap.2016.06.018⟩. ⟨hal-01532587⟩
  • Marie-Emilie Willemin, Sophie Desmots, Rozenn Le Grand, François Lestremau, Florence Anna Zeman, et al.. PBPK modeling of the cis- and trans-permethrin isomers and their major urinary metabolites in rats. Toxicology and Applied Pharmacology, Elsevier, 2016, 294, pp.65-77. ⟨10.1016/j.taap.2016.01.011⟩. ⟨ineris-01862928⟩
  • Nicoleta Suciu, Alice Tediosi, Philippe Ciffroy, Annette Altenpohl, Céline Brochot, et al.. Potential for MERLIN-Expo, an advanced tool for higher tier exposure assessment, within the EU chemical legislative frameworks. Science of the Total Environment, Elsevier, 2016, 562, pp.474-479. ⟨10.1016/j.scitotenv.2016.04.072⟩. ⟨ineris-01854123⟩
  • Artur Radomyski, Elisa Giubilato, Philippe Ciffroy, Andrea Critto, Céline Brochot, et al.. Modelling ecological and human exposure to POPs in Venice lagoon. Part II : Quantitative uncertainty and sensitivity analysis in coupled exposure models. Science of the Total Environment, Elsevier, 2016, 569-570, pp.1635-1649. ⟨10.1016/j.scitotenv.2016.07.057⟩. ⟨ineris-01854320⟩
  • Philippe Ciffroy, Boris Alfonso, A. Altenpohl, Zoran Banjac, J. Bierkens, et al.. Modelling the exposure to chemicals for risk assessment : a comprehensive library of multimedia and PBPK models for integration, prediction, uncertainty and sensitivity analysis - the MERLIN-Expo tool. Science of the Total Environment, Elsevier, 2016, 568, pp.770-784. ⟨10.1016/j.scitotenv.2016.03.191⟩. ⟨ineris-01854119⟩
  • Elisa Giubilato, Artur Radomyski, Andrea Critto, Philippe Ciffroy, Céline Brochot, et al.. Modelling ecological and human exposure to POPs in Venice lagoon. Part I - Application of MERLIN-Expo tool for integrated exposure assessment. Science of the Total Environment, Elsevier, 2016, 565, pp.961-976. ⟨10.1016/j.scitotenv.2016.04.146⟩. ⟨ineris-01854120⟩
  • Céline Brochot. Modélisation toxicocinétique de la perméthrine pour lier l’exposition aux biomarqueurs mesurés lors des campagnes de biosurveillance humaine. Rapport Scientifique INERIS, 2016, 2015-2016, pp.54-55. ⟨ineris-01869630⟩
  • Florence Zeman, Céline Brochot. Le projet européen HELIX : exposome et modélisation toxicocinétique. Rapport Scientifique INERIS, 2015, 2014-2015, pp.34-35. ⟨ineris-01869530⟩
  • Marie-Emilie Willemin, Ali Kadar, Georges de Sousa, E. Leclerc, Roger Rahmani, et al.. In vitro human metabolism of permethrin isomers alone or as a mixture and the formation of the major metabolites in cryopreserved primary hepatocytes. Toxicology in Vitro, Elsevier, 2015, 29 (4), pp.803-812. ⟨10.1016/j.tiv.2015.03.003⟩. ⟨ineris-01855035⟩
  • Alexandre R.R. Pery, James Devillers, Céline Brochot, Enrico Mombelli, Olivier Palluel, et al.. A Physiologically Based Toxicokinetic Model for the Zebrafish Danio rerio. Environmental Science and Technology, American Chemical Society, 2014, 48 (1), pp.781-790. ⟨10.1021/es404301q⟩. ⟨ineris-01710151⟩
  • Martine Vrijheid, Rémy Slama, Olivier Robinson, Leda Chatzi, Muireann Coen, et al.. The human early-life exposome (HELIX) : Project rationale and design. Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2014, 122 (6), pp.535-544. ⟨10.1289/ehp.1307204⟩. ⟨ineris-01863935⟩
  • Marie-Emilie Willemin, Ali Kadar, Georges de Sousa, Roger Rahmani, Céline Brochot. In vitro metabolism of permethrin and two metabolites by human primary hepatocytes. Toxicology Letters, Elsevier, 2014, 229, pp.S122. ⟨10.1016/j.toxlet.2014.06.438⟩. ⟨hal-02629554⟩
  • Francois Lestremau, Marie-Emilie Willemin, Claudine Chatellier, Sophie Desmots, Céline Brochot. Determination of cis-permethrin, trans-permethrin and associated metabolites in rat blood and organs by gas chromatography–ion trap mass spectrometry. Analytical and Bioanalytical Chemistry, Springer Verlag, 2014, 406 (14), pp.3477-3487. ⟨10.1007/s00216-014-7774-z⟩. ⟨ineris-01710209⟩
  • Céline Boudet, Karine Tack, Céline Brochot, Florence Zeman. Évaluation de l’exposition des femmes enceintes françaises aux phtalates. Rapport Scientifique INERIS, 2014, 2013-2014, pp.22-23. ⟨ineris-01869494⟩
  • Alexandre R.R. Pery, Céline Brochot, Florence Anna Zeman, Enrico Mombelli, Sophie Desmots, et al.. Prediction of dose-hepatotoxic response in humans based on toxicokinetic/toxicodynamic modeling with or without in vivo data : A case study with acetaminophen. Toxicology Letters, Elsevier, 2013, 220 (1), pp.26-34. ⟨10.1016/j.toxlet.2013.03.032⟩. ⟨ineris-00961804⟩
  • Leila Choucha-Snouber, Caroline Aninat, Laurent Grsicom, Geoffrey Madalinski, Céline Brochot, et al.. Investigation of ifosfamide nephrotoxicity induced in a liver-kidney co-culture biochip.. Biotechnology and Bioengineering, Wiley, 2013, 110 (2), pp.597-608. ⟨10.1002/bit.24707⟩. ⟨inserm-00864839⟩
  • Florence Anna Zeman, Céline Boudet, Karine Tack, Adeline Barneaud, Céline Brochot, et al.. Exposure assessment of phthalates in French pregnant women : Results of the ELFE pilot study. International Journal of Hygiene and Environmental Health, Elsevier, 2013, 216 (3), pp.271-279. ⟨10.1016/j.ijheh.2012.12.005⟩. ⟨ineris-00963467⟩
  • Leila Choucha-Snouber, Andrei Bunescu, Cécile Legallais, Céline Brochot, Marc-Emmanuel Dumas, et al.. Metabolomics-on-a-chip of hepatotoxicity induced by anticancer drug flutamide and its active metabolite hydroxyflutamide using HepG2/C3a microfluidic biochips. Toxicological Sciences, Oxford University Press (OUP), 2013, 132 (1), pp.8-20. ⟨10.1093/toxsci/kfs230⟩. ⟨ineris-00963445⟩
  • Régis Baudoin, Jean-Matthieu Prot, Grégory Nicolas, Jessy Brocheton, Céline Brochot, et al.. Evaluation of seven drug metabolisms and clearances by cryopreserved human primary hepatocytes cultivated in microfluidic biochips. Xenobiotica, Taylor & Francis, 2013, 43 (2), pp.140-152. ⟨10.3109/00498254.2012.706725⟩. ⟨ineris-00963431⟩
  • Céline Brochot. Développement de méthodes alternatives en expérimentation animale : caractérisation de la toxicité et du métabolisme in vitro de xénobiotiques au sein de biopuces hépatiques et rénales. Rapport Scientifique INERIS, 2013, 2012-2013, pp.20-22. ⟨ineris-01869452⟩
  • Djomangan Adama Ouattara, Jean-Matthieu Prot, Andrei Bunescu, Marc-Emmanuel Dumas, Bénédicte Elena-Herrmann, et al.. Metabolomics-on-a-chip and metabolic flux analysis for label-free modeling of the internal metabolism of HepG2/C3A cells. Molecular BioSystems, Royal Society of Chemistry, 2012, 8 (7), pp.1908-1920. ⟨10.1039/c2mb25049g⟩. ⟨ineris-00963393⟩
  • Laetitia Shintu, Régis Baudoin, Vincent Navratil, Jean-Matthieu Prot, Clément Pontoizeau, et al.. Metabolomics-on-a-Chip and Predictive Systems Toxicology in Microfluidic Bioartificial Organs. Analytical Chemistry, American Chemical Society, 2012, 84 (4), pp.1840-1848. ⟨10.1021/ac2011075⟩. ⟨hal-00699575⟩
  • Jean-Matthieu Prot, Andrei Bunescu, Bénédicte Elena-Herrmann, Caroline Aninat, Leila Choucha Snouber, et al.. Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: Application to acetaminophen injury. Toxicology and Applied Pharmacology, Elsevier, 2012, 259 (3), pp.270-280. ⟨10.1016/j.taap.2011.12.017⟩. ⟨hal-00699551⟩
  • Maria Ulaszewska, Philippe Ciffroy, Fazia Tahraoui, Florence Anna Zeman, Ettore Capri, et al.. Interpreting PCB levels in breast milk using a physiologically based pharmacokinetic model to reconstruct the dynamic exposure of Italian women. Journal of Exposure Science and Environmental Epidemiology, Nature Publishing Group, 2012, 22 (6), pp.601-609. ⟨10.1038/jes.2012.36⟩. ⟨ineris-00963410⟩
  • Djomangan Adama Ouattara, Sue-Hyung Choi, yasuyuki Sakai, Alexandre R.R. Pery, Céline Brochot. Kinetic modelling of in vitro cell-based assays to characterize non-specific bindings and ADME processes in a static and a perfused fluidic system. Toxicology Letters, Elsevier, 2011, 205 (3), pp.310-319. ⟨10.1016/j.toxlet.2011.06.021⟩. ⟨ineris-00963306⟩
  • Alexandre R.R. Pery, Céline Brochot, Sophie Desmots, Magali Boize, Lydie Sparfel, et al.. Predicting in vivo gene expression in macrophages after exposure to benzo(a)pyrene based on in vitro assays and toxicokinetic/toxicodynamic models. Toxicology Letters, Elsevier, 2011, 201 (1), pp.8-14. ⟨10.1016/j.toxlet.2010.11.017⟩. ⟨hal-00873317⟩
  • Philippe Ciffroy, Taku Tanaka, E. Johansson, Céline Brochot. Linking fate model in freshwater and PBPK model to assess human internal dosimetry of B(a)P associated with drinking water. Environmental Geochemistry and Health, Springer Verlag (Germany), 2011, 33 (4), pp.371-387. ⟨10.1007/s10653-011-9382-6⟩. ⟨ineris-00963283⟩
  • Jean-Matthieu Prot, Orianne Videau, Céline Brochot, Cécile Legallais, Henri Benech, et al.. A cocktail of metabolic probes demonstrates the relevance of primary human hepatocyte cultures in a microfluidic biochip for pharmaceutical drug screening. International Journal of Pharmaceutics, Elsevier, 2011, 108 (1-2), pp.67-75. ⟨10.1016/j.ijpharm.2011.01.054⟩. ⟨ineris-00963290⟩
  • Jean Matthieu Prot, Caroline Aninat, Laurent Griscom, Florence Razan, Céline Brochot, et al.. Improvement of HepG2/C3a cell functions in a microfluidic biochip.. Biotechnology and Bioengineering, Wiley, 2011, 108 (7), pp.1704-15. ⟨10.1002/bit.23104⟩. ⟨hal-00740224⟩
  • Loïc yengo, Céline Brochot, Alexandre R.R. Pery. Combined global sensitivity analysis and population PBPK modeling for assessing consistency of TCDD toxicokinetics data in mice. Procedia - Social and Behavioral Sciences, Elsevier, 2010, 2 (6), pp.7770-7771. ⟨10.1016/j.sbspro.2010.05.220⟩. ⟨ineris-00963242⟩
  • Dany Habka, Alexandre R.R. Pery, Cécile Legallais, Céline Brochot. Prédiction de la toxicocinétique in vivo de substances chimiques à partir de données in vitro et de modèles QSAR. Environnement, Risques and Santé, John Libbey Eurotext, 2010, 9 (6), pp.489-501. ⟨ineris-00963259⟩
  • Frédéric y. Bois, Dany Habka, Céline Brochot. An integrated modelling approach for in vitro to in vivo extrapolations. ALTEX - Alternatives to Animal Experimentations, 2010, 27 (Special issue Proceedings), pp.103-108. ⟨ineris-00961757⟩
  • Rémy Beaudouin, Sandrine Micallef, Céline Brochot. A stochastic whole-body physiologically based pharmacokinetic model to assess the impact of inter-individual variability on tissue dosimetry over the human lifespan. Regulatory Toxicology and Pharmacology, Elsevier, 2010, 57 (1), pp.103-116. ⟨10.1016/j.yrtph.2010.01.005⟩. ⟨ineris-00963225⟩
  • Alexandre R.R. Pery, Céline Brochot, Peter Hoet, Abderrahim Nemmar, Frédéric y. Bois. Development of a physiologically based kinetic model for 99m-Technetium-labelled carbon nanoparticles inhaled by humans. Inhalation Toxicology, Taylor & Francis, 2009, 21 (13), pp.1099-1107. ⟨10.3109/08958370902748542⟩. ⟨ineris-00961947v2⟩
  • Alexandre R.R. Pery, Magali Boize, Céline Brochot. Utilisation de modèles mécanistiques de cinétique et d'effets pour l'évaluation du risque lié à l'exposition aux faibles doses. La Lettre de l'Association pour la Recherche en Toxicologie, 2008, pp.1-3. ⟨ineris-00963124⟩
  • Thomas J. Smith, Frédéric y. Bois, yu-Sheng Lin, Céline Brochot, Sandrine Micallef, et al.. Quantifying heterogeneity in exposure-risk relationships using exhaled breath biomarkers for 1, 3-butadiene exposure. Journal of Breath Research, IOP Science, 2008, 2 (3), pp.art 037018. ⟨10.1088/1752-7155/2/3/037018⟩. ⟨ineris-00963129⟩
  • Céline Brochot, Thomas J. Smith, Frédéric y. Bois. Development of a physiologically based toxicokinetic model for butadiene and four major metabolites in humans : global sensivity analysis for experimental design issues. Chemico-Biological Interactions, Elsevier, 2007, 167 (3), pp.168-183. ⟨10.1016/j.cbi.2007.02.010⟩. ⟨ineris-00963065⟩
  • Michel Bouvier d'yvoire, Pilar Prieto, Bas J. Blaauboer, Frédéric y. Bois, Alan Boobis, et al.. Physiologically-based kinetic modelling (PBK modelling) : meeting the 3Rs agenda. ATLA - Alternatives to Laboratory Animals, 2007, 35 (6), pp.661-671. ⟨ineris-00963095⟩
  • Céline Brochot, Sandrine Micallef, Frédéric y. Bois. La modélisation physiologique en toxicologie. Rapport Scientifique INERIS, 2007, 2006-2007, pp.30-33. ⟨ineris-01869082⟩
  • Céline Brochot, Bertrand Bessoud, Daniel Balvay, Charles-André Cuénod, Nathalie Siauve, et al.. Evaluation of antiangiogenic treatment effects on tumors' microcirculation by Bayesian physiological pharmacokinetic modeling and magnetic resonance imaging.. Magnetic Resonance Imaging, Elsevier, 2006, 24 (8), pp.1059-67. ⟨10.1016/j.mri.2006.04.002⟩. ⟨inserm-00140800⟩
  • Céline Brochot, Frédéric y. Bois. Use of a chemical probe to increase safety for human volunteers in toxicokinetic studies. Risk Analysis, Wiley, 2005, 25 (6), pp.1559-1571. ⟨10.1111/j.1539-6925.2005.00682.x⟩. ⟨ineris-00962971⟩
  • Frédéric y. Bois, Céline Brochot, Cheikh Diak, Sandrine Micallef. Modélisation des risques et décisions sanitaires. Rapport Scientifique INERIS, 2005, 2004-2005, pp.36-37. ⟨ineris-01868975⟩
  • Céline Brochot, Janos Toth, Frédéric y. Bois. Lumping in pharmacokinetics. Journal of Pharmacokinetics and Pharmacodynamics, Springer Verlag, 2005, 32 (5-6), pp.719-736. ⟨10.1007/s10928-005-0054-y⟩. ⟨ineris-00962970⟩
  • Sandrine Micallef, Céline Brochot, Frédéric y. Bois. L'analyse statistique bayésienne de données toxicocinétiques. Environnement, Risques and Santé, John Libbey Eurotext, 2005, 4 (1), pp.21-34. ⟨ineris-00961895⟩
  • Céline Brochot, S. Marchand, William Couet, Andrew Gelman, Frédéric y. Bois. Extension of the isobolographic approach to interactions studies between more than two drugs : illustration with the convulsant interaction between pefloxacin, norfloxacin and theophylline in rats. Journal of Pharmaceutical Sciences, Wiley, 2004, 93 (3), pp.553-562. ⟨10.1002/jps.10574⟩. ⟨ineris-00962878⟩

Conference papers72 documents

  • Céline Brochot. Évaluer les expositions cumulées aux pyréthrinoïdes des populations par la modélisation toxicocinétique. 11. Congrès national santé et environnement "Multi-expositions, conditions de vie et santé : de la connaissance à l'action" (SFSE), Nov 2020, En ligne, France. ⟨ineris-03236302⟩
  • D.A. Sarigiannis, Spryros Karakitsios, A. Gotti, V. Kumar, Michel Schuhmacher, et al.. Risk assessment of EDCs in Europe based on human biomonitoring data. 55. Congress of the European Societies of Toxicology (EUROTOX 2019), Sep 2019, Helsinki, Finland. pp.S295. ⟨ineris-03237279⟩
  • Marc Codaccioni, Céline Brochot. Development and evaluation of a pregnancy Physiologically Based Toxicokinetic (pPBTK) model for high-throughput application. Joint Meeting of the International Society of Exposure Science and the International Society of Indoor Air Quality and Climate (ISES-ISIAQ 2019), Aug 2019, Kaunas, Lithuania. ⟨ineris-03237244⟩
  • Céline Brochot, Maribel Casas, Catherine Thomsen, Cyntia Manzano-Salgado, Florence Anna Zeman, et al.. Development of new indicators of exposure for risk assessment. 3. International Conference on Food Contaminants "Challenges on risk assessment" (ICFC 2019), Sep 2019, Aveiro, Portugal. pp.14. ⟨ineris-03237772⟩
  • Florence Anna Zeman, Cléo Tebby, Maribel Casas, Amrit K. Sakhi, Berit Granum, et al.. Exposure assessment for pregnant women to a non persistant chemical based on human biomonitoring data by reverse dosimetry modelling. 11. International Symposium on Biological Monitoring in Occupational and Environmental Health (ISBM 11), Aug 2019, Louvain, Belgium. ⟨ineris-03237777⟩
  • Ségolène Simeon, Julien Caudeville, Cléo Tebby, Céline Brochot. A spatial analysis approach combining multi-media and human models to map the lead exposure of children in a French region. Rencontres nationales santé environnement 2019, Jan 2019, Bordeaux, France. ⟨ineris-03229544⟩
  • Céline Brochot, Cléo Tebby, Paul Quindroit. PBPK modelling for assessing the exposure to chemical mixtures. 3. International Akademie Fresenius MIXTOX Conference "Toxicity of Chemical Mixtures: Risk, Hazard and Exposure Assessment", Oct 2019, Cologne, Germany. ⟨ineris-03237257⟩
  • Corentin Regrain, Florence Anna Zeman, Mohammed Guedda, Céline Brochot, Roseline Bonnard, et al.. Caractérisation de l’exposition environnementale spatialisée aux pyréthrinoïdes en Picardie. Rencontres nationales santé environnement 2019, Jan 2019, Bordeaux, France. ⟨ineris-03229545⟩
  • Corentin Regrain, Florence Anna Zeman, Mohammed Guedda, Céline Brochot, Roseline Bonnard, et al.. Caractérisation de l’exposition environnementale spatialisée aux pyréthrinoïdes en Picardie. Colloque INRA "Agriculture et qualité de l'air", Mar 2019, Paris, France. ⟨ineris-03229547⟩
  • Corentin Regrain, Florence Anna Zeman, Mohammed Guedda, Céline Brochot, Roseline Bonnard, et al.. Caractérisation des inégalités d'exposition au chlorpyrifos en Picardie. 10. Congrès national santé et environnement "Les inégalités socio-environnementales de santé : Pour une approche interdisciplinaire" (SFSE), Nov 2019, Paris, France. ⟨ineris-03229565⟩
  • Julien Caudeville, Sarah Habran, Corentin Regrain, Roseline Bonnard, Florence Anna Zeman, et al.. The territorialized exposome concept to characterize cumulative risk at the population level. Joint Annual Meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology (ISES-ISEE 2018), Aug 2018, Ottawa, Canada. ⟨ineris-03229533⟩
  • Marc Codaccioni, Céline Brochot. Development of a pregnancy-physiologically based toxicokinetic (p-PBTK) model for high-throughput screening of chemicals. Journées du Groupe de Métabolisme et Pharmacocinétique (GMP 2018), Oct 2018, Paris, France. ⟨ineris-03239301⟩
  • Sandrine Fraize-Frontier, Isabelle Albert, Soraya Boudia, Nathalie Bonvallot, Amélie Crepet, et al.. A general framework to deal with uncertainty in expert panel risk assessment. Joint Annual Meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology (ISES-ISEE 2018), Aug 2018, Ottawa, Canada. ⟨ineris-03239722⟩
  • Florence Zeman, Maribel Casas, Amrit K. Sakhi, Berit Granum, Cyntia Manzano, et al.. Exposure assessment of pregnant women to Di(2-ethylhexyl) phthalate by reverse dosimetry : Variability in repeated spot sample. 1. European Exposure Science Strategy Workshop (ISES Europe 2018), Jun 2018, Dortmund, Germany. pp.58. ⟨ineris-01853365⟩
  • Cléo Tebby, Rémy Beaudouin, Audrey Grech, Céline Brochot. Application d'un modèle PBPK poisson à des mélanges binaires. Colloque de la Société Française d'Ecotoxicologie Fondamentale et Appliquée (SEFA), Jun 2018, Montpellier, France. pp.28. ⟨ineris-01853207⟩
  • Jean-Lou Dorne, Billy Amzal, Nadia Quignot, W. Wiecek, Camille Bechaux, et al.. Reconnecting exposure, toxicokinetics and toxicity in food safety : OpenFoodTox and TKplate for human health, animal health and ecological risk assessment. 54. Congress of the European Societies of Toxicology (EUROTOX 2018), Sep 2018, Bruxelles, Belgium. pp.S29, ⟨10.1016/j.toxlet.2018.06.1128⟩. ⟨ineris-03224935⟩
  • Cléo Tebby, Céline Brochot, Jean-Lou Dorne, Rémy Beaudouin. Application d'un modèle PBPK poisson à des mélanges binaires. Journée du GDR Ecotoxicologie Aquatique, Dec 2018, Antony, France. ⟨ineris-03225117⟩
  • Marie Vanacker, Paul Quindroit, Céline Brochot, Amélie Crepet. Aggregate and cumulative exposure to pyrethroids of French population. Joint Annual Meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology (ISES-ISEE 2018), Aug 2018, Ottawa, Canada. ⟨ineris-03239664⟩
  • Jean-Lou Dorne, Billy Amzal, Nadia Quignot, W. Wiecek, Camille Bechaux, et al.. Developing TK databases and tools to support food safety assessment. 54. Congress of the European Societies of Toxicology (EUROTOX 2018), Sep 2018, Bruxelles, Belgium. pp.S5, ⟨10.1016/j.toxlet.2018.06.023⟩. ⟨ineris-03224934⟩
  • Céline Brochot, Maribel Casas, Cathrine Thomsen, Cyntia Manzano, Florence Zeman, et al.. Estimating the early-life exposure to perfluorinated compounds using PBPK modeling and biomarker measurements. 1. European Exposure Science Strategy Workshop (ISES Europe 2018), Jun 2018, Dortmund, Germany. pp.52. ⟨ineris-01853366⟩
  • Maribel Casas, Xavier Basagana, Amrit K. Sakhi, Line S. Haug, Claire Philippat, et al.. Variability of the non‐persistent chemical exposome in pregnant women and school-age children. 6. PPTOX Conference, May 2018, Torshavn, Faroe Islands. ⟨ineris-01853203⟩
  • Cléo Tebby, Rémy Beaudouin, Audrey Grech, Céline Brochot. Application of a generic fish PBTK model for binary mixtures of chemicals. 28. SETAC Europe annual meeting, May 2018, Rome, Italy. ⟨ineris-01853358⟩
  • Céline Brochot, Maribel Casas, Catherine Thomsen, Cyntia Manzano, Florence Zeman, et al.. Estimating early-life exposure to two perfluorinated compounds (PFOS and PFOA) using PBPK modeling and biomarker measurements. HELIX Scientific Symposium 2017 "New Horizons for Early Life Exposome Research", Oct 2017, Barcelone, Spain. ⟨ineris-01853151⟩
  • Mirja van Holderbeke, Tine Fierens, Arnout Standaert, Christa Cornelis, Céline Brochot, et al.. Modelling Pb blood concentrations in pre-school children living in a residential setting using MERLIN-Expo. 27. SETAC Europe annual meeting, May 2017, Bruxelles, France. ⟨ineris-01863856⟩
  • Florence Zeman, Maribel Casas, Amrit K. Sakhi, Berit Granum, Cyntia Manzano, et al.. Exposure assessment of pregnant women to Di(2-ethylhexyl) phtalate by reverse dosimetry : variability in repeated spot sample. HELIX Scientific Symposium 2017 "New Horizons for Early Life Exposome Research", Oct 2017, Barcelone, Spain. ⟨ineris-01853551⟩
  • Tine Fierens, Philippe Ciffroy, Mirja van Holderbeke, Arnout Standaert, Christa Cornelis, et al.. Modelling Pb blood concentrations in pre-school children living in a residential setting using MERLIN-Expo. 27. SETAC Europe annual meeting, May 2017, Bruxelles, France. ⟨ineris-01853441⟩
  • Audrey Grech, Céline Brochot, Nadia Quignot, Jean-Lou Dorne, Frédéric y. Bois, et al.. Développement et application de modèles toxicocinétiques génériques chez le poisson : étude des facteurs de variabilité. Colloque de la Société Française d'Ecotoxicologie Fondamentale et Appliquée (SEFA), Jun 2017, Lille, France. pp.42. ⟨ineris-01853482⟩
  • Paul Quindroit, Céline Brochot. Development of a toxicokinetic modeling approach to estimate the cumulative exposure to pyrethroids. ISES 2017 Annual Meeting "Integrating exposure science across diverses communities", Oct 2017, Research Triangle Park, United States. pp.159. ⟨ineris-01853150⟩
  • Céline Brochot. L’évaluation des risques sanitaires en expertise institutionnelle : vers une formalisation de la prise en compte de l’incertitude. Congrès ADELF-SFSP "Sciences et acteurs en santé : articuler connaissances et pratiques", Oct 2017, Amiens, France. ⟨ineris-01853550⟩
  • Céline Brochot, Maribel Casas, Line S. Haug, Cyntia Manzano-Salgado, Florence Anna Zeman, et al.. Estimating the early-life exposure to two perfluorinated compounds (PFOS and PFOA) using PBPK modeling and biomarker measurements. ISES 2016 Annual Meeting, Oct 2016, Utrecht, Netherlands. pp.455. ⟨ineris-01854695⟩
  • Artur Radomyski, Elisa Giubilato, Andrea Critto, Philippe Ciffroy, Céline Brochot, et al.. Integration of environmental and human PBPK exposure models: application of MERLIN-Expo modelling tool to POPs exposure in Venice lagoon. 26. SETAC Europe annual meeting, May 2016, Nantes, France. ⟨ineris-01854185⟩
  • Ségolène Simeon, Julien Caudeville, Cléo Tebby, Céline Brochot. A spatial analysis approach combining multi-media and human models to map the lead exposure of children in a French region. ISES 2016 Annual Meeting, Oct 2016, Utrecht, Netherlands. pp.277. ⟨ineris-01854693⟩
  • Artur Radomyski, Elisa Giubilato, Andrea Critto, Philippe Ciffroy, Céline Brochot, et al.. Integration of environmental and human PBPK exposure models : application of MERLIN-Expo modelling tool to POPs exposure in Venice lagoon. ISES 2016 Annual Meeting, Oct 2016, Utrecht, Netherlands. pp.458. ⟨ineris-01854696⟩
  • Paul Quindroit, Céline Brochot. Development of a generic PBPK model for pyrethroids to assess the cumulative exposure of populations. ISES 2016 Annual Meeting, Oct 2016, Utrecht, Netherlands. pp.786. ⟨ineris-01854698⟩
  • Céline Brochot. L'exposome : panorama de nos expositions environnementales. Les rencontres santé environnement du SEM-EDF "Quand la santé rencontre l'environnement", Oct 2016, Paris, France. ⟨ineris-01853079⟩
  • Audrey Grech, Nadia Quignot, Céline Brochot, Jean-Lou Dorne, Frédéric y. Bois, et al.. Développement et application de modèles toxicocinétiques génériques chez le poisson pour l'évaluation du risque environnemental de substances chimiques. Colloque de la Société Française d'Ecotoxicologie Fondamentale et Appliquée (SEFA), Jun 2016, Reims, France. pp.54. ⟨ineris-01853048⟩
  • Audrey Grech, Nadia Quignot, Céline Brochot, J. Dorne, Frédéric y. Bois, et al.. Development and application of generic toxicokinetic models in fish to environmental risk assessment of chemicals. 26. SETAC Europe annual meeting, May 2016, Nantes, France. ⟨ineris-01854198⟩
  • Paul Quindroit, Céline Brochot. Development of a generic PBPK model for pyrethroids to assess the cumulative exposure of populations. 4. European doctoral college on environment and health (EDCEH 2016), Jun 2016, Rennes, France. ⟨ineris-01854258⟩
  • Doris Tan, Florence Anna Zeman, Maribel Casas, Amrit K. Sakhi, Berit Granum, et al.. Assessing the impact of a single biomarker measurement to reconstruct the exposure of pregnant women to Di(2-ethylhexyl) phthalate. ISES 2016 Annual Meeting, Oct 2016, Utrecht, Netherlands. pp.370. ⟨ineris-01854694⟩
  • Charles Hazlerigg, James Garratt, Philippe Ciffroy, Céline Brochot, Boris Alfonso, et al.. MERLIN-Expo : A new tool to evaluate the fate and effects of chemicals in the environment. Environmental Risk Workshop, Nov 2015, Roskilde, Denmark. ⟨ineris-01852996⟩
  • Céline Brochot, Enrico Mombelli. Remplacement : la place des méthodes in silico. Colloque OPAL-FRANCOPA "Place des méthodes de remplacement en expérimentation biologique", Nov 2015, Paris, France. ⟨ineris-01852998⟩
  • A. Radomyski, Elisa Giubilato, Andrea Critto, Philippe Ciffroy, Céline Brochot, et al.. Demonstration of the new modelling tool "MERLIN-Expo" : a case-study on environmental and human exposure to POPs in Venice lagoon. 25. SETAC Europe annual meeting, May 2015, Barcelone, Spain. pp.282. ⟨ineris-01852941⟩
  • Marianne Chopard-Lallier, Elisabeth Perdu, Emilien L. Jamin, Céline Brochot, Jean Pierre J. P. Cravedi. Disposition of benzo[c] fluorene in rats. 50. Congress of the European Societies of Toxicology (EUROTOX 2014), Sep 2014, Edinburgh, United Kingdom. pp.S249, ⟨10.1016/j.toxlet.2014.06.838⟩. ⟨ineris-01855592⟩
  • Michèle Bisson, Marie Thomas, Vincent Vaillant, Céline Brochot, Sandrine Andres. Consideration of neurologic effects in case of exceeding toxicological threshold value ?. 1. International congress "Global environmental contamination : challenges for the well-being of the human brain", Sep 2014, Luxembourg, Luxembourg. pp.86. ⟨ineris-01855633⟩
  • Rémy Beaudouin, James Devillers, Céline Brochot, François Brion, Alexandre R.R. Pery. A physiologically-based toxicokinetic model dor the zebrafish Danio rerio. International symposium & workshop "Fish and amphibian embryos as alternative models in toxicology and teratology", Dec 2014, Aulnay-sous-Bois, France. ⟨ineris-01852871⟩
  • Marie-Emilie Willemin, Ali Kadar, Georges de Sousa, Roger Rahmani, Céline Brochot. In vitro metabolism of permethrin and two metabolites by human primary hepatocytes. 50. Congress of the European Societies of Toxicology (EUROTOX 2014), Sep 2014, Edinburgh, United Kingdom. pp.S122, ⟨10.1016/j.toxlet.2014.06.438⟩. ⟨ineris-01855591⟩
  • Alexandre R.R. Pery, James Devillers, Céline Brochot, Enrico Mombelli, François Brion, et al.. A physiological-based toxicokinetics model for the zebrafish. 7. International Symposium on Computational Methods in Toxicology and Pharmacology Integrating Internet Resources, Oct 2013, Seoul, South Korea. ⟨ineris-00971255⟩
  • Marie-Emilie Willemin, Sophie Desmots, Rozenn Le Grand, Florence Anna Zeman, François Lestremau, et al.. Elaboration d'un modèle toxicocinétique de la cis et trans-perméthrine et de ses métabolites chez le rat. 5. journées internationales de toxicologie, Oct 2013, Liège, Belgium. ⟨ineris-00971203⟩
  • Claire Lopez, Mathilde Bayet-Robert, Marc-Emmanuel Dumas, Jean-Matthieu Prot, Alexandre R.R. Pery, et al.. Pharmaco-metabonomic investigation of acetaminophen toxicity on rat primary hepatocytes in microfluidic biochips. 7e Journées scientifiques du Réseau Français de Métabolomique et Fluxomique (RFMF), Jun 2013, Amiens, France. ⟨hal-00980023⟩
  • José-Manuel Zaldivar, Céline Brochot, Florence Anna Zeman, Juan G. Diaz, Joachim Bucher, et al.. In vivo to in vitro forcing (IVIVF) : the acetaminophen case study. 15. International Workshop on Quantitative Structure-Activity Relationships in Environmental and Health Sciences (QSAR 2012), Jun 2012, Tallinn, Estonia. ⟨ineris-00971006⟩
  • Alexandre R.R. Pery, Céline Brochot, Florence Anna Zeman, Elena Fioravanzo, M. Pavan, et al.. Calibration of PBPK models based on data from alternative methods. 15. International Workshop on Quantitative Structure-Activity Relationships in Environmental and Health Sciences (QSAR 2012), Jun 2012, Tallinn, Estonia. ⟨ineris-00971005⟩
  • Florence Anna Zeman, Céline Boudet, Adeline Floch-Barneaud, Karine Tack, Céline Brochot, et al.. Exposure assessment of phthalates in French pregnant women using reverse dosimetry and biomonitoring data from the Elfe pilot study. 7. International Conference on the Science of Exposure Assessment (X2012), Jul 2012, Edimbourg, United Kingdom. ⟨ineris-00971030⟩
  • Monika Gajewska, Alexandre R.R. Pery, Céline Brochot, Florence Anna Zeman, Juan G. Diaz, et al.. Multi-scale modelling in toxicology : how to bridge the gaps between scales ?. 2. Annual meeting - SEURAT-1 "Towards the replacement of in vivo repeated dose systemic toxicity testing", Feb 2012, Lisbonne, Portugal. ⟨ineris-00970934⟩
  • Marianne Chopard-Lallier, Daniel Zalko, Elisabeth Perdu, Anne Hillenweck, Florence Blas-y-Estrada, et al.. Preliminary data on the disposition of Benzo[c]fluorene in rat. 4. Health Food Symposium (SAS 2012), Jul 2012, Toulouse, France. ⟨ineris-00971113⟩
  • Maria Ulaszewska, Philippe Ciffroy, Fazia Tahraoui, Florence Anna Zeman, Ettore Capri, et al.. Reconstruction of the dynamic exposure to PCBs for Italian population using physiologically based pharmacokinetic (PBPK) model and a complex approach combining human biomonitoring studies and environmental data. 7. International Conference on the Science of Exposure Assessment (X2012), Jul 2012, Edimbourg, United Kingdom. ⟨ineris-00971031⟩
  • Rémy Beaudouin, François Brion, Alexandre R.R. Pery, Enrico Mombelli, Céline Brochot, et al.. Integrated modelling of endocrine disruption in zebrafish at different biological levels (MOZAIC). 1. European Conference on the Replacement, Reduction and Refinement of Animal Experiments in Ecotoxicology, Jun 2012, Dübendorf, Switzerland. ⟨ineris-00971018⟩
  • Taku Tanaka, Céline Brochot, Ettore Capri, N. Suciu, E. Johansson, et al.. Application of an integrated approach to evaluate health risks for toxic chemicals by linking multimedia environmental and PBPK models. 21. SETAC Europe annual meeting "Ecosystem protection in a sustainable world : a challenge for science and regulation", May 2011, Milan, Italy. ⟨ineris-00973612⟩
  • S. Maurau, Philippe Ciffroy, Céline Brochot, y. Roustan, L. Marang. Linking multimedia environmental and PBPK models to assess health risks of lead associated to drinking water - A case study. 21. SETAC Europe annual meeting "Ecosystem protection in a sustainable world : a challenge for science and regulation", May 2011, Milan, Italy. ⟨ineris-00970792⟩
  • E. Casimiro, Philippe Ciffroy, P. Serpa, E. Johansson, C. Legind, et al.. Environmental health risk assessment of ambient lead levels in Lisbon, Portugal : a full chain study approach. 47. European Congress of Toxicology (EUROTOX 2011), Aug 2011, Paris, France. ⟨ineris-00970857⟩
  • Alexandre R.R. Pery, Céline Brochot, M. Dumas, Magali Boize, Sophie Desmots, et al.. Apports des approches " omiques " pour modéliser la cinétique et les effets de xénobiotiques chez l'homme. Colloque ARET, Jun 2010, Paris, France. ⟨hal-00674296⟩
  • Alexandre R.R. Pery, Céline Brochot. Modélisation en toxicocinétique. Congrès de la SPTC. Sociétés de Pharmacologie-Toxicologie Cellulaire "Toxicologie Prédictive : les Voies du Futur", May 2010, Paris, France. ⟨ineris-00970624⟩
  • Céline Brochot, Cédric Vinson, Marylore Chenel, François Bouzom. DDI PBPK modeling in humans : bayesian estimation of key parameters. 6. International Symposium on Measurement and Kinetics of In Vivo Drug Effects, Apr 2010, Noordwijkerhout, Netherlands. ⟨ineris-00970584⟩
  • Florence Anna Zeman, Céline Boudet, Karine Tack, Adeline Floch-Barneaud, Céline Brochot, et al.. Exposure assessment of phthalates in French pregnant women : Results of ELFE pilot study. Conference "From human biomonitoring to policy : a sustainable marriage between health and environment", Oct 2010, Bruxelles, Belgium. ⟨ineris-00970686⟩
  • Céline Brochot, Taku Tanaka, E. Johansson, Rémy Beaudouin, Florence Anna Zeman, et al.. Integrating multimedia environmental models and effects models on a common platform for risk assessment. 12. International Congress of Toxicology (IUTOX 2010), Jul 2010, Barcelone, Spain. ⟨ineris-00970649⟩
  • Dany Habka, Alexandre R.R. Pery, C. Aninat, A. Corlu, C. Guguen-Guillouzo, et al.. Calibration of PBPK models based on in vivo and in vitro data to describe complex biotransformation processes. 12. International Congress of Toxicology (IUTOX 2010), Jul 2010, Barcelone, Spain. ⟨ineris-00970650⟩
  • L. Choucha Snouber, Laurent Griscom, Pe Poleni, Florence Razan, Céline Brochot, et al.. liver-kidney microfluidic bioreactor for cell co-culture in drug studies. MICROTAS, Oct 2010, GRONINGEN, Netherlands. pp.0328. ⟨hal-00756580⟩
  • Céline Brochot, Alexandre R.R. Pery. Physiological modeling in toxicology. Physiologically based toxicokinetic models. 1. European Doctoral College on Environment and Health (EDCEH), Jun 2010, Rennes, France. ⟨ineris-00970642⟩
  • Maria Ulaszewska, Rémy Beaudouin, Florence Anna Zeman, Ettore Capri, Céline Brochot. Bayesian analysis of a PBPK model to reconstruct the exposure of Italian women to PCB-153 via breast milk concentrations. Conference "From human biomonitoring to policy : a sustainable marriage between health and environment", Oct 2010, Bruxelles, Belgium. ⟨ineris-00970687⟩
  • Djomangan Adama Ouattara, S. Choi, y. Sakai, Céline Brochot. Determination of absorption and biotransformation of benzo[a]pyrene in a perfusion co-culture system for physiologically based pharmacokinetics models. 12. International Congress of Toxicology (IUTOX 2010), Jul 2010, Barcelone, Spain. ⟨ineris-00970651⟩
  • Alexandre R.R. Pery, Rémy Beaudouin, Céline Brochot, E. Fabian, R. Landsiedel, et al.. PBPK models to assess nanoparticles kinetics and distribution in human and rats. International Conference on Safe Production and Use of Nanomaterials (NANOSAFE 2008), Nov 2008, Grenoble, France. ⟨ineris-00970406⟩
  • Alexandre R.R. Pery, Magali Boize, Céline Brochot. Utilisation de modèles mécanistiques de cinétique et d'effets pour l'évaluation du risque lié à l'exposition aux faibles doses. Colloque ARET 2008 "Exposition aux faibles doses : un défi pour l'évaluation et la gestion des risques pour l'homme et l'environnement", Jun 2008, Paris, France. ⟨ineris-00973302⟩
  • Céline Brochot, Frédéric y. Bois. Increasing safety of toxicokinetic studies for human volunteers through the use of tracers. Conference on exposure assessment in a changing environment, Jun 2004, Utrecht, Netherlands. ⟨ineris-00969920⟩

Book sections5 documents

  • Florence Zeman, Céline Brochot. Evaluation de l'exposition à partir de données d'imprégnation. CAMEL, Valérie; RIVIERE, Gilles; LE BIZEC, Bruno. Risques chimiques liés aux aliments : Principes et applications, Lavoisier, pp.51-64, 2018. ⟨ineris-03319538⟩
  • Céline Brochot, Paul Quindroit. Modelling the fate of chemicals in humans using a lifetime physiologically based pharmacokinetic (PBPK) model in MERLIN-expo. CIFFROY, Philippe; TEDIOSI, Alice; CAPRI, Ettore. Modelling the Fate of Chemicals in the Environment and the Human Body, 57, Springer, pp.215-257, 2018, The Handbook of Environmental Chemistry, 9783319595009. ⟨10.1007/978-3-319-59502-3_10⟩. ⟨ineris-01853113⟩
  • Paul Quindroit, Frédéric y. Bois, Céline Brochot. Exposome. Year book Santé et Environnement, John Libbey Eurotext Ltd., pp.201-204, 2016. ⟨ineris-01854742⟩
  • Frédéric y. Bois, Céline Brochot. Modeling Pharmacokinetics. BENFENATI, Emilio. In Silico Methods for Predicting Drug Toxicity, 1425, Springer, pp.37-62, 2016, Methods in Molecular Biology, 9781493936076. ⟨10.1007/978-1-4939-3609-0_3⟩. ⟨ineris-01854228⟩
  • José M. Zaldivar Comenges, Alexandre R.R. Pery, Céline Brochot, Bas J. Blaauboer. Biokinetics Working Group : In vitro to in vivo extrapolation. GOCHT, Tilman ; SCHWARZ, Michael. The consolidation of the research strategy : Towards the replacement of in vivo repeated dose systemic toxicity testing, Volume 2, Coach Consortium. Paris, pp.290-296, 2012, SEURAT-1. ⟨ineris-00969454⟩

Reports2 documents

  • David Makowski, Isabelle Albert, Nathalie Bonvallot, Soraya Boudia, Céline Brochot, et al.. Prise en compte de l’incertitude en évaluation des risques : revue de la littérature et recommandations pour l’Anses.. [Autre] Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail. 2016, 90 p. ⟨hal-01617680⟩
  • David Makowski, Isabelle Albert, Nathalie Bonvallot, Soraya Boudia, Céline Brochot, et al.. Évaluation du poids des preuves à l’Anses : revue critique de la littérature et recommandations à l’étape d’identification des dangers. [Autre] 2015-SA-0089, 2016, 116 p. ⟨hal-01617668⟩

Theses1 document

  • Céline Brochot. Paramétrisation des modèles physiologiques toxico/pharmacocinétiques. Sciences du Vivant [q-bio]. Université Pierre et Marie Curie - Paris VI, 2004. Français. ⟨tel-00107374⟩