Recherche - Archive ouverte HAL Accéder directement au contenu

Filtrer vos résultats

20 résultats
Page :
triés par
Image document

Therapeutic modulators of the serotonin 5-HT4 receptor: a patent review (2014-present)

 Caroline Lanthier , Patrick Dallemagne , Cédric Lecoutey , Sylvie Claeysen , Cédric Lecoutey
Expert Opinion on Therapeutic Patents, 2020, ⟨10.1080/13543776.2020.1767587⟩
Article dans une revue hal-02863879v1

Design, synthesis and biological evaluation of novel indano- and thiaindano-pyrazoles with potential interest for Alzheimer's disease.

 David Genest , Christophe Rochais , Cédric Lecoutey , Jana Sopkova-de Oliveira Santos , Céline Ballandonne , et al.
MedChemComm, 2013, 4, pp.925-931
Article dans une revue hal-00840942v1

Development of a nasal drug delivery composite nanosystem for Alzheimer’s desease treatment

 Adnet Thomas , Anne-Claire Groo , Loïc Le Pluart , Celine Picard , A. Davis , et al.
Journée normande de recherche biomédicale, Nov 2017, caen, France
Poster de conférence hal-02295929v1
Image document

Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT6 receptor antagonist with therapeutic interest in Alzheimer’s disease

 François-Xavier Toublet , Julien Lalut , Bérénice Hatat , Cédric Lecoutey , Audrey Davis , et al.
European Journal of Medicinal Chemistry, 2021, 210, pp.113059. ⟨10.1016/j.ejmech.2020.113059⟩
Article dans une revue hal-03082877v1
Image document

Rational design of novel benzisoxazole derivatives with acetylcholinesterase inhibitory and serotoninergic 5-HT4 receptors activities for the treatment of Alzheimer’s disease

 Julien Lalut , Hugo Payan , Audrey Davis , Cédric Lecoutey , Rémi Legay , et al.
Scientific Reports, 2020, 10, pp.3014. ⟨10.1038/s41598-020-59805-7⟩
Article dans une revue hal-02485740v1
Image document

Novel Multitarget-Directed Ligands (MTDLs) with Acetylcholinesterase (AChE) Inhibitory and Serotonergic Subtype 4 Receptor (5-HT 4 R) Agonist Activities As Potential Agents against Alzheimer’s Disease: The Design of Donecopride

 Cédric Lecoutey , Cédric Lecoutey , Florence Gaven , Patrizia Giannoni , Katia Hamidouche , et al.
Journal of Medicinal Chemistry, 2015, 58 (7), pp.3172-3187. ⟨10.1021/acs.jmedchem.5b00115⟩
Article dans une revue hal-02043873v1
Image document

Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment

 Cédric Lecoutey , Damien Hedou , Thomas Freret , Patrizia Giannoni , Florence Gaven , et al.
Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (36), pp.E3825--30. ⟨10.1073/pnas.1410315111⟩
Article dans une revue hal-01800439v2

Benzylphenylpyrrolizinones with Anti-amyloid and Radical Scavenging Effects, Potentially Useful in Alzheimer's Disease Treatment

 Jean-Pierre Jourdan , Marc Since , Laïla El kihel , Cédric Lecoutey , Sophie Corvaisier , et al.
ChemMedChem, 2017, 12 (12), pp.913-916. ⟨10.1002/cmdc.201700102⟩
Article dans une revue hal-02043731v1

Efficient Room-Temperature One-Pot Synthesis of 2-Amino-3-alkyl(3-aryl)quinazolin-4(3H)-ones

 Cédric Lecoutey , Christine Fossey , Sylvain Rault , Frédéric Fabis
European Journal of Organic Chemistry, 2011, 2011 (15), pp.2785-2788
Article dans une revue hal-02018181v1
Image document

A Novel in vivo Anti-amnesic Agent, Specially Designed to Express Both Acetylcholinesterase (AChE) Inhibitory, Serotonergic Subtype 4 Receptor (5-HT4R) Agonist and Serotonergic Subtype 6 Receptor (5-HT6R) Inverse Agonist Activities, With a Potential Interest Against Alzheimer’s Disease

 Bérénice Hatat , Samir Yahiaoui , Cédric Lecoutey , Audrey Davis , Thomas Freret , et al.
Frontiers in Aging Neuroscience, 2019, 11, pp.148. ⟨10.3389/fnagi.2019.00148⟩
Article dans une revue hal-02399864v1
Image document

Donecopride, a Swiss army knife with potential interest against Alzheimer's disease

 Christophe Rochais , Cédric Lecoutey , Katia Hamidouche , Patrizia Giannoni , Florence Gaven , et al.
British Journal of Pharmacology, In press, 177 (9), pp.1988-2005. ⟨10.1111/bph.14964⟩
Article dans une revue hal-02428730v1
Image document

Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer’s Disease

 François-Xavier Toublet , Cédric Lecoutey , Julien Lalut , Bérénice Hatat , Audrey Davis , et al.
Molecules, 2019, 24 (15), pp.2786. ⟨10.3390/molecules24152786⟩
Article dans une revue hal-02399906v1
Image document

Phenanthrolinic analogs of quinolones show antibacterial activity against M. tuberculosis

 Songuigama Coulibaly , Mena Cimino , Mahama Ouattara , Cédric Lecoutey , Maria V Buchieri , et al.
European Journal of Medicinal Chemistry, 2020, 207, pp.112821. ⟨10.1016/j.ejmech.2020.112821⟩
Article dans une revue pasteur-03261309v1

Novel multitarget-directed ligands targeting acetylcholinesterase and σ1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase

 Julien Lalut , Gianluca Santoni , Delphine Karila , Cédric Lecoutey , Audrey Davis , et al.
European Journal of Medicinal Chemistry, 2019, 162, pp.234-248. ⟨10.1016/j.ejmech.2018.10.064⟩
Article dans une revue hal-01994096v1

Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment

 Jean-Pierre Jourdan , Marc Since , Laïla El Kihel , Cédric Lecoutey , Sophie Corvaisier , et al.
European Journal of Medicinal Chemistry, 2016, 114, pp.365-379. ⟨10.1016/j.ejmech.2016.03.023⟩
Article dans une revue hal-02043765v1

Synthesis of dual AChE/5-HT4 receptor multi-target directed ligands.

 Cédric Lecoutey , Christophe Rochais , David Genest , Sabrina Butt-Gueulle , Céline Ballandonne , et al.
MedChemComm, 2012, 3, pp.627-634
Article dans une revue hal-00764795v1

Acetylcholinesterase Inhibitor Compounds and 5ht4 Serotonergic Receptor Agonists, with Promnesia Effect, Methods for the Preparation Thereof and Pharmaceutical Compositions Containing Same

 Patrick Dallemagne , Christophe Rochais , Cédric Lecoutey , Michel Boulouard , Thomas Freret
France, Patent n° : WO2014195593 (A2). 2014
Brevet hal-02042939v1
Image document

Novel multi target-directed ligands targeting 5-HT4 receptors with in cellulo antioxidant properties as promising leads in Alzheimer's disease

 Caroline Lanthier , Hugo Payan , Irene Liparulo , Bérénice Hatat , Cédric Lecoutey , et al.
European Journal of Medicinal Chemistry, 2019, 182, pp.111596. ⟨10.1016/j.ejmech.2019.111596⟩
Article dans une revue hal-02399942v1

Synthesis and evaluation of novel serotonin 4 receptor radiotracers for single photon emission computed tomography

 Julien Lalut , Benjamin B. Tournier , Thomas Cailly , Cédric Lecoutey , Sophie Corvaisier , et al.
European Journal of Medicinal Chemistry, 2016, 116, pp.90-101. ⟨10.1016/j.ejmech.2016.03.059⟩
Article dans une revue hal-02011098v1

Impact of T161, Y318 and S363 alanine mutations on regulation of the human delta-opioid receptor (hDOPr) induced by peptidic and alkaloid agonists

 Elise Camacho , Nicolas Marie , Quentin Dupas , Caroline Martel , Marie Nowoczyn , et al.
Neuropharmacology, In press, 179, ⟨10.1016/j.neuropharm.2020.108286⟩
Article dans une revue hal-03021820v1
Page :