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Cedric Le May

DR2 CNRS
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Domaines de recherche

Physiologie [q-bio.TO] Endocrinologie et métabolisme

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Publications

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Generation of an induced pluripotent stem cell line (ITXi012-A) from a patient with genetically determined high-lipoprotein(a) plasma levels

Amandine Caillaud , Lise Bray , Aurore Girardeau , Zoé Begué-Racapé , Lucie Vince
Stem Cell Research, 2023, 72, ⟨10.1016/j.scr.2023.103205⟩
Article dans une revue hal-04212298v1

LDL lowering effect of PCSK9 inhibition is reduced in women

Veronika Myasoedova , Antoine Rimbert , Marina Camera , Cedric Le May , Romain Capoulade
European Heart Journal - Cardiovascular Pharmacotherapy, 2023, 9 (4), pp.337-342. ⟨10.1093/ehjcvp/pvad009⟩
Article dans une revue hal-04212334v1
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Identification of a Gain-of-Function LIPC Variant as a Novel Cause of Familial Combined Hypocholesterolemia

Wieneke Dijk , Mathilde Di-Filippo Charcosset , Sander Kooijman , Robin Van Eenige , Antoine Rimbert
Circulation, 2022, 146 (10), pp.724-739. ⟨10.1161/circulationaha.121.057978⟩
Article dans une revue inserm-03831077v1

Generation of a GPR146 knockout human induced pluripotent stem cell line (ITXi001-A-1)

Lise Bray , Amandine Caillaud , Aurore Girardeau , Murielle Patitucci , Cédric Le May
Stem Cell Research, 2022, 60, pp.102721. ⟨10.1016/j.scr.2022.102721⟩
Article dans une revue hal-03869113v1
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PCSK9 deficiency results in a specific shedding of excess LDLR in female mice only: Role of hepatic cholesterol

Anna Roubtsova , Damien Garçon , Sandrine Lacoste , Ann Chamberland , Jadwiga Marcinkiewicz
Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, 2022, 1867 (12), pp.159217. ⟨10.1016/j.bbalip.2022.159217⟩
Article dans une revue hal-03869056v1

Taste-Driven Responsiveness to Fat and Sweet Stimuli in Mouse Models of Bariatric Surgery

Aurélie Dastugue , Cédric Le May , Séverine Ledoux , Cindy Le Bourgot , Pascaline Delaby
Biomedicines, 2022, Special Issue Animal Models of Human Pathology: Revision, Relevance and Refinements, 10 (4), pp.741. ⟨10.3390/biomedicines10040741⟩
Article dans une revue hal-03869074v1

Plasma apolipoprotein concentrations and incident diabetes in subjects with prediabetes

Mikaël Croyal , Matthieu Wargny , Kevin Chemello , Chloé Chevalier , Valentin Blanchard
Cardiovascular Diabetology, 2022, 21 (1), pp.21. ⟨10.1186/s12933-022-01452-5⟩
Article dans une revue hal-03869138v1
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Seipin localizes at endoplasmic-reticulum-mitochondria contact sites to control mitochondrial calcium import and metabolism in adipocytes

Yoann Combot , Veijo T. Salo , Gilliane Chadeuf , Maarit Hölttä , Katharina Ven
Cell Reports, 2022, 38 (2), pp.110213. ⟨10.1016/j.celrep.2021.110213⟩
Article dans une revue hal-03534214v1

Nutritional biomarkers and heart failure requiring hospitalization in patients with type 2 diabetes: the SURDIAGENE cohort

Matthieu Wargny , Mikaël Croyal , Stéphanie Ragot , Elise Gand , David Jacobi
Cardiovascular Diabetology, 2022, 21 (1), pp.101. ⟨10.1186/s12933-022-01505-9⟩
Article dans une revue hal-03869068v1
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Effect of Parathyroidectomy on Metabolic Homeostasis in Primary Hyperparathyroidism

Samuel Frey , Raphaël Bourgade , Cédric Le May , Mikaël Croyal , Edith Bigot-Corbel
Journal of Clinical Medicine, 2022, 11, ⟨10.3390/jcm11051373⟩
Article dans une revue hal-03869109v1

Transintestinal cholesterol excretion in health and disease

Damien Garçon , Jean-Matthieu Berger , Bertrand Cariou , Cédric Le May
Current Atherosclerosis Reports, 2022, 24 (3), pp.153-160. ⟨10.1007/s11883-022-00995-y⟩
Article dans une revue hal-03869126v1
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Orosensory perception of fat/sweet stimuli and appetite-regulating peptides before and after sleeve gastrectomy or gastric by-pass in adult women with obesity

Arnaud Bernard , Johanne Le Beyec-Le Bihan , Loredana Radoi , Muriel Coupaye , Ouidad Sami
Nutrients, 2021, 13 (3), pp.878. ⟨10.3390/nu13030878⟩
Article dans une revue hal-03170655v1

The Complex ABCG5/ABCG8 Regulates Vitamin D Absorption Rate and Contributes to its Efflux from the Intestine

Tiffany Antoine , Cedric Le May , Marielle Margier , Charlotte Halimi , Marion Nowicki
Molecular Nutrition and Food Research, 2021, 65 (21), pp.2100617. ⟨10.1002/mnfr.202100617⟩
Article dans une revue hal-03451191v1
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The Tryptophan/Kynurenine Pathway: A Novel Cross-Talk between Nutritional Obesity, Bariatric Surgery and Taste of Fat

Arnaud Bernard , Cédric Le May , Aurélie Dastugue , Audrey Ayer , Claire Blanchard
Nutrients, 2021, 13 (4), pp.1366. ⟨10.3390/nu13041366⟩
Article dans une revue hal-03328777v1

PCSK9 is not secreted from mature differentiated intestinal cells

François Moreau , Aurélie Thédrez , Damien Garçon , Audrey Ayer , Thibaud Sotin
Journal of Lipid Research, 2021, 62, pp.100096. ⟨10.1016/j.jlr.2021.100096⟩
Article dans une revue hal-03350100v1
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Routine use of statins and increased COVID-19 related mortality in inpatients with type 2 diabetes: Results from the CORONADO study

Bertrand Cariou , Thomas Goronflot , Antoine Rimbert , Sandrine Boullu , Cedric Le May
Journal of Diabetes & Metabolism, 2021, 47 (2), pp.101202. ⟨10.1016/j.diabet.2020.10.001⟩
Article dans une revue hal-03100948v1
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PCSK9 regulates the NODAL signaling pathway and cellular proliferation in hiPSCs

Meryl Roudaut , Salam Idriss , Amandine Caillaud , Aurore Girardeau , Antoine Rimbert
Stem Cell Reports, 2021, ⟨10.1016/j.stemcr.2021.10.004⟩
Article dans une revue hal-03451184v1
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Circulating PCSK9 levels are not associated with the conversion to type 2 diabetes

Stéphane Ramin-Mangata , Matthieu Wargny , Matthieu Pichelin , Cedric Le May , Aurélie Thédrez
Atherosclerosis, 2020, 293, pp.49-56. ⟨10.1016/j.atherosclerosis.2019.11.027⟩
Article dans une revue hal-03013257v1
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VLDL (Very-Low-Density Lipoprotein)-Apo E (Apolipoprotein E) May Influence Lp(a) (Lipoprotein [a]) Synthesis or Assembly

Mikaël Croyal , Valentin Blanchard , Khadija Ouguerram , Maud Chétiveaux , Léa Cabioch
Arteriosclerosis, Thrombosis, and Vascular Biology, 2020, 40 (3), pp.819-829. ⟨10.1161/ATVBAHA.119.313877⟩
Article dans une revue hal-03098122v1
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Circulating Rather Than Intestinal PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) Regulates Postprandial Lipemia in Mice

Damien Garçon , François Moreau , Audrey Ayer , Wieneke Dijk , Xavier Prieur
Arteriosclerosis, Thrombosis, and Vascular Biology, 2020, 40 (9), pp.2084-2094. ⟨10.1161/ATVBAHA.120.314194⟩
Article dans une revue hal-03012708v1
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Roux-en-Y gastric bypass, but not sleeve gastrectomy, decreases plasma PCSK9 levels in morbidly obese patients

C. Blanchard , S. Ledoux , A. Verhaegen , M. Wargny , E. Letessier
Journal of Diabetes & Metabolism, 2020, 46 (6), pp.480-487. ⟨10.1016/j.diabet.2020.01.003⟩
Article dans une revue hal-03013255v1
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Genetic Inhibition of PCSK9 and Liver Function

Antoine Rimbert , Sarra Smati , Wieneke Dijk , Cedric Le May , Bertrand Cariou
JAMA Cardiology, 2020, ⟨10.1001/jamacardio.2020.5341⟩
Article dans une revue hal-03100949v1

Circulating PCSK9 levels are not associated with the conversion to type 2 diabetes

Stéphane Ramin-Mangata , Matthieu Wargny , Matthieu Pichelin , Cédric Le May , Aurélie Thédrez
Atherosclerosis, 2020, 293, pp.49-56. ⟨10.1016/j.atherosclerosis.2019.11.027⟩
Article dans une revue hal-04465329v1

P-glycoprotein (ABCB1) is involved in vitamin K efflux

Marielle Margier , Cedric Le May , Tiffany Antoine , Charlotte Halimi , Marion Nowicki
Food Chemistry, 2020, 343, pp.1-5. ⟨10.1016/j.foodchem.2020.128510⟩
Article dans une revue hal-03012693v1
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A high-throughput mass spectrometry-based assay for large-scale profiling of circulating human apolipoproteins

Valentin Blanchard , Damien Garçon , Catherine Jaunet , Kevin Chemello , Stéphanie Billon-Crossouard
Journal of Lipid Research, 2020, 61 (7), pp.1128-1139. ⟨10.1194/jlr.D120000835⟩
Article dans une revue hal-03098131v1

Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice

Audrey Ayer , Frederic Borel , Francois Moreau , Xavier Prieur , Michel Neunlist
Journal of visualized experiments : JoVE, 2017, Equipe IV, 121, ⟨10.3791/54905⟩
Article dans une revue hal-01832948v1
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Impact of protease inhibitors on circulating PCSK9 levels in HIV-infected antiretroviral-naive patients from an ongoing prospective cohort

Franck Boccara , Mathilde Ghislain , Laurence Meyer , Cecile Goujard , Cedric Le May
AIDS. Official journal of the international AIDS Society, 2017, Equipe IV, 31 (17), pp.2367--2376. ⟨10.1097/QAD.0000000000001633⟩
Article dans une revue hal-01832935v1

The Role of Estrogens in Pancreatic Islet Physiopathology

Franck Mauvais-Jarvis , Cedric Le May , Joseph P. Tiano , Suhuan Liu , Gamze Kilic-Berkmen
Advances in Experimental Medicine and Biology, 2017, Equipe IV, 1043, pp.385--399. ⟨10.1007/978-3-319-70178-3_18⟩
Article dans une revue hal-01833109v1
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PPARγ Modulates Long Chain Fatty Acid Processing in the Intestinal Epithelium

Kalina Duszka , Matej Oresic , Cedric Le May , Jürgen König , Walter Wahli
International Journal of Molecular Sciences, 2017, Equipe IV, 18 (12), ⟨10.3390/ijms18122559⟩
Article dans une revue hal-01832934v1

Retrograde cholesterol transport in the human Caco-2/TC7 cell line: a model to study trans-intestinal cholesterol excretion in atherogenic and diabetic dyslipidemia

Camille Dugardin , Olivier Briand , Véronique Touche , Marleen Schonewille , François Moreau
Acta Diabetologica, 2017, 54 (2), pp.191-199. ⟨10.1007/s00592-016-0936-z⟩
Article dans une revue hal-03013305v1

Impact of Sleeve Gastrectomy on Intestinal Permeability in Diet-Induced Obese Mice

Claire Blanchard , Audrey Ayer , Julien Chevalier , François Moreau , Jean-Paul Pais de Barros
Surgery for Obesity and Related Diseases, 2016, 12 (7), pp.S10 - S11. ⟨10.1016/j.soard.2016.08.043⟩
Article dans une revue hal-01503082v1

FGF21 Improves the Adipocyte Dysfunction Related to Seipin Deficiency

Lucile Dollet , Clara Levrel , Tamer Coskun , Soazig Le Lay , Cedric Le May
Diabetes, 2016, Equipe 5, 65 (11), pp.3410--3417. ⟨10.2337/db16-0327⟩
Article dans une revue hal-01831750v1

L’excrétion trans -intestinale de cholestérol (TICE)

Claire Blanchard , François Moreau , Bertrand Cariou , Cedric Le May
Médecine/Sciences, 2014, 30 (10), pp.896-901. ⟨10.1051/medsci/20143010017⟩
Article dans une revue hal-03013320v1

Preserved adrenal function in fully PCSK9-deficient subject

Bertrand Cariou , Isabelle Benoit , Cedric Le May
International Journal of Cardiology, 2014, 176 (2), pp.499-500. ⟨10.1016/j.ijcard.2014.07.057⟩
Article dans une revue hal-03013322v1

Congenital Lipodystrophies and Dyslipidemias

Xavier Prieur , Cedric Le May , Jocelyne Magré , Bertrand Cariou
Current Atherosclerosis Reports, 2014, 16 (9), ⟨10.1007/s11883-014-0437-x⟩
Article dans une revue hal-03013323v1

Transintestinal Cholesterol Excretion Is an Active Metabolic Process Modulated by PCSK9 and Statin Involving ABCB1

Cedric Le May , Jean Mathieu Berger , Anne Lespine , Bruno Pillot , Xavier Prieur
Arteriosclerosis, Thrombosis, and Vascular Biology, 2013, 33 (7), pp.1484-1493. ⟨10.1161/ATVBAHA.112.300263⟩
Article dans une revue hal-03013326v1
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Plasma PCSK9 concentrations during an oral fat load and after short term high-fat, high-fat high-protein and high-fructose diets.

Bertrand Cariou , Cédric Langhi , Maëlle Le Bras , Murielle Bortolotti , Kim-Anne Lê
Nutrition and Metabolism, 2013, 10 (1), pp.4. ⟨10.1186/1743-7075-10-4⟩
Article dans une revue inserm-00778104v1

Thiazolidinediones partially reverse the metabolic disturbances observed in Bscl2/seipin-deficient mice

X. Prieur , L. Dollet , M. Takahashi , M. Nemani , B. Pillot
Diabetologia, 2013, 56 (8), pp.1813-1825. ⟨10.1007/s00125-013-2926-9⟩
Article dans une revue hal-03013324v1

Transintestinal Cholesterol Excretion Is an Active Metabolic Process Modulated by PCSK9 and Statin Involving ABCB1

Cedric Le May , Jean Mathieu Berger , Anne Lespine , Bruno Pillot , Xavier Prieur
Arteriosclerosis, Thrombosis, and Vascular Biology, 2013, 33 (7), pp.1484 - 1493. ⟨10.1161/ATVBAHA.112.300263⟩
Article dans une revue hal-02650431v1

Clinical aspects of PCSK9

Bertrand Cariou , Cedric Le May , Philippe Costet
Atherosclerosis, 2011, 216 (2), pp.258-265. ⟨10.1016/j.atherosclerosis.2011.04.018⟩
Article dans une revue hal-03013330v1

Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents β cell failure in rodent models of type 2 diabetes

Joseph Tiano , Viviane Delghingaro-Augusto , Cedric Le May , Suhuan Liu , Meenakshi Kaw
Journal of Clinical Investigation, 2011, 121 (8), pp.3331-3342. ⟨10.1172/JCI44564⟩
Article dans une revue hal-03013329v1

Extranuclear estrogen receptor- stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis

W. Wong , J. Tiano , S. Liu , S. Hewitt , Cedric Le May
Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 (29), pp.13057-13062. ⟨10.1073/pnas.0914501107⟩
Article dans une revue hal-03013333v1

Association between plasma PCSK9 and gamma-glutamyl transferase levels in diabetic patients

Bertrand Cariou , Maëlle Le Bras , Cédric Langhi , Cedric Le May , Béatrice Guyomarc’h-Delasalle
Atherosclerosis, 2010, 211 (2), pp.700-702. ⟨10.1016/j.atherosclerosis.2010.04.015⟩
Article dans une revue hal-03013334v1

PCSK9 is expressed in pancreatic δ-cells and does not alter insulin secretion

Cédric Langhi , Cedric Le May , Valéry Gmyr , Brigitte Vandewalle , Julie Kerr-Conte
Biochemical and Biophysical Research Communications, 2009, 390 (4), pp.1288-1293. ⟨10.1016/j.bbrc.2009.10.138⟩
Article dans une revue hal-03013335v1

Proprotein Convertase Subtilisin Kexin Type 9 Null Mice Are Protected From Postprandial Triglyceridemia

Cedric Le May , Cédric Le May , Sanae Kourimate , Cédric Langhi , Maud Chétiveaux
Arteriosclerosis, Thrombosis, and Vascular Biology, 2009, 29 (5), pp.684-690. ⟨10.1161/ATVBAHA.108.181586⟩
Article dans une revue hal-03013340v1

Importance of Extranuclear Estrogen Receptor- and Membrane G Protein-Coupled Estrogen Receptor in Pancreatic Islet Survival

S. Liu , Cedric Le May , W. P.S. Wong , R. Ward , D. Clegg
Diabetes, 2009, 58 (10), pp.2292-2302. ⟨10.2337/db09-0257⟩
Article dans une revue hal-03013339v1
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Proprotein convertase subtilisin kexin type 9 null mice are protected from postprandial triglyceridemia

Cedric Le May , Sanae Kourimate , Cédric Langhi , Maud Chétiveaux , Anne Jarry
Arteriosclerosis, Thrombosis, and Vascular Biology, 2009, 29 (5), pp.684-690. ⟨10.1161/ATVBAHA.108.181586⟩
Article dans une revue hal-02661775v1

PCSK9 Dominant Negative Mutant Results in Increased LDL Catabolic Rate and Familial Hypobetalipoproteinemia

Cedric Le May , Bertrand Cariou , Khadija Ouguerram , Yassine Zaïr , Raphael Guerois
Arteriosclerosis, Thrombosis, and Vascular Biology, 2009, 29 (12), pp.2191-2197. ⟨10.1161/ATVBAHA.109.194191⟩
Article dans une revue hal-03013337v1

Activation of the farnesoid X receptor represses PCSK9 expression in human hepatocytes

Cédric Langhi , Cedric Le May , Sanae Kourimate , Sandrine Caron , Bart Staels
FEBS Letters, 2008, 582 (6), pp.949-955. ⟨10.1016/j.febslet.2008.02.038⟩
Article dans une revue hal-03013345v1

Involvement of ZIP/p62 in the regulation of PPARα transcriptional activity by p38-MAPK

Claire Diradourian , Cedric Le May , Michèle Caüzac , Jean Girard , Anne-Françoise Burnol
BBA - Biochimica et Biophysica Acta, 2008, 1781 (5), pp.239-244. ⟨10.1016/j.bbalip.2008.02.002⟩
Article dans une revue hal-03013344v1

Dual Mechanisms for the Fibrate-mediated Repression of Proprotein Convertase Subtilisin/Kexin Type 9

Sanae Kourimate , Cedric Le May , Cédric Langhi , Anne Laure Jarnoux , Khadija Ouguerram
Journal of Biological Chemistry, 2008, 283 (15), pp.9666-9673. ⟨10.1074/jbc.M705831200⟩
Article dans une revue hal-03013347v1

Estrogens protect pancreatic beta-cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice

Cedric Le May , K. Chu , M. Hu , C. Ortega , E. Simpson
Proceedings of the National Academy of Sciences of the United States of America, 2006, 103 (24), pp.9232-9237. ⟨10.1073/pnas.0602956103⟩
Article dans une revue hal-03013348v1

Fatty Acids Induce L-CPT I Gene Expression through a PPARα-Independent Mechanism in Rat Hepatoma Cells

Cedric Le May , Cédric Le May , Michèle Caüzac , Claire Diradourian , Dominique Perdereau
Journal of Nutrition, 2005, 135 (10), pp.2313-2319. ⟨10.1093/jn/135.10.2313⟩
Article dans une revue hal-03013352v1

PAX4 gene variations predispose to ketosis-prone diabetes

Cedric Le May , Franck Mauvais-Jarvis , Stuart Smith , Cédric Le May , Suzanne Leal
Human Molecular Genetics, 2004, 13 (24), pp.3151-3159. ⟨10.1093/hmg/ddh341⟩
Article dans une revue hal-03013354v1

Antidiabetic actions of estrogen: Insight from human and genetic mouse models

Cedric Le May , Jean-Francois Louet , Cedric Lemay , Franck Mauvais-Jarvis
Current Atherosclerosis Reports, 2004, 6 (3), pp.180-185. ⟨10.1007/s11883-004-0030-9⟩
Article dans une revue hal-03013357v1

Control of Gene Expression by Fatty Acids

Cedric Le May , Jean-Paul Pégorier , Cédric Le May , Jean Girard
Journal of Nutrition, 2004, 134 (9), pp.2444S-2449S. ⟨10.1093/jn/134.9.2444S⟩
Article dans une revue hal-03013355v1

Regulation of liver carnitine palmitoyltransferase I gene expression by hormones and fatty acids

J.-F. Louet , Cedric Le May , J.-P. Pégorier , J.-F. Decaux , J. Girard
Biochemical Society Transactions, 2001, 29 (2), pp.310. ⟨10.1042/0300-5127:0290310⟩
Article dans une revue hal-03013360v1

Reduced hepatic fatty acid oxidation in fasting PPARα null mice is due to impaired mitochondrial hydroxymethylglutaryl-CoA synthase gene expression

Cedric Le May , Thierry Pineau , Karine Bigot , Claude Kohl , Jean Girard
FEBS Letters, 2000, 475 (3), pp.163-166. ⟨10.1016/s0014-5793(00)01648-3⟩
Article dans une revue hal-03013361v1

Plasma cholesterol is excreted in the feces of patients with complete common bile duct obstruction : in vivo evidence for tice pathway in humans

François Moreau , Claire Blanchard , Christophe Perret , Laurent Flet , Frédéric Douane
85th Congress of the European-Atherosclerosis-Society (EAS), European Atherosclerosis Society. SWE., Apr 2017, Prague, Czech Republic. pp.2
Communication dans un congrès hal-02737439v1