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Cecile Legallais

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Présentation

**Cécile LEGALLAIS** Date of birth : 07/03/1968 <a>cecile.legallais@utc.fr</a> **PRESENT POSITION** 2018 - : Head of Laboratory of Biomechanics and Bioengineering (joint lab Université de Technologie de Compiè(UTC)/CNRS) **APPOINTMENTS** 2006 - : Directeur de recherche CNRS (CNRS Senior researcher). Laboratory of Biomechanics and Bioengineering, Université de Technologie de Compiègne (FR) 2015 - 2018 :Associate Researcher (part time) Assistance Publique Hôpitaux de Paris (APHP) 1996 - 1997 : Post-doctoral Fellow, University of Calabria (Italy) &amp; Membrana GmbH (Germany) 1993 - 2006 : Chargé de recherche CNRS (CNRS Researcher). UTC Compiègne **ACADEMIC QUALIFICATIONS** H.D.R. 1998 “Habilitation” to supervise Ph.D. Thesis. Université de Technologie de Compiègne (FR). Blood toxins removal by membrane processes. Ph. D. 1993Université de Technologie de Compiègne (FR). Specialty : Biomedical Eng. LDL-cholesterol removal from human plasma based on cascade filtration. MS/Eng. D 1990 Ecole Nationale Supérieure de Mécanique et Aérotechnique (Poitiers) – Engineer in Fluid Mechanics **AWARDS** Bronze Medal from the CNRS, 2003. **RESEARCH ACTIVITIES : Biomechanics of Organ Supply systems** Since 1995 : **Bioartificial liver** at different scales. Encapsulation of hepatoctes in alginate beads. Design and characterization of fluidized bed bioreactor. Full extracorporeal circulation. PI of ANR TecSan SUPPLIVER (2011 -2015). WP Leader RHU Ilite (Innovations in Liver tissue Engineering) (2016-2022). PI of ANR MimLiveronChip (Organ on Chip) (2019-2023) Since 2006: **Bone and musculo-skeletal tissue engineering** based on stretching bioreactors – Mechanical and biological characterization. Since 1994: **Flow and** **Mass transfer in hemodialysis and hemodiafiltration** : Collaboration with Membrana GmbH, Fresenius Medical Care, Amiens Hospital Since 2000 : **Blood flow simulations** in 3D vessels reconstructed from medical images. **PUBLICATIONS and COMMUNICATIONS** \- **105 papers** in international journals with peer review \- 6 book chapters, **4 patents** **SYNERGISTIC ACTIVITIES** \- Past President (2019-2021) of European Society for Artificial Organs (ESAO). Formerly Governor (2005-2011), General Secretary (2011-2015), President Elect (2015-2017)&amp; President (2017-2019). \- Member of the Board of the International Federation for Artificial Organs (IFAO) \- President of the XXXVIth ESAO Congress (2009) in Compiègne, France (400 participants) \- Reviewer for Artificial Organs, Journal of Membrane Science, Biotechnology Bioengineering, Separation Science and Technology, Journal of Polymer Science, Journal of Biomechanics, Medical Engineering and Physics, Plos One, Tissue Engineering, Biomaterials. **SUPERVISION** \- 25 PhD students at UTC (22 achieved, 3 ongoing) \- 3 HDR Habilitation at UTC **TEACHING ACTIVITIES** \- Lecture on Artificial Organs (UTC) – 20h/y \- Hands on activities for engineering students (tissue engineering, hemodialysis)

Publications

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Investigation of the metabolomic crosstalk between liver sinusoidal endothelial cells and hepatocytes exposed to paracetamol using organ-on-chip technology

Taha Messelmani , Anne Le Goff , Fabrice Soncin , Françoise Gilard , Zied Souguir
Toxicology, 2023, 492, pp.153550. ⟨10.1016/j.tox.2023.153550⟩
Article dans une revue hal-04212804v1
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Flow rate variations in microfluidic circuits with free surfaces

Taha Messelmani , Isabela Zarpellon Nascimento , Eric Leclerc , Cécile Legallais , Adam Meziane
Microfluidics and Nanofluidics, 2023, 27 (12), pp.79. ⟨10.1007/s10404-023-02691-y⟩
Article dans une revue hal-04257314v1
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Groupe Néphrologie verte de la SFNDT : premières réflexions

Charles Chazot , Hafsah Hachad , Pierre Filipozzi , Cécile Legallais , Perrine Jullien
Néphrologie & Thérapeutique, 2023, 19 (1), pp.23-33. ⟨10.1684/ndt.2023.1⟩
Article dans une revue hal-04294264v1
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Microencapsulated Hepatocytes Differentiated from Human Induced Pluripotent Stem Cells: Optimizing 3D Culture for Tissue Engineering Applications

Marwa Hussein , Mattia Pasqua , Ulysse Pereira , Nassima Benzoubir , Jean-Charles Duclos-Vallée
Cells, 2023, 12 (6), pp.865. ⟨10.3390/cells12060865⟩
Article dans une revue hal-04193769v1
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Generation of β-like cell subtypes from differentiated human induced pluripotent stem cells in 3D spheroids

Lisa Morisseau , Fumiya Tokito , Stéphane Poulain , Valérie Plaisance , Valerie Pawlowski
Molecular Omics, 2023, 19 (10), pp.810-822. ⟨10.1039/D3MO00050H⟩
Article dans une revue hal-04209565v1
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Evidence of Adult Features and Functions of Hepatocytes Differentiated from Human Induced Pluripotent Stem Cells and Self-Organized as Organoids

Antonietta Messina , Eléanor Luce , Nassima Benzoubir , Mattia Pasqua , Ulysse Pereira
Cells, 2022, 11 (3), ⟨10.3390/cells11030537⟩
Article dans une revue hal-03561619v1
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Validation of HepG2/C3A Cell Cultures in Cyclic Olefin Copolymer Based Microfluidic Bioreactors

Leire Etxeberria , Taha Messelmani , Jon Haitz Badiola , Andreu Llobera , Luis Fernandez
Polymers, 2022, 14 (21), pp.4478. ⟨10.3390/polym14214478⟩
Article dans une revue hal-03861408v1
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Electrodialysis Can Lower the Environmental Impact of Hemodialysis

Ahmed Abarkan , Nabil Grimi , Hubert Métayer , Tarik Sqalli Houssaïni , C. Legallais
Membranes, 2022, 12 (1), pp.45. ⟨10.3390/membranes12010045⟩
Article dans une revue hal-03590375v1
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Liver organ-on-chip models for toxicity studies and risk assessment

Taha Messelmani , Lisa Morisseau , Yasuyuki Sakai , Cécile Legallais , Anne Le Goff
Lab on a Chip, 2022, 22 (13), pp.2423-2450. ⟨10.1039/d2lc00307d⟩
Article dans une revue hal-03861401v1
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Analysis of the transcriptome and metabolome of pancreatic spheroids derived from human induced pluripotent stem cells and matured in an organ-on-a-chip

Amal Essaouiba , Rachid Jellali , Stéphane Poulain , Fumiya Tokito , Françoise Gilard
Molecular Omics, 2022, 18 (8), pp.791-804. ⟨10.1039/d2mo00132b⟩
Article dans une revue hal-03861419v1
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Development of Liver-on-Chip Integrating a Hydroscaffold Mimicking the Liver’s Extracellular Matrix

Taha Messelmani , Anne Le Goff , Zied Souguir , Victoria Maes , Méryl Roudaut
Bioengineering, 2022, 9, ⟨10.3390/bioengineering9090443⟩
Article dans une revue hal-03861410v1
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Multiscale-Engineered Muscle Constructs: PEG Hydrogel Micro-Patterning on an Electrospun PCL Mat Functionalized with Gold Nanoparticles

Megane Beldjilali-Labro , Rachid Jellali , Alexander David Brown , Alejandro Garcia Garcia , Augustin Lerebours
International Journal of Molecular Sciences, 2022, 23 (1), pp.260. ⟨10.3390/ijms23010260⟩
Article dans une revue hal-03590377v1
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Investigation of the Exometabolomic Profiles of Rat Islets of Langerhans Cultured in Microfluidic Biochip

Amal Essaouiba , Rachid Jellali , Françoise Gilard , Bertrand Gakière , Teru Okitsu
Metabolites, 2022, 12 (12), pp.1270. ⟨10.3390/metabo12121270⟩
Article dans une revue hal-04213642v1
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Preclinical characterization of alginate‐Poly‐L‐Lysine encapsulated HepaRG for extracorporeal liver supply

Mattia Pasqua , Ulysse Pereira , Claire de Lartigue , Jonathan Nicolas , Pascale Vigneron
Biotechnology and Bioengineering, 2021, 118 (1), ⟨10.1002/bit.27583⟩
Article dans une revue hal-02961888v1
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Monitoring mechanical stimulation for optimal tendon tissue engineering: a mechanical and biological multiscale study

Alejandro Garcia Garcia , Jean-Baptiste Perot , Megane Beldjilali-Labro , Quentin Dermigny , Marie Naudot
Journal of Biomedical Materials Research Part A, 2021, ⟨10.1002/jbm.a.37180⟩
Article dans une revue hal-03029652v1
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Cryogel-Integrated Biochip for Liver Tissue Engineering

Lilandra Boulais , Rachid Jellali , Ulysse Pereira , Eric Leclerc , Sidi A Bencherif
ACS Applied Bio Materials, 2021, 4 (7), pp.5617-5626. ⟨10.1021/acsabm.1c00425⟩
Article dans une revue hal-03322953v1
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Electrospinning of biomedically relevant gradient scaffolds: From honeycomb to randomly-oriented microstructure

Christopher Leon-Valdivieso , Alejandro Garcia-Garcia , Cécile Legallais , Fahmi Bedoui
Polymer, 2020, 202, pp.122606. ⟨10.1016/j.polymer.2020.122606⟩
Article dans une revue hal-02884169v1
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The combination of a poly‐caprolactone/nano‐hydroxyapatite honeycomb scaffold and mesenchymal stem cells promotes bone regeneration in rat calvarial defects

Marie Naudot , Alejandro Garcia Garcia , Nicolas Jankovsky , Anaïs Barre , Luciane Zabijak
Journal of Tissue Engineering and Regenerative Medicine, 2020, 65, pp.20-31. ⟨10.1002/term.3114⟩
Article dans une revue hal-02961861v1
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Development of a pancreas-liver organ-on-chip coculture model for organ-to-organ interaction studies

Amal Essaouiba , Teru Okitsu , R. Kinoshita , Rachid Jellali , Yasuyuki Sakai
Biochemical Engineering Journal, 2020, 164, pp.107783. ⟨10.1016/j.bej.2020.107783⟩
Article dans une revue hal-03095499v1
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Cold-to-warm machine perfusion of the liver: a novel circuit for an uninterrupted combined perfusion protocol

Claire Goumard , Eric Savier , Jerome Danion , Jérôme Pelissie , Cécile Legallais
HPB, 2020, 22 (6), pp.927-933. ⟨10.1016/j.hpb.2020.04.001⟩
Article dans une revue hal-02884180v1
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HepaRG Self-Assembled Spheroids in Alginate Beads Meet the Clinical Needs for Bioartificial Liver

Mattia Pasqua , Ulysse Pereira , Antonietta Messina , Claire de Lartigue , Pascale Vigneron
Tissue Engineering: Parts A, B, and C, 2020, 26 (11-12), pp.613-622. ⟨10.1089/ten.tea.2019.0262⟩
Article dans une revue hal-02884175v1
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Microwell-based pancreas-on-chip model enhances genes expression and functionality of rat islets of Langerhans

Amal Essaouiba , Teru Okitsu , Rachid Jellali , Marie Shinohara , Mathieu Danoy
Molecular and Cellular Endocrinology, 2020, 112, pp.110892. ⟨10.1016/j.mce.2020.110892⟩
Article dans une revue hal-02884096v1
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In Vitro Bone Cell Response to Tensile Mechanical Solicitations: Is There an Optimal Protocol?

Timothée Baudequin , Cécile Legallais , Fahmi Bedoui
Biotechnology Journal, 2019, 14 (1), pp.1800358. ⟨10.1002/biot.201800358⟩
Article dans une revue hal-02061207v1
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Bioartificial liver: biomechanical considerations

L. Boulais , M. Pasqua , C. de Lartigue , R. Jellali , U. Pereira
Computer Methods in Biomechanics and Biomedical Engineering, 2019, 44th Congress of the Société de Biomécanique, 22 (sup1), pp.S370-S372. ⟨10.1080/10255842.2020.1714948⟩
Article dans une revue hal-03322978v1
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Nanotechnology and Bioartificial Liver Engineering. Two Rival Paths for “Converging Technology”

Xavier Guchet , Cécile Legallais
Philosophia Scientiae, 2019, 23-1, pp.121-135. ⟨10.4000/philosophiascientiae.1839⟩
Article dans une revue hal-02140040v1

Mass Transfers in a Fluidized Bed Bioreactor using Alginate Beads for a Future Bioartificial Liver

B. David , E. Dore , M.Y. Jaffrin , C. Legallais
The International Journal of Artificial Organs, 2018, 27 (4), pp.284-293. ⟨10.1177/039139880402700404⟩
Article dans une revue hal-02149863v1
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Poly(ε-caprolactone)/Hydroxyapatite 3D Honeycomb Scaffolds for a Cellular Microenvironment Adapted to Maxillofacial Bone Reconstruction

Alejandro Garcia Garcia , Anne Hebraud , Jean-Luc Duval , Corinne Wittmer , Ludovic Gaut
ACS Biomaterials Science and Engineering, 2018, 4 (9), pp.3317-3326. ⟨10.1021/acsbiomaterials.8b00521⟩
Article dans une revue hal-02393845v1

Metabolomics-on-a-chip approach to study hepatotoxicity of DDT, permethrin and their mixtures

Rachid Jellali , Françoise Gilard , Vittoria Pandolfi , Audrey Legendre , Marie-José Fleury
Journal of Applied Toxicology, 2018, 38 (8), pp.1121-1134. ⟨10.1002/jat.3624⟩
Article dans une revue hal-02357461v1
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Biomaterials in Tendon and Skeletal Muscle Tissue Engineering: Current Trends and Challenges

Megane Beldjilali-Labro , Alejandro Garcia Garcia , Firas Farhat , Fahmi Bedoui , Jean-François Grosset
Materials, 2018, 11 (7), pp.1116. ⟨10.3390/ma11071116⟩
Article dans une revue hal-01956820v1
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Bioengineering Organs for Blood Detoxification

Cécile Legallais , Dooli Kim , Sylvia Mihaila , Milos Mihajlovic , Marina Figliuzzi
Advanced Healthcare Materials, 2018, 7 (21), pp.1800430. ⟨10.1002/adhm.201800430⟩
Article dans une revue hal-01956818v1
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The Osteogenic and Tenogenic Differentiation Potential of C3H10T1/2 (Mesenchymal Stem Cell Model) Cultured on PCL/PLA Electrospun Scaffolds in the Absence of Specific Differentiation Medium

Timothée Baudequin , Ludovic Gaut , Marc Mueller , Angela Huepkes , Birgit Glasmacher
Materials, 2017, 10 (12), pp.1387. ⟨10.3390/ma10121387⟩
Article dans une revue hal-02938374v1

Expansion properties of alginate beads as cell carrier in the fluidized bed bioartificial liver

Seyed Danial Naghib , Vittoria Pandolfi , Ulysse Pereira , Rossella Girimonte , Efrem Curcio
Powder Technology, 2017, 316, pp.711-717. ⟨10.1016/j.powtec.2016.12.047⟩
Article dans une revue hal-02938369v1
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A new prescription model for regional citrate anticoagulation in therapeutic plasma exchanges

Sébastien Kissling , Cécile Legallais , Menno Pruijm , Daniel Teta , Bruno Vogt
BMC Nephrology, 2017, 18 (1), pp.81. ⟨10.1186/s12882-017-0494-9⟩
Article dans une revue hal-02938371v1

Optimizing the fluidized bed bioreactor as an external bioartificial liver

Sarah Figaro , Ulysse Pereira , Hiram Rada , Nicolas Semenzato , Dominique Pouchoulin
The International Journal of Artificial Organs, 2017, 40 (4), pp.196-203. ⟨10.5301/ijao.5000567⟩
Article dans une revue hal-02938255v1
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Alginate-Based Cell Microencapsulation for Tissue Engineering and Regenerative Medicine

Vittoria Pandolfi , Ulysse Pereira , Murielle Dufresne , Cécile Legallais
Current Pharmaceutical Design, 2017, 23 (26), ⟨10.2174/1381612823666170609084016⟩
Article dans une revue hal-02938367v1

SUPPLIVER: Bioartificial supply for liver failure

S. Figaro , Ulysse Pereira , A-S. Dumé , H. Rada , S. Capone
Innovation and Research in BioMedical engineering, 2015, 36 (2), pp.101-109. ⟨10.1016/j.irbm.2015.01.010⟩
Article dans une revue hal-03411627v1
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Towards the Development and Characterization of an Easy Handling Sheet-Like Biohybrid Bone Substitute

Timothée Baudequin , Fahmi Bedoui , Murielle Dufresne , Patrick Paullier , Cécile Legallais
Tissue Engineering: Parts A, B, and C, 2015, 21 (11-12), pp.1895-1905. ⟨10.1089/ten.tea.2014.0580⟩
Article dans une revue hal-03433119v1

Influence of an Arterial Stenosis on the Hemodynamics Within an Arteriovenous Fistula (AVF): Comparison Before and After Balloon-Angioplasty

Iolanda Decorato , Anne-Virginie Salsac , Cécile Legallais , Mona Alimohammadi , Vanessa Diaz-Zuccarini
Cardiovascular Engineering and Technology, 2014, 5 (3), pp.233-243. ⟨10.1007/s13239-014-0185-7⟩
Article dans une revue hal-02019623v1

Comparison of two Endovascular Treatments of a Stenosed Arteriovenous Fistula: Balloon-Angioplasty with and without Stenting

Iolanda Decorato , Zaher Kharboutly , Cécile Legallais , Anne-Virginie Salsac
The International Journal of Artificial Organs, 2014, 37 (10), pp.763-772. ⟨10.5301/ijao.5000324⟩
Article dans une revue hal-02019770v1

Numerical simulation of the fluid structure interactions in a compliant patient-specific arteriovenous fistula

Iolanda Decorato , Zaher Kharboutly , Tommaso Vassallo , Justin Penrose , Cécile Legallais
International Journal for Numerical Methods in Biomedical Engineering, 2014, 30 (2), pp.143-159. ⟨10.1002/cnm.2595⟩
Article dans une revue hal-02019727v1

An appropriate selection of 3D alginate culture model for hepatic Huh-7 cell line encapsulation intended for viral studies

N.M. Tran , M. Dufresne , Gilles Duverlie , Sandrine Castelain , Christian Défarge
Tissue Engineering: Parts A, B, and C, 2013, 19 (1-2), pp.103-113. ⟨10.1089/ten.tea.2012.0139⟩
Article dans une revue insu-00723045v1
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Human hepatic cell behavior on polysulfone membrane with double porosity level

Murielle Dufresne , Patrice Bacchin , Giulia Cerino , Jean-Christophe Remigy , Gerard Nathanael Adrianus
Journal of Membrane Science, 2013, vol. 428, pp. 454-461. ⟨10.1016/j.memsci.2012.10.041⟩
Article dans une revue hal-00788387v1

Evaluation of seven drug metabolisms and clearances by cryopreserved human primary hepatocytes cultivated in microfluidic biochips

Régis Baudoin , Jean-Matthieu Prot , Grégory Nicolas , Jessy Brocheton , Céline Brochot
Xenobiotica, 2013, 43 (2), pp.140-152. ⟨10.3109/00498254.2012.706725⟩
Article dans une revue ineris-00963431v1

Metabolomics-on-a-chip of hepatotoxicity induced by anticancer drug flutamide and its active metabolite hydroxyflutamide using HepG2/C3a microfluidic biochips

Leila Choucha-Snouber , Andrei Bunescu , Cécile Legallais , Céline Brochot , Marc-Emmanuel Dumas
Toxicological Sciences, 2013, 132 (1), pp.8-20. ⟨10.1093/toxsci/kfs230⟩
Article dans une revue ineris-00963445v1
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Impact of Alginate Composition: From Bead Mechanical Properties to Encapsulated HepG2/C3A Cell Activities for In Vivo Implantation

Stephanie Capone , Murielle Dufresne , Mathias Rechel , Marie-José Fleury , Anne-Virginie Salsac
PLoS ONE, 2013, 8 (4), pp.e62032. ⟨10.1371/journal.pone.0062032⟩
Article dans une revue hal-02019744v1

Investigation of ifosfamide nephrotoxicity induced in a liver-kidney co-culture biochip.

Leila Choucha-Snouber , Caroline Aninat , Laurent Grsicom , Geoffrey Madalinski , Céline Brochot
Biotechnology and Bioengineering, 2013, 110 (2), pp.597-608. ⟨10.1002/bit.24707⟩
Article dans une revue inserm-00864839v1
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Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: Application to acetaminophen injury

Jean-Matthieu Prot , Andrei Bunescu , Bénédicte Elena-Herrmann , Caroline Aninat , Leila Choucha Snouber
Toxicology and Applied Pharmacology, 2012, 259 (3), pp.270-280. ⟨10.1016/j.taap.2011.12.017⟩
Article dans une revue hal-00699551v1

Metabolomics-on-a-Chip and Predictive Systems Toxicology in Microfluidic Bioartificial Organs

Laetitia Shintu , Régis Baudoin , Vincent Navratil , Jean-Matthieu Prot , Clément Pontoizeau
Analytical Chemistry, 2012, 84 (4), pp.1840-1848. ⟨10.1021/ac2011075⟩
Article dans une revue hal-00699575v1

A cocktail of metabolic probes demonstrates the relevance of primary human hepatocyte cultures in a microfluidic biochip for pharmaceutical drug screening

Jean-Matthieu Prot , Orianne Videau , Céline Brochot , Cécile Legallais , Henri Benech
International Journal of Pharmaceutics, 2011, 108 (1-2), pp.67-75. ⟨10.1016/j.ijpharm.2011.01.054⟩
Article dans une revue ineris-00963290v1

Improvement of HepG2/C3a cell functions in a microfluidic biochip.

Jean Matthieu Prot , Caroline Aninat , Laurent Griscom , Florence Razan , Céline Brochot
Biotechnology and Bioengineering, 2011, 108 (7), pp.1704-15. ⟨10.1002/bit.23104⟩
Article dans une revue hal-00740224v1

ENDOCOM: Implantable wireless pressure sensor for the follow-up of abdominal aortic aneurysm stented

Olivier Romain , Johan Mazeyrat , Patrick Garda , Hakeim Talleb , David Lautru
Innovation and Research in BioMedical engineering, 2011, 32 (3), pp.163 - 168. ⟨10.1016/j.irbm.2011.01.017⟩
Article dans une revue hal-00665334v1

Integrated proteomic and transcriptomic investigation of the acetaminophen toxicity in liver microfluidic biochip

J.M. Prot , A.S. Briffaut , F. Letourneur , P. Chafey , F. Merlier
PLoS ONE, 2011, 6 (8), pp.e21268. ⟨10.1371/journal.pone.0021268⟩
Article dans une revue hal-00637409v1

Prédiction de la toxicocinétique in vivo de substances chimiques à partir de données in vitro et de modèles QSAR

Dany Habka , Alexandre R.R. Pery , Cécile Legallais , Céline Brochot
Environnement, Risques & Santé, 2010, 9 (6), pp.489-501. ⟨10.1684/ers.2010.0396⟩
Article dans une revue ineris-00963259v1

Analysis of the mass transfers in an artificial kidney microchip

A. Ould-Dris , P. Paullier , Laurent Griscom , Cécile Legallais , E. Leclerc
Journal of Membrane Science, 2010, 352, pp.116-125. ⟨10.1016/j.memsci.2010.02.007⟩
Article dans une revue hal-00592403v1

Numerical and experimental study of blood flow through a patient-specific arteriovenous fistula used for hemodialysis

Zaher Kharboutly , Valérie Deplano , Eric Bertrand , Cécile Legallais
Medical Engineering & Physics, 2010, 32, pp.111-118. ⟨10.1016/j.medengphy.2009.10.013⟩
Article dans une revue hal-00429960v1

Hollow fiber bioartificial liver: Physical and biological characterization with C3A cells

A. Gautier , A. Ould-Dris , M. Dufresne , P. Paullier , B. von Harten
Journal of Membrane Science, 2009, 341 ((1-2)), pp.203-213. ⟨10.1016/j.memsci.2009.06.007⟩
Article dans une revue hal-00437709v1

Les dispositifs de suppléance hépatique

A. Gautier , C. Legallais
Réanimation, 2009, 18 (5), pp.413-419. ⟨10.1016/j.reaurg.2009.05.010⟩
Article dans une revue hal-00437800v1

Artificial and bioartificial liver devices: present and future.

B. Carpentier , A. Gautier , C. Legallais
Gut, 2009, 58 (12), pp.1690-1702. ⟨10.1136/gut.2008.175380⟩
Article dans une revue hal-00437697v1

Alginate-encapsulated HepG2 Cells in a Fluidized Bed Bioreactor Maintain Function in Human Liver Failure Plasma

Sam Coward , Cécile Legallais , Bertrand David , Michael Thomas , Ying Foo
Artificial Organs, 2009, 33 (12), pp.1117-1126. ⟨10.1111/j.1525-1594.2009.00821.x⟩
Article dans une revue hal-02149842v1

In vitro tests and modelization of bicarbonate kinetics and mass transfers during online hemodiafiltration

H. Morel , M.Y. Jaffrin , P. Paullier , C. Legallais
The International Journal of Artificial Organs, 2009, 32, pp.482-491. ⟨10.1177/039139880903200802⟩
Article dans une revue hal-00437233v1

Solid–liquid mass transfers in an airlift reactor incorporating alginate beads for the application as a bioartificial liver

S. Demming , A. Gautier , C. Legallais , A. Ould-Dris
Chemical Engineering and Processing: Process Intensification, 2008, 47 (12), pp.2370-2378. ⟨10.1016/j.cep.2008.01.013⟩
Article dans une revue hal-00336365v1

The place of adsorption and biochromatography in extracorporeal liver support systems

C. Legallais , A. Gautier , M. Dufresne , B. Carpentier , R. Baudoin
Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences, 2008, 961 (2), pp.171-176. ⟨10.1016/j.jchromb.2007.07.048⟩
Article dans une revue hal-00339871v1

Three-dimensional growth of human hepatoma C3A cells within alginate beads for fluidized bioartificial liver

A. Kinasiewicz , A. Gautier , D. Lewińska , A. Śmietanka , C. Legallais
The International Journal of Artificial Organs, 2008, 31 (4), pp.340- 347. ⟨10.1177/039139880803100411⟩
Article dans une revue hal-00339867v1

Générateurs d'hémodialyse : état du marché français

S. Merlo , A. Donadey , B. Coevoet , C. Legallais
ITBM RBM, 2007, 28, pp.150-168. ⟨10.1016/j.rbmret.2007.07.004⟩
Article dans une revue hal-00282676v1

Trends in the development of microfluidic cell biochips for in vitro hepatotoxicity

R. Baudoin , Anne Corlu , L. Griscom , C. Legallais , E. Leclerc
Toxicology in Vitro, 2007, 21, pp.535-544. ⟨10.1016/j.tiv.2006.11.004⟩
Article dans une revue hal-00172268v1

Culture of C3A Cells in Alginate Beads for Fluidized Bed Bioartificial Liver.

A. Kinasiewicz , A. Gautier , D. Lewinska , J. Bukowski , C. Legallais
Transplantation Proceedings, 2007, 39 (9), pp.2911-2913. ⟨10.1016/j.transproceed.2007.08.062⟩
Article dans une revue hal-00282673v1

Development of a renal microchip for in vitro distal tubule models

R. Baudoin , L. Griscom , M. Monge , C. Legallais , E. Leclerc
Biotechnology Progress, 2007, 23, pp.1245-1253. ⟨10.1021/bp0603513⟩
Article dans une revue hal-00196149v1

A theoretical study of oxygen transfer including cell necrosis for the design of a bioartificial pancreas

J.L. Dulong , C. Legallais
Biotechnology and Bioengineering, 2007, 96, pp.990-998. ⟨10.1002/bit.21140⟩
Article dans une revue hal-00282668v1

Selective control of liver and kidney cells migration during organotypic cocultures inside fibronectin-coated rectangular silicone microchannels

Eric Leclerc , Régis Baudoin , Anne Corlu , Laurent Griscom , Jean Luc Duval
Biomaterials, 2007, 28 (10), pp.1820-1829. ⟨10.1016/j.biomaterials.2006.11.044⟩
Article dans une revue hal-00172298v1

Mechanical properties of alginate beads hosting hepatocytes in a fluidized bed bioreactor.

C David , L. Barbe , D. Barthès-Biesel , C. Legallais
The International Journal of Artificial Organs, 2006, 29 (8), pp.756-63. ⟨10.1177/039139880602900805⟩
Article dans une revue hal-02149847v1

Guidance of liver and kidney organotypic cultures inside rectangular silicone microchannels.

E. Leclerc , A. Corlu , L. Griscom , R. Baudoin , C. Legallais
Biomaterials, 2006, 27, pp.4109-4119. ⟨10.1016/j.biomaterials.2006.03.031⟩
Article dans une revue hal-00090178v1

Study of Osteoblastic Cells in a Microfluidic Environment

E. Leclerc , B. David , L Griscom , Bruno Le Pioufle , T. Fujii
Biomaterials, 2006, 27 (4), pp.558-595. ⟨10.1016/j.biomaterials.2005.06.002⟩
Article dans une revue hal-00778216v1

Perfusion culture of mammalian cells in microfluidic environments for tissue engineering applications 

Eric Leclerc , Bertrand David , Laurent Griscom , Bruno Lepioufle , Yasuyuki Sakai
La Houille Blanche - Revue internationale de l'eau, 2006, 3 (3), pp.56-59. ⟨10.1051/lhb:200603008⟩
Article dans une revue hal-02149903v1

What are the relevant parameters for the geometrical optimization of an implantable bioartificial pancreas ?

J.L. Dulong , C. Legallais
Journal of Biomechanical Engineering, 2005, 127 (7), pp.1054-1061. ⟨10.1115/1.2073407⟩
Article dans une revue hal-00017278v1

In vitro assessment of encapsulated C3A hepatocytes functions in a fluidized bed bioreactor

B. David , M. M. Dufresne , M. Nagel , C. Legallais
Biotechnology Progress, 2004, 20 (4), pp.1204-1212. ⟨10.1021/bp034301z⟩
Article dans une revue hal-02149856v1

Bioartificial livers (BAL): current technological aspects and future developments

C. Legallais , B David , E. Dore
Journal of Membrane Science, 2001, 181 (1), pp.81-95. ⟨10.1016/S0376-7388(00)00539-1⟩
Article dans une revue hal-02149872v1

Investigation of Oleic Acid, Palmitic Acid and their mixture on the development of hepatic steatosis using liver-on-chip technology

Lisa Morisseau , C. Legallais , Amar Abderrahmani , Yasuyoshi Sakai , Eric Leclerc
49th ESAO Congress, Aug 2023, Bergamo, Italy
Communication dans un congrès hal-04476949v1

Development of liver-on-chip model integrating LSEC barrier and hepatocytes organoids for toxicity application

Taha Messelmani , Anne Le Goff , Fabrice Soncin , Zied Souguir , Elodie Vandenhaute
The 1st edition of the MicroPhysio conference on "Micro-physiological models: From organoids to organs-on-chip", Apr 2022, Cargese (Corse), France
Communication dans un congrès hal-04497703v1

Membranes and Porous Scaffolds for Bioartificial Organs

C. Legallais
EuroMembrane 2022, Nov 2022, Sorrento (Italie), Italy
Communication dans un congrès hal-04475702v1

Development of an advanced liver organ-on-chip integrating hydroscaffold mimicking cell matrix

Taha Messelmani , Zied Souguir , Victoria Maes , Anne Le Goff , Elodie Vandenhaute
47th ESAO Congress, Sep 2021, London (U.K.), United Kingdom
Communication dans un congrès hal-04497725v1

3D liver-on-chip model integrating hydrogel mimicking cell matrix

Taha Messelmani , Zied Souguir , Victoria Maes , Anne Le Goff , Eric Leclerc
TERMIS 6th World Congress, Nov 2021, Maastricht (Netherland), Netherlands
Communication dans un congrès hal-04500618v1

Investigation of the Behavior of Rat Pancreatic Islets in an Organ-On-Chip Model

Amal Essaouiba , Teru Okitsu , Rachid Jellali , Marie Shinohara , Mathieu Danoy
IFAO-JSAO Congress, Nov 2019, Osaka (JP), Japan
Communication dans un congrès hal-04475774v1

The benefits of multiscale approaches in Liver Tissue Engineering

C. Legallais
XLVI ESAO Congress, Sep 2019, Hannover - Germany, Germany
Communication dans un congrès hal-04475719v1

Cryogel integrated microchip : towards a human 3D model of liver cancer

Lilandra Boulais , Rachid Jellali , Ulysse Pereira , Patrick Paullier , Eric Leclerc
Cancer Cells-on-Chip 2, Mar 2019, Lyon, France
Communication dans un congrès hal-04475771v1

Bioartificial liver : What’s next ?

C. Legallais
European Society for Orthotopic Transplantation (ESOT) Congress, Sep 2019, Copenaghen, Denmark
Communication dans un congrès hal-04475716v1

Liver on chip platform: key questions following 15 years of development

C. Legallais , Rachid Jellali , Eric Leclerc
International MicroNanoconference, Dec 2018, Amsterdam, Netherlands
Communication dans un congrès hal-04475722v1

Mechanical stimulation monitoring towards optimal tendon tissue reconstruction

Alejandro Garcia Garcia , Jean-Baptiste Perot , Marie Naudot , Sophie Le Ricousse , C. Legallais
XLV ESAO Congress, Sep 2018, Madrid, Spain
Communication dans un congrès hal-04475768v1

Electrically Conductive Multi Dimensional Scaffolds With Controllable Architecture For Skeletal Muscle Engineering

Megane Beldjilali-Labro , Alejandro Garcia Garcia , Fahmi Bedoui , Rachid Jellali , Murielle Dufresne
5th TERMIS World Congress, Aug 2018, Kyoto (Japan), Japan
Communication dans un congrès hal-04475764v1

Development and validation of a bioartificial liver device with fluidized bed bioreactors hosting alginate-encapsulated hepatocyte spheroids

S. Figaro , Ulysse Pereira , H. Rada , N. Semenzato , D. Pouchoulin
2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Aug 2015, Milan, France. pp.1335-1338, ⟨10.1109/embc.2015.7318615⟩
Communication dans un congrès hal-03411623v1

RFID implantable pressure sensor for the follow-up of abdominal aortic aneurysm stented

Olivier Romain , Johan Mazeyrat , Patrick Garda , Hakeim Talleb , David Lautru
IEEE DTIS 2011 : 6th International conference on Design & Technology of Integrated Systems in nanoscale era, Apr 2011, Athens, Greece. pp.1-6, ⟨10.1109/DTIS.2011.5941418⟩
Communication dans un congrès hal-00600948v1

Liver-kidney microfluidic bioreactor for cell co-culture in drug studies

L. Choucha Snouber , Laurent Griscom , Pe Poleni , Florence Razan , Céline Brochot
MICROTAS, Oct 2010, GRONINGEN, Netherlands. pp.0328
Communication dans un congrès hal-00756580v1

Calibration of PBPK models based on in vivo and in vitro data to describe complex biotransformation processes

Dany Habka , Alexandre R.R. Pery , C. Aninat , A. Corlu , C. Guguen-Guillouzo
12. International Congress of Toxicology (IUTOX 2010), Jul 2010, Barcelone, Spain
Communication dans un congrès ineris-00970650v1

Toxicologie predictive: les voies du futur

Ph Detilleux , L Vallier , C Legallais , E Leclerc , M Prot J
Congrès de la SPTC - Société de Pharmaco-Toxicologie Cellulaire, May 2010, Paris, France
Communication dans un congrès hal-01122677v1

Microfluidic biochip for in vitro toxicity analysis

R. Baudoin , J.M. Prot , C. Legallais , E. Leclerc
ESAO 2009, Sep 2009, Compiègne, France
Communication dans un congrès hal-00456973v1

Comparison of the growth kinetics of hepatocarcinoma cells in a microfluidic bioreactor and Petri dishes

J.M. Prot , R. Baudoin , L. Griscom , C. Legallais , E. Leclerc
MMB 2009, Apr 2009, Québec, Canada
Communication dans un congrès hal-00457134v1

Use of a liver biochip as a tool in toxicological study.

J.M. Prot , R. Baudoin , L. Griscom , C. Legallais , E. Leclerc
XXXVI Annual meeting European Society for Artificial Organs. ESAO 2009, Sep 2009, Compiègne, France
Communication dans un congrès hal-00457136v1

In vitro bicarbonate and urea kinetics during hemodialysis and online hemodiafiltration.

H. Morel , M.Y. Jaffrin , C. Legallais , J. Vienken
33ème Congrès de la Société de Biomécanique, Sep 2008, Compiègne, France. pp.167
Communication dans un congrès hal-00344995v1

Bicarbonate and urea kinetics modeling during hemodialysis and online postdilution hemodiafiltration.

H. Morel , M.Y. Jaffrin , J. Vienken , C. Legallais
ESAO 2008, XXXV Annual Meeting European Society for Artificial Organs, Sep 2008, Genève, Switzerland. pp.65
Communication dans un congrès hal-00345030v1

Flow and mass transfer modeling for tissue engineering applications.

B. Carpentier , A. Gautier , P. Paullier , A. Ould-Dris , P. Layrolle
33ème Congrès de la Société de Biomécanique, Sep 2008, Compiègne, France. pp.53-55
Communication dans un congrès hal-00345817v1

Cell Micro-Encapsulation and Bioartificial Liver.

C. Legallais , A. Gautier , B. Carpentier , Q. Vu Dinh , M. Dufresne
8th World Biomaterials Congress, May 2008, Amsterdam, Netherlands
Communication dans un congrès hal-00345819v1

Modélisations numérique et expérimentale des écoulements sanguins dans une fistule artério veineuse

Zaher Kharboutly , Cécile Legallais , Valérie Deplano , Eric Bertrand
8ème Colloque National en calcul des structures, May 2007, Giens, France
Communication dans un congrès hal-00455960v1
Image document

Modélisations numérique et expérimentale des écoulements sanguins dans une fistule artério-veineuse

Zaher Kharboutly , Cécile Legallais , Valérie Deplano , Eric Bertrand
8e Colloque national en calcul des structures, CSMA, May 2007, Giens, France
Communication dans un congrès hal-01507578v1

Three dimensional growth of hepatic cells in alginate beads. Studies of beads optimization for fluidized bed bioreactor.

A. Kinasiewicz , A. Gautier , D. Lewinska , M. Dufresne , A. Smietanka
34th ESAO Congress, Sep 2007, Krems, Austria
Communication dans un congrès hal-00290051v1

Development of a cellular biochip mimicking in vitro organs for chronic toxicity analysis.

R. Baudoin , L. Griscom , A. Corlu , P. Layrolle , C. Legallais
Transducers'07, 14th International Conference on Solid-State Sensors, actuators and Microsystems, Jun 2007, Lyon, France
Communication dans un congrès hal-00289965v1

An example of bioartificial organ : combination of hepatocytes microencapsulation and fluidized bed technology for extracorporeal liver support.

A. Gautier , M. Dufresne , B. Carpentier , P. Paullier , C. Legallais
International Congress on “Biochromatography and Nanobiotechnologies", Feb 2007, Vellore, India
Communication dans un congrès hal-00289993v1

Bioartificial liver based on hollow fiber membrane : physical and biological characterization at micro scale level.

A. Gautier , H.D. Lemke , B. von Harten , M. Dufresne , C. Legallais
34th ESAO Congress, Sep 2007, Krems, Austria
Communication dans un congrès hal-00290030v1

Modélisations numérique et expérimentale des écoulements sanguins dans une fistule artério-veineuse.

Z. Kharboutly , C. Legallais , V. Deplano , E. Bertrand
8ème Colloque National en Calcul des Structures, May 2007, Giens, France
Communication dans un congrès hal-00294647v1

Production of bone substitutes in bioreactors : Modeling and culture of bone marrow stem cells.

B. Carpentier , J. Sohier , P. Layrolle , C. Legallais
34th ESAO Congress, Sep 2007, Krems, Austria
Communication dans un congrès hal-00289975v1

Caractérisation des écoulements dans une fistule artério veineuse. Comparaison numérique expérimentale.

Zaher Kharboutly , Cécile Legallais , Eric Bertrand , Valérie Deplano
Journées scientifiques du GDR2760 : Interactions fluide structure biologiques, May 2007, Marseille, France
Communication dans un congrès hal-00456057v1

Validation des procédures de maillage pour l'étude des écoulements sanguins dans une fistule artério-veineuse réelle.

Z. Kharboutly , J.M. Treutenaere , I. Claude , M. Fenech , C. Legallais
18ème Congrès Français de Mécanique, Aug 2007, Grenoble, France
Communication dans un congrès hal-00294651v1

Development of a renal microfluidic device for future in vitro kidney model reconstruction.

R. Baudoin , L. Griscom , C. Legallais , E. Leclerc
XXXIII ESAO Congress, Jun 2006, Umea, Sweden
Communication dans un congrès hal-00116598v1

Application of cells microencapsulation for bioartificial liver in fluidized bed bioreactor.

A. Gautier , B. Carpentier , M. Dufresne , P. Paullier , C. Legallais
14th International Workshop on Bioencapsulation, Oct 2006, Lausanne, Switzerland
Communication dans un congrès hal-00118146v1

Mass transfer studies in a model of fluidized bed bioartificial liver.

B. Carpentier , A. Gautier , P. Paullier , C. Legallais
XXXIII ESAO Congress, Jun 2006, Umea, Sweden
Communication dans un congrès hal-00118114v1

PDMS microdevices as new supports for in vitro bioartificial organs.

R. Baudoin , L. Griscom , C. Legallais , E. Leclerc
XXXIII ESAO Congress, Jun 2006, Umea, Sweden
Communication dans un congrès hal-00116600v1

Human liver cells in a pilot-scale fluidised-bed bioreactor maintain performance in human liver failure plasma making them suitable for a bioartificial liver.

S. Coward , C. Legallais , A. Gautier , P. Paullier , M. Thomas
5th World Congress of Biomechanics, Jul 2006, Munich, Germany
Communication dans un congrès hal-00118127v1

In vitro optimization of alginate bead production for hepatocytes encapsulation in the fluidized bed bioartificial liver.

A. Gautier , A. Kinasiewicz , B. Carpentier , D. Lewinska , P. Paullier
5th World Congress of Biomechanics, Jul 2006, Munich, Germany
Communication dans un congrès hal-00118148v1

Development of a microfluidic devices for in vitro liver model.

R. Baudoin , L. Griscom , A. Corlu , C. Legallais , E. Leclerc
5th World Congress of Biomechanics, Jul 2006, Munich, Germany
Communication dans un congrès hal-00116596v1

Liver organotypic chick embryo cultures on silicone microchannels.

E. Leclerc , A. Corlu , L. Griscom , R. Baudoin , C. Legallais
ESB 20th European Conference on Biomaterials, Sep 2006, Nantes, France
Communication dans un congrès hal-00118400v1

Numerical Simulation of Blood Flow in a side-to-end fistula for hemodialysis.

Z. Kharboutly , J.M. Treutenaere , M. Fenech , T. Chambon , I. Claude
5th World Congress of Biomechanics, Jul 2006, Munich, Germany
Communication dans un congrès hal-00118280v1

Activity of cells within alginate beads produced for fluidized bed bioreactor (bioartificial liver).

A. Kinasiewicz , A. Gautier , D. Lewinska , M. Dufresne , P. Paullier
XXIII ESAO Congress, Jun 2006, Umea, Sweden
Communication dans un congrès hal-00118286v1

CFD modeling of unsteady blood flow in a arteriovenous fistula reconstructed from angioscanner.

Z. Kharboutly , M. Fenech , J.M. Treutenaere , I. Claude , C. Legallais
30ème Congrès de la Société de Biomécanique. In Computer Methods in Biomechanics and Biomedical Engineering, 8,, 2005, Bruxelles, Belgium. pp.161-162
Communication dans un congrès hal-00019374v1

Investigation of Human Hepatoma cell line microfluidic devices.

E. Leclerc , L. Griscom , Bruno Le Pioufle , C. Guguen-Guillouzo , A. Corlu
3rd annual International IEEE EMBS special topic conference on microtechnologies in medicine and biology., 2005, Oahu, Hawaii, United States
Communication dans un congrès hal-00019381v1

Blood flow simulation in an arteriovenous fistula.

Z. Kharboutly , M. Fenech , J.M. Treutenaere , I. Claude , C. Legallais
XXth Congress International Society for Biomechanics, 2005, Cleveland, Ohio, United States
Communication dans un congrès hal-00019375v1

Hydrodynamic behaviour of several types of fluidized bed bioreactor used in a bioartificial liver.

R. Baudoin , A. Gautier , S.M. Coward , B. David , H.J.F. Hodgson
XXXII ESAO Congress, 2005, Bologne, Italy
Communication dans un congrès hal-00018719v1

Behaviour of osteoblast-like cells in cellular microdevices

E. Leclerc , B. David , R. Warocquier-Clerout , L. Griscom , Bruno Le Pioufle
Micro Total Analysis Systems 2004, Vol 1, 2005, Netherlands. pp.396-398
Communication dans un congrès hal-00795188v1
Image document

Chapter 4 : Membrane bioreactors for bio-artificial pancreas

Rachid Jellali , Amal Essaouiba , Eric Leclerc , Cécile Legallais
Current Trends and Future Developments on (Bio-) Membranes, Elsevier, pp.77-108, 2020, ⟨10.1016/b978-0-12-814225-7.00004-8⟩
Chapitre d'ouvrage hal-04476956v1

Are Co-Culture Approaches Able to Improve Biological Functions of Bioartificial Livers?

V. Pandolfi , Ulysse Pereira , Murielle Dufresne , C. Legallais
Biomedical Membranes and (Bio)Artificial Organs, 2, WORLD SCIENTIFIC, pp.179-210, 2018, 978-981-3223-97-4. ⟨10.1142/9789813223974_0007⟩
Chapitre d'ouvrage hal-03411616v1

Hemodynamics inside autologous arteriovenous fistulas.

Iolanda Decorato , Zaher Kharboutly , Cécile Legallais , Anne-Virginie Salsac
Medical Devices Design in Cardiovascular Applications., 2013
Chapitre d'ouvrage hal-02019796v1

Microencapsulation d'hépatocytes pour le développement d'un système de suppléance hépatique.

A. Gautier , B. Carpentier , C. Legallais
Coord. Vandamme, Poncelet, Subra-Paternault. Microencapsulation : des sciences aux technologies, Lavoisier Editions Tec&Doc, pp.295-312, 2007
Chapitre d'ouvrage hal-00289971v1

Plasma Separation and Purification by Membrane

M.Y. Jaffrin , C. Legallais
Encyclopedia of Biomedical Engineering, Wiley-Interscience,, pp.2795-2804, 2006, 9780471740360. ⟨10.1002/9780471740360.ebs0935⟩
Chapitre d'ouvrage hal-00096787v1