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CV Cécile Legallais


2018- :          Director of joint Université de Technologie de Compiègne (UTC)/CNRS Laboratory - UMR CNRS 7338 Biomechanics and Bioengineering



2015 - :         Associate Researcher (part time) Assistance Publique Hôpitaux de Paris (APHP)

2006 - :         Directeur de recherche CNRS (CNRS Senior researcher). Laboratory of Biomechanics and Bioengineering, Université de Technologie de Compiègne (FR)

1996-1997 :   Post-doctoral Fellow, University of Calabria (Italy) & Membrana GmbH (Germany)

1993 - 2006 : Chargé de recherche CNRS (CNRS Researcher). UTC Compiègne


ACADEMIC QUALIFICATIONS                                                                                                    

H.D.R.            1998    “Habilitation” to supervise Ph.D. Thesis. Université de Technologie de Compiègne (FR). Blood toxins removal by membrane processes.

Ph. D.              1993Université de Technologie de Compiègne (FR). Specialty : Biomedical Eng.  LDL-cholesterol removal from human plasma based on cascade filtration.



-          Bronze Medal from the CNRS, 2003.

-          Finalist (6 over 136 projects) of the Altran Foundation in 2007, “ Mending the human body”.

RESEARCH ACTIVITIES : Biomechanics and Bioengineering                                                        

Since 1995 :  Bioartificial liver at different scales : application to liver supply. Encapsulation of hepatoctes in alginate beads. Design of fluidized bed bioreactor. Full extracorporeal circulation. Coordinator of ANR TecSan SUPPLIVER (2011 -2015). WP Leader RHU Ilite (Innovations in Liver tissue Engineering) 2016-2020. Collaboration with Centre HépatoBiliaire, Villejuif (FR).

Since 2006 : Bone and musculo-skeletal tissue engineering based on flat sheet bioreactors

1994 - 2008: Mass transfer in hemodialysis and hemodiafiltration : Collaboration with Membrana GmbH, Fresenius Medical Care, Amiens Hospital

Since 2000 : Blood flow simulations in 3D vessels reconstructed from medical images.


PUBLICATIONS and COMMUNICATIONS                                                                                            

-          85 papers in international journals with peer review

-          6 book chapters

-          4 patents


SYNERGISTIC ACTIVITIES                                                                                                                      

-          President (2017-2019) of European Society for Artificial Organs (ESAO). Formerly Governor (2005-2011), General Secretary (2011-2015) & President Elect (2015-2017),

-          President of the XXXVIth ESAO Congress (2009) in Compiègne, France (400 participants)

-          Section Editor for International Journal for Artificial Organs

-          Reviewer for Artificial Organs, Journal of Membrane Science, Biotechnology Bioengineering, Separation Science and Technology, Journal of Polymer Science, Journal of Biomechanics, Medical Engineering and Physics, Plos One, Tissue Engineering, Biomaterials.

-  Member of the ITN Marie Curie BioArt.


PhD SUPERVISION                                                                                                                                            

-22 PhD students at UTC : E. DORE (1999), J-L. DULONG (2002), B. DAVID (2002), B. BERTHIER (2005), Z. KHARBOUTLY (2007), A. GAUTIER (2008) with co-sup A. OULDDRIS, B. CARPENTIER (2009) with co-sup P. LAYROLLE, H. MOREL (2009) with co-sup M. JAFFRIN, J.M. PROT (2010) with co-sup E. LECLERC, D. HABKA (2011) with co-sup C. BROCHOT, S. CAPONE (2012) with co-sup DAUJAT, N.M. TRAN (2012) with co-sup M. DUFRESNE, S. FIGARO (CIFRE 2015) with co-sup G. VANTARD (Gambro),  T. BAUDEQUIN (2015) with co-sup F. BEDOUI (UMR CNRS 7337), V. PANDOLFI (2016),  D. BRESSON (2016) with co-sup), W. YAKOUB, (CIFRE 2017) with co-sup D. Balvay (Span Diagnostics), A. GARCIA GARCIA (2015-) with co-sup F. BEDOUI (UMR CNRS 7337), M. BELD-JILALI (2016-) with co-sup JF Grosset, L. BOULAIS (2016-) with co-sup S. Bencherif, M. PASQUA (2016-) with co-sup U. Pereira, A. ESSAOUIBA (2017 with co-sup E. Leclerc.


Journal articles33 documents

  • Christopher Leon-Valdivieso, Alejandro Garcia-Garcia, Cécile Legallais, Fahmi Bedoui. Electrospinning of biomedically relevant multi-region scaffolds: From honeycomb to randomly-oriented microstructure. Polymer, Elsevier, 2020, 202, pp.122606. ⟨10.1016/j.polymer.2020.122606⟩. ⟨hal-02884169⟩
  • Claire Goumard, Eric Savier, Jerome Danion, Jérôme Pelissie, Cécile Legallais, et al.. Cold-to-warm machine perfusion of the liver: a novel circuit for an uninterrupted combined perfusion protocol. HPB, Wiley, 2020, 22 (6), pp.927-933. ⟨10.1016/j.hpb.2020.04.001⟩. ⟨hal-02884180⟩
  • Mattia Pasqua, Ulysse Pereira, Antonietta Messina, Claire de Lartigue, Pascale Vigneron, et al.. HepaRG Self-Assembled Spheroids in Alginate Beads Meet the Clinical Needs for Bioartificial Liver. Tissue Engineering: Parts A, B, and C, Mary Ann Liebert, 2020, 26 (11-12), pp.613-622. ⟨10.1089/ten.tea.2019.0262⟩. ⟨hal-02884175⟩
  • Amal Essaouiba, Teru Okitsu, Rachid Jellali, Marie Shinohara, Mathieu Danoy, et al.. Microwell-based pancreas-on-chip model enhances genes expression and functionality of rat islets of Langerhans. Molecular and Cellular Endocrinology, Elsevier, 2020, 112, pp.110892. ⟨10.1016/j.mce.2020.110892⟩. ⟨hal-02884096⟩
  • Xavier Guchet, Cécile Legallais. Nanotechnology and Bioartificial Liver Engineering. Two Rival Paths for “Converging Technology”. Philosophia Scientiae, Editions Kime, 2019, pp.121-135. ⟨10.4000/philosophiascientiae.1839⟩. ⟨hal-02140040⟩
  • Timothée Baudequin, Cécile Legallais, Fahmi Bedoui. In Vitro Bone Cell Response to Tensile Mechanical Solicitations: Is There an Optimal Protocol?. Biotechnology Journal, Wiley-VCH Verlag, 2019, 14 (1), pp.1800358. ⟨10.1002/biot.201800358⟩. ⟨hal-02061207⟩
  • Rachid Jellali, Françoise Gilard, Vittoria Pandolfi, Audrey Legendre, Marie-José Fleury, et al.. Metabolomics-on-a-chip approach to study hepatotoxicity of DDT, permethrin and their mixtures. Journal of Applied Toxicology, Wiley, 2018, 38 (8), pp.1121-1134. ⟨10.1002/jat.3624⟩. ⟨hal-02357461⟩
  • Cécile Legallais, Dooli Kim, Sylvia Mihaila, Milos Mihajlovic, Marina Figliuzzi, et al.. Bioengineering Organs for Blood Detoxification. Advanced Healthcare Materials, Wiley, 2018, 7 (21), pp.1800430. ⟨hal-01956818⟩
  • Alejandro Garcia Garcia, Anne Hebraud, Jean-Luc Duval, Corinne Wittmer, Ludovic Gaut, et al.. Poly(ε-caprolactone)/Hydroxyapatite 3D Honeycomb Scaffolds for a Cellular Microenvironment Adapted to Maxillofacial Bone Reconstruction. ACS Biomaterials Science and Engineering, ACS, 2018, 4 (9), pp.3317-3326. ⟨hal-01954881⟩
  • Alejandro Garcia Garcia, Anne Hebraud, Jean-Luc Duval, Corinne Wittmer, Ludovic Gaut, et al.. Poly(ε-caprolactone)/Hydroxyapatite 3D Honeycomb Scaffolds for a Cellular Microenvironment Adapted to Maxillofacial Bone Reconstruction. ACS Biomaterials Science and Engineering, ACS, 2018, 4 (9), pp.3317-3326. ⟨10.1021/acsbiomaterials.8b00521⟩. ⟨hal-02393845⟩
  • Vittoria Pandolfi, Ulysse Pereira, Murielle Dufresne, Cécile Legallais. Alginate-Based Cell Microencapsulation for Tissue Engineering and Regenerative Medicine. Current Pharmaceutical Design, Bentham Science Publishers, 2017, 23 (26), ⟨10.2174/1381612823666170609084016⟩. ⟨hal-02938367⟩
  • Seyed Danial Naghib, Vittoria Pandolfi, Ulysse Pereira, Rossella Girimonte, Efrem Curcio, et al.. Expansion properties of alginate beads as cell carrier in the fluidized bed bioartificial liver. Powder Technology, Elsevier, 2017, 316, pp.711-717. ⟨10.1016/j.powtec.2016.12.047⟩. ⟨hal-02938369⟩
  • Sébastien Kissling, Cécile Legallais, Menno Pruijm, Daniel Teta, Bruno Vogt, et al.. A new prescription model for regional citrate anticoagulation in therapeutic plasma exchanges. BMC Nephrology, BioMed Central, 2017, 18 (1), ⟨10.1186/s12882-017-0494-9⟩. ⟨hal-02938371⟩
  • Timothée Baudequin, Ludovic Gaut, Marc Mueller, Angela Huepkes, Birgit Glasmacher, et al.. The Osteogenic and Tenogenic Differentiation Potential of C3H10T1/2 (Mesenchymal Stem Cell Model) Cultured on PCL/PLA Electrospun Scaffolds in the Absence of Specific Differentiation Medium. Materials, MDPI, 2017, 10 (12), pp.1387. ⟨10.3390/ma10121387⟩. ⟨hal-02938374⟩
  • Sarah Figaro, Ulysse Pereira, Hiram Rada, Nicolas Semenzato, Dominique Pouchoulin, et al.. Optimizing the fluidized bed bioreactor as an external bioartificial liver. International Journal of Artificial Organs, Wichtig Editore, 2017, 40 (4), pp.196-203. ⟨10.5301/ijao.5000567⟩. ⟨hal-02938255⟩
  • Iolanda Decorato, Zaher Kharboutly, Cécile Legallais, Anne-Virginie Salsac. Comparison of two Endovascular Treatments of a Stenosed Arteriovenous Fistula: Balloon-Angioplasty with and without Stenting. International Journal of Artificial Organs, Wichtig Editore, 2014, 37 (10), pp.763-772. ⟨hal-02019770⟩
  • Iolanda Decorato, Anne-Virginie Salsac, Cécile Legallais, Mona Alimohammadi, Vanessa Diaz-Zuccarini, et al.. Influence of an Arterial Stenosis on the Hemodynamics Within an Arteriovenous Fistula (AVF): Comparison Before and After Balloon-Angioplasty. Cardiovascular Engineering and Technology, Springer, 2014, 5 (3), pp.233-243. ⟨hal-02019623⟩
  • Iolanda Decorato, Zaher Kharboutly, Tommaso Vassallo, Justin Penrose, Cécile Legallais, et al.. Numerical simulation of the fluid structure interactions in a compliant patient-specific arteriovenous fistula. International Journal for Numerical Methods in Biomedical Engineering, John Wiley and Sons, 2014, 30 (2), pp.143-159. ⟨hal-02019727⟩
  • Stephanie Capone, Murielle Dufresne, Mathias Rechel, Marie-José Fleury, Anne-Virginie Salsac, et al.. Impact of Alginate Composition: From Bead Mechanical Properties to Encapsulated HepG2/C3A Cell Activities for In Vivo Implantation. PLoS ONE, Public Library of Science, 2013, 8 (4), pp.e62032. ⟨10.1371/journal.pone.0062032⟩. ⟨hal-02019744⟩
  • Leila Choucha-Snouber, Andrei Bunescu, Cécile Legallais, Céline Brochot, Marc-Emmanuel Dumas, et al.. Metabolomics-on-a-chip of hepatotoxicity induced by anticancer drug flutamide and its active metabolite hydroxyflutamide using HepG2/C3a microfluidic biochips. Toxicological Sciences, Oxford University Press (OUP), 2013, 132 (1), pp.8-20. ⟨10.1093/toxsci/kfs230⟩. ⟨ineris-00963445⟩
  • Régis Baudoin, Jean-Matthieu Prot, Grégory Nicolas, Jessy Brocheton, Céline Brochot, et al.. Evaluation of seven drug metabolisms and clearances by cryopreserved human primary hepatocytes cultivated in microfluidic biochips. Xenobiotica, Taylor & Francis, 2013, 43 (2), pp.140-152. ⟨10.3109/00498254.2012.706725⟩. ⟨ineris-00963431⟩
  • Murielle Dufresne, Patrice Bacchin, Giulia Cerino, Jean-Christophe Remigy, Gerard Nathanael Adrianus, et al.. Human hepatic cell behavior on polysulfone membrane with double porosity level. Journal of Membrane Science, Elsevier, 2013, vol. 428, pp. 454-461. ⟨10.1016/j.memsci.2012.10.041⟩. ⟨hal-00788387⟩
  • Leila Choucha-Snouber, Caroline Aninat, Laurent Grsicom, Geoffrey Madalinski, Céline Brochot, et al.. Investigation of ifosfamide nephrotoxicity induced in a liver-kidney co-culture biochip.. Biotechnology and Bioengineering, Wiley, 2013, 110 (2), pp.597-608. ⟨10.1002/bit.24707⟩. ⟨inserm-00864839⟩
  • Jean-Matthieu Prot, Andrei Bunescu, Bénédicte Elena-Herrmann, Caroline Aninat, Leila Choucha Snouber, et al.. Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: Application to acetaminophen injury. Toxicology and Applied Pharmacology, Elsevier, 2012, 259 (3), pp.270-280. ⟨10.1016/j.taap.2011.12.017⟩. ⟨hal-00699551⟩
  • Laetitia Shintu, Régis Baudoin, Vincent Navratil, Jean-Matthieu Prot, Clément Pontoizeau, et al.. Metabolomics-on-a-Chip and Predictive Systems Toxicology in Microfluidic Bioartificial Organs. Analytical Chemistry, American Chemical Society, 2012, 84 (4), pp.1840-1848. ⟨10.1021/ac2011075⟩. ⟨hal-00699575⟩
  • Jean-Matthieu Prot, Orianne Videau, Céline Brochot, Cécile Legallais, Henri Benech, et al.. A cocktail of metabolic probes demonstrates the relevance of primary human hepatocyte cultures in a microfluidic biochip for pharmaceutical drug screening. International Journal of Pharmaceutics, Elsevier, 2011, 108 (1-2), pp.67-75. ⟨10.1016/j.ijpharm.2011.01.054⟩. ⟨ineris-00963290⟩
  • Jean Matthieu Prot, Caroline Aninat, Laurent Griscom, Florence Razan, Céline Brochot, et al.. Improvement of HepG2/C3a cell functions in a microfluidic biochip.. Biotechnology and Bioengineering, Wiley, 2011, 108 (7), pp.1704-15. ⟨10.1002/bit.23104⟩. ⟨hal-00740224⟩
  • Olivier Romain, Johan Mazeyrat, Patrick Garda, Hakeim Talleb, David Lautru, et al.. ENDOCOM: Implantable wireless pressure sensor for the follow-up of abdominal aortic aneurysm stented. Innovation and Research in BioMedical engineering, Elsevier Masson, 2011, 32 (3), pp.163 - 168. ⟨10.1016/j.irbm.2011.01.017⟩. ⟨hal-00665334⟩
  • Zaher Kharboutly, Valérie Deplano, Eric Bertrand, Cécile Legallais. Numerical and experimental study of blood flow through a patient-specific arteriovenous fistula used for hemodialysis. Medical Engineering and Physics, Elsevier, 2010, 32, pp.111-118. ⟨10.1016/j.medengphy.2009.10.013⟩. ⟨hal-00429960⟩
  • Dany Habka, Alexandre R.R. Pery, Cécile Legallais, Céline Brochot. Prédiction de la toxicocinétique in vivo de substances chimiques à partir de données in vitro et de modèles QSAR. Environnement, Risques and Santé, John Libbey Eurotext, 2010, 9 (6), pp.489-501. ⟨ineris-00963259⟩
  • A. Ould-Dris, P. Paullier, Laurent Griscom, Cécile Legallais, E. Leclerc. Analysis of the mass transfers in an artificial kidney microchip. Journal of Membrane Science, Elsevier, 2010, 352, pp.116-125. ⟨10.1016/j.memsci.2010.02.007⟩. ⟨hal-00592403⟩
  • Sam Coward, Cécile Legallais, Bertrand David, Michael Thomas, Ying Foo, et al.. Alginate-encapsulated HepG2 Cells in a Fluidized Bed Bioreactor Maintain Function in Human Liver Failure Plasma. Artificial Organs, Wiley, 2009, 33 (12), pp.1117-1126. ⟨10.1111/j.1525-1594.2009.00821.x⟩. ⟨hal-02149842⟩
  • Eric Leclerc, Bertrand David, Laurent Griscom, Bruno Lepioufle, Yasuyuki Sakai, et al.. Perfusion culture of mammalian cells in microfluidic environments for tissue engineering applications . La Houille Blanche - Revue internationale de l'eau, EDP Sciences, 2006, pp.56-59. ⟨10.1051/lhb:200603008⟩. ⟨hal-02149903⟩

Conference papers5 documents

  • Olivier Romain, Johan Mazeyrat, Patrick Garda, Hakeim Talleb, David Lautru, et al.. RFID implantable pressure sensor for the follow-up of abdominal aortic aneurysm stented. IEEE DTIS 2011 : 6th International conference on Design & Technology of Integrated Systems in nanoscale era, Apr 2011, Athens, Greece. pp.1-6, ⟨10.1109/DTIS.2011.5941418⟩. ⟨hal-00600948⟩
  • Dany Habka, Alexandre R.R. Pery, C. Aninat, A. Corlu, C. Guguen-Guillouzo, et al.. Calibration of PBPK models based on in vivo and in vitro data to describe complex biotransformation processes. 12. International Congress of Toxicology (IUTOX 2010), Jul 2010, Barcelone, Spain. ⟨ineris-00970650⟩
  • Zaher Kharboutly, Cécile Legallais, Eric Bertrand, Valérie Deplano. Caractérisation des écoulements dans une fistule artério veineuse. Comparaison numérique expérimentale.. Journées scientifiques du GDR2760 : Interactions fluide structure biologiques, May 2007, Marseille, France. ⟨hal-00456057⟩
  • Zaher Kharboutly, Cécile Legallais, Valérie Deplano, Eric Bertrand. Modélisations numérique et expérimentale des écoulements sanguins dans une fistule artério veineuse. 8ème Colloque National en calcul des structures, May 2007, Giens, France. ⟨hal-00455960⟩
  • Zaher Kharboutly, Cécile Legallais, Valérie Deplano, Eric Bertrand. Modélisations numérique et expérimentale des écoulements sanguins dans une fistule artério-veineuse. 8e Colloque national en calcul des structures, CSMA, May 2007, Giens, France. ⟨hal-01507578⟩

Book sections2 documents

  • Rachid Jellali, Amal Essaouiba, Eric Leclerc, Cécile Legallais. Membrane bioreactors for bio-artificial pancreas. Current Trends and Future Developments on (Bio-) Membranes, Elsevier, pp.77-108, 2020, ⟨10.1016/B978-0-12-814225-7.00004-8⟩. ⟨hal-02357450⟩
  • Iolanda Decorato, Zaher Kharboutly, Cécile Legallais, Anne-Virginie Salsac. Hemodynamics inside autologous arteriovenous fistulas.. Medical Devices Design in Cardiovascular Applications., 2013. ⟨hal-02019796⟩