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108

CV Cécile Legallais


 

Cécile LEGALLAIS                                                  

 

Date of birth : 07/03/1968

 

cecile.legallais@utc.fr                                                 

 

PRESENT POSITION

 

2018 - :       Head of Laboratory of Biomechanics and Bioengineering (joint lab Université de Technologie de Compiè(UTC)/CNRS)

 

APPOINTMENTS                                                                                                                           

 

2006 -       :  Directeur de recherche CNRS (CNRS Senior researcher). Laboratory of Biomechanics and Bioengineering, Université de Technologie de Compiègne (FR)

 

2015 - 2018 :Associate Researcher (part time) Assistance Publique Hôpitaux de Paris (APHP)

 

1996 - 1997 : Post-doctoral Fellow, University of Calabria (Italy) & Membrana GmbH (Germany)

 

1993 - 2006 : Chargé de recherche CNRS (CNRS Researcher). UTC Compiègne

 

ACADEMIC QUALIFICATIONS                                                                                                    

 

H.D.R.           1998 “Habilitation” to supervise Ph.D. Thesis. Université de Technologie de Compiègne (FR). Blood toxins removal by membrane processes.

 

Ph. D.             1993Université de Technologie de Compiègne (FR). Specialty : Biomedical Eng.  LDL-cholesterol removal from human plasma based on cascade filtration.

 

MS/Eng. D     1990 Ecole Nationale Supérieure de Mécanique et Aérotechnique (Poitiers) – Engineer in Fluid Mechanics

 

AWARDS                                                                                                                                          

 

Bronze Medal from the CNRS, 2003.

 

RESEARCH ACTIVITIES : Biomechanics of Organ Supply systems                                               

 

Since 1995 : Bioartificial liver at different scales. Encapsulation of hepatoctes in alginate beads. Design and characterization of fluidized bed bioreactor. Full extracorporeal circulation. PI of ANR TecSan SUPPLIVER (2011 -2015). WP Leader RHU Ilite (Innovations in Liver tissue Engineering) (2016-2022).  PI of ANR MimLiveronChip (Organ on Chip) (2019-2023)

 

Since 2006:  Bone and musculo-skeletal tissue engineering based on stretching bioreactors – Mechanical and biological characterization.

 

Since 1994:   Flow and Mass transfer in hemodialysis and hemodiafiltration : Collaboration with Membrana GmbH, Fresenius Medical Care, Amiens Hospital

 

Since 2000 :   Blood flow simulations in 3D vessels reconstructed from medical images.

 

PUBLICATIONS and COMMUNICATIONS                                                                                            

 

-          105 papers in international journals with peer review

 

-          6 book chapters, 4 patents

 

SYNERGISTIC ACTIVITIES                                                                                                                      

 

-          Past President (2019-2021) of European Society for Artificial Organs (ESAO). Formerly Governor (2005-2011), General Secretary (2011-2015),  President Elect (2015-2017)& President (2017-2019).

 

-          Member of the Board of the International Federation for Artificial Organs (IFAO)

 

-          President of the XXXVIth ESAO Congress (2009) in Compiègne, France (400 participants)

 

-          Reviewer for Artificial Organs, Journal of Membrane Science, Biotechnology Bioengineering, Separation Science and Technology, Journal of Polymer Science, Journal of Biomechanics, Medical Engineering and Physics, Plos One, Tissue Engineering, Biomaterials.

 

SUPERVISION                                                                                                                                                    

 

- 25 PhD students at UTC (22 achieved, 3 ongoing)

 

- 3 HDR Habilitation at UTC

 

TEACHING ACTIVITIES                                                                                                                                

 

-          Lecture on Artificial Organs (UTC) – 20h/y

 

-          Hands on activities for engineering students (tissue engineering, hemodialysis)

 


Journal articles70 documents

  • Antonietta Messina, Eléanor Luce, Nassima Benzoubir, Mattia Pasqua, Ulysse Pereira, et al.. Evidence of Adult Features and Functions of Hepatocytes Differentiated from Human Induced Pluripotent Stem Cells and Self-Organized as Organoids. Cells, MDPI, 2022, 11 (3), ⟨10.3390/cells11030537⟩. ⟨hal-03561619⟩
  • Ahmed Abarkan, Nabil Grimi, Hubert Métayer, Tarik Sqalli Houssaïni, C. Legallais. Electrodialysis Can Lower the Environmental Impact of Hemodialysis. Membranes, MDPI, 2022, 12 (1), pp.45. ⟨10.3390/membranes12010045⟩. ⟨hal-03590375⟩
  • Megane Beldjilali-Labro, Rachid Jellali, Alexander David Brown, Alejandro Garcia Garcia, Augustin Lerebours, et al.. Multiscale-Engineered Muscle Constructs: PEG Hydrogel Micro-Patterning on an Electrospun PCL Mat Functionalized with Gold Nanoparticles. International Journal of Molecular Sciences, MDPI, 2022, 23 (1), pp.260. ⟨10.3390/ijms23010260⟩. ⟨hal-03590377⟩
  • Mattia Pasqua, Ulysse Pereira, Claire Lartigue, Jonathan Nicolas, Pascale Vigneron, et al.. Preclinical characterization of alginate‐Poly‐L‐Lysine encapsulated HepaRG for extracorporeal liver supply. Biotechnology and Bioengineering, Wiley, 2021, 118 (1), ⟨10.1002/bit.27583⟩. ⟨hal-02961888⟩
  • Alejandro Garcia Garcia, Jean-Baptiste Perot, Megane Beldjilali-Labro, Quentin Dermigny, Marie Naudot, et al.. Monitoring mechanical stimulation for optimal tendon tissue engineering: a mechanical and biological multiscale study. Journal of Biomedical Materials Research Part A, Wiley, 2021, ⟨10.1002/jbm.a.37180⟩. ⟨hal-03029652⟩
  • Lilandra Boulais, Rachid Jellali, Ulysse Pereira, Eric Leclerc, Sidi A Bencherif, et al.. Cryogel-Integrated Biochip for Liver Tissue Engineering. ACS Applied Bio Materials, ACS Publications, 2021, 4 (7), pp.5617-5626. ⟨10.1021/acsabm.1c00425⟩. ⟨hal-03322953⟩
  • Marie Naudot, Alejandro Garcia Garcia, Nicolas Jankovsky, Anaïs Barre, Luciane Zabijak, et al.. The combination of a poly‐caprolactone/nano‐hydroxyapatite honeycomb scaffold and mesenchymal stem cells promotes bone regeneration in rat calvarial defects. Journal of Tissue Engineering and Regenerative Medicine, John Wiley & Sons Ltd., 2020, ⟨10.1002/term.3114⟩. ⟨hal-02961861⟩
  • Christopher Leon-Valdivieso, Alejandro Garcia-Garcia, Cécile Legallais, Fahmi Bedoui. Electrospinning of biomedically relevant gradient scaffolds: From honeycomb to randomly-oriented microstructure. Polymer, Elsevier, 2020, 202, pp.122606. ⟨10.1016/j.polymer.2020.122606⟩. ⟨hal-02884169⟩
  • Mattia Pasqua, Ulysse Pereira, Antonietta Messina, Claire de Lartigue, Pascale Vigneron, et al.. HepaRG Self-Assembled Spheroids in Alginate Beads Meet the Clinical Needs for Bioartificial Liver. Tissue Engineering: Parts A, B, and C, Mary Ann Liebert, 2020, 26 (11-12), pp.613-622. ⟨10.1089/ten.tea.2019.0262⟩. ⟨hal-02884175⟩
  • Claire Goumard, Eric Savier, Jerome Danion, Jérôme Pelissie, Cécile Legallais, et al.. Cold-to-warm machine perfusion of the liver: a novel circuit for an uninterrupted combined perfusion protocol. HPB, Wiley, 2020, 22 (6), pp.927-933. ⟨10.1016/j.hpb.2020.04.001⟩. ⟨hal-02884180⟩
  • Amal Essaouiba, Teru Okitsu, Rachid Jellali, Marie Shinohara, Mathieu Danoy, et al.. Microwell-based pancreas-on-chip model enhances genes expression and functionality of rat islets of Langerhans. Molecular and Cellular Endocrinology, Elsevier, 2020, 112, pp.110892. ⟨10.1016/j.mce.2020.110892⟩. ⟨hal-02884096⟩
  • Amal Essaouiba, Teru Okitsu, R. Kinoshita, Rachid Jellali, Yasuyuki Sakai, et al.. Development of a pancreas-liver organ-on-chip coculture model for organ-to-organ interaction studies. Biochemical Engineering Journal, Elsevier, 2020, 164, pp.107783. ⟨10.1016/j.bej.2020.107783⟩. ⟨hal-03095499⟩
  • L. Boulais, M. Pasqua, C. de Lartigue, R. Jellali, U. Pereira, et al.. Bioartificial liver: biomechanical considerations. Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis, 2019, 44th Congress of the Société de Biomécanique, 22 (sup1), pp.S370-S372. ⟨10.1080/10255842.2020.1714948⟩. ⟨hal-03322978⟩
  • Timothée Baudequin, Cécile Legallais, Fahmi Bedoui. In Vitro Bone Cell Response to Tensile Mechanical Solicitations: Is There an Optimal Protocol?. Biotechnology Journal, Wiley-VCH Verlag, 2019, 14 (1), pp.1800358. ⟨10.1002/biot.201800358⟩. ⟨hal-02061207⟩
  • Xavier Guchet, Cécile Legallais. Nanotechnology and Bioartificial Liver Engineering. Two Rival Paths for “Converging Technology”. Philosophia Scientiae, Editions Kime, 2019, pp.121-135. ⟨10.4000/philosophiascientiae.1839⟩. ⟨hal-02140040⟩
  • B. David, E. Dore, M.Y. Jaffrin, C. Legallais. Mass Transfers in a Fluidized Bed Bioreactor using Alginate Beads for a Future Bioartificial Liver. International Journal of Artificial Organs, Wichtig Editore, 2018, 27 (4), pp.284-293. ⟨10.1177/039139880402700404⟩. ⟨hal-02149863⟩
  • Rachid Jellali, Françoise Gilard, Vittoria Pandolfi, Audrey Legendre, Marie-José Fleury, et al.. Metabolomics-on-a-chip approach to study hepatotoxicity of DDT, permethrin and their mixtures. Journal of Applied Toxicology, Wiley, 2018, 38 (8), pp.1121-1134. ⟨10.1002/jat.3624⟩. ⟨hal-02357461⟩
  • Alejandro Garcia Garcia, Anne Hebraud, Jean-Luc Duval, Corinne Wittmer, Ludovic Gaut, et al.. Poly(ε-caprolactone)/Hydroxyapatite 3D Honeycomb Scaffolds for a Cellular Microenvironment Adapted to Maxillofacial Bone Reconstruction. ACS Biomaterials Science and Engineering, ACS, 2018, 4 (9), pp.3317-3326. ⟨10.1021/acsbiomaterials.8b00521⟩. ⟨hal-02393845⟩
  • Cécile Legallais, Dooli Kim, Sylvia Mihaila, Milos Mihajlovic, Marina Figliuzzi, et al.. Bioengineering Organs for Blood Detoxification. Advanced Healthcare Materials, Wiley, 2018, 7 (21), pp.1800430. ⟨10.1002/adhm.201800430⟩. ⟨hal-01956818⟩
  • Megane Beldjilali-Labro, Alejandro Garcia Garcia, Firas Farhat, Fahmi Bedoui, Jean-François Grosset, et al.. Biomaterials in Tendon and Skeletal Muscle Tissue Engineering: Current Trends and Challenges. Materials, MDPI, 2018, 11 (7), pp.1116. ⟨10.3390/ma11071116⟩. ⟨hal-01956820⟩
  • Seyed Danial Naghib, Vittoria Pandolfi, Ulysse Pereira, Rossella Girimonte, Efrem Curcio, et al.. Expansion properties of alginate beads as cell carrier in the fluidized bed bioartificial liver. Powder Technology, Elsevier, 2017, 316, pp.711-717. ⟨10.1016/j.powtec.2016.12.047⟩. ⟨hal-02938369⟩
  • Timothée Baudequin, Ludovic Gaut, Marc Mueller, Angela Huepkes, Birgit Glasmacher, et al.. The Osteogenic and Tenogenic Differentiation Potential of C3H10T1/2 (Mesenchymal Stem Cell Model) Cultured on PCL/PLA Electrospun Scaffolds in the Absence of Specific Differentiation Medium. Materials, MDPI, 2017, 10 (12), pp.1387. ⟨10.3390/ma10121387⟩. ⟨hal-02938374⟩
  • Sarah Figaro, Ulysse Pereira, Hiram Rada, Nicolas Semenzato, Dominique Pouchoulin, et al.. Optimizing the fluidized bed bioreactor as an external bioartificial liver. International Journal of Artificial Organs, Wichtig Editore, 2017, 40 (4), pp.196-203. ⟨10.5301/ijao.5000567⟩. ⟨hal-02938255⟩
  • Sébastien Kissling, Cécile Legallais, Menno Pruijm, Daniel Teta, Bruno Vogt, et al.. A new prescription model for regional citrate anticoagulation in therapeutic plasma exchanges. BMC Nephrology, BioMed Central, 2017, 18 (1), ⟨10.1186/s12882-017-0494-9⟩. ⟨hal-02938371⟩
  • Vittoria Pandolfi, Ulysse Pereira, Murielle Dufresne, Cécile Legallais. Alginate-Based Cell Microencapsulation for Tissue Engineering and Regenerative Medicine. Current Pharmaceutical Design, Bentham Science Publishers, 2017, 23 (26), ⟨10.2174/1381612823666170609084016⟩. ⟨hal-02938367⟩
  • Timothée Baudequin, Fahmi Bedoui, Murielle Dufresne, Patrick Paullier, Cécile Legallais. Towards the Development and Characterization of an Easy Handling Sheet-Like Biohybrid Bone Substitute. Tissue Engineering: Parts A, B, and C, Mary Ann Liebert, 2015, 21 (11-12), pp.1895-1905. ⟨10.1089/ten.tea.2014.0580⟩. ⟨hal-03433119⟩
  • Iolanda Decorato, Anne-Virginie Salsac, Cécile Legallais, Mona Alimohammadi, Vanessa Diaz-Zuccarini, et al.. Influence of an Arterial Stenosis on the Hemodynamics Within an Arteriovenous Fistula (AVF): Comparison Before and After Balloon-Angioplasty. Cardiovascular Engineering and Technology, Springer, 2014, 5 (3), pp.233-243. ⟨hal-02019623⟩
  • Iolanda Decorato, Zaher Kharboutly, Cécile Legallais, Anne-Virginie Salsac. Comparison of two Endovascular Treatments of a Stenosed Arteriovenous Fistula: Balloon-Angioplasty with and without Stenting. International Journal of Artificial Organs, Wichtig Editore, 2014, 37 (10), pp.763-772. ⟨hal-02019770⟩
  • Iolanda Decorato, Zaher Kharboutly, Tommaso Vassallo, Justin Penrose, Cécile Legallais, et al.. Numerical simulation of the fluid structure interactions in a compliant patient-specific arteriovenous fistula. International Journal for Numerical Methods in Biomedical Engineering, John Wiley and Sons, 2014, 30 (2), pp.143-159. ⟨hal-02019727⟩
  • N.M. Tran, M. Dufresne, Gilles Duverlie, Sandrine Castelain, Christian Défarge, et al.. An appropriate selection of 3D alginate culture model for hepatic Huh-7 cell line encapsulation intended for viral studies. Tissue Engineering: Parts A, B, and C, Mary Ann Liebert, 2013, 19 (1-2), pp.103-113. ⟨10.1089/ten.tea.2012.0139⟩. ⟨insu-00723045⟩
  • Murielle Dufresne, Patrice Bacchin, Giulia Cerino, Jean-Christophe Remigy, Gerard Nathanael Adrianus, et al.. Human hepatic cell behavior on polysulfone membrane with double porosity level. Journal of Membrane Science, Elsevier, 2013, vol. 428, pp. 454-461. ⟨10.1016/j.memsci.2012.10.041⟩. ⟨hal-00788387⟩
  • Leila Choucha-Snouber, Andrei Bunescu, Cécile Legallais, Céline Brochot, Marc-Emmanuel Dumas, et al.. Metabolomics-on-a-chip of hepatotoxicity induced by anticancer drug flutamide and its active metabolite hydroxyflutamide using HepG2/C3a microfluidic biochips. Toxicological Sciences, Oxford University Press (OUP), 2013, 132 (1), pp.8-20. ⟨10.1093/toxsci/kfs230⟩. ⟨ineris-00963445⟩
  • Leila Choucha-Snouber, Caroline Aninat, Laurent Grsicom, Geoffrey Madalinski, Céline Brochot, et al.. Investigation of ifosfamide nephrotoxicity induced in a liver-kidney co-culture biochip.. Biotechnology and Bioengineering, Wiley, 2013, 110 (2), pp.597-608. ⟨10.1002/bit.24707⟩. ⟨inserm-00864839⟩
  • Stephanie Capone, Murielle Dufresne, Mathias Rechel, Marie-José Fleury, Anne-Virginie Salsac, et al.. Impact of Alginate Composition: From Bead Mechanical Properties to Encapsulated HepG2/C3A Cell Activities for In Vivo Implantation. PLoS ONE, Public Library of Science, 2013, 8 (4), pp.e62032. ⟨10.1371/journal.pone.0062032⟩. ⟨hal-02019744⟩
  • Régis Baudoin, Jean-Matthieu Prot, Grégory Nicolas, Jessy Brocheton, Céline Brochot, et al.. Evaluation of seven drug metabolisms and clearances by cryopreserved human primary hepatocytes cultivated in microfluidic biochips. Xenobiotica, Taylor & Francis, 2013, 43 (2), pp.140-152. ⟨10.3109/00498254.2012.706725⟩. ⟨ineris-00963431⟩
  • Jean-Matthieu Prot, Andrei Bunescu, Bénédicte Elena-Herrmann, Caroline Aninat, Leila Choucha Snouber, et al.. Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: Application to acetaminophen injury. Toxicology and Applied Pharmacology, Elsevier, 2012, 259 (3), pp.270-280. ⟨10.1016/j.taap.2011.12.017⟩. ⟨hal-00699551⟩
  • Laetitia Shintu, Régis Baudoin, Vincent Navratil, Jean-Matthieu Prot, Clément Pontoizeau, et al.. Metabolomics-on-a-Chip and Predictive Systems Toxicology in Microfluidic Bioartificial Organs. Analytical Chemistry, American Chemical Society, 2012, 84 (4), pp.1840-1848. ⟨10.1021/ac2011075⟩. ⟨hal-00699575⟩
  • Jean-Matthieu Prot, Orianne Videau, Céline Brochot, Cécile Legallais, Henri Benech, et al.. A cocktail of metabolic probes demonstrates the relevance of primary human hepatocyte cultures in a microfluidic biochip for pharmaceutical drug screening. International Journal of Pharmaceutics, Elsevier, 2011, 108 (1-2), pp.67-75. ⟨10.1016/j.ijpharm.2011.01.054⟩. ⟨ineris-00963290⟩
  • Olivier Romain, Johan Mazeyrat, Patrick Garda, Hakeim Talleb, David Lautru, et al.. ENDOCOM: Implantable wireless pressure sensor for the follow-up of abdominal aortic aneurysm stented. Innovation and Research in BioMedical engineering, Elsevier Masson, 2011, 32 (3), pp.163 - 168. ⟨10.1016/j.irbm.2011.01.017⟩. ⟨hal-00665334⟩
  • J.-M. Prot, C. Animat, L. Griscom, Florence Razan, C. Brochot, et al.. Improvement of HepG2/C3a cell functions in a microfluidic biochip. Biotechnology and Bioengineering, Wiley, 2011, 108 (7), pp.1704-1715. ⟨hal-00755944⟩
  • Jean Matthieu Prot, Caroline Aninat, Laurent Griscom, Florence Razan, Céline Brochot, et al.. Improvement of HepG2/C3a cell functions in a microfluidic biochip.. Biotechnology and Bioengineering, Wiley, 2011, 108 (7), pp.1704-15. ⟨10.1002/bit.23104⟩. ⟨hal-00740224⟩
  • J.M. Prot, A.S. Briffaut, F. Letourneur, P. Chafey, F. Merlier, et al.. Integrated proteomic and transcriptomic investigation of the acetaminophen toxicity in liver microfluidic biochip.. PLoS ONE, Public Library of Science, 2011, 6 (8), pp.e21268. ⟨10.1371/journal.pone.0021268⟩. ⟨hal-00637409⟩
  • Dany Habka, Alexandre R.R. Pery, Cécile Legallais, Céline Brochot. Prédiction de la toxicocinétique in vivo de substances chimiques à partir de données in vitro et de modèles QSAR. Environnement, Risques et Santé, John Libbey Eurotext, 2010, 9 (6), pp.489-501. ⟨ineris-00963259⟩
  • A. Ould-Dris, P. Paullier, Laurent Griscom, Cécile Legallais, E. Leclerc. Analysis of the mass transfers in an artificial kidney microchip. Journal of Membrane Science, Elsevier, 2010, 352, pp.116-125. ⟨10.1016/j.memsci.2010.02.007⟩. ⟨hal-00592403⟩
  • Zaher Kharboutly, Valérie Deplano, Eric Bertrand, Cécile Legallais. Numerical and experimental study of blood flow through a patient-specific arteriovenous fistula used for hemodialysis. Medical Engineering and Physics, Elsevier, 2010, 32, pp.111-118. ⟨10.1016/j.medengphy.2009.10.013⟩. ⟨hal-00429960⟩
  • A. Gautier, A. Ould-Dris, M. Dufresne, P. Paullier, B. von Harten, et al.. Hollow fiber bioartificial liver: Physical and biological characterization with C3A cells.. Journal of Membrane Science, Elsevier, 2009, 341 ((1-2)), pp.203-213. ⟨hal-00437709⟩
  • B. Carpentier, A. Gautier, C. Legallais. Artificial and bioartificial liver devices: present and future.. Gut, BMJ Publishing Group, 2009, 58 (12), pp.1690-1702. ⟨10.1136/gut.2008.175380⟩. ⟨hal-00437697⟩
  • A. Gautier, C. Legallais. Les dispositifs de suppléance hépatique.. Réanimation, Elsevier Masson, 2009, 18 (5), pp.413-419. ⟨hal-00437800⟩
  • H. Morel, M.Y. Jaffrin, P. Paullier, C. Legallais. In vitro tests and modelization of bicarbonate kinetics and mass transfers during online hemodiafiltration.. International Journal of Artificial Organs, Wichtig Editore, 2009, 32, pp.482-491. ⟨hal-00437233⟩
  • Sam Coward, Cécile Legallais, Bertrand David, Michael Thomas, Ying Foo, et al.. Alginate-encapsulated HepG2 Cells in a Fluidized Bed Bioreactor Maintain Function in Human Liver Failure Plasma. Artificial Organs, Wiley, 2009, 33 (12), pp.1117-1126. ⟨10.1111/j.1525-1594.2009.00821.x⟩. ⟨hal-02149842⟩
  • S. Demming, A. Gautier, C. Legallais, A. Ould-Dris. A. Solid–liquid mass transfers in an airlift reactor incorporating alginate beads for the application as a bioartificial liver.. Chemical Engineering and Processing: Process Intensification, Elsevier, 2008, 47, pp.2370-2378. ⟨hal-00336365⟩
  • C. Legallais, A. Gautier, M. Dufresne, B. Carpentier, R. Baudoin. The place of adsorption and biochromatography in extracorporeal liver support systems.. Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences, Elsevier, 2008, 961, pp.171-176. ⟨hal-00339871⟩
  • A. Kinasiewicz, A. Gautier, D. Lewinska, A. Smietanka, C. Legallais, et al.. hree-dimensional growth of human hepatoma C3A cells within alginate beads for fluidized bioartificial liver.. International Journal of Artificial Organs, Wichtig Editore, 2008, 31, pp.340 Â- 347. ⟨hal-00339867⟩
  • Z. Kharboutly, M. Fenech, J.M. Treutenaere, I. Claude, C. Legallais. Investigations into the relationship between hemodynamics and vascular alterations in an established arteriovenous fistula.. Medical Engineering and Physics, Elsevier, 2007, 29, pp.999-1007. ⟨hal-00282672⟩
  • S. Merlo, A. Donadey, B. Coevoet, C. Legallais. Générateurs d'hémodialyse : état du marché français.. ITBM RBM, Elsevier, 2007, 28, pp.150-168. ⟨hal-00282676⟩
  • A. Kinasiewicz, A. Gautier, D. Lewinska, J. Bukowski, C. Legallais, et al.. Culture of C3A Cells in Alginate Beads for Fluidized Bed Bioartificial Liver.. Transplantation Proceedings, Elsevier, 2007, 39, pp.2911-2913. ⟨hal-00282673⟩
  • R. Baudoin, Anne Corlu, L. Griscom, C. Legallais, E. Leclerc. Trends in the development of microfluidic cell biochips for in vitro hepatotoxicity.. Toxicol. In vitro, 2007, 21, pp.535-544. ⟨hal-00172268⟩
  • J.L. Dulong, C. Legallais. A theoretical study of oxygen transfer including cell necrosis for the design of a bioartificial pancreas.. Biotechnology and Bioengineering, Wiley, 2007, 96, pp.990-998. ⟨hal-00282668⟩
  • E. Leclerc, R. Baudoin, Anne Corlu, L. Griscom, J.L. Duval, et al.. Selective control of liver and kidney cells migration during organotypic cocultures inside fibronectin-coated rectangular silicone microchannels.. Biomaterials, Elsevier, 2007, 28, pp.1820-1829. ⟨hal-00172298⟩
  • R. Baudoin, L. Griscom, M. Monge, C. Legallais, E. Leclerc. Development of a renal microchip for in vitro distal tubule models.. Biotechnol. Prog, 2007, 23, pp.1245-1253. ⟨hal-00196149⟩
  • B. David, L. Barbe, C. Legallais, D. Barthès-Biesel. Mechanical properties of alginate beads hosting hepatocytes in a fluidized bed bioreactor.. International Journal of Artificial Organs, Wichtig Editore, 2006, 29, pp.756-763. ⟨hal-00090597⟩
  • E. Leclerc, A. Corlu, L. Griscom, R. Baudoin, C. Legallais. Guidance of liver and kidney organotypic cultures inside rectangular silicone microchannels.. Biomaterials, Elsevier, 2006, 27, pp.4109-4119. ⟨hal-00090178⟩
  • C David, L. Barbe, D. Barthès-Biesel, C. Legallais. Mechanical properties of alginate beads hosting hepatocytes in a fluidized bed bioreactor.. International Journal of Artificial Organs, Wichtig Editore, 2006, 29 (8), pp.756-63. ⟨hal-02149847⟩
  • Eric Leclerc, Bertrand David, Laurent Griscom, Bruno Lepioufle, Yasuyuki Sakai, et al.. Perfusion culture of mammalian cells in microfluidic environments for tissue engineering applications . La Houille Blanche - Revue internationale de l'eau, EDP Sciences, 2006, pp.56-59. ⟨10.1051/lhb:200603008⟩. ⟨hal-02149903⟩
  • E. Leclerc, B. David, L. Griscom, Bruno Le Pioufle, T. Fujii, et al.. Study of osteoblastic cells in a microfluidic environment. Biomaterials, Elsevier, 2006, 27 (4), pp.586-595. ⟨10.1016/j.biomaterials.2005.06.002⟩. ⟨hal-02149853⟩
  • E. Leclerc, B. David, L Griscom, Bruno Le Pioufle, T. Fujii, et al.. Study of Osteoblastic Cells in a Microfluidic Environment. Biomaterials, Elsevier, 2006, 27 (4), pp.558-595. ⟨hal-00778216⟩
  • E. Leclerc, B. David, L. Griscom, Bruno Le Pioufle, T. Fujii, et al.. Perfusion culture of mammalian cells in microfluidic environments for tissue engineering applications.. La Houille Blanche - Revue internationale de l'eau, EDP Sciences, 2006, 3, pp.56-59. ⟨hal-00090259⟩
  • J.L. Dulong, C. Legallais. What are the relevant parameters for the geometrical optimization of an implantable bioartificial pancreas ?. Journal of Biomechanical Engineering, American Society of Mechanical Engineers, 2005, 127, pp.1054-1061. ⟨hal-00017278⟩
  • B. David, M. M. Dufresne, M. Nagel, C. Legallais. In vitro assessment of encapsulated C3A hepatocytes functions in a fluidized bed bioreactor. Biotechnology Progress, Wiley, 2004, 20 (4), pp.1204-1212. ⟨10.1021/bp034301z⟩. ⟨hal-02149856⟩
  • C. Legallais, B David, E. Dore. Bioartificial livers (BAL): current technological aspects and future developments. Journal of Membrane Science, Elsevier, 2001, 181 (1), pp.81-95. ⟨10.1016/S0376-7388(00)00539-1⟩. ⟨hal-02149872⟩

Conference papers35 documents

  • Olivier Romain, Johan Mazeyrat, Patrick Garda, Hakeim Talleb, David Lautru, et al.. RFID implantable pressure sensor for the follow-up of abdominal aortic aneurysm stented. IEEE DTIS 2011 : 6th International conference on Design & Technology of Integrated Systems in nanoscale era, Apr 2011, Athens, Greece. pp.1-6, ⟨10.1109/DTIS.2011.5941418⟩. ⟨hal-00600948⟩
  • L. Choucha Snouber, Laurent Griscom, Pe Poleni, Florence Razan, Céline Brochot, et al.. Liver-kidney microfluidic bioreactor for cell co-culture in drug studies. MICROTAS, Oct 2010, GRONINGEN, Netherlands. pp.0328. ⟨hal-00756580⟩
  • Ph Detilleux, L Vallier, C Legallais, E Leclerc, M Prot J, et al.. Toxicologie predictive: les voies du futur. Congrès de la SPTC - Société de Pharmaco-Toxicologie Cellulaire, May 2010, Paris, France. ⟨hal-01122677⟩
  • R. Baudoin, J.M. Prot, C. Legallais, E. Leclerc. Microfluidic biochip for in vitro toxicity analysis. ESAO 2009, Sep 2009, Compiègne, France. ⟨hal-00456973⟩
  • J.M. Prot, R. Baudoin, L. Griscom, C. Legallais, E. Leclerc. Use of a liver biochip as a tool in toxicological study.. XXXVI Annual meeting European Society for Artificial Organs. ESAO 2009, Sep 2009, Compiègne, France. ⟨hal-00457136⟩
  • J.M. Prot, R. Baudoin, L. Griscom, C. Legallais, E. Leclerc. Comparison of the growth kinetics of hepatocarcinoma cells in a microfluidic bioreactor and Petri dishes. MMB 2009, Apr 2009, Québec, Canada. ⟨hal-00457134⟩
  • B. Carpentier, A. Gautier, P. Paullier, A. Ould-Dris, P. Layrolle, et al.. Flow and mass transfer modeling for tissue engineering applications.. 33ème Congrès de la Société de Biomécanique, Sep 2008, Compiègne, France. pp.53-55. ⟨hal-00345817⟩
  • H. Morel, M.Y. Jaffrin, C. Legallais, J. Vienken. In vitro bicarbonate and urea kinetics during hemodialysis and online hemodiafiltration.. 33ème Congrès de la Société de Biomécanique, Sep 2008, Compiègne, France. pp.167. ⟨hal-00344995⟩
  • H. Morel, M.Y. Jaffrin, J. Vienken, C. Legallais. Bicarbonate and urea kinetics modeling during hemodialysis and online postdilution hemodiafiltration.. ESAO 2008, XXXV Annual Meeting European Society for Artificial Organs, Sep 2008, Genève, Switzerland. pp.65. ⟨hal-00345030⟩
  • C. Legallais, A. Gautier, B. Carpentier, Q. Vu Dinh, M. Dufresne, et al.. Cell Micro-Encapsulation and Bioartificial Liver.. 8th World Biomaterials Congress, May 2008, Amsterdam, Netherlands. ⟨hal-00345819⟩
  • Zaher Kharboutly, Cécile Legallais, Valérie Deplano, Eric Bertrand. Modélisations numérique et expérimentale des écoulements sanguins dans une fistule artério veineuse. 8ème Colloque National en calcul des structures, May 2007, Giens, France. ⟨hal-00455960⟩
  • A. Gautier, H.D. Lemke, B. von Harten, M. Dufresne, C. Legallais. Bioartificial liver based on hollow fiber membrane : physical and biological characterization at micro scale level.. 34th ESAO Congress, Sep 2007, Krems, Austria. ⟨hal-00290030⟩
  • R. Baudoin, L. Griscom, A. Corlu, P. Layrolle, C. Legallais, et al.. Development of a cellular biochip mimicking in vitro organs for chronic toxicity analysis.. Transducers'07, 14th International Conference on Solid-State Sensors, actuators and Microsystems, Jun 2007, Lyon, France. ⟨hal-00289965⟩
  • A. Gautier, M. Dufresne, B. Carpentier, P. Paullier, C. Legallais. An example of bioartificial organ : combination of hepatocytes microencapsulation and fluidized bed technology for extracorporeal liver support.. International Congress on “Biochromatography and Nanobiotechnologies", Feb 2007, Vellore, India. ⟨hal-00289993⟩
  • A. Kinasiewicz, A. Gautier, D. Lewinska, M. Dufresne, A. Smietanka, et al.. Three dimensional growth of hepatic cells in alginate beads. Studies of beads optimization for fluidized bed bioreactor.. 34th ESAO Congress, Sep 2007, Krems, Austria. ⟨hal-00290051⟩
  • Zaher Kharboutly, Cécile Legallais, Valérie Deplano, Eric Bertrand. Modélisations numérique et expérimentale des écoulements sanguins dans une fistule artério-veineuse. 8e Colloque national en calcul des structures, CSMA, May 2007, Giens, France. ⟨hal-01507578⟩
  • Zaher Kharboutly, Cécile Legallais, Eric Bertrand, Valérie Deplano. Caractérisation des écoulements dans une fistule artério veineuse. Comparaison numérique expérimentale.. Journées scientifiques du GDR2760 : Interactions fluide structure biologiques, May 2007, Marseille, France. ⟨hal-00456057⟩
  • B. Carpentier, J. Sohier, P. Layrolle, C. Legallais. Production of bone substitutes in bioreactors : Modeling and culture of bone marrow stem cells.. 34th ESAO Congress, Sep 2007, Krems, Austria. ⟨hal-00289975⟩
  • Z. Kharboutly, J.M. Treutenaere, I. Claude, M. Fenech, C. Legallais. Validation des procédures de maillage pour l'étude des écoulements sanguins dans une fistule artério-veineuse réelle.. 18ème Congrès Français de Mécanique, Aug 2007, Grenoble, France. ⟨hal-00294651⟩
  • Z. Kharboutly, C. Legallais, V. Deplano, E. Bertrand. Modélisations numérique et expérimentale des écoulements sanguins dans une fistule artério-veineuse.. 8ème Colloque National en Calcul des Structures, May 2007, Giens, France. ⟨hal-00294647⟩
  • A. Gautier, B. Carpentier, M. Dufresne, P. Paullier, C. Legallais. Application of cells microencapsulation for bioartificial liver in fluidized bed bioreactor.. 14th International Workshop on Bioencapsulation, Oct 2006, Lausanne, Switzerland. ⟨hal-00118146⟩
  • R. Baudoin, L. Griscom, C. Legallais, E. Leclerc. Development of a renal microfluidic device for future in vitro kidney model reconstruction.. XXXIII ESAO Congress, Jun 2006, Umea, Sweden. ⟨hal-00116598⟩
  • R. Baudoin, L. Griscom, A. Corlu, C. Legallais, E. Leclerc. Development of a microfluidic devices for in vitro liver model.. 5th World Congress of Biomechanics, Jul 2006, Munich, Germany. ⟨hal-00116596⟩
  • A. Gautier, A. Kinasiewicz, B. Carpentier, D. Lewinska, P. Paullier, et al.. In vitro optimization of alginate bead production for hepatocytes encapsulation in the fluidized bed bioartificial liver.. 5th World Congress of Biomechanics, Jul 2006, Munich, Germany. ⟨hal-00118148⟩
  • R. Baudoin, L. Griscom, C. Legallais, E. Leclerc. PDMS microdevices as new supports for in vitro bioartificial organs.. XXXIII ESAO Congress, Jun 2006, Umea, Sweden. ⟨hal-00116600⟩
  • S. Coward, C. Legallais, A. Gautier, P. Paullier, M. Thomas, et al.. Human liver cells in a pilot-scale fluidised-bed bioreactor maintain performance in human liver failure plasma making them suitable for a bioartificial liver.. 5th World Congress of Biomechanics, Jul 2006, Munich, Germany. ⟨hal-00118127⟩
  • B. Carpentier, A. Gautier, P. Paullier, C. Legallais. Mass transfer studies in a model of fluidized bed bioartificial liver.. XXXIII ESAO Congress, Jun 2006, Umea, Sweden. ⟨hal-00118114⟩
  • Z. Kharboutly, J.M. Treutenaere, M. Fenech, T. Chambon, I. Claude, et al.. Numerical Simulation of Blood Flow in a side-to-end fistula for hemodialysis.. 5th World Congress of Biomechanics, Jul 2006, Munich, Germany. ⟨hal-00118280⟩
  • A. Kinasiewicz, A. Gautier, D. Lewinska, M. Dufresne, P. Paullier, et al.. Activity of cells within alginate beads produced for fluidized bed bioreactor (bioartificial liver).. XXIII ESAO Congress, Jun 2006, Umea, Sweden. ⟨hal-00118286⟩
  • E. Leclerc, A. Corlu, L. Griscom, R. Baudoin, C. Legallais. Liver organotypic chick embryo cultures on silicone microchannels.. ESB 20th European Conference on Biomaterials, Sep 2006, Nantes, France. ⟨hal-00118400⟩
  • E. Leclerc, L. Griscom, Bruno Le Pioufle, C. Guguen-Guillouzo, A. Corlu, et al.. Investigation of Human Hepatoma cell line microfluidic devices.. 3rd annual International IEEE EMBS special topic conference on microtechnologies in medicine and biology., 2005, Oahu, Hawaii, United States. ⟨hal-00019381⟩
  • Z. Kharboutly, M. Fenech, J.M. Treutenaere, I. Claude, C. Legallais. CFD modeling of unsteady blood flow in a arteriovenous fistula reconstructed from angioscanner.. 30ème Congrès de la Société de Biomécanique. In Computer Methods in Biomechanics and Biomedical Engineering, 8,, 2005, Bruxelles, Belgium. pp.161-162. ⟨hal-00019374⟩
  • R. Baudoin, A. Gautier, S.M. Coward, B. David, H.J.F. Hodgson, et al.. Hydrodynamic behaviour of several types of fluidized bed bioreactor used in a bioartificial liver.. XXXII ESAO Congress, 2005, Bologne, Italy. ⟨hal-00018719⟩
  • E. Leclerc, B. David, R. Warocquier-Clerout, L. Griscom, Bruno Le Pioufle, et al.. Behaviour of osteoblast-like cells in cellular microdevices. Micro Total Analysis Systems 2004, Vol 1, 2005, Netherlands. pp.396-398. ⟨hal-00795188⟩
  • Z. Kharboutly, M. Fenech, J.M. Treutenaere, I. Claude, C. Legallais. Blood flow simulation in an arteriovenous fistula.. XXth Congress International Society for Biomechanics, 2005, Cleveland, Ohio, United States. ⟨hal-00019375⟩

Book sections3 documents

  • Iolanda Decorato, Zaher Kharboutly, Cécile Legallais, Anne-Virginie Salsac. Hemodynamics inside autologous arteriovenous fistulas.. Medical Devices Design in Cardiovascular Applications., 2013. ⟨hal-02019796⟩
  • A. Gautier, B. Carpentier, C. Legallais. Microencapsulation d'hépatocytes pour le développement d'un système de suppléance hépatique.. Coord. Vandamme, Poncelet, Subra-Paternault. Microencapsulation : des sciences aux technologies, Lavoisier Editions Tec&Doc, pp.295-312, 2007. ⟨hal-00289971⟩
  • M.Y. Jaffrin, C. Legallais. Plasma Separation and Purification by Membrane. Encyclopedia of Biomedical Engineering, Wiley-Interscience, vol. 5, pp.2795-2804, 2006. ⟨hal-00096787⟩