Carlotta Figliola

**Education and professional experiences** In 2015 I obtained my Ph.D. with the thesis "\[Fe−Fe\]−Hydrogenase synthetic mimics based on peri−substituted dichalcogenides" on the synthesis and study of various analogues of the active site of the enzyme as catalysts for the proton reduction. In January 2015 I was employed as Postdoctoral Fellow in Dr. Alison Thompson group at Dalhousie Univesity in Halifax (Canada). During this staying my research involved the synthesis of mimics of the natural product “prodigiosin” as well as the design and the preparation of their bioconjugates to target specific cancers. I also worked on the synthesis of dipyrrins and BODIPYs and the development of new methodologies on pyrrole reactivity. In June 2017 I moved to Marseille (France), where, as Postdoctoral Fellow in the STéRéO group, I started to work both on the diastereoselective functionalization of enantiopure and bicyclic boranes and towards the synthesis of chiral diborene and boryl species. Following this experience I was employed in 2018 as a researcher at the ENS Lyon, where I worked on the synthesis of photosensitizers for photodynamic therapy, and in 2020 at the CEA in Paris Saclay, where I developped a new methodology for late stage C14-labelling of drugs candidate. In February 2021 I was appointed "Chargée de Recherche" in the group of "Chimie Organique pour les Matériaux, la Biologie et l'Optique" et the "Institut de Chimie et Procédés pour l'Energie, l'Environnement et la Santé" (ICPEES) in Strasbourg. **Research topic** Photodynamic therapy is a photochemistry−based treatment using light in combination with a photosensitizer (PS) and molecular oxygen in antimicrobial and anticancer therapy. PDT is underutilised in clinics and has not yet been considered as a standalone care due to the lack of international protocols and guidelines. In order to develop PS responding to specific clinical conditions, I propose the design and the preparation of new photosensitizers to reply to the current challenges linked to the PDT: light penetration depths, therapy efficiency and accuracy, selectivity and hypoxia.