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Carine Vergne-Vaxelaire

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Documents

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Publications

Adapting an acyl CoA ligase from Metallosphaera sedula for lactam formation by structure-guided protein engineering

Nikolas Capra , Chloé Lelièvre , Océane Touré , Aurélie Fossey-Jouenne , Carine Vergne-Vaxelaire
Frontiers in Catalysis, 2024, 4, ⟨10.3389/fctls.2024.1360129⟩
Article dans une revue hal-04489511v1
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Native amine dehydrogenases can catalyze the direct reduction of carbonyl compounds to alcohols in the absence of ammonia

Aurélie Fossey-Jouenne , Laurine Ducrot , Ewald Jongkind , Eddy Elisée , Anne Zaparucha
Frontiers in Catalysis, 2023, 3, pp.1105948. ⟨10.3389/fctls.2023.1105948⟩
Article dans une revue hal-04178006v1
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Expanding the substrate scope of native amine dehydrogenases through in silico structural exploration and targeted protein engineering

Laurine Ducrot , Megan Bennett , Gwenaëlle André-Leroux , Eddy Elisée , Sacha Marynberg
ChemCatChem, 2022, 2022, pp.e202200880. ⟨10.1002/cctc.202200880⟩
Article dans une revue cea-03781286v1

Synthesis of Chiral Amines via a Bi‐Enzymatic Cascade Using an Ene‐Reductase and Amine Dehydrogenase

Ewald Jongkind , Aurélie Fossey-Jouenne , Ombeline Mayol , Anne Zaparucha , Carine Vergne-Vaxelaire
ChemCatChem, 2022, 14 (2), ⟨10.1002/cctc.202101576⟩
Article dans une revue hal-04177991v1

Structure and Mutation of the Native Amine Dehydrogenase MATOUAmDH2

Megan Bennett , Laurine Ducrot , Carine Vergne‐vaxelaire , Gideon Grogan
ChemBioChem, 2022, 23 (10), ⟨10.1002/cbic.202200136⟩
Article dans une revue hal-04177998v1

Complete Genome Sequences of Two Pseudomonas Species Isolated from Marine Environments of the Pacific Ocean

Shi-Zhen Wang , Corinne Cruaud , Jean-Marc Aury , David Vallenet , Julie Poulain
Microbiology Resource Announcements, 2021, 10 (16), ⟨10.1128/mra.01062-19⟩
Article dans une revue hal-04178012v1

Biocatalytic Reductive Amination by Native Amine Dehydrogenases to Access Short Chiral Alkyl Amines and Amino Alcohols

Laurine Ducrot , Megan Bennett , Adam Caparco , Julie Champion , Andreas Bommarius
Frontiers in Catalysis, 2021, 1, ⟨10.3389/fctls.2021.781284⟩
Article dans une revue hal-04178002v1

Purification and Characterization of Nitphym, a Robust Thermostable Nitrilase From Paraburkholderia phymatum

Thomas Bessonnet , Aline Mariage , Jean-Louis Petit , Virginie Pellouin , Adrien Debard
Frontiers in Bioengineering and Biotechnology, 2021, 9, ⟨10.3389/fbioe.2021.686362⟩
Article dans une revue cea-03664095v1
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NAD(P)H‐dependent enzymes for reductive amination: active site description and carbonyl‐containing compound spectrum

Laurine Ducrot , Megan Bennett , Gideon Grogan , Carine Vergne-Vaxelaire
Advanced Synthesis and Catalysis, 2021, 363, pp.328-351. ⟨10.1002/adsc.202000870⟩
Article dans une revue hal-02945508v1

Metagenomic Mining for Amine Dehydrogenase Discovery

Adam Caparco , Eric Pelletier , Jean Louis Petit , Aurélie Jouenne , Bettina Bommarius
Advanced Synthesis and Catalysis, 2020, 362 (12), pp.2427-2436. ⟨10.1002/adsc.202000094⟩
Article dans une revue hal-04150129v1
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A family of native amine dehydrogenases for the asymmetric reductive amination of ketones

Ombeline Mayol , Karine Bastard , Lilian Beloti , Amina Frese , Johan P Turkenburg
Nature Catalysis, 2019, 2 (4), pp.324-333. ⟨10.1038/s41929-019-0249-z⟩
Article dans une revue hal-02945525v1

ATP Regeneration System in Chemoenzymatic Amide Bond Formation with Thermophilic CoA Ligase

Chloé Lelièvre , Mélanie Balandras , Jean‐louis Petit , Carine Vergne-Vaxelaire , Anne Zaparucha
ChemCatChem, 2019, 12 (4), pp.1184-1189. ⟨10.1002/cctc.201901870⟩
Article dans une revue hal-04167114v1
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XszenFHal, a novel tryptophan 5-halogenase from Xenorhabdus szentirmaii

Jérémy Domergue , Diane Erdmann , Aurélie Fossey-Jouenne , Jean-Louis Petit , Adrien Debard
AMB Express, 2019, 9 (1), pp.175. ⟨10.1186/s13568-019-0898-y⟩
Article dans une revue pasteur-03026562v1

XszenFHal, a novel tryptophan 5-halogenase from Xenorhabdus szentirmaii

Jérémy Domergue , Diane Erdmann , Aurélie Fossey-Jouenne , Jean-Louis Petit , Adrien Debard
AMB Express, 2019, 9 (1), pp.175. ⟨10.1186/s13568-019-0898-y⟩
Article dans une revue hal-04166372v1

Achiral Hydroxypyruvaldehyde Phosphate as a Platform for Multi-Aldolases Cascade Synthesis of Diuloses and for a Quadruple Acetaldehyde Addition Catalyzed by 2-Deoxyribose-5-Phosphate Aldolases

Victor Laurent , Virgil Hélaine , Carine Vergne-Vaxelaire , Lionel Nauton , Mounir Traïkia
ACS Catalysis, 2019, 9 (10), pp.9508-9512. ⟨10.1021/acscatal.9b02668⟩
Article dans une revue hal-02329545v1

Enzymatic cascade reactions for the synthesis of chiral amino alcohols from L-lysine

Aurélie Fossey-Jouenne , Carine Vergne-Vaxelaire , Anne Zaparucha
Journal of visualized experiments : JoVE, 2018, 132, pp.e56926. ⟨10.3791/56926⟩
Article dans une revue cea-04311404v1
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Characterization of a thermotolerant ROK-type mannofructokinase from Streptococcus mitis: application to the synthesis of phosphorylated sugars

Carine Vergne-Vaxelaire , Aline Mariage , Jean-Louis Petit , Aurélie Fossey-Jouenne , Christine Guérard-Hélaine
Applied Microbiology and Biotechnology, 2018, 102 (13), pp.5569-5583. ⟨10.1007/s00253-018-9018-1⟩
Article dans une revue hal-02323767v1

Biocatalytic Approaches towards the Synthesis of Chiral Amino Alcohols from Lysine: Cascade Reactions Combining alpha-Keto Acid Oxygenase Hydroxylation with Pyridoxal Phosphate- Dependent Decarboxylation

Damien Baud , Olivier Peruch , Pierre-Loïc Saaidi , Aurélie Fossey , Aline Mariage
Advanced Synthesis & Catalysis, 2017, 359 (9), pp.1563-1569. ⟨10.1002/adsc.201600934⟩
Article dans une revue hal-04167194v1

Parallel evolution of non-homologous isofunctional enzymes in methionine biosynthesis

Karine Bastard , Alain Perret , Aline Mariage , Thomas Bessonnet , Agnès Pinet-Turpault
Nature Chemical Biology, 2017, 13, pp.858-866. ⟨10.1038/nchembio.2397⟩
Article dans une revue cea-02132779v1

Asymmetric reductive amination by a wild-type amine dehydrogenase from the thermophilic bacteria Petrotoga mobilis

Ombeline Mayol , Sylvain David , Ekaterina Darii , Adrien Debard , Aline Mariage
Catalysis Science & Technology, 2016, 6 (20), pp.7421-7428. ⟨10.1039/C6CY01625A⟩
Article dans une revue hal-04177990v1

Revealing the hidden functional diversity of an enzyme family

Karine Bastard , Adam Alexander Thil Smith , Carine Vergne-Vaxelaire , Alain Perret , Anne Zaparucha
Nature Chemical Biology, 2014, 10 (1), pp.42-49. ⟨10.1038/nchembio.1387⟩
Article dans une revue hal-02504067v1

Large α-aminonitrilase activity screening of nitrilase superfamily members: Access to conversion and enantiospecificity by LC–MS

Franck Bordier , Mark Stam , Ekaterina Darii , Sabine Tricot , Aurélie Fossey
Journal of Molecular Catalysis B: Enzymatic, 2014, 107, pp.79-88. ⟨10.1016/j.molcatb.2014.05.019⟩
Article dans une revue hal-02504052v1

Nitrilase Activity Screening on Structurally Diverse Substrates: Providing Biocatalytic Tools for Organic Synthesis

Carine Vergne-Vaxelaire , Franck Bordier , Aurélie Fossey , Marielle Besnard-Gonnet , Adrien Debard
Advanced Synthesis and Catalysis, 2013, 355 (9), pp.1763-1779. ⟨10.1002/adsc.201201098⟩
Article dans une revue hal-02503873v1

3-Keto-5-aminohexanoate cleavage enzyme: a common fold for an uncommon Claisen-type condensation

Marco Bellinzoni , Karine Bastard , Alain Perret , Anne Zaparucha , Nadia Perchat
Journal of Biological Chemistry, 2011, 286 (31), pp.27399-27405. ⟨10.1074/jbc.M111.253260⟩
Article dans une revue pasteur-03137933v1
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Anodic Oxidation: An Attractive Alternative to CAN-Mediated Cleavage of para -Methoxyphenyl Ethers

Carine Vaxelaire , Florence Souquet , Marie-Isabelle Lannou , Janick Ardisson , Jacques Royer
European Journal of Organic Chemistry, 2009, 2009 (19), pp.3138-3140. ⟨10.1002/ejoc.200900262⟩
Article dans une revue hal-02371104v1

A Conserved Gene Cluster Rules Anaerobic Oxidative Degradation of L-Ornithine

Nuria Fonknechten , A. Perret , N. Perchat , S. Tricot , C. Lechaplais
Journal of Bacteriology, 2009, 191 (9), pp.3162-3167. ⟨10.1128/JB.01777-08⟩
Article dans une revue hal-02503069v1
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Comparison of the biocatalytic performances of immobilized nitrilase in milli-scale reactors for continuous production of nicotinic acid

Maïté Michaud , Zoe Anxionnaz-Minvielle , Véronique de Berardinis , Guillaume Nonglaton , Anne Zaparucha
BIOTRANS - 16th International Symposium on Biocatalysis & Biotransformations, Jun 2023, La Rochelle, France
Communication dans un congrès cea-04431030v1
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Milli-structured bioreactor with immobilized commercial nitrilase for continuous production of nicotinic acid

Maïté Michaud , Carine Vergne-Vaxelaire , Véronique de Berardinis , Anne Zaparucha , Guillaume Nonglaton
EPIC 8 - 8th European Process Intensification Conference, May 2023, Varsovie, Poland
Communication dans un congrès cea-04431033v1

Diverse Amine dehydrogenases for the biocatalytic synthesis of amines

Carine Vergne-Vaxelaire , Eddy Elisée , Laurine Ducrot , Ombeline Mayol , Raphael Meheust
ENZYNOV'2, Oct 2023, Paris-Romainville, France
Communication dans un congrès hal-04327765v1
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Immobilized nitrilase in continuous bioreactors: packed bed reactor vs. milli-structured pillar reactor

Maïté Michaud , Carine Vergne-Vaxelaire , Véronique de Berardinis , Anne Zaparucha , Guillaume Nonglaton
ECCEECAB 2023 - 14th European Congress of Chemical Engineering and 7th European Congress of Applied Biotechnology, Sep 2023, Berlin, Germany
Communication dans un congrès cea-04431029v1

Expanding the portfolio of enzymes for biocatalysis by extensive biodiversity screening

Carine Vergne-Vaxelaire , Eddy Elisée , Laurine Ducrot , Raphael Meheust , Mark Stam
6e Symposium International de l'AFERP, Jul 2023, Orsay - Paris, France
Communication dans un congrès hal-04327790v1

Expanding the portfolio of native Amine Dehydrogenases by extensive biodiversity screening

Carine Vergne-Vaxelaire , Eddy Elisée , Laurine Ducrot , Raphael Meheust , Mark Stam
BioTrans 2023, Jun 2023, La Rochelle, France
Communication dans un congrès hal-04327737v1

Metagenomic expansion and active site analysis of the Amine Dehydrogenase family

Elisée Eddy , Laurine Ducrot , Raphaël Méheust , Mark Stam , Pelletier Eric
International Congress on Biocatalysis 2022, Aug 2022, Hamburg, Germany
Communication dans un congrès hal-04360123v1

Expanding the portfolio of native Amine Dehydrogenases by extensive biodiversity screening

Carine Vergne-Vaxelaire , Eddy Elisée , Laurine Ducrot , Raphael Meheust , Mark Stam
Amine BioCat 5.0, Nov 2022, Groningen, Netherlands
Communication dans un congrès hal-04328280v1

MODAMDH: identification of diverse Amine Dehydrogenases by screening biodiversity using sequence and structure-based approaches

Elisée Eddy , Laurine Ducrot , Raphaël Méheust , Karine Bastard , Aurélie Fossey-Jouenne
29th Conference on Intelligent Systems for Molecular Biology (ISMB) - 20th European Conference on Computational Biology (ECCB), Jul 2021, Virtual conference, United States
Communication dans un congrès hal-04359840v1

Expanding the substrate scope of Amine Dehydrogenases by protein engineering

Carine Vergne-Vaxelaire , Megan Bennett , Laurine Ducrot , Eddy Elisée , Anne Zaparucha
BioTrans 2021, Jul 2021, Graz (virtual conference), Austria
Communication dans un congrès hal-04328324v1

An overview of the native amine dehydrogenase family : discovery, structural and genomic exploration, protein engineering and biocatalytic applications

Carine Vergne-Vaxelaire , Laurine Ducrot , Megan Bennett , Eddy Elisée , Karine Bastard
28e colloque du Club de Biocatalyse en Synthèse Organique, Arkema; Proteus; CBSO, Sep 2021, Lège Cap-Ferret, France
Communication dans un congrès hal-04328296v1

Large scale exploration of the biocatalytic capability of biodiversity for biocatalysis & synthetic biology applications

Véronique de Berardinis , Jean-Louis Petit , Carine Vergne-Vaxelaire , David Vallenet , Anne Zaparucha
First International symposium on High-Throughput Catalysts Design, Jun 2021, Virtual conference (Lille), France
Communication dans un congrès hal-04315412v1

MODAMDH: identification of diverse Amine Dehydrogenases by screening biodiversity using innovative in silico approaches

Eddy Elisée , Raphael Meheust , Laurine Ducrot , Mark Stam , Eric Pelletier
International Symposium on High-Throughput Catalyst Design, Jun 2021, Lille (Virtual), France
Communication dans un congrès hal-04328578v1

Metagenomic mining for Amine Dehydrogenase discovery

Carine Vergne-Vaxelaire , Adam Caparco , Eric Pelletier , Jean-Louis Petit , Aurélie Fossey-Jouenne
Amine Biocatalysis 4.0, Feb 2020, Stuttgart, Germany
Communication dans un congrès hal-04327878v1

Exploring biodiversity for biocatalyst discovery: applications to synthetic chemistry and synthetic biology

Véronique de Berardinis , Anne Zaparucha , David Vallenet , Carine Vergne , Jean-Louis Petit
GMGM Open Scientific day & IPCB Inauguration, May 2019, Strabourg, France
Communication dans un congrès hal-04315453v1

Enzymatic cascade synthesis of chiral building-blocks from L-lysine

Anne Zaparucha , Raphael Dubois , Olivier Peruch , Damien Baud , Pierre-Loic Saaidi
Multiple Enzyme Cascade Processes Congress, Mar 2018, Trondheim ( Norvège), Norway
Communication dans un congrès hal-04303639v1

A family of Native Amine Dehydrogenases for the Asymmetric Reductive Amination of Ketones

Carine Vergne-Vaxelaire , Ombeline Mayol , Karine Bastard , Lilian Beloti , Amina Frese
Novel Enzymes 2018, Technische Universitat Darmstadt, Oct 2018, Damstadt, Germany
Communication dans un congrès hal-04328306v1

Enzymatic cascades for the synthesis of amino alcohols

Anne Zaparucha , Damien Baud , Olivier Peruch , Pierre-Loic Saaidi , Aurélie Fossey
BIOTRANS, Jul 2017, Budapest (Hungary), Hungary
Communication dans un congrès hal-04303631v1

Large nitrilase activity screening on structurally diverse substrates: providing new biocatalytic tools for organic synthesis

Anne Zaparucha , Carine Vergne-Vaxelaire , Franck Bordier , Ekaterina Darii , Aurélie Fossey
BIOTRANS, Jul 2013, Manchester (UK), United Kingdom
Communication dans un congrès hal-04303622v1

DEVELOPMENT OF A BIOLOGICAL CHASSIS FOR AMINE SYNTHESIS

Josemarco Mendoza-Avila , Volker Döring , Madeleine Bouzon , Louis M.M. Mouterde , Tanja Knaus
BioTrans 2023, Jun 2023, La Rochelle, France
Poster de conférence hal-04328913v1

An integrative bioinformatics approach to explore the biodiversity of enzyme families

Elisée Eddy , Mark Stam , Raphaël Méheust , Carine Vergne-Vaxelaire , David Vallenet
Journées Ouvertes en Biologie, Informatique et Mathématiques (JOBIM) 2022, Jul 2022, Rennes, France
Poster de conférence hal-04360074v1

Metagenomic expansion and active site analysis of the Amine Dehydrogenase family

Elisée Eddy , Laurine Ducrot , Raphaël Méheust , Mark Stam , Pelletier Eric
International Congress on Biocatalysis 2022, Aug 2022, Hamburg, Germany
Poster de conférence hal-04360138v1

Development of a biological chassis for amine synthesis

Josemarco Mendoza-Avila , Volker Döring , Madeleine Bouzon , Louis M.M. Mouterde , Tanja Knaus
Amine BioCat 5.0, Nov 2022, Groningen, Netherlands
Poster de conférence hal-04328699v1

One-pot bi-enzymatic cascade with an Old Yellow Enzyme and a native amine dehydrogenase to synthesize chiral amines

Ewald Jongkind , Aurélie Fossey-Jouenne , Ombeline Mayol , Anne Zaparucha , Carine Vergne-Vaxelaire
BioTrans 2021, Jul 2021, Graz (virtual conference), Austria
Poster de conférence hal-04328842v1

MODAMDH: identification of diverse Amine Dehydrogenases by screening biodiversity using sequence and structure-based approaches

Elisée Eddy , Laurine Ducrot , Raphaël Méheust , Karine Bastard , Aurélie Fossey-Jouenne
29th Conference on Intelligent Systems for Molecular Biology (ISMB) - 20th European Conference on Computational Biology (ECCB), Jul 2021, Virtual conference, United States
Poster de conférence hal-04359878v1

MODAMDH: identification of diverse Amine Dehydrogenases by screening biodiversity using sequence and structure-based approaches

Elisée Eddy , Laurine Ducrot , Raphaël Méheust , Karine Bastard , Aurélie Fossey-Jouenne
BioTrans 2021, Jul 2021, Graz (Virtual Conference), Austria
Poster de conférence hal-04360034v1

Smart ATP regeneration system for chemoenzymatic amide bond formation

Chloé M. Lelièvre , Mélanie Balandras , Adrien Debard , Virginie Pellouin , Jean-Louis Petit
14th Biotrans symposium, Jul 2019, Groningen, Netherlands
Poster de conférence hal-04354478v1

Chapter 1. Genome Mining for Enzyme Discovery

Anne Zaparucha , Véronique de Berardinis , Carine Vaxelaire-Vergne
Modern Biocatalysis, Royal Society of Chemistry, pp.1-27, 2018, Catalysis Series, ⟨10.1039/9781788010450-00001⟩
Chapitre d'ouvrage hal-04150687v1