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Crystal structures ofLymphocytic choriomeningitis virusendonuclease domain complexed with diketo-acid ligands

Magali Saez-Ayala , Elsie Yekwa , Mauro Carcelli , Bruno Canard , Karine Alvarez , et al.
International Union of Crystallography journal, 2018, 5 (1), pp.223 - 235. ⟨10.1107/s2052252518001021⟩
Article dans une revue hal-03078366v1

Gln151 of HIV-1 reverse transcriptase acts as a steric gate towards clinically relevant acyclic phosphonate nucleotide analogues.

Antoine Frangeul , Cécile Bussetta , Jérôme Deval , Karine Barral , Karine Alvarez , et al.
Antiviral Therapy, 2019, 13 (1), pp.115-24
Article dans une revue hal-02061712v1

In Vitro Suppression of K65R Reverse Transcriptase-Mediated Tenofovir- and Adefovir-5'-Diphosphate Resistance Conferred by the Boranophosphonate Derivatives

A. Frangeul , Karine Barral , K. Alvarez , B. Canard
Antimicrobial Agents and Chemotherapy, 2007, 51 (9), pp.3162-3167. ⟨10.1128/AAC.00145-07⟩
Article dans une revue hal-02061675v1

Substrate selectivity of Dengue and Zika virus NS5 polymerase towards 2′-modified nucleotide analogues

Supanee Potisopon , Francois Ferron , Véronique Fattorini , Barbara Selisko , Bruno Canard
Antiviral Research, 2017, 140, pp.25 - 36. ⟨10.1016/j.antiviral.2016.12.021⟩
Article dans une revue hal-01802946v1

SPINE bioinformatics and data-management aspects of high-throughput structural biology.

S. Albeck , Pedro Maria Alzari , C. Andreini , L. Banci , I. M. Berry , et al.
Acta crystallographica Section D : Structural biology [1993-..], 2006, 62 (Pt 10), pp.1184-95. ⟨10.1107/S090744490602991X⟩
Article dans une revue hal-00187834v1

Synthesis and Anti-BVDV Activity of Acridones As New Potential Antiviral Agents 1

Oriana Tabarrini , Giuseppe Manfroni , Arnaldo Fravolini , Violetta Cecchetti , Stefano Sabatini , et al.
Journal of Medicinal Chemistry, 2006, 49 (8), pp.2621-2627. ⟨10.1021/jm051250z⟩
Article dans une revue istex hal-02459231v1

Biodiversity as a source of potent and selective inhibitors of Chikungunya virus replication

Pieter Leyssen , Jacqueline Smadja , Philippe Rasoanaivo , Ameenah Gurib-Fakim , Mohamad Fawzi-Mahomoodally , et al.
Gurib-Fakim, A. Novel Plant Bioresources, Applications in Food, Medicine and Cosmetics,, John Wiley & Sons, Ltd, Chichester UK., pp.151-160, 2014, 978-1-118-46061-0. ⟨10.1002/9781118460566.ch11⟩
Chapitre d'ouvrage hal-01163238v1

The Imidazopyrrolopyridine Analogue AG110 Is a Novel, Highly Selective Inhibitor of Pestiviruses That Targets the Viral RNA-Dependent RNA Polymerase at a Hot Spot for Inhibition of Viral Replication

Jan Paeshuyse , Jean-Michel Chezal , Matheus Froeyen , Pieter Leyssen , Hélène Dutartre , et al.
Journal of Virology, 2007, 81 (20), pp.11046-11053. ⟨10.1128/JVI.00388-07⟩
Article dans une revue hal-02459217v1

Structural Analysis of the Activation of Ribavirin Analogs by NDP Kinase: Comparison with Other Ribavirin Targets

Sarah Gallois-Montbrun , Yuxing Chen , Hélène Dutartre , Magali Sophys , Solange Moréra , et al.
Molecular Pharmacology, 2003, 63 (3), pp.538-546. ⟨10.1124/mol.63.3.538⟩
Article dans une revue hal-02459258v1
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The viral capping enzyme nsP1: a novel target for the inhibition of chikungunya virus infection

L. Delang , C. Li , A. Tas , G. Querat , I. C. Albulescu , et al.
Scientific Reports, 2016, 6, pp.31819. ⟨10.1038/srep31819⟩
Article dans une revue hal-01439113v1

Alkylated flavanones from the bark of Cryptocarya chartacea as dengue virus NS5 polymerase inhibitors.

Pierre-Marie Allard , Elise Tran Huu Dau , Cécilia Eydoux , Jean-Claude Guillemot , Vincent Dumontet , et al.
Journal of Natural Products, 2011, 74 (11), pp.2446-53. ⟨10.1021/np200715v⟩
Article dans une revue hal-00684627v1

Autolysis of Clostridium acetobutylicum ATCC 824

Christian Croux , B. Canard , G. Goma , Philippe Soucaille
Journal of general microbiology, 1992, 138, pp.861-869
Article dans une revue hal-02712998v1
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The enzymes for genome size increase and maintenance of large (+)RNA viruses

Francois Ferron , Bhawna Sama , Etienne Decroly , Bruno Canard
Trends in Biochemical Sciences, 2021, ⟨10.1016/j.tibs.2021.05.006⟩
Article dans une revue hal-03345450v1

Structure and Sequence Requirements for RNA Capping at the Venezuelan Equine Encephalitis Virus RNA 5′ End

Oney Ortega Granda , Coralie Valle , Ashleigh Shannon , Etienne Decroly , Bruno Canard , et al.
Journal of Virology, 2021, 95 (15), ⟨10.1128/JVI.00777-21⟩
Article dans une revue hal-03426112v1
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A high-throughput fluorescence polarization assay to discover inhibitors of arenavirus and coronavirus exoribonucleases

Sergio Hernández , Mikael Feracci , Carolina Trajano de Jesus , Priscila El-Kazzi , Rafik Kaci , et al.
2022
Pré-publication, Document de travail hal-03660938v1
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The Curious Case of the Nidovirus Exoribonuclease: Its Role in RNA Synthesis and Replication Fidelity

Natacha S Ogando , Francois Ferron , Etienne Decroly , Bruno Canard , Clara C Posthuma , et al.
Frontiers in Microbiology, 2019, 10, ⟨10.3389/fmicb.2019.01813⟩
Article dans une revue hal-02353805v1

General Catalytic Deficiency of Hepatitis C Virus RNA Polymerase with an S282T Mutation and Mutually Exclusive Resistance towards 2'-Modified Nucleotide Analogues

Hélène Dutartre , Cécile Bussetta , Joëlle Boretto , Bruno Canard
Antimicrobial Agents and Chemotherapy, 2006, 50 (12), pp.4161-4169. ⟨10.1128/AAC.00433-06⟩
Article dans une revue hal-02459219v1
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Crystal Structure of the RNA Polymerase Domain of the West Nile Virus Non-structural Protein 5

Hélène Malet , Marie-Pierre Egloff , Barbara Selisko , Rebecca E Butcher , Peter J Wright , et al.
Journal of Biological Chemistry, 2007, ⟨10.1074/jbc.M607273200⟩
Article dans une revue hal-03160533v1

Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position.

D. Topalis , K. Alvarez , K. Barral , Hélène Munier-Lehmann , B. Schneider , et al.
Nucleosides, Nucleotides and Nucleic Acids, 2008, 27 (4), pp.319-31. ⟨10.1080/15257770801941952⟩
Article dans une revue pasteur-00316017v1

Preparation of purine and pyrimidine acyclic nucleotide analogs as antiviral agents

Karine Barral , Bruno Canard , Karine Alvarez , Jean-Louis Romette , Johan Neyts , et al.
France, Patent n° : WO 2007-IB4233. 2007
Brevet hal-02063281v1

A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase

Jan Paeshuyse , Carine Letellier , Matheus Froeyen , Hélène Dutartre , Robert Vrancken , et al.
Antiviral Research, 2009, 82 (3), pp.141-147. ⟨10.1016/j.antiviral.2009.02.192⟩
Article dans une revue istex hal-02459207v1
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Conformational plasticity of the VEEV macro domain is important for binding of ADP-ribose

Garyfallia Makrynitsa , Dioni Ntonti , Konstantinos Marousis , Maria Birkou , Minos-Timotheos Matsoukas , et al.
Journal of Structural Biology, 2019, 206 (1), pp.119-127. ⟨10.1016/j.jsb.2019.02.008⟩
Article dans une revue inserm-02416973v1

The Crystal Structures of Chikungunya and Venezuelan Equine Encephalitis Virus nsP3 Macro Domains Define a Conserved Adenosine Binding Pocket

H. Malet , B. Coutard , S. Jamal , H. Dutartre , N. Papageorgiou , et al.
Journal of Virology, 2009, 83 (13), pp.6534-6545. ⟨10.1128/JVI.00189-09⟩
Article dans une revue hal-02459209v1
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A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase

Ashleigh Shannon , Véronique Fattorini , Bhawna Sama , Barbara Selisko , Mikael Feracci , et al.
Nature Communications, 2022, 13, ⟨10.1038/s41467-022-28113-1⟩
Article dans une revue hal-03572811v1
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Combining Antivirals and Immunomodulators to Fight COVID-19

Vincent Feuillet , Bruno Canard , Alain Trautmann
Trends in Immunology, 2021, 42 (1), pp.31-44. ⟨10.1016/j.it.2020.11.003⟩
Article dans une revue hal-03375353v1
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The WHO mission report struggles to trace the origins of the SARS-CoV-2 epidemic

Etienne Decroly , Jean-Michel Claverie , Bruno Canard
Virologie, In press, pp.1-7
Article dans une revue hal-03204818v1
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An appeal for an objective, open, and transparent scientific debate about the origin of SARS-CoV-2

Jacques van Helden , Colin Butler , Guillaume Achaz , Bruno Canard , Didier Casane , et al.
The Lancet, 2021, 398 (10309), pp.1402-1404. ⟨10.1016/S0140-6736(21)02019-5⟩
Article dans une revue hal-03358748v1

Protein-primed RNA synthesis in SARS-CoVs and structural basis for inhibition by AT-527

Ashleigh Shannon , Véronique Fattorini , Bhawna Sama , Barbara Selisko , Mikael Feracci , et al.
2023
Pré-publication, Document de travail hal-04061889v1

A Relaxed Discrimination of 2′- O -Methyl-GTP Relative to GTP between de Novo and Elongative RNA Synthesis by the Hepatitis C RNA-dependent RNA Polymerase NS5B

Hélène Dutartre , Joëlle Boretto , Jean Claude Guillemot , Bruno Canard
Journal of Biological Chemistry, 2005, 280 (8), pp.6359-6368. ⟨10.1074/jbc.M410191200⟩
Article dans une revue hal-02459254v1

Phylogenetic analysis of the pathogenic anaerobe Clostridium perfringens using the 16S rRNA nucleotide sequence.

Bruno Canard , Thierry Garnier , Bénédicte Lafay , Richard Christen , Stewart T. Cole
International Journal of Systematic Bacteriology, 1992, 42 (2), pp.312-4. ⟨10.1099/00207713-42-2-312⟩
Article dans une revue hal-00412941v1