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Using the structural diversity of RNA: protein interfaces to selectively target RNA with small molecules in cells: methods and perspectives

Aixiao Li , Ahmed Bouhss , Marie-Jeanne Clément , Cyril Bauvais , J. Paul Taylor , et al.
Frontiers in Molecular Biosciences, 2023, 10, ⟨10.3389/fmolb.2023.1298441⟩
Article dans une revue hal-04485882v1

5'-Methylene-triazole-substituted-aminoribosyl uridines as MraY inhibitors: synthesis, biological evaluation and molecular modeling.

Mickaël J Fer , Ahmed Bouhss , Mariana Patrão , Laurent Le Corre , Nicolas Pietrancosta , et al.
Organic & Biomolecular Chemistry, 2015, 13 (26), pp.7193-222. ⟨10.1039/c5ob00707k⟩
Article dans une revue hal-01433063v1
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Lin28, a major translation reprogramming factor, gains access to YB-1-packaged mRNA through its cold-shock domain

Anastasiia Samsonova , Krystel El Hage , Bénédicte Desforges , Vandana Joshi , Marie-Jeanne Clément , et al.
Communications Biology, 2021, 4 (1), pp.359. ⟨10.1038/s42003-021-01862-3⟩
Article dans une revue hal-03176308v1

Characterization of colicin M and its orthologs targeting bacterial cell wall peptidoglycan biosynthesis.

Hélène Barreteau , Meriem El Ghachi , Aurélie Barnéoud-Arnoulet , Emmanuelle Sacco , Thierry Touzé , et al.
Microb. Drug Resist., 2012, 18 (3), pp.222--9. ⟨10.1089/mdr.2011.0230⟩
Article dans une revue hal-01458251v1
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A Sub-Micromolar MraYAA Inhibitor with an Aminoribosyl Uridine Structure and a (S,S)-Tartaric Diamide: Synthesis, Biological Evaluation and Molecular Modeling

Martin Oliver , Laurent Le Corre , Mélanie Poinsot , Michaël Bosco , Hongwei Wan , et al.
Molecules, 2022, 27 (6), pp.1769. ⟨10.3390/molecules27061769⟩
Article dans une revue hal-03632451v1

Specific Interactions of Clausin, a New Lantibiotic, with Lipid Precursors of the Bacterial Cell Wall

Ahmed Bouhss , Bayan Al-Dabbagh , Michel Vincent , Benoît Odaert , Magali Aumont-Nicaise , et al.
Biophysical Journal, 2009, 97 (5), pp.1390-1397. ⟨10.1016/j.bpj.2009.06.029⟩
Article dans une revue hal-00697279v1

X-Ray Structure and Site-Directed Mutagenesis Analysis of the Escherichia coli Colicin M Immunity Protein

Fabien Gérard , Mark A Brooks , Hélène Barreteau , Thierry Touzé , Marc Graille , et al.
Journal of Bacteriology, 2011, 193, pp.205 - 214. ⟨10.1128/jb.01119-10⟩
Article dans une revue hal-03298538v1
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Synthesis of lipid-carbohydrate-peptidyl-RNA conjugates to explore the limits imposed by the substrate specificity of cell wall enzymes on the acquisition of drug resistance

Matthieu Fonvielle , Ahmed Bouhss , Coralie Hoareau , Delphine Patin , Dominique Mengin-Lecreulx , et al.
Chemistry - A European Journal, 2018, 24 (56), pp.14911-14915. ⟨10.1002/chem.201802360⟩
Article dans une revue hal-01962025v1
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YB-1, an abundant core mRNA-binding protein, has the capacity to form an RNA nucleoprotein filament: a structural analysis

Dmitry Kretov , Marie-Jeanne Clément , Guillaume Lambert , Dominique Durand , Dmitry Lyabin , et al.
Nucleic Acids Research, 2019, 47 (6), pp.3127-3141. ⟨10.1093/nar/gky1303⟩
Article dans une revue hal-02114790v1

Colicin M, a peptidoglycan lipid-II-degrading enzyme: potential use for antibacterial means?

Thierry Touzé , Hélène Barreteau , Meriem El Ghachi , Ahmed Bouhss , Aurélie Barnéoud-Arnoulet , et al.
Biochem. Soc. Trans., 2012, 40 (6), pp.1522--7. ⟨10.1042/BST20120189⟩
Article dans une revue hal-01458253v1
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Microtubules as platforms for probing liquid–liquid phase separation in cells – application to RNA-binding proteins

Alexandre Maucuer , Bénédicte Desforges , Vandana Joshi , Mirela Boca , Dmitry Kretov , et al.
Journal of Cell Science, 2018, 131 (11), pp.jcs214692. ⟨10.1242/jcs.214692⟩
Article dans une revue hal-02166855v1
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YB-1 unwinds mRNA secondary structures in vitro and negatively regulates stress granule assembly in HeLa cells

Karina Budkina , Krystel El Hage , Marie-Jeanne Clément , Bénédicte Desforges , Ahmed Bouhss , et al.
Nucleic Acids Research, 2021, 49 (17), pp.10061-10081. ⟨10.1093/nar/gkab748⟩
Article dans une revue hal-03333572v1
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Targeting RNA:protein interactions with an integrative approach leads to the identification of potent YBX1 inhibitors

Krystel El Hage , Nicolas Babault , Olek Maciejak , Bénédicte Desforges , Pierrick Craveur , et al.
eLife, 2023, 12, pp.e80387. ⟨10.7554/eLife.80387⟩
Article dans une revue hal-03955052v1
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The cooperative binding of TDP-43 to GU-rich RNA repeats antagonizes TDP-43 aggregation

Juan Carlos Rengifo-Gonzalez , Krystel El Hage , Marie-Jeanne Clément , Emilie Steiner , Vandana Joshi , et al.
eLife, 2021, 10, pp.e.67605. ⟨10.7554/eLife.67605⟩
Article dans une revue hal-03343496v1
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Synthesis, biological evaluation and molecular modeling of urea-containing MraY inhibitors

Martin Oliver , Laurent Le Corre , Mélanie Poinsot , Alessandra Corio , Léa Madegard , et al.
Organic & Biomolecular Chemistry, 2021, 19 (26), pp.5844-5866. ⟨10.1039/D1OB00710F⟩
Article dans une revue hal-03432617v1

Nanoscale Analysis Reveals the Maturation of Neurodegeneration-Associated Protein Aggregates

Sanae Abrakhi , Dmitry Kretov , Bénédicte Desforges , Ioana Dobra , Ahmed Bouhss , et al.
ACS Nano, 2017, 11 (7), pp.7189-7200. ⟨10.1021/acsnano.7b03071⟩
Article dans une revue hal-02173623v1

Deciphering the Catalytic Domain of Colicin M, a Peptidoglycan Lipid II-degrading Enzyme

Hélène Barreteau , Ahmed Bouhss , Fabien Gérard , Denis Duché , Boubekeur Boussaid , et al.
Journal of Biological Chemistry, 2010, 285 (16), pp.12378-12389. ⟨10.1074/jbc.M109.093583⟩
Article dans une revue hal-02893839v1
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FUS RRM regulates poly(ADP-ribose) levels after transcriptional arrest and PARP-1 activation on DNA damage

Evgeniya Mamontova , Marie-Jeanne Clément , Maria Sukhanova , Vandana Joshi , Ahmed Bouhss , et al.
Cell Reports, 2023, 42 (10), pp.113199. ⟨10.1016/j.celrep.2023.113199⟩
Article dans une revue hal-04231448v1

Catalytic mechanism of MraY and WecA, two paralogues of the polyprenyl-phosphate N-acetylhexosamine 1-phosphate transferase superfamily.

Bayan Al-Dabbagh , Samir Olatunji , Muriel Crouvoisier , Meriem El Ghachi , Didier Blanot , et al.
Biochimie, 2016, 127, pp.249-57. ⟨10.1016/j.biochi.2016.06.005⟩
Article dans une revue hal-01441817v1

FtsW activity and lipid II synthesis are required for recruitment of MurJ to midcell during cell division in Escherichia coli

Xiaolong Liu , Nils Meiresonne , Ahmed Bouhss , Tanneke den Blaauwen
Molecular Microbiology, 2018, 109 (6), pp.865-884. ⟨10.1111/mmi.14104⟩
Article dans une revue hal-02160441v1

Membrane Topology and Biochemical Characterization of the Escherichia coli BacA Undecaprenyl-Pyrophosphate Phosphatase.

Guillaume Manat , Meriem El Ghachi , Rodolphe Auger , Karima Baouche , Samir Olatunji , et al.
PLoS ONE, 2015, 10 (11), pp.e0142870. ⟨10.1371/journal.pone.0142870⟩
Article dans une revue hal-01429857v1

Synthesis and biological evaluation of potential new inhibitors of the bacterial transferase MraY with a β-ketophosphonate structure

Nicolas Auberger , Rok Frlan , Bayan Al-Dabbagh , Ahmed Bouhss , Muriel Crouvoisier , et al.
Organic & Biomolecular Chemistry, 2011, 9 (24), pp.8301. ⟨10.1039/c1ob06124k⟩
Article dans une revue hal-02188360v1
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PARP-1 Activation Directs FUS to DNA Damage Sites to Form PARG-Reversible Compartments Enriched in Damaged DNA

Anastasia Singatulina , Loic Hamon , Maria Sukhanova , Bénédicte Desforges , Vandana Joshi , et al.
Cell Reports, 2019, 27 (6), pp.1809-1821. ⟨10.1016/j.celrep.2019.04.031⟩
Article dans une revue hal-02167709v1

Structural characterization by nuclear magnetic resonance spectroscopy of a genetically engineered high-affinity calmodulin-binding peptide derived from Bordetella pertussis adenylate cyclase.

Hélène Munier , A. Bouhss , A. M. Gilles , Nicolae Palibroda , O. Bârzu , et al.
Archives of Biochemistry and Biophysics, 1995, 320 (2), pp.224-35. ⟨10.1016/0003-9861(95)90004-7⟩
Article dans une revue istex pasteur-00167088v1

Conformational transitions within the calmodulin-binding site of Bordetella pertussis adenylate cyclase studied by time-resolved fluorescence of Trp242 and circular dichroism.

Ahmed Bouhss , Michel Vincent , Hélène Munier , Anne-Marie Gilles , Masayuchi Takahashi , et al.
European Journal of Biochemistry, 1996, 237 (3), pp.619-28. ⟨10.1111/j.1432-1033.1996.0619p.x⟩
Article dans une revue pasteur-00167087v1
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CbrA mediates colicin M resistance in Escherichia coli through modification of undecaprenyl-phosphate-linked peptidoglycan precursors

Hélène Barreteau , Delphine Patin , Ahmed Bouhss , Didier Blanot , Dominique Mengin-Lecreulx , et al.
Journal of Bacteriology, 2020, 202 (23), ⟨10.1128/JB.00436-20⟩
Article dans une revue hal-02968370v1

Structural flexibility of the calmodulin-binding locus in Bordetella pertussis adenylate cyclase. Reconstitution of catalytically active species from fragments or inactive forms of the enzyme.

Hélène Munier , Ahmed Bouhss , A. M. Gilles , Evelyne Krin , Philippe Glaser , et al.
European Journal of Biochemistry, 1993, 217 (2), pp.581-6. ⟨10.1111/j.1432-1033.1993.tb18280.x⟩
Article dans une revue pasteur-00167090v1

Cooperative phenomena in binding and activation of Bordetella pertussis adenylate cyclase by calmodulin.

Ahmed Bouhss , Evelyne Krin , Hélène Munier , Anne-Marie Gilles , Antoine Danchin , et al.
Journal of Biological Chemistry, 1993, 268 (3), pp.1690-4
Article dans une revue pasteur-00167092v1

Bacterial Transferase MraY, a Source of Inspiration towards New Antibiotics

Mickaël Fer , Laurent Le Corre , Nicolas Pietrancosta , Nathalie Evrard-Todeschi , Samir Olatunji , et al.
Current Medicinal Chemistry, 2018, 25 (42), pp.6013-6029. ⟨10.2174/0929867325666180330095154⟩
Article dans une revue hal-02364241v1
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Squalamine and Aminosterol Mimics Inhibit the Peptidoglycan Glycosyltransferase Activity of PBP1b

Adrien Boes , Jean-Michel Brunel , Adeline Derouaux , Frederic Kerff , Ahmed Bouhss , et al.
Antibiotics, 2020, 9 (7), pp.373. ⟨10.3390/antibiotics9070373⟩
Article dans une revue hal-03085034v1